Detailed information for compound 176393

Basic information

Technical information
  • TDR Targets ID: 176393
  • Name: N-[9-[4-(methanesulfonamido)anilino]acridin-3 -yl]propanamide
  • MW: 434.511 | Formula: C23H22N4O3S
  • H donors: 3 H acceptors: 4 LogP: 3.68 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)Nc1ccc2c(c1)nc1c(c2Nc2ccc(cc2)NS(=O)(=O)C)cccc1
  • InChi: 1S/C23H22N4O3S/c1-3-22(28)24-17-12-13-19-21(14-17)26-20-7-5-4-6-18(20)23(19)25-15-8-10-16(11-9-15)27-31(2,29)30/h4-14,27H,3H2,1-2H3,(H,24,28)(H,25,26)
  • InChiKey: JLDRJBKWKCCLSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[9-[4-(methanesulfonamido)anilino]-3-acridinyl]propanamide
  • N-[9-[[4-(methylsulfonylamino)phenyl]amino]acridin-3-yl]propanamide
  • N-[9-[4-(methanesulfonamido)anilino]acridin-3-yl]propionamide
  • N-[9-[(4-methanesulfonamidophenyl)amino]acridin-3-yl]propanamide
  • N-[9-[(4-methanesulfonamidophenyl)amino]-3-acridinyl]propanamide
  • N-[9-[(4-methanesulfonamidophenyl)amino]acridin-3-yl]propionamide
  • 59988-06-6
  • Methanesulfonanilide, 4'-(3-propionamido-9-acridinylamino)-
  • N-(p-(9-(3-Propionamidoacridinyl)amino)phenyl)methanesulfonamide
  • BRN 4030147

