Detailed information for compound 1774768

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1494.8 | Formula: C40H52N20O31P6
  • H donors: 16 H acceptors: 30 LogP: -13.41 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@@H]1[C@@H](COP(=O)(O[C@@H]2[C@H](O)[C@H](O[C@H]2n2cnc3c2c(N)ncn3)COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O)O[C@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1c(N)ncn2)O)n1cnc2c1c(N)ncn2)O)n1cnc2c1c(N)ncn2
  • InChi: 1S/C40H52N20O31P6/c41-29-17-33(49-5-45-29)53-9-57(17)37-25(65)21(61)13(83-37)1-79-93(69,70)87-26-22(62)14(84-38(26)58-10-54-34-18(58)30(42)46-6-50-34)2-80-94(71,72)88-27-23(63)15(85-39(27)59-11-55-35-19(59)31(43)47-7-51-35)3-81-95(73,74)89-28-24(64)16(4-82-96(75,76)91-97(77,78)90-92(66,67)68)86-40(28)60-12-56-36-20(60)32(44)48-8-52-36/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
  • InChiKey: JKYYBAUTGPWQDT-HKIDEBSPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.004 0.0608 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.0043 0.0087
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0082 0.1289 1
Schistosoma mansoni dynamin 0.0013 0.018 0.0178
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0016 0.0222 0.0219
Loa Loa (eye worm) IRE protein kinase 0.0036 0.0552 0.1666
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0148 0.0133
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0667
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0473
Echinococcus granulosus lysine specific histone demethylase 1A 0.0082 0.1289 0.1483
Loa Loa (eye worm) syntrophin-1 0.0003 0.0015 0.0038
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0222 0.018
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0005 0.0043 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0222 0.1436
Loa Loa (eye worm) hypothetical protein 0.0005 0.0043 0.0125
Brugia malayi Muscleblind-like protein 0.0208 0.3304 1
Loa Loa (eye worm) AIDA-1b 0.0005 0.0048 0.014
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0066 0.1019 0.1018
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0043 0.0012
Echinococcus multilocularis dynamin 0.0013 0.018 0.0178
Echinococcus granulosus protein numb 0.0005 0.0048 0.0053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0158 0.0115
Mycobacterium tuberculosis Possible oxidoreductase 0.0082 0.1289 0.1452
Loa Loa (eye worm) hypothetical protein 0.0005 0.0043 0.0125
Echinococcus granulosus hypothetical protein 0.0005 0.0048 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0549 1
Toxoplasma gondii dynamin-related protein DRPA 0.0013 0.018 0.1096
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0222 0.0631
Echinococcus multilocularis voltage dependent calcium channel 0.0066 0.1019 0.1018
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0042 0.0641 0.1903
Leishmania major UDP-galactopyranose mutase 0.0082 0.1289 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0005 0.0043 0.0012
Schistosoma mansoni hypothetical protein 0.0005 0.0048 0.0046
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0066 0.1019 0.1018
Trichomonas vaginalis mgm1, putative 0.0013 0.018 0.3278
Onchocerca volvulus 0.0005 0.0048 0.036
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.004 0.0608 0.4534
Schistosoma mansoni voltage-gated cation channel 0.0066 0.1019 0.1018
Brugia malayi Dynamin 0.0014 0.0196 0.0552
Schistosoma mansoni amine oxidase 0.0082 0.1289 0.1287
Entamoeba histolytica dynamin-like protein 0.0013 0.018 0.2832
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0005 0.0043 0.0087
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0222 0.018
Onchocerca volvulus 0.0005 0.0043 0.0321
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0082 0.1289 1
Brugia malayi Mammalian fe65 homolog protein 1 0.0005 0.0048 0.0102
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0016 0.0222 0.018
Onchocerca volvulus 0.0005 0.0043 0.0321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0473
Loa Loa (eye worm) hypothetical protein 0.0082 0.1289 0.3897
Brugia malayi hypothetical protein 0.0045 0.069 0.2055
Plasmodium vivax dynamin protein, putative 0.0013 0.018 0.1096
Brugia malayi Dynamin central region family protein 0.0013 0.018 0.0502
Trichomonas vaginalis antibiotic synthetase, putative 0.0005 0.0043 0.079
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0036 0.0552 0.0634
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0222 0.3646
Echinococcus granulosus dynamin 1 protein 0.0013 0.018 0.0205
Brugia malayi AMP-binding enzyme family protein 0.0005 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0189 0.0566
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0013 0.018 0.3278
Loa Loa (eye worm) oxidoreductase 0.0005 0.0043 0.0125
Schistosoma mansoni tensin-related 0.0005 0.0048 0.0046
Brugia malayi hypothetical protein 0.0005 0.0048 0.0102
Entamoeba histolytica protein kinase, putative 0.0036 0.0552 1
Schistosoma mansoni tensin-related 0.0005 0.0048 0.0046
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0005 0.0043 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0005 0.0043 0.0087
Echinococcus granulosus dynamin 0.0013 0.018 0.0205
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0066 0.1019 0.1173
Schistosoma mansoni amine oxidase 0.0082 0.1289 0.1287
