Detailed information for compound 177760

Basic information

Technical information
  • TDR Targets ID: 177760
  • Name: (2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naph thalen-2-yl-1-oxopropan-2-yl]-1-N-(2-nitrophe nyl)pyrrolidine-1,2-dicarboxamide
  • MW: 579.646 | Formula: C33H33N5O5
  • H donors: 2 H acceptors: 5 LogP: 5.62 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@@H](NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-])Cc1ccc2c(c1)cccc2)N(Cc1ccccc1)C
  • InChi: 1S/C33H33N5O5/c1-36(22-23-10-3-2-4-11-23)32(40)28(21-24-17-18-25-12-5-6-13-26(25)20-24)34-31(39)30-16-9-19-37(30)33(41)35-27-14-7-8-15-29(27)38(42)43/h2-8,10-15,17-18,20,28,30H,9,16,19,21-22H2,1H3,(H,34,39)(H,35,41)/t28-,30-/m0/s1
  • InChiKey: PCVSIMQAFWRUEC-JDXGNMNLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-N2-[(1S)-2-[benzyl(methyl)amino]-1-(2-naphthylmethyl)-2-oxo-ethyl]-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N2-[(1S)-2-[benzyl(methyl)amino]-1-(2-naphthalenylmethyl)-2-oxoethyl]-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N2-[(2S)-1-[methyl(phenylmethyl)amino]-3-naphthalen-2-yl-1-oxo-propan-2-yl]-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N'-[(1S)-2-[benzyl(methyl)amino]-2-keto-1-(2-naphthylmethyl)ethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N'-[(2S)-1-(methyl-(phenylmethyl)amino)-3-naphthalen-2-yl-1-oxopropan-2-yl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N'-[(1S)-2-(methyl-(phenylmethyl)amino)-1-(2-naphthylmethyl)-2-oxo-ethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N'-[(1S)-2-(methyl-(phenylmethyl)amino)-1-(2-naphthylmethyl)-2-oxoethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N'-[(1S)-2-(benzyl-methyl-amino)-2-keto-1-(2-naphthylmethyl)ethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2S)-N'-[(2S)-1-(methyl-(phenylmethyl)amino)-3-naphthalen-2-yl-1-oxo-propan-2-yl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • NCGC00159557-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0458 0.0421
Echinococcus granulosus serotonin receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0029 0.0123 0.6219
Echinococcus granulosus g protein coupled receptor 0.006 0.0458 0.0474
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Loa Loa (eye worm) hypothetical protein 0.0206 0.2055 0.3158
Loa Loa (eye worm) hypothetical protein 0.0047 0.0312 0.0479
Echinococcus multilocularis somatostatin receptor 0.006 0.0458 0.0421
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi Dopamine receptor protein 2 0.006 0.0458 0.0703
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0034 0.0174 0.0268
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0029 0.012 0.0093
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0034 0.0174 0.9563
Brugia malayi RE15519p 0.006 0.0458 0.0703
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.018 0.0161
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Echinococcus granulosus heat shock protein 90 0.0034 0.0174 0.0154
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.0182 0.0145
Loa Loa (eye worm) runx1 0.0067 0.0534 0.082
Schistosoma mansoni heat shock protein 0.0034 0.0174 0.0154
Echinococcus multilocularis neuropeptide receptor 0.006 0.0458 0.0421
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0174 0.0473
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0038 0.0211 0.0325
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0458 0.0474
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0182 0.0163
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0458 0.0474
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0174 0.0677
Trichomonas vaginalis chromobox protein, putative 0.007 0.0564 0.1824
Onchocerca volvulus 0.0035 0.0182 0.0083
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0174 0.0211
Plasmodium falciparum DNA topoisomerase 2 0.0034 0.0174 1
Brugia malayi G-protein coupled receptor 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0614 0.6508 1
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0458 0.0474
Brugia malayi vesicle-fusing ATPase 0.0018 0.00000048294 0.00000074207
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0458 0.0474
Brugia malayi heat shock protein 90 0.0034 0.0174 0.0268
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Echinococcus multilocularis acetylcholinesterase 0.0206 0.2055 0.2025
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Echinococcus multilocularis acetylcholinesterase 0.0206 0.2055 0.2025
Echinococcus multilocularis sex peptide receptor 0.006 0.0458 0.0421
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.1437 0.1405
Echinococcus multilocularis heat shock protein 90 0.0034 0.0174 0.0137
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0174 0.0473
Loa Loa (eye worm) endoplasmin 0.0034 0.0174 0.0268
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0458 0.0421
Onchocerca volvulus 0.006 0.0458 0.0583
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0458 0.0703
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0029 0.0123 0.5406
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Brugia malayi Protein kinase domain containing protein 0.0051 0.0355 0.0546
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni opsin-like receptor 0.006 0.0458 0.0474
Trypanosoma cruzi DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Brugia malayi Pre-SET motif family protein 0.0036 0.0195 0.0299
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0458 0.0703
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Schistosoma mansoni adenoreceptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0034 0.0174 0.9563