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0688 0.1205 0.1205
Loa Loa (eye worm) hypothetical protein 0.1124 0.2001 0.199
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0356 0.0602 0.0602
Echinococcus multilocularis fk506 binding protein 0.0063 0.0067 0.0054
Entamoeba histolytica hypothetical protein 0.0356 0.0602 0.0574
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.018 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.3264 0.5897 0.5897
Trichomonas vaginalis PIKK family atypical protein kinase 0.148 0.2649 0.2649
Trypanosoma brucei rac serine-threonine kinase, putative 0.0067 0.0075 0.0007
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0028 0.0015
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0356 0.0602 0.0602
Toxoplasma gondii FATC domain-containing protein 0.1043 0.1854 0.2428
Echinococcus multilocularis nervana 2 0.0041 0.0028 0.0015
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0356 0.0602 0.0589
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0602 0.0574
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0356 0.0602 0.0589
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.185 0.3323 0.3323
Trichomonas vaginalis PIKK family atypical protein kinase 0.5517 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0356 0.0602 0.0602
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0356 0.0602 0.0726
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0356 0.0602 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0356 0.0602 0.0574
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.471 0.8531 0.8531
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0356 0.0602 0.0574
Loa Loa (eye worm) hypothetical protein 0.0807 0.1422 0.1411
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.4388 0.7944 0.7944
Trichomonas vaginalis PIKK family atypical protein kinase 0.1043 0.1854 0.1854
Mycobacterium leprae conserved hypothetical protein 0.0356 0.0602 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5378 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.4103 0.7426 0.7426
Giardia lamblia Hypothetical protein 0.0356 0.0602 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5378 0.5378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1043 0.1854 0.1843
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5517 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0356 0.0602 0.0589
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0063 0.0067 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.4103 0.7426 0.7426
Leishmania major phosphatidylinositol kinase related protein, putative 0.0356 0.0602 0.0538
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0063 0.0067 0.0038
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0356 0.0602 0.0589
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0037 0.0023
Giardia lamblia Phosphatidylinositol 4-kinase 0.0356 0.0602 0.0574
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0063 0.0067 0.0054
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.0602 0.0589
Plasmodium vivax hypothetical protein, conserved 0.0356 0.0602 1
Loa Loa (eye worm) hypothetical protein 0.0688 0.1205 0.1194
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0807 0.1422 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.3297 0.5957 0.5957
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0356 0.0602 0.0574
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0602 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.3264 0.5897 0.5897
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0075 0.0075
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.0602 0.0589
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0063 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.0356 0.0602 0.0574
Echinococcus multilocularis Zinc finger, PHD finger 0.0356 0.0602 0.0589
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.2975 0.537 0.537
Trichomonas vaginalis PIKK family atypical protein kinase 0.185 0.3323 0.3323
Leishmania major phosphatidylinositol 3-related kinase, putative 0.185 0.3323 0.3277
Schistosoma mansoni immunophilin 0.0063 0.0067 0.0054
Entamoeba histolytica protein kinase rad3, putative 0.1043 0.1854 0.183
Schistosoma mansoni immunophilin 0.0063 0.0067 0.0054
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0356 0.0602 0.0589
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0114 0.0161 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.0602 0.0602
Echinococcus granulosus serine/threonine protein kinase 0.0046 0.0037 0.0023
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0063 0.0067 0.0669
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0063 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.1163 0.2071 0.206
Trypanosoma cruzi Protein kinase B 0.0046 0.0037 0.0008
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0356 0.0602 1
Trichomonas vaginalis conserved hypothetical protein 0.0807 0.1422 0.1422
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1043 0.1854 0.1843
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0063 0.0067 0.0067
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5517 1 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1043 0.1854 0.183
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0356 0.0602 0.0574
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.185 0.3323 0.3303
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.185 0.3323 0.3303
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0356 0.0602 0.0589
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1043 0.1854 0.1798
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5517 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0602 0.0538
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0356 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.2975 0.537 0.537
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0356 0.0602 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3297 0.5957 0.5957
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0063 0.0067 0.0054
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0075 0.0075
Trypanosoma cruzi target of rapamycin kinase 3 0.4393 0.7953 0.7947
Echinococcus granulosus serine protein kinase ATM 0.1043 0.1854 0.1843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.1205 0.1205
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0356 0.0602 1
Onchocerca volvulus 0.0356 0.0602 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0356 0.0602 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0356 0.0602 0.0602
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0063 0.0067 0.0038
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0356 0.0602 0.0538
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5517 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5517 1 1
Entamoeba histolytica protein kinase, putative 0.0067 0.0075 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0356 0.0602 0.0574
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4393 0.7953 0.7939
Loa Loa (eye worm) AGC/AKT protein kinase 0.0067 0.0075 0.0062
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1043 0.1854 0.183
Loa Loa (eye worm) hypothetical protein 0.0054 0.0052 0.0038
Schistosoma mansoni immunophilin 0.0054 0.0052 0.0038
Toxoplasma gondii target of rapamycin (TOR), putative 0.4103 0.7426 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0574
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0106 0.0147 0.0147
Echinococcus granulosus nervana 2 0.0041 0.0028 0.0015
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0356 0.0602 0.0726
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.018 0.0166
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0356 0.0602 0.0574
Leishmania major phosphatidylinositol kinase, putative 0.0356 0.0602 0.0538
Entamoeba histolytica protein kinase, putative 0.0067 0.0075 0.0046
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.5517 1 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0028 0.0015
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0356 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.185 0.3323 0.3323
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0356 0.0602 0.0574
Entamoeba histolytica hypothetical protein 0.0356 0.0602 0.0574
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0356 0.0602 0.0574
Echinococcus multilocularis serine protein kinase ATM 0.1043 0.1854 0.1843
Loa Loa (eye worm) phosphatidylinositol kinase 0.0356 0.0602 0.0589
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0037 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0602 0.0589
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0028 0.0015
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5517 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2292 0.4126 0.4086
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0356 0.0602 0.0538
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0067 0.0038
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0356 0.0602 0.0726
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.185 0.3323 0.3314
Leishmania major hypothetical protein, unknown function 0.0356 0.0602 0.0538
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0067 0.0038
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0688 0.1205 0.118
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0356 0.0602 0.0602
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5517 1 1
Entamoeba histolytica protein kinase, putative 0.0063 0.0067 0.0038
