Detailed information for compound 1774703

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.464 | Formula: C20H21N3O3S
  • H donors: 1 H acceptors: 3 LogP: 2.56 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)N1CCN([C@H](C1)C)S(=O)(=O)c1c[nH]c2c1cccc2
  • InChi: 1S/C20H21N3O3S/c1-15-14-22(20(24)16-7-3-2-4-8-16)11-12-23(15)27(25,26)19-13-21-18-10-6-5-9-17(18)19/h2-10,13,15,21H,11-12,14H2,1H3/t15-/m0/s1
  • InChiKey: XZADTAXOFGSUFI-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.006 0.0135
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0047 0.0069
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0166 0.1647
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.018 0.0348
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.3559 1
Brugia malayi SRC-1 0.0045 0.0474 0.1468
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.018 0.0982
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.018 0.0504
Schistosoma mansoni hypothetical protein 0.0435 0.5169 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.1454
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.006 0.0111
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.1008 0.1008
Entamoeba histolytica glycogenphosphorylase, putative 0.0054 0.0579 0.1627
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.2365
Schistosoma mansoni tyrosine kinase 0.001 0.0044 0.0084
Loa Loa (eye worm) hypothetical protein 0.0141 0.1622 0.5234
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0219 0.0597
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0219 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0497 0.0961
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0125 0.0242
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0115
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0458 0.4548
Plasmodium falciparum phosphodiesterase delta, putative 0.0011 0.006 0.1454
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.002 0.0039
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0458 0.4548
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0313 0.1937
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.006 0.006
Echinococcus granulosus cpg binding protein 0.0032 0.0318 0.0615
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Brugia malayi Probable ATP-dependent helicase DHX35 0.0167 0.1946 0.6293
Schistosoma mansoni growth factor receptor-bound protein 0.0008 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0115
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0011 0.006 0.2365
Brugia malayi hypothetical protein 0.001 0.0047 0.0069
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0166 0.6539
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.006 0.2365
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.006 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Onchocerca volvulus 0.001 0.0047 0.0027
Chlamydia trachomatis serine/threonine protein kinase 0.0214 0.251 1
Brugia malayi Serine/threonine-protein kinase Nek7 0.0214 0.251 0.8145
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0047 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.0142
Echinococcus granulosus geminin 0.018 0.21 0.4062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0125 0.0125
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0426 0.0426
Echinococcus granulosus insulin receptor 0.0261 0.3076 0.595
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.1056
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.018 0.0348
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0047 0.0069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.018 0.0348
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.006 0.2365
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0961 0.0961
Entamoeba histolytica glycogen phosphorylase, putative 0.0125 0.1433 0.4026
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0219 0.2177
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0063 0.246
Brugia malayi carbohydrate phosphorylase 0.0125 0.1433 0.4612
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.006 0.0135
Onchocerca volvulus 0.001 0.0047 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.0142
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.0214 0.251 0.8145
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0047 0.0047
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0011 0.006 0.2745
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1702 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.018 0.0504
Brugia malayi tailless protein 0.001 0.0047 0.0069
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0166 0.6521
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.018 0.0348
Echinococcus multilocularis caspase 2 0.0032 0.0313 0.0313
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0474 0.0917
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.018 0.018
Echinococcus multilocularis glycogen phosphorylase 0.0125 0.1433 0.1433
Schistosoma mansoni tyrosine kinase 0.0115 0.1317 0.2548
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0125 0.4915
Loa Loa (eye worm) SRC-1 0.0045 0.0474 0.1468
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.018 0.0982
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.002 0.0039
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0414 0.1012
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Schistosoma mansoni thyroid hormone receptor 0.0021 0.018 0.0348
Brugia malayi nuclear receptor NHR-67 0.001 0.0047 0.0069
Entamoeba histolytica hypothetical protein 0.0024 0.0219 0.0616
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.006 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.018 0.0504
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0166 0.6521
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.006 0.006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0166 0.0458
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.009 0.1008 0.2708
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0166 0.6521
Entamoeba histolytica glycogen phosphorylase, putative 0.0054 0.0579 0.1627
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0125 0.4915
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.018 0.0348
Echinococcus granulosus caspase 2 0.0032 0.0313 0.0605
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.018 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.018 0.0504
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Loa Loa (eye worm) TK/INSR protein kinase 0.0261 0.3076 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Loa Loa (eye worm) DR-78 0.001 0.0047 0.0069
Leishmania major hypothetical protein, conserved 0.0011 0.006 0.2745
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.1056
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0047 0.0092
Brugia malayi steroid hormone receptor 0.0021 0.018 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.006 0.0135
Loa Loa (eye worm) TK protein kinase 0.0037 0.0376 0.1148