Schistosoma mansoni dynamin 0.0014 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.0005 0.0048 0.014
Loa Loa (eye worm) hypothetical protein 0.0082 0.1289 0.3897
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0667
Echinococcus multilocularis 0.0082 0.1289 0.1287
Loa Loa (eye worm) DRP-1 protein 0.0013 0.018 0.0539
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0222 0.018
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0005 0.0043 0.0041
Entamoeba histolytica protein kinase, putative 0.0036 0.0552 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0043 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0222 0.3646
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0222 0.018
Echinococcus granulosus muscleblind protein 0.0208 0.3304 0.3805
Loa Loa (eye worm) calcium channel 0.0066 0.1019 0.3082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0196 0.0588
Echinococcus multilocularis sodium channel protein 0.0028 0.0415 0.0413
Schistosoma mansoni acetyl-CoA synthetase 0.0005 0.0043 0.0041
Leishmania major GTP-binding protein, putative 0.0013 0.018 0.1096
Loa Loa (eye worm) hypothetical protein 0.0082 0.1289 0.3897
Echinococcus multilocularis carboxyl terminal PDZ ligand of neuronal nitric 0.0005 0.0048 0.0046
Echinococcus multilocularis protein numb 0.0005 0.0048 0.0046
Plasmodium falciparum protoporphyrinogen oxidase 0.0082 0.1289 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0016 0.0222 0.018
Echinococcus multilocularis dynamin 1 0.0014 0.0196 0.0194
Brugia malayi AIDA-1b 0.0005 0.0048 0.0102
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0005 0.0043 0.0012
Trichomonas vaginalis dynamin, putative 0.0013 0.018 0.3278
Loa Loa (eye worm) hypothetical protein 0.0208 0.3304 1
Onchocerca volvulus 0.0016 0.0222 0.1711
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0158 0.0922
Schistosoma mansoni dynamin 0.0014 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0473
Trypanosoma brucei dynamin-1-like protein 0.0013 0.018 0.2418
Mycobacterium ulcerans oxidoreductase 0.0082 0.1289 0.1251
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0222 0.0631
Trichomonas vaginalis dynamin, putative 0.0013 0.018 0.3278
Loa Loa (eye worm) hypothetical protein 0.0005 0.0048 0.014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0016 0.0222 0.018
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0066 0.1019 0.1173
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0036 0.0549 1
Trichomonas vaginalis dynamin, putative 0.0013 0.018 0.3278
Mycobacterium ulcerans dehydrogenase 0.0082 0.1289 0.1251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0148 0.0133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0486
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0222 0.018
Plasmodium vivax hypothetical protein, conserved 0.0082 0.1289 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0552 0.055
Echinococcus granulosus voltage dependent calcium channel 0.0066 0.1019 0.1173
Trichomonas vaginalis dynamin, putative 0.0013 0.018 0.3278
Entamoeba histolytica dynamin-1-like protein, putative 0.0013 0.018 0.2832
Brugia malayi AMP-binding enzyme family protein 0.0005 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.0082 0.1289 0.3897
Echinococcus multilocularis muscleblind protein 1 0.0208 0.3304 0.3303
Brugia malayi SWIRM domain containing protein 0.0082 0.1289 0.3874
Echinococcus multilocularis SHC transforming protein 3 0.0005 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.0005 0.0048 0.014
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0066 0.1019 0.1173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0148 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0148 0.0133
Brugia malayi CED-6 protein 0.0005 0.0048 0.0102
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0082 0.1289 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0222 0.1436
Brugia malayi AMP-binding enzyme family protein 0.0005 0.0043 0.0087
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0005 0.0043 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0048 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0043 0.0012
Onchocerca volvulus 0.0005 0.0043 0.0321
Echinococcus granulosus dynamin 1 0.0014 0.0196 0.0224
Plasmodium falciparum dynamin-like protein 0.0013 0.018 0.1096
Trichomonas vaginalis antibiotic synthetase, putative 0.0005 0.0043 0.079
Brugia malayi TBC domain containing protein 0.0005 0.0048 0.0102
Echinococcus multilocularis muscleblind protein 0.0208 0.3304 0.3303
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0627 1 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0627 1 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0005 0.0043 0.0125
Echinococcus multilocularis tensin 0.0005 0.0048 0.0046
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0066 0.1019 0.1018
Loa Loa (eye worm) hypothetical protein 0.0005 0.0048 0.014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0473
Echinococcus granulosus voltage dependent calcium channel 0.0014 0.0189 0.0215
Plasmodium vivax dynamin-like protein, putative 0.0013 0.018 0.1096
Toxoplasma gondii transporter, cation channel family protein 0.0014 0.0189 0.1169
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0222 0.0631
Loa Loa (eye worm) hypothetical protein 0.0208 0.3304 1
