Detailed information for compound 177921

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.527 | Formula: C23H24N4O2S
  • H donors: 3 H acceptors: 3 LogP: 4.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNS(=O)(=O)c1ccc(cc1)Nc1c2ccccc2nc2c1ccc(c2)N
  • InChi: 1S/C23H24N4O2S/c1-2-3-14-25-30(28,29)18-11-9-17(10-12-18)26-23-19-6-4-5-7-21(19)27-22-15-16(24)8-13-20(22)23/h4-13,15,25H,2-3,14,24H2,1H3,(H,26,27)
  • InChiKey: VYINWHFGAYMLMT-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0415 0.0601 0.0584
Brugia malayi FAT domain containing protein 0.0941 0.1422 0.1422
Trichomonas vaginalis PIKK family atypical protein kinase 0.3844 0.5956 0.5956
Trichomonas vaginalis conserved hypothetical protein 0.0802 0.1205 0.1205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.3469 0.537 0.537
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0415 0.0601 0.0601
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0415 0.0601 0.0601
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0415 0.0601 0.0601
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0115 0.0132 0.0114
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0415 0.0601 0.0601
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0415 0.0601 1
Echinococcus multilocularis fk506 binding protein 0.0115 0.0132 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.3806 0.5897 0.5897
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.4785 0.7425 0.7425
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0115 0.0132 0.0132
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6434 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1217 0.1853 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5378 0.5378
Echinococcus multilocularis 0.0415 0.0601 0.0601
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0415 0.0601 0.0601
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0584
Loa Loa (eye worm) hypothetical protein 0.0099 0.0107 0.0107
Brugia malayi p70 ribosomal S6 kinase beta 0.0063 0.0052 0.0052
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0415 0.0601 0.0601
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0115 0.0132 0.0114
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0415 0.0601 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0941 0.1422 0.1422
Echinococcus multilocularis nervana 2 0.0042 0.0018 0.0018
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0415 0.0601 0.0546
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0415 0.0601 0.0584
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2158 0.3322 0.3322
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1217 0.1853 0.1853
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6434 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0115 0.0132 0.5
Loa Loa (eye worm) hypothetical protein 0.1217 0.1853 0.1853
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0058 0.0058
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1217 0.1853 0.1853
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0115 0.0132 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 0.3322 0.3322
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2158 0.3322 0.331
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0025 0.0007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1356 0.207 0.2737
Schistosoma mansoni immunophilin 0.0099 0.0107 0.0107
Trichomonas vaginalis immunophilin, putative 0.0115 0.0132 0.0132
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0025 0.0025
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0415 0.0601 0.0601
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0153 0.0191 0.0191
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0415 0.0601 0.0601
Loa Loa (eye worm) phosphatidylinositol 3 0.0415 0.0601 0.0601
Echinococcus granulosus Glutaredoxin protein 5 0.0042 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1217 0.1853 0.1853
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.0018 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0213 0.0213
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0042 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0415 0.0601 0.0584
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0099 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.1311 0.2 0.2
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0415 0.0601 0.0601
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0802 0.1205 0.1189
Loa Loa (eye worm) hypothetical protein 0.0044 0.0022 0.0022
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0115 0.0132 0.0132
Echinococcus granulosus nervana 2 0.0042 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1726 0.2649 0.2649
Trichomonas vaginalis PIKK family atypical protein kinase 0.3806 0.5897 0.5897
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0941 0.1422 0.1422
Trichomonas vaginalis PIKK family atypical protein kinase 0.5117 0.7944 0.7944
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0415 0.0601 0.0745
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0584
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.4785 0.7425 0.7425
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5378 0.5378
Toxoplasma gondii FATC domain-containing protein 0.1217 0.1853 0.2443
Entamoeba histolytica hypothetical protein 0.0415 0.0601 0.0584
Plasmodium vivax hypothetical protein 0.0415 0.0601 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.5493 0.8531 0.8531
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0115 0.0132 0.0074
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0415 0.0601 0.0584
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0415 0.0601 0.0601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0601 0.0601
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.6434 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 0.3322 0.3322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.0601 0.0601
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0415 0.0601 0.0601
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0022 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6434 1 1
Echinococcus multilocularis nervana 2 0.0042 0.0018 0.0018
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0415 0.0601 0.0601
Entamoeba histolytica protein kinase rad3, putative 0.1217 0.1853 0.1838
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0584
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0415 0.0601 0.0584
Leishmania major hypothetical protein, conserved 0.0415 0.0601 0.0475