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0011 0.006 0.2365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Loa Loa (eye worm) hypothetical protein 0.0086 0.0961 0.3067
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0361 0.0361
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0011 0.006 0.2365
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0255 0.2526
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.1454
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0297 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.006 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.018 0.0504
Brugia malayi nuclear hormone receptor 0.001 0.0047 0.0069
Trichomonas vaginalis glycogen phosphorylase, putative 0.0125 0.1433 0.4006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.009 0.1008 1
Echinococcus granulosus glycogen phosphorylase 0.0125 0.1433 0.2772
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Schistosoma mansoni zinc finger protein 0.001 0.0047 0.0092
Entamoeba histolytica protein kinase, putative 0.0037 0.0376 0.1058
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.018 0.0348
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0255 0.0492
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi nuclear hormone receptor 0.0021 0.018 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.1008 0.1949
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0063 0.0176
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0062 0.0119
Schistosoma mansoni growth factor receptor-bound protein 0.0008 0.0026 0.0051
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0876 0.1695
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.006 0.2365
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0062 0.0119
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0047 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.006 0.2365
Schistosoma mansoni tyrosine kinase 0.0014 0.0092 0.0177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0125 0.0242
Echinococcus multilocularis geminin 0.018 0.21 0.21
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0115
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0497 0.1543
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Entamoeba histolytica glycogen phosphorylase, putative 0.0125 0.1433 0.4026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0115
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.006 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.018 0.0504
Brugia malayi Protein kinase domain containing protein 0.001 0.0044 0.0056
Schistosoma mansoni tyrosine kinase 0.0115 0.1317 0.2548
Brugia malayi Protein kinase domain containing protein 0.001 0.0044 0.0056
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.006 0.0116
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.006 0.0111
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Loa Loa (eye worm) TK/ABL protein kinase 0.001 0.0044 0.0056
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0166 0.0321
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.018 0.0348
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.006 0.0116
Echinococcus granulosus c src tyrosine kinase 0.0014 0.0092 0.0177
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0166 0.0466
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0219 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Echinococcus granulosus Glycosyl transferase family 35 0.0125 0.1433 0.2772
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0255 0.0748
Schistosoma mansoni tyrosine kinase 0.0045 0.0474 0.0917
Schistosoma mansoni tyrosine kinase 0.0261 0.3076 0.595
Onchocerca volvulus Glycogen phosphorylase homolog 0.0125 0.1433 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0115
Schistosoma mansoni nuclear hormone receptor 0.0021 0.018 0.0348
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.018 0.0504
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0474 0.0474
Echinococcus multilocularis Glycosyl transferase, family 35 0.0125 0.1433 0.1433
Schistosoma mansoni hypothetical protein 0.0009 0.0032 0.0062
Loa Loa (eye worm) acetyltransferase 0.015 0.1729 0.5583
Echinococcus granulosus apoptotic protease activating factor 1 0.0032 0.0313 0.0605
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0047 0.0047
Schistosoma mansoni glycogen phosphorylase 0.0054 0.0579 0.112
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.001 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.0142
Brugia malayi nuclear receptor RXR 0.0011 0.0062 0.0115
Echinococcus multilocularis c src tyrosine kinase 0.0014 0.0092 0.0092
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0125 0.1631
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0497 0.0497
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0458 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0166 0.0321
Echinococcus granulosus tyrosine protein kinase Srms 0.001 0.0044 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0599
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0047 0.0069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0063 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Brugia malayi follicle stimulating hormone receptor 0.0239 0.2805 0.9113
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0047 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0017 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.018 0.0504
Schistosoma mansoni nuclear receptor 0.001 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Giardia lamblia Glycogen phosphorylase 0.0125 0.1433 0.3923
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0047 0.0047
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0209 0.8208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0497 0.0961
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0961 0.3067
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0497 0.0961
Schistosoma mansoni tyrosine kinase 0.0115 0.1317 0.2548
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0474 0.0474
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0166 0.6521
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.018 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.018 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Brugia malayi hypothetical protein 0.001 0.0044 0.0056
Brugia malayi Cell death protein 3 precursor 0.0032 0.0313 0.0939
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.006 0.0116
Brugia malayi isocitrate dehydrogenase 0.0016 0.0125 0.0324
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Loa Loa (eye worm) PDE1B protein 0.0011 0.006 0.0111
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi FAT domain containing protein 0.0009 0.0032 0.0019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0426 0.0426
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0376 0.0727
Brugia malayi Protein kinase domain containing protein 0.001 0.0044 0.0056