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0312 0.0479
Brugia malayi Pre-SET motif family protein 0.0251 0.2546 0.3911
Schistosoma mansoni biogenic amine receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0034 0.0174 0.5
Loa Loa (eye worm) TOPoisomerase family member 0.0034 0.0174 0.0268
Echinococcus multilocularis carboxylesterase 5A 0.0206 0.2055 0.2025
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0458 0.0703
Echinococcus granulosus neuropeptide receptor A26 0.059 0.6244 0.7002
Schistosoma mansoni heat shock protein 0.0034 0.0174 0.0154
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0458 0.0421
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0033 0.0165 0.0143
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0082 0.0701 0.0749
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.021
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0382 0.0588
Echinococcus granulosus carboxylesterase 5A 0.0206 0.2055 0.2276
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0458 0.0703
Mycobacterium ulcerans putative regultory protein 0.0034 0.0174 0.9563
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0034 0.0174 0.0211
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0174 0.5
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0034 0.0174 1
Echinococcus granulosus Immunoglobulin 0.0029 0.012 0.0093
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0029 0.012 0.0083
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.1861 0.183
Loa Loa (eye worm) carboxylesterase 0.0035 0.0182 0.028
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0458 0.0474
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0034 0.0174 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0458 0.0474
Loa Loa (eye worm) carboxylesterase 0.0035 0.0182 0.028
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Plasmodium vivax DNA gyrase subunit B, putative 0.0034 0.0174 0.8692
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0458 0.0703
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0458 0.0703
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0182 1
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0195 0.0158
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0458 0.0421
Echinococcus multilocularis g protein coupled receptor 0.006 0.0458 0.0421
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0458 0.0421
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0458 0.0474
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0458 0.0474
Echinococcus multilocularis g protein coupled receptor 0.006 0.0458 0.0421
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8901 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi neuropeptide F receptor 0.006 0.0458 0.0703
Onchocerca volvulus 0.0035 0.0182 0.0083
Leishmania major developmentally regulated phosphoprotein-like protein 0.0614 0.6508 1
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0458 0.0421
Onchocerca volvulus 0.006 0.0458 0.0583
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0174 0.0211
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0174 0.0211
Brugia malayi mbt repeat family protein 0.0047 0.0312 0.0479
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Echinococcus multilocularis fmrfamide receptor 0.006 0.0458 0.0421
Echinococcus granulosus defective proboscis extension response 0.0029 0.012 0.0093
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0038 0.0219 0.0337
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0034 0.0174 0.0473
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0458 0.0474
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0034 0.0174 1
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0031 0.014 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Echinococcus multilocularis fmrfamide receptor 0.006 0.0458 0.0421
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0034 0.0174 0.0677
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.032 0.0318
Echinococcus granulosus allatostatin A receptor 0.006 0.0458 0.0474
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0034 0.0174 0.0268
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Echinococcus granulosus acetylcholinesterase 0.0206 0.2055 0.2276
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0029 0.0123 0.0096
Loa Loa (eye worm) hypothetical protein 0.0614 0.6508 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0458 0.0474
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0262 0.0775
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0458 0.0474
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0034 0.0174 0.9563
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0458 0.0703
Echinococcus multilocularis serotonin receptor 0.006 0.0458 0.0421
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0034 0.0174 0.0068
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis roundabout 2 0.0038 0.0211 0.0174
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0174 0.0211
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0034 0.0174 1
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0036 0.0195 0.0299
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0104 0.023
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0458 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi kinase, mitochondrial precursor 0.0614 0.6508 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0219 0.0337
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Trypanosoma cruzi DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.0182 0.05