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2158 0.3322 0.3322
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0415 0.0601 0.0745
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.0022 0.0022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.0176 0.0176
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0115 0.0132 0.0132
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0415 0.0601 0.0601
Echinococcus multilocularis Zinc finger, PHD finger 0.0415 0.0601 0.0601
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0213 0.0213
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0042 0.0018 0.0018
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0115 0.0132 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0415 0.0601 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2158 0.3322 0.3283
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0115 0.0132 0.0132
Giardia lamblia GTOR 0.6434 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0802 0.1205 0.1205
Echinococcus granulosus nervana 2 0.0042 0.0018 0.0018
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6434 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0415 0.0601 0.0745
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0025 0.0025
Onchocerca volvulus 0.0415 0.0601 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2158 0.3322 0.3283
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0584
Loa Loa (eye worm) AGC/AKT protein kinase 0.0067 0.0058 0.0058
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2672 0.4126 0.4092
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0415 0.0601 0.0584
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5123 0.7953 0.7925
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0115 0.0132 0.0114
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0115 0.0132 0.0132
Leishmania major phosphatidylinositol 4-kinase, putative 0.0415 0.0601 0.0475
Loa Loa (eye worm) hypothetical protein 0.0802 0.1205 0.1205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1217 0.1853 0.1853
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6434 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0601 0.0601
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0415 0.0601 0.0601
Schistosoma mansoni fkbp-rapamycin associated protein 0.1217 0.1853 0.1853
Loa Loa (eye worm) phosphatidylinositol 3 0.2158 0.3322 0.3322
Loa Loa (eye worm) phosphatidylinositol 3 0.0415 0.0601 0.0601
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.3844 0.5956 0.5956
Trichomonas vaginalis PIKK family atypical protein kinase 0.3469 0.537 0.537
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0058 0.0058
Entamoeba histolytica protein kinase, putative 0.0063 0.0052 0.0033
Echinococcus granulosus serine protein kinase ATM 0.1217 0.1853 0.1853
Loa Loa (eye worm) FKBP5 protein 0.0115 0.0132 0.0132
Trypanosoma cruzi target of rapamycin kinase 3 0.5123 0.7953 0.7949
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0415 0.0601 0.0584
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.4785 0.7425 0.7425
Trichomonas vaginalis PIKK family atypical protein kinase 0.6434 1 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.0018 0.0018
Leishmania major phosphatidylinositol kinase, putative 0.0415 0.0601 0.0475
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0058 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0601 0.0601
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0415 0.0601 0.0601
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0415 0.0601 0.0584
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0115 0.0132 0.195
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6434 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5123 0.7953 0.7941
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0415 0.0601 0.0601
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0058 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0022 0.0022
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0153 0.0191 0.0191
Leishmania major phosphatidylinositol kinase related protein, putative 0.0415 0.0601 0.0475
Loa Loa (eye worm) phosphatidylinositol 3 0.0415 0.0601 0.0601
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0115 0.0132 0.0114
Entamoeba histolytica hypothetical protein 0.0415 0.0601 0.0584
Trypanosoma cruzi Protein kinase B 0.0046 0.0025 0.0007
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0415 0.0601 0.0584
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1217 0.1853 0.1838
Trichomonas vaginalis PIKK family atypical protein kinase 0.5117 0.7944 0.7944
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0415 0.0601 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1217 0.1853 0.1805
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0415 0.0601 0.0546
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 0.3322 0.3322
Loa Loa (eye worm) phosphatidylinositol 3 0.0415 0.0601 0.0601
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0058 0.0058
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0415 0.0601 0.0601
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0115 0.0132 0.195
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 0.3322 0.3322
Leishmania major phosphatidylinositol 3-kinase, putative 0.2158 0.3322 0.3233
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0415 0.0601 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5117 0.7944 0.7944
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0415 0.0601 0.0601
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6434 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0415 0.0601 0.0601
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0153 0.0191 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.3844 0.5956 0.5956
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2158 0.3322 0.3322
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0025 0.0007
Schistosoma mansoni immunophilin 0.0115 0.0132 0.0132
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0584
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6434 1 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0415 0.0601 0.0584
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6434 1 1
Brugia malayi Protein kinase domain containing protein 0.0067 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.6434 1 1
Echinococcus multilocularis rac serine:threonine kinase 0.0046 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 0.3322 0.3322
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0115 0.0132 0.0132