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.1729 0.3345
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0078 0.0185
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.006 0.2365
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Schistosoma mansoni nuclear receptor 0.001 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0939
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0219 0.3997
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.1008 0.1008
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0063 0.0176
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0047 0.0069
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Echinococcus multilocularis NCK adaptor protein 0.0008 0.0026 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.018 0.0504
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0125 0.3021
Schistosoma mansoni hypothetical protein 0.018 0.21 0.4062
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Entamoeba histolytica SH2-protein kinase domain containing protein 0.001 0.0044 0.0122
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0426 0.0824
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0961 0.186
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0313 0.0605
Echinococcus multilocularis glycogen phosphorylase 0.0125 0.1433 0.1433
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.1008 0.1949
Loa Loa (eye worm) hypothetical protein 0.009 0.1008 0.3218
Schistosoma mansoni tyrosine kinase 0.001 0.0044 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.006 0.2365
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.1056
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0474 0.0917
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.3559 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0011 0.006 0.2365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.0142
Onchocerca volvulus 0.0086 0.0961 0.6607
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.006 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.018 0.0504
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.006 0.0135
Echinococcus granulosus tyrosine kinase 0.001 0.0044 0.0084
Echinococcus granulosus epidermal growth factor receptor 0.0121 0.1382 0.2674
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0255 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0219 0.8616
Onchocerca volvulus 0.0032 0.0313 0.1937
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0054 0.0579 0.2879
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0062 0.0119
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0078 0.0773
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0497 0.0961
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0961 0.186
Brugia malayi Nuclear hormone receptor E75 0.001 0.0047 0.0069
Schistosoma mansoni hypothetical protein 0.0025 0.0232 0.0449
Echinococcus multilocularis insulin receptor 0.0261 0.3076 0.3076
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Echinococcus granulosus NCK adaptor protein 0.0008 0.0026 0.0051
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0426 0.0426
Leishmania major hypothetical protein, conserved 0.0011 0.006 0.2745
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0056
Onchocerca volvulus 0.0021 0.018 0.0982
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0119
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.2805 0.9113
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.006 0.2365
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0063 0.0063
Loa Loa (eye worm) TK/EGFR protein kinase 0.0121 0.1382 0.4447
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.018 0.018
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.006 0.0116
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0062 0.0115
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0009 0.0032 0.0032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.002 0.002
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3559 1
Schistosoma mansoni tyrosine kinase 0.0121 0.1382 0.2674
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0474 0.0917
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0047 0.0092
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0474 0.0474
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0414 0.1164
Schistosoma mansoni cpg binding protein 0.0031 0.0297 0.0574
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi hypothetical protein 0.0037 0.0376 0.1146
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0458 0.1258
Brugia malayi Nuclear hormone receptor E75 0.001 0.0047 0.0069
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.5169 0.5169
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0166 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0019
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.006 0.0111
Schistosoma mansoni cpg binding protein 0.0032 0.0318 0.0615
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Schistosoma mansoni thyroid hormone receptor 0.0021 0.018 0.0348
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0125 0.0324
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.018 0.0348
Schistosoma mansoni glycogen phosphorylase 0.0125 0.1433 0.2772
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.006 0.2365
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0043
Brugia malayi Protein kinase domain containing protein 0.001 0.0044 0.0056
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0426 0.0824
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0474 0.0917
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.1008 0.1949
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.006 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.006 0.0111
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0166 0.0321
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.006 0.0111
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.018 0.0348
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.006 0.0116
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0125 0.5705
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.048 0.0928
Schistosoma mansoni tyrosine kinase 0.0121 0.1382 0.2674
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0166 0.6521
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0219 0.2177
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.006 0.2365
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.1729 0.1729
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.018 0.018
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0125 0.0125
Schistosoma mansoni tyrosine kinase 0.0121 0.1382 0.2674
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.1729 0.5583
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0125 0.1242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0255 0.0683
Brugia malayi nuclear receptor NHR-88 0.001 0.0047 0.0069