Trichomonas vaginalis receptor histidine kinase, putative 0.0034 0.0174 0.0473
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0312 0.0309
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.0038 0.0211 0.0325
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0458 0.0474
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi Furin-like cysteine rich region family protein 0.015 0.1437 0.2208
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0034 0.0174 0.9563
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0458 0.0421
Leishmania major DNA topoisomerase ii 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0458 0.0474
Echinococcus granulosus roundabout 2 0.0038 0.0211 0.0196
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus epidermal growth factor receptor 0.0082 0.0701 0.0749
Echinococcus multilocularis neuropeptide s receptor 0.059 0.6244 0.6229
Trypanosoma brucei developmentally regulated phosphoprotein 0.0614 0.6508 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0034 0.0174 0.0068
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0095 0.084 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.0182 0.05
Onchocerca volvulus 0.0035 0.0182 0.0083
Schistosoma mansoni chromobox protein 0.007 0.0564 0.0594
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0458 0.0703
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0174 0.5
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0034 0.0174 0.9563
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0215 0.2146 0.3258
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0458 0.0474
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0034 0.0174 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0174 0.0211
Brugia malayi sulfakinin receptor protein 0.006 0.0458 0.0703
Echinococcus granulosus g-protein coupled receptor 0.006 0.0458 0.0474
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0034 0.0174 0.9563
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0474
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0034 0.0174 0.9563
Brugia malayi AKH receptor 0.006 0.0458 0.0703
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0312 0.0309
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2925 1
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni hypothetical protein 0.0289 0.2952 0.3288
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0355 0.0358
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.0182 0.0163
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0034 0.0174 0.0211
Trypanosoma brucei Valosin-containing protein 0.0029 0.0123 0.0131
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1291
Onchocerca volvulus 0.006 0.0458 0.0583
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0458 0.0474
Schistosoma mansoni chromobox protein 0.007 0.0564 0.0594
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0355 0.0546
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0031 0.014 0.0115
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0458 0.0421
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.012 0.0184
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0034 0.0174 0.0473
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0458 0.0474
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0458 0.0474
Mycobacterium tuberculosis Carboxylesterase LipT 0.0035 0.0182 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.0564 0.1824
Loa Loa (eye worm) TK/EGFR protein kinase 0.015 0.1437 0.2208
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus granulosus somatostatin receptor 0.006 0.0458 0.0474
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.1861 0.2057
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0029 0.012 0.0093
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0034 0.0174 0.9563
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0034 0.0174 0.0473
Onchocerca volvulus 0.006 0.0458 0.0583
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis 0.0045 0.0294 0.0257
Schistosoma mansoni opsin-like receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi Melatonin receptor type 1A 0.006 0.0458 0.0703
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.0182 0.0145
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi Carboxylesterase family protein 0.0206 0.2055 0.3158
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0031 0.014 0.0103
Echinococcus granulosus neuroligin 0.0035 0.0182 0.0163
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0458 0.0474
Onchocerca volvulus 0.006 0.0458 0.0583
Brugia malayi Serotonin receptor 0.006 0.0458 0.0703
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0382 0.0389
Brugia malayi ORL1-like opioid receptor 0.006 0.0458 0.0703
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0262 0.0775
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0421
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Leishmania major mitochondrial DNA topoisomerase II 0.0034 0.0174 0.0211
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Toxoplasma gondii DNA topoisomerase 2, putative 0.0034 0.0174 0.0677
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0458 0.0474
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0038 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0458 0.0474
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.0029 0.012 0.0184
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0034 0.0174 0.9563
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0458 0.0474
Echinococcus granulosus chromobox protein 1 0.007 0.0564 0.0594