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2158 0.3322 0.3322
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0025 0.0007
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0153 0.0191 0.0191
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0601 0.0601
Schistosoma mansoni immunophilin 0.0115 0.0132 0.0132
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0415 0.0601 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4177 0.6475 0.6475
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0415 0.0601 0.0601
Entamoeba histolytica hypothetical protein 0.0415 0.0601 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5378 0.5378
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0415 0.0601 0.0584
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2158 0.3322 0.331
Echinococcus granulosus serine/threonine protein kinase 0.0046 0.0025 0.0025
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1217 0.1853 0.1838
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0415 0.0601 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0042 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0415 0.0601 0.0601
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0415 0.0601 0.0601
Loa Loa (eye worm) phosphatidylinositol kinase 0.0415 0.0601 0.0601
Loa Loa (eye worm) phosphatidylinositol 3 0.6434 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0415 0.0601 0.0475
Plasmodium vivax hypothetical protein, conserved 0.0415 0.0601 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1217 0.1853 0.1838
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0115 0.0132 0.0132
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0058 0.0058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0415 0.0601 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3043 0.4704 0.4673
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.5117 0.7944 0.7944
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.0022 0.0022
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0415 0.0601 0.0584
Loa Loa (eye worm) hypothetical protein 0.0133 0.016 0.016
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5378 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.5117 0.7944 0.7944
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.3469 0.537 0.537
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1217 0.1853 0.1853
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2158 0.3322 0.3233
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0415 0.0601 0.0601
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0415 0.0601 0.0601
Entamoeba histolytica hypothetical protein 0.1217 0.1853 0.1838
Trichomonas vaginalis PIKK family atypical protein kinase 0.4785 0.7425 0.7425
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0415 0.0601 0.0584
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0115 0.0132 0.0114
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0415 0.0601 0.0601
Trichomonas vaginalis fk506-binding protein, putative 0.0115 0.0132 0.0132
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1217 0.1853 0.1853
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0022 0.0022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0115 0.0132 0.0074
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.0018 0.0018
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0099 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0415 0.0601 0.0601
Entamoeba histolytica protein kinase, putative 0.0067 0.0058 0.004
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0415 0.0601 1
Echinococcus multilocularis serine protein kinase ATM 0.1217 0.1853 0.1853
Loa Loa (eye worm) hypothetical protein 0.0941 0.1422 0.1422
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0115 0.0132 0.0114
Onchocerca volvulus 0.0415 0.0601 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6434 1 1
Loa Loa (eye worm) hypothetical protein 0.1356 0.207 0.207
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0115 0.0132 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.0601 0.0601
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0415 0.0601 0.0584
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0115 0.0132 0.0114
Mycobacterium leprae conserved hypothetical protein 0.0415 0.0601 0.5
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0058 0.0058
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0415 0.0601 0.0601
Entamoeba histolytica protein kinase, putative 0.0067 0.0058 0.004
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0415 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.4785 0.7425 0.7425
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0415 0.0601 0.0745
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0415 0.0601 0.0601
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0415 0.0601 0.0584
Leishmania major hypothetical protein, unknown function 0.0415 0.0601 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.4785 0.7425 0.7425
Trichomonas vaginalis PIKK family atypical protein kinase 0.4785 0.7425 0.7425
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0063 0.0052 0.0052
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0415 0.0601 0.0601
Toxoplasma gondii target of rapamycin (TOR), putative 0.4785 0.7425 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4316 0.6692 0.6692
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0415 0.0601 0.0601
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0941 0.1422 0.1422
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0415 0.0601 0.0745
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6434 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0115 0.0132 0.0132
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.0601 0.0601
Giardia lamblia Hypothetical protein 0.0415 0.0601 0.0584
Leishmania major phosphatidylinositol 3-kinase, putative 0.0415 0.0601 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.1217 0.1853 0.1853
Echinococcus granulosus voltage gated potassium channel 0.0044 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.1356 0.207 0.207
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0415 0.0601 0.0584
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0941 0.1422 0.1422

Activities

Activity type Activity value Assay description Source Reference
Log 1/D50 (functional) = 4.18 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 4.18 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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