Echinococcus multilocularis tyrosine protein kinase Abl 0.0014 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Schistosoma mansoni hypothetical protein 0.0032 0.0313 0.0605
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0166 0.7569
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.018 0.0348
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.0142
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.006 0.0116
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0063 0.0121
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0166 0.6521
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0166 0.0321
Echinococcus multilocularis apoptotic protease activating factor 1 0.0032 0.0313 0.0313
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.006 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0376 0.0376
Brugia malayi ecdysteroid receptor 0.0021 0.018 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.018 0.0504
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0125 0.4915
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0414 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.018 0.0504
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0876 0.0876
Loa Loa (eye worm) DEAH box polypeptide 35 0.0167 0.1946 0.6293
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.018 0.0504
Echinococcus multilocularis 0.0034 0.0335 0.0335
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0083
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0166 0.6521
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0042 0.0082
Brugia malayi hypothetical protein 0.0011 0.0062 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.018 0.0504
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0166 0.6521
Brugia malayi SH2 domain containing protein 0.001 0.0044 0.0056
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0876 0.2787
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0474 0.0474
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0474 0.0474
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Loa Loa (eye worm) TK protein kinase 0.0041 0.0426 0.131
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.018 0.018
Brugia malayi Furin-like cysteine rich region family protein 0.0121 0.1382 0.4447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0032 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.006 0.0111
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.006 0.0116
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.0376 0.0376
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0054 0.0579 0.2427
Schistosoma mansoni tyrosine kinase 0.0261 0.3076 0.595
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.018 0.0504
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0047 0.0069
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0047 0.0047
Chlamydia trachomatis glycogen phosphorylase 0.0125 0.1433 0.5297
Brugia malayi SH2 domain containing protein 0.001 0.0044 0.0056
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0474 0.0917
Echinococcus granulosus growth factor receptor bound protein 2 0.0008 0.0026 0.0051
Entamoeba histolytica glycogen phosphorylase, putative 0.0054 0.0579 0.1627
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.006 0.2365
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0047 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.018 0.0504
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.018 0.018
Plasmodium falciparum phosphodiesterase gamma, putative 0.0011 0.006 0.1454
Echinococcus multilocularis growth factor receptor bound protein 2 0.0008 0.0026 0.0026
Echinococcus granulosus dnaJ subfamily B 0.0435 0.5169 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0166 0.0458
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3559 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.018 0.0348
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.018 0.018
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.006 0.0116
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0078 0.306
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0497 0.1543
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0458 0.1258
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi Tyrosine-protein kinase abl-1 0.0014 0.0092 0.0214
Brugia malayi hypothetical protein 0.0032 0.0313 0.0939
Entamoeba histolytica hypothetical protein 0.0027 0.0255 0.0715
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0166 0.6521
Echinococcus multilocularis tyrosine protein kinase shark 0.001 0.0044 0.0044
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1679 0.3247
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus multilocularis epidermal growth factor receptor 0.0121 0.1382 0.1382
Echinococcus granulosus epidermal growth factor receptor 0.0121 0.1382 0.2674
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.006 0.0111
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0125 0.1242
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.002 0.002
Schistosoma mansoni hypothetical protein 0.018 0.21 0.4062
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0219 0.5296
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0709 0.1372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0497 0.0961
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0876 0.2787
Schistosoma mansoni tyrosine kinase 0.0014 0.0092 0.0177
Echinococcus multilocularis epidermal growth factor receptor 0.0121 0.1382 0.1382
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Brugia malayi CXXC zinc finger family protein 0.0031 0.0297 0.0887
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.006 0.0116
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0167 0.1946 0.6293
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.018 0.0348
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.2365
Brugia malayi hypothetical protein 0.0011 0.0062 0.0115
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.018 0.0348
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Schistosoma mansoni adapter molecule crk 0.0008 0.0026 0.0051
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0255 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0166 0.7569
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0047 0.0092
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3559 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0063 0.0121
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0261 0.3076 0.595
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.0142
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0474 0.0917
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.006 0.0116
Onchocerca volvulus 0.0031 0.0297 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0017 0.0013
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0014 0.0092 0.0177
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0014 0.0092 0.0092
Brugia malayi hypothetical protein 0.001 0.0047 0.0069
Echinococcus granulosus tyrosine protein kinase shark 0.001 0.0044 0.0084