Echinococcus multilocularis neuroligin 0.0035 0.0182 0.0145
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0614 0.6508 0.6495
Echinococcus multilocularis serotonin receptor 0.006 0.0458 0.0421
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0614 0.6508 0.73
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0034 0.0174 0.9563
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0458 0.0474
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0174 0.0473
Brugia malayi neuropeptide F receptor 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0174 0.0677
Onchocerca volvulus 0.006 0.0458 0.0583
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8901 1
Onchocerca volvulus 0.006 0.0458 0.0583
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0458 0.0474
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0458 0.0583
Brugia malayi Endoplasmin precursor 0.0034 0.0174 0.0268
Echinococcus granulosus fmrfamide receptor 0.006 0.0458 0.0474
Echinococcus multilocularis insulin receptor 0.0051 0.0355 0.0318
Trichomonas vaginalis DNA topoisomerase II, putative 0.0034 0.0174 0.0473
Brugia malayi GnHR receptor homolog 0.006 0.0458 0.0703
Toxoplasma gondii exonuclease III APE 0.0022 0.0038 0.0134
Giardia lamblia Pms1-like protein 0.0034 0.0174 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0458 0.0421
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0312 0.0275
Trichomonas vaginalis receptor histidine kinase, putative 0.0034 0.0174 0.0473
Loa Loa (eye worm) hypothetical protein 0.0535 0.5642 0.8669
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Echinococcus granulosus sex peptide receptor 0.006 0.0458 0.0474
Echinococcus granulosus twitchin 0.0033 0.0167 0.0146
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus multilocularis chromobox protein 1 0.007 0.0564 0.0529
Echinococcus granulosus acetylcholinesterase 0.0206 0.2055 0.2276
Schistosoma mansoni cell adhesion molecule 0.0033 0.0165 0.0143
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0206 0.2055 0.2276
Plasmodium falciparum DNA gyrase subunit B 0.0034 0.0174 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0034 0.0174 0.9563
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0034 0.0174 0.9563
Echinococcus granulosus neuropeptide s receptor 0.059 0.6244 0.7002
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0229 0.0663
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Mycobacterium ulcerans two component sensor kinase MprB 0.0034 0.0174 0.9563
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0195 0.0158
Trichomonas vaginalis sensor histidine kinase, putative 0.0034 0.0174 0.0473
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0029 0.0123 0.0131
Echinococcus granulosus neuropeptide receptor 0.006 0.0458 0.0474
Mycobacterium leprae Probable two-component sensor kinase 0.0034 0.0174 0.5
Loa Loa (eye worm) acetylcholinesterase 1 0.0206 0.2055 0.3158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8901 0.8897
Schistosoma mansoni tyrosine kinase 0.0077 0.0647 0.0687
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0034 0.0174 0.9563
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0458 0.0474
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0174 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0034 0.0174 0.9563
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0614 0.6508 0.6495
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0458 0.0421
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0174 0.1702
Mycobacterium ulcerans two component regulator - sensor kinase 0.0034 0.0174 0.9563
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0382 0.0346
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni myosin xvIII 0.006 0.0458 0.0474
Brugia malayi G protein-coupled receptor 0.006 0.0458 0.0703
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0195 0.0177
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0174 0.8692
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0034 0.0174 0.9563
Schistosoma mansoni lozenge 0.0067 0.0534 0.056
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0034 0.0174 0.0211
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0174 0.0211
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus epidermal growth factor receptor 0.015 0.1437 0.1579
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0458 0.0474
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0458 0.0474
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0458 0.0421
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0034 0.0174 0.0068
Schistosoma mansoni tyrosine kinase 0.0077 0.0647 0.0687
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0034 0.0174 0.9563
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0195 0.0759
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0195 0.0177
Echinococcus granulosus orexin receptor type 2 0.006 0.0458 0.0474
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0312 0.0309
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0038 0.198
Loa Loa (eye worm) hypothetical protein 0.0206 0.2055 0.3158
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0182 0.0163
Schistosoma mansoni endoplasmin 0.0034 0.0174 0.0154
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0312 0.0318
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0215 0.2146 0.3258
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0458 0.0421
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma brucei DNA topoisomerase ii 0.0034 0.0174 0.0211
Onchocerca volvulus 0.0047 0.0312 0.0318
Mycobacterium ulcerans carboxylesterase, LipT 0.0035 0.0182 1