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.185 0.3323 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.3582 0.6475 0.6475
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0602 0.0589
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0063 0.0067 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0114 0.0161 0.0147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0602 0.0589
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.0029 0.0016
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.185 0.3323 0.3314
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0356 0.0602 0.0589
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0356 0.0602 0.0726
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0063 0.0067 0.5
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5517 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0063 0.0067 0.0054
Leishmania major phosphatidylinositol 3-kinase, putative 0.185 0.3323 0.3277
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.0602 0.0589
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0037 0.0023
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5517 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4388 0.7944 0.7944
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.0602 0.0589
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2609 0.4705 0.4669
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0356 0.0602 0.0589
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0063 0.0067 0.0669
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0063 0.0067 0.0054
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.0029 0.0016
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.1043 0.1854 0.1854
Trichomonas vaginalis PIKK family atypical protein kinase 0.185 0.3323 0.3323
Echinococcus multilocularis rac serine:threonine kinase 0.0046 0.0037 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5378 0.5378
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0356 0.0602 0.0602
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1043 0.1854 0.1843
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0356 0.0602 0.0589
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0538
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0356 0.0602 0.0602
Plasmodium vivax hypothetical protein 0.0356 0.0602 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5517 1 1
Loa Loa (eye worm) hypothetical protein 0.0356 0.0602 0.0589
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0356 0.0602 0.0589
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0037 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0075 0.0075
Entamoeba histolytica hypothetical protein 0.0356 0.0602 0.0574
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0356 0.0602 0.0602
Leishmania major hypothetical protein, conserved 0.0356 0.0602 0.0538
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1043 0.1854 0.1843
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0356 0.0602 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.4388 0.7944 0.7944
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1043 0.1854 0.183
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0052 0.0038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0602 0.0589
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4393 0.7953 0.7939
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0356 0.0602 0.0574
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0114 0.0161 0.0147
Echinococcus multilocularis nervana 2 0.0041 0.0028 0.0015
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.185 0.3323 0.3277
Trichomonas vaginalis PIKK family atypical protein kinase 0.3297 0.5957 0.5957
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0114 0.0161 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.0602 0.0602
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5517 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0356 0.0602 0.0602
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0356 0.0602 0.0589
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0356 0.0602 0.0726
Loa Loa (eye worm) phosphatidylinositol 3 0.5517 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0063 0.0067 0.0038
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0037 0.0008
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.0602 0.0589
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.185 0.3323 0.3314
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0063 0.0067 0.0054
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0356 0.0602 0.0589
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0063 0.0067 0.0054
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.0029 0.0016
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.185 0.3323 0.3277
Trichomonas vaginalis PIKK family atypical protein kinase 0.4388 0.7944 0.7944
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.185 0.3323 0.3323
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0356 0.0602 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0602 0.0589
Loa Loa (eye worm) hypothetical protein 0.0356 0.0602 0.0589
Schistosoma mansoni hypothetical protein 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.4103 0.7426 0.7426
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0054 0.0052 0.0038
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.4103 0.7426 0.7426
Trichomonas vaginalis PIKK family atypical protein kinase 0.4103 0.7426 0.7426
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0356 0.0602 0.0574
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0063 0.0067 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.1163 0.2071 0.2071
Giardia lamblia GTOR 0.5517 1 1
Loa Loa (eye worm) FKBP5 protein 0.0063 0.0067 0.0054
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0574
Trichomonas vaginalis fk506-binding protein, putative 0.0063 0.0067 0.0067
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0356 0.0602 0.0589
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0063 0.0067 0.0038
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0574
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0356 0.0602 0.0602
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0075 0.0075
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5517 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0807 0.1422 0.1411
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0356 0.0602 0.0589
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0028 0.0015
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1163 0.2071 0.2723
Loa Loa (eye worm) hypothetical protein 0.1043 0.1854 0.1843
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0574
Mycobacterium tuberculosis Conserved hypothetical protein 0.0356 0.0602 0.5
Leishmania major phosphatidylinositol 4-kinase, putative 0.0356 0.0602 0.0538
Brugia malayi FAT domain containing protein 0.0807 0.1422 0.1411
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0106 0.0147 0.0147
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.3701 0.6692 0.6692
Trichomonas vaginalis PIKK family atypical protein kinase 0.4103 0.7426 0.7426
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0356 0.0602 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.4103 0.7426 0.7426
Schistosoma mansoni fkbp-rapamycin associated protein 0.1043 0.1854 0.1843
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0356 0.0602 0.0589
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0356 0.0602 0.0602
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1043 0.1854 0.1843
Trichomonas vaginalis immunophilin, putative 0.0063 0.0067 0.0067
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0356 0.0602 0.0589
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0075 0.0075
Onchocerca volvulus 0.0356 0.0602 0.5
Leishmania major phosphatidylinositol 3-kinase, putative 0.0356 0.0602 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.2975 0.537 0.537
Trichomonas vaginalis PIKK family atypical protein kinase 0.2979 0.5378 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.4388 0.7944 0.7944
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0356 0.0602 0.0574
Loa Loa (eye worm) hypothetical protein 0.0099 0.0133 0.012
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0356 0.0602 0.0574
Loa Loa (eye worm) phosphatidylinositol 3 0.185 0.3323 0.3314
Entamoeba histolytica hypothetical protein 0.1043 0.1854 0.183
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0356 0.0602 0.0589
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0063 0.0067 0.0038
Echinococcus multilocularis 0.0356 0.0602 0.0589
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0807 0.1422 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.1043 0.1854 0.1854
Brugia malayi Protein kinase domain containing protein 0.0067 0.0075 0.0062
Echinococcus granulosus nervana 2 0.0041 0.0028 0.0015
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0356 0.0602 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0063 0.0067 0.0054

Activities

Activity type Activity value Assay description Source Reference
LD10 (ADMET) = 55 mg kg-1 Toxicity in ip dosed C3H/DBA2F1 hybrid mouse allografted with mouse L1210 cells administered for 5 days measured up to 8 days ChEMBL. 660586
Log 1/D50 (functional) = 4.47 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 3.99 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706
pKa = 7.35 Ionization constant (pKa) ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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