Schistosoma mansoni nuclear hormone receptor 0.001 0.0047 0.0092
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.006 0.2365
Echinococcus multilocularis tyrosine protein kinase ABL1 0.001 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.018 0.0504
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0041 0.0049
Leishmania major cAMP-specific phosphodiesterase, putative 0.0011 0.006 0.2745
Schistosoma mansoni cpg binding protein 0.0032 0.0318 0.0615
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.018 0.018
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Brugia malayi Protein kinase domain containing protein 0.001 0.0044 0.0056
Schistosoma mansoni nuclear hormone receptor 0.001 0.0047 0.0092
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0047 0.0069
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0125 0.0125
Echinococcus granulosus tyrosine protein kinase ABL1 0.001 0.0044 0.0084
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0166 0.7569
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0125 0.0125
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0047 0.0027
Schistosoma mansoni tyrosine kinase 0.0045 0.0474 0.0917
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Schistosoma mansoni hypothetical protein 0.0037 0.0376 0.0727
Brugia malayi Protein kinase domain containing protein 0.0261 0.3076 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.018 0.0504
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.018 0.018
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0166 0.0166
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0458 0.0887
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.018 0.0504
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0376 0.0727
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1702 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0121 0.1382 0.2674
Brugia malayi ecdysone receptor 0.001 0.0047 0.0069
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0014 0.0092 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.006 0.2365
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.018 0.0504
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0125 0.4915
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.018 0.0504
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0062 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.018 0.0504
Echinococcus multilocularis cpg binding protein 0.0032 0.0318 0.0318
Brugia malayi nuclear receptor RXR 0.001 0.0047 0.0069
Echinococcus multilocularis tyrosine kinase 0.001 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0474 0.0474
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0008 0.0026 0.0051
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0361 0.0697
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0047 0.0092
Giardia lamblia GTOR 0.002 0.0166 0.0302
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0043 0.0054
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0504
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0166 0.0466
Loa Loa (eye worm) glycogen phosphorylase 0.0125 0.1433 0.4612
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.018 0.0504
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.018 0.0348
Brugia malayi protein-tyrosine kinase 0.0041 0.0426 0.131
Schistosoma mansoni glycogen phosphorylase 0.0125 0.1433 0.2772
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0044 0.0056
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.006 0.1454
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.006 0.2365
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.006 0.0116
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0166 0.759
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0166 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0474 0.0917
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0939
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.018 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.018 0.018
Echinococcus granulosus FTZ F1 alpha 0.0021 0.018 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0063 0.0142
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0125 0.0324
Echinococcus granulosus tyrosine protein kinase Fps85D 0.001 0.0044 0.0084
Brugia malayi conserved hypotetical protein 0.001 0.0047 0.0069
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.006 0.0135
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0062 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.006 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0166 0.0433
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0009 0.0032 0.0062
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0047 0.0092
Echinococcus granulosus glycogen phosphorylase 0.0125 0.1433 0.2772
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0255 0.0492
Schistosoma mansoni coup transcription factor 0.0021 0.018 0.0348
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.006 0.0116
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0166 0.6521
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.002 0.0039
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.0376 0.0728
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.006 0.2365
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0166 0.7569
Schistosoma mansoni nck2/grb4 0.0008 0.0026 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.067 0.665
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.018 0.0348
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Brugia malayi Protein kinase domain containing protein 0.0146 0.1688 0.5448
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.006 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0078 0.0185
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0169
Echinococcus granulosus tyrosine kinase 0.0041 0.0426 0.0824
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.018 0.0348
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.006 0.2365
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0474 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.251 0.4856
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.006 0.006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0047 0.0027
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0062 0.0062
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1702 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0166 0.7569
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0125 0.0125
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.006 0.0598
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0255 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.006 0.0135
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0261 0.3076 0.3076
Trichomonas vaginalis glycogen phosphorylase, putative 0.0125 0.1433 0.4006

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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