Echinococcus granulosus SHC transforming protein 3 0.0005 0.0048 0.0053
Echinococcus granulosus lysine specific histone demethylase 1A 0.0082 0.1289 0.1483
Toxoplasma gondii dynamin gtpase 0.0009 0.0108 0.0519
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.0544 0.868 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0082 0.1289 0.1287
Loa Loa (eye worm) hypothetical protein 0.0082 0.1289 0.3897
Entamoeba histolytica acyl-coA synthetase, putative 0.0016 0.0222 0.3646
Schistosoma mansoni numb 0.0005 0.0048 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0222 0.1436
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0003 0.0013 0.0032
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0066 0.1019 0.3055
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0066 0.1019 0.1018
Toxoplasma gondii hypothetical protein 0.0012 0.0162 0.0956
Onchocerca volvulus 0.0005 0.0043 0.0321
Loa Loa (eye worm) hypothetical protein 0.0082 0.1289 0.3897
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.0222 0.018
Echinococcus multilocularis protoporphyrinogen oxidase 0.0627 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0667
Brugia malayi amine oxidase, flavin-containing family protein 0.0082 0.1289 0.3874
Mycobacterium ulcerans monoamine oxidase 0.0082 0.1289 0.1251
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.1289 1
Brugia malayi Dynamin 0.0014 0.0196 0.0552
Schistosoma mansoni shc transforming protein 0.0005 0.0048 0.0046
Schistosoma mansoni syntrophin 0.0003 0.0015 0.0013
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0005 0.0043 0.0012
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0082 0.1289 0.1251
Loa Loa (eye worm) voltage-dependent calcium channel 0.0014 0.0189 0.0566
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0028 0.0415 0.0476
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0082 0.1289 0.1251
Mycobacterium ulcerans hypothetical protein 0.0016 0.0222 0.018
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0036 0.0552 0.055
Brugia malayi protein M110.5 0.0005 0.0048 0.0102
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0043 0.0012
Brugia malayi Ribonuclease 2-5A family protein 0.0036 0.0552 0.1634
Loa Loa (eye worm) hypothetical protein 0.0045 0.069 0.2085
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0005 0.0043 0.0204
Echinococcus multilocularis dynamin 1 protein 0.0013 0.018 0.0178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0473
Echinococcus granulosus beta 1 syntrophin 0.0003 0.0015 0.0015
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0005 0.0043 0.0012
Trypanosoma cruzi dynamin-1-like protein 0.0013 0.018 0.1096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0222 0.0219
Trichomonas vaginalis dynamin, putative 0.0013 0.018 0.3278
Toxoplasma gondii histone lysine-specific demethylase 0.0082 0.1289 1
Toxoplasma gondii dynamin-related protein DRPB 0.0013 0.018 0.1096
Trypanosoma brucei dynamin-1-like protein 0.0013 0.018 0.2418
Echinococcus granulosus protoporphyrinogen oxidase 0.0544 0.868 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0012 0.0158 0.0922
Onchocerca volvulus 0.0005 0.0048 0.036
Giardia lamblia Dynamin 0.0013 0.018 1
Plasmodium falciparum dynamin-like protein 0.0013 0.018 0.1096
Loa Loa (eye worm) X11 protein 0.0047 0.072 0.2174
Echinococcus multilocularis voltage dependent calcium channel 0.0066 0.1019 0.1018
Loa Loa (eye worm) hypothetical protein 0.0066 0.1019 0.3082
Loa Loa (eye worm) hypothetical protein 0.0005 0.0048 0.014
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0066 0.1019 0.1018
Echinococcus multilocularis beta 1 syntrophin 0.0003 0.0015 0.0013
Schistosoma mansoni amyloid beta A4 protein related 0.0047 0.072 0.0718
Trypanosoma cruzi UDP-galactopyranose mutase 0.0082 0.1289 1
Echinococcus multilocularis amyloid beta A4 protein 0.0047 0.072 0.0718
Brugia malayi hypothetical protein 0.0082 0.1289 0.3874
Loa Loa (eye worm) hypothetical protein 0.0005 0.0048 0.014
Trypanosoma cruzi UDP-galactopyranose mutase 0.0082 0.1289 1
Echinococcus granulosus carboxyl terminal PDZ ligand of neuronal nitric 0.0005 0.0048 0.0053
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0158 0.0145
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0082 0.1289 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0066 0.1019 0.1018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0162 0.0486
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0627 1 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0005 0.0043 0.0048
Onchocerca volvulus 0.0082 0.1289 1
Echinococcus granulosus amyloid beta A4 protein 0.0047 0.072 0.0827
Trichomonas vaginalis dynamin, putative 0.0013 0.018 0.3278
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0082 0.1289 0.1287
Plasmodium vivax hypothetical protein, conserved 0.0082 0.1289 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0005 0.0043 0.0125
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.1289 0.1452

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 6.1 nM Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed as substrate cleavage measured for 50 mins by FRET assay ChEMBL. 23810677

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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