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0458 0.0421
Onchocerca volvulus 0.006 0.0458 0.0583
Echinococcus multilocularis Immunoglobulin 0.0029 0.012 0.0083
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus 0.0035 0.0182 0.0083
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Plasmodium vivax SET domain protein, putative 0.0036 0.0195 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0458 0.0421
Schistosoma mansoni nephrin 0.0033 0.0167 0.0146
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0268
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.0182 0.0145
Brugia malayi hypothetical protein 0.0035 0.0182 0.028
Onchocerca volvulus 0.0535 0.5642 1
Schistosoma mansoni pyruvate dehydrogenase 0.058 0.6135 0.6879
Onchocerca volvulus 0.006 0.0458 0.0583
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0095 0.084 1
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0458 0.0703
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0174 0.8692
Echinococcus multilocularis neuropeptide receptor A26 0.059 0.6244 0.6229
Entamoeba histolytica DNA topoisomerase II, putative 0.0034 0.0174 0.1702
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0458 0.0474
Echinococcus multilocularis heat shock protein 0.0034 0.0174 0.0137
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0458 0.0474
Echinococcus multilocularis neuropeptide receptor 0.006 0.0458 0.0421
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0312 0.0309
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0038 0.0058
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0034 0.0174 0.5
Schistosoma mansoni pyruvate dehydrogenase 0.0614 0.6508 0.73
Schistosoma mansoni opsin-like receptor 0.006 0.0458 0.0474
Onchocerca volvulus 0.0286 0.2925 0.5064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0195 0.0177
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0034 0.0174 0.9563
Brugia malayi Carboxylesterase family protein 0.0206 0.2055 0.3158
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0458 0.0421
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0229 0.0663
Schistosoma mansoni biogenic amine receptor 0.006 0.0458 0.0474
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0458 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Plasmodium vivax DNA topoisomerase II, putative 0.0034 0.0174 0.8692
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0458 0.0474
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi hypothetical protein 0.0535 0.5642 0.8669
Brugia malayi Fibronectin type III domain containing protein 0.0029 0.012 0.0184
Echinococcus granulosus heat shock protein 0.0034 0.0174 0.0154
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Echinococcus multilocularis g protein coupled receptor 0.006 0.0458 0.0421
Echinococcus granulosus g protein coupled receptor 0.006 0.0458 0.0474
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0458 0.0421
Toxoplasma gondii cell division protein CDC48CY 0.0031 0.014 0.0541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0458 0.0703
Schistosoma mansoni acetylcholinesterase 0.0035 0.0182 0.0163
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi mbt repeat family protein 0.0047 0.0312 0.0479
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0182 0.0163
Plasmodium falciparum endoplasmin, putative 0.0034 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0174 0.0211
Schistosoma mansoni vesicular amine transporter 0.0029 0.012 0.0093
Loa Loa (eye worm) carboxylesterase 0.0206 0.2055 0.3158
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi Probable DNA topoisomerase II 0.0034 0.0174 0.0268
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.0182 0.0163
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0034 0.0174 0.0154
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0249 0.2519 1
Echinococcus multilocularis neuroglian 0.0033 0.0167 0.013
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Mycobacterium ulcerans DNA gyrase subunit B 0.0034 0.0174 0.9563
Echinococcus multilocularis allatostatin A receptor 0.006 0.0458 0.0421
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0458 0.0474
Echinococcus granulosus hypothetical protein 0.006 0.0458 0.0474
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0564 0.0867
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Plasmodium vivax endoplasmin, putative 0.0034 0.0174 0.8692
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0034 0.0174 0.0473
Schistosoma mansoni pyruvate dehydrogenase 0.058 0.6135 0.6879
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0262 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0104 0.023
Brugia malayi Serotonin receptor 0.006 0.0458 0.0703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Entamoeba histolytica cdc48-like protein, putative 0.0029 0.0123 0.1059
Onchocerca volvulus 0.0035 0.0182 0.0083
Schistosoma mansoni tyrosine kinase 0.0082 0.0701 0.0749
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Leishmania major hypothetical protein, conserved 0.0034 0.0174 0.0211
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0038 0.1894
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2546 0.3911
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Echinococcus granulosus neuroglian 0.0033 0.0167 0.0146
Echinococcus granulosus insulin receptor 0.0051 0.0355 0.0358
Schistosoma mansoni tyrosine kinase 0.0082 0.0701 0.0749
Schistosoma mansoni DNA topoisomerase II 0.0034 0.0174 0.0154
Echinococcus multilocularis orexin receptor type 2 0.006 0.0458 0.0421
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0029 0.0123 0.1059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0268
Schistosoma mansoni tyrosine kinase 0.015 0.1437 0.1579
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Echinococcus granulosus chromobox protein 1 0.007 0.0564 0.0594
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0034 0.0174 0.9563
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Brugia malayi follicle stimulating hormone receptor 0.006 0.0458 0.0703
Brugia malayi larval opioid receptor 0.006 0.0458 0.0703
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0034 0.0174 0.0677
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0182 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.0182 0.0163
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0382 0.0389
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0535 0.5642 0.8669
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0229 0.0168
Schistosoma mansoni biogenic amine receptor 0.006 0.0458 0.0474
Schistosoma mansoni tyrosine kinase 0.0051 0.0355 0.0358
Echinococcus multilocularis chromobox protein 1 0.007 0.0564 0.0529
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0174 0.1702
Brugia malayi chromobox protein homolog 3 0.0039 0.0229 0.0352
Trypanosoma cruzi Valosin-containing protein, putative 0.0029 0.0123 0.0131
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0458 0.0583
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0458 0.0474
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0034 0.0174 0.0211
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0195 0.0177
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0034 0.0174 0.9563
Loa Loa (eye worm) MBCTL1 0.0053 0.0382 0.0588
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0034 0.0174 0.0137
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0312 0.0275
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0034 0.0174 1
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0458 0.0474
Toxoplasma gondii cell division protein CDC48AP 0.0019 0.0004 0.0000019203
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0253
Mycobacterium tuberculosis Possible two component sensor kinase 0.0034 0.0174 0.9563
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0382 0.0346
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0312 0.0309
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.0182 0.0163
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Plasmodium falciparum heat shock protein 90 0.0034 0.0174 1
Onchocerca volvulus 0.006 0.0458 0.0583
Brugia malayi G-protein coupled receptor 0.006 0.0458 0.0703
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0031 0.014 0.0355
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0215 0.2146 0.8517
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0458 0.0474
Schistosoma mansoni histamine h1 receptor 0.006 0.0458 0.0474
Brugia malayi putative neuropeptide receptor 0.006 0.0458 0.0703
Schistosoma mansoni tyrosine kinase 0.0051 0.0355 0.0358
Mycobacterium leprae Probable two component sensor kinase MprB 0.0034 0.0174 0.5
Schistosoma mansoni endoplasmin 0.0034 0.0174 0.0154
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0352
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0031 0.014 0.0115
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0458 0.0703
Brugia malayi Heterochromatin protein 1 0.007 0.0564 0.0867
Echinococcus granulosus g protein coupled receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0053 0.0382 0.0588
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0458 0.0421
Schistosoma mansoni tyrosine kinase 0.0077 0.0647 0.0687
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0215 0.2146 0.3258
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Onchocerca volvulus 0.006 0.0458 0.0583
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0382 0.0389
Echinococcus multilocularis Immunoglobulin 0.0029 0.012 0.0083
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0174 0.0268
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0034 0.0174 1
Mycobacterium tuberculosis Conserved protein 0.0034 0.0174 0.9563
Onchocerca volvulus 0.006 0.0458 0.0583
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0034 0.0174 0.0473
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0458 0.0474
Brugia malayi Dopamine receptor protein 1 0.006 0.0458 0.0703
Schistosoma mansoni gliotactin 0.0035 0.0182 0.0163
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0458 0.0703
Brugia malayi Dopamine receptor 0.006 0.0458 0.0703
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.0182 0.0163
Onchocerca volvulus 0.0047 0.032 0.0333
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0458 0.0474
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Mycobacterium tuberculosis Probable two component sensor kinase 0.0034 0.0174 0.9563
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0458 0.0421
Echinococcus multilocularis Protein lozenge 0.0067 0.0534 0.0498
Echinococcus multilocularis epidermal growth factor receptor 0.0082 0.0701 0.0666
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0038 0.1894
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0355 0.0318
Echinococcus granulosus neuropeptide receptor 0.006 0.0458 0.0474

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 82.4 uM In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R ChEMBL. 9703462
IC50 (binding) = 82.4 uM In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R ChEMBL. 9703462
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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