TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.292 | Formula: C18H13F6NO
H donors: 1 H acceptors: 1 LogP: 5.3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)C1(CC1)C(F)(F)F)Nc1ccc(cc1)C(F)(F)F
InChi: 1S/C18H13F6NO/c19-17(20,21)13-5-7-14(8-6-13)25-15(26)11-1-3-12(4-2-11)16(9-10-16)18(22,23)24/h1-8H,9-10H2,(H,25,26)
InChiKey: IIICFIDURUZIMJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0083	0.0144	0.1773
Entamoeba histolytica	fatty acid elongase, putative	0.0208	0.0391	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0001	0.0008
Plasmodium vivax	pyruvate kinase, putative	0.0034	0.0047	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.16	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Echinococcus multilocularis	pyruvate kinase	0.0027	0.0033	0.02
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0001	0.0007
Brugia malayi	amine oxidase, flavin-containing family protein	0.0356	0.0685	1
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0034	0.0047	0.0693
Loa Loa (eye worm)	TAR-binding protein	0.0129	0.0235	0.3426
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.16	0.315	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0001	0.0008
Onchocerca volvulus		0.0075	0.0127	0.1859
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0001	0.0007
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0047	0.0693
Entamoeba histolytica	fatty acid elongase, putative	0.0208	0.0391	1
Echinococcus granulosus	Protein patched homolog 1	0.0086	0.015	0.1849
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0127	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0685	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0356	0.0685	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0127	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.0127	1
Echinococcus granulosus	epidermal growth factor receptor	0.0083	0.0143	0.1769
Echinococcus granulosus	muscleblind protein	0.0153	0.0283	0.3499
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.0127	0.1859
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.001	0.0153
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0086	0.015	0.2186
Onchocerca volvulus		0.0075	0.0127	0.1859
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.000000057572	0.0000008358
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.0127	0.0086
Schistosoma mansoni	tyrosine kinase	0.0049	0.0077	0.095
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0127	0.1859
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Leishmania major	hypothetical protein, conserved	0.0075	0.0127	0.1253
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0001	0.0003
Echinococcus multilocularis	muscleblind protein	0.0153	0.0283	0.1709
Plasmodium falciparum	protoporphyrinogen oxidase	0.0356	0.0685	0.2175
Schistosoma mansoni	cpg binding protein	0.0029	0.0038	0.0468
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0356	0.0685	0.2175
Entamoeba histolytica	pyruvate kinase, putative	0.0024	0.0027	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0027	0.0393
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0047	0.0693
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.0127	0.1859
Onchocerca volvulus		0.0012	0.0004	0.0053
Trypanosoma brucei	pyruvate kinase 1	0.0034	0.0047	0.3726
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0034	0.0047	0.0693
Brugia malayi	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0001	0.0008
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0001	0.0007
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.0127	0.0127
Echinococcus multilocularis	tar DNA binding protein	0.0129	0.0235	0.1415
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0848	0.1659	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.001	0.0153
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.001	0.0153
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0127	0.1859
Loa Loa (eye worm)	patched family protein	0.0012	0.0004	0.0053
Schistosoma mansoni	tyrosinase precursor	0.0092	0.0162	0.1999
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Brugia malayi	ShTK domain containing protein	0.0092	0.0162	0.2363
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0083	0.0143	0.1769
Schistosoma mansoni	tyrosinase precursor	0.0092	0.0162	0.1999
Echinococcus multilocularis	geminin	0.0177	0.0331	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0001	0.0003
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0001	0.0003
Onchocerca volvulus	Protein patched homolog	0.0012	0.0004	0.0053
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.000000057572	0.00000071051
Plasmodium vivax	pyruvate kinase 2, putative	0.0018	0.0014	0.0046
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0001	0.0003
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.5058	1	1
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0203	0.0382	0.4719
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0001	0.0008
Plasmodium falciparum	pyruvate kinase 2	0.0018	0.0014	0.0046
Echinococcus granulosus	geminin	0.0177	0.0331	0.4079
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.0127	0.0768
Echinococcus granulosus	replication factor c subunit 1	0.001	0.000000057572	0.00000071051
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.000000057572	0.0000014711
Echinococcus multilocularis	cpg binding protein	0.0031	0.0041	0.0249
Mycobacterium tuberculosis	Possible oxidoreductase	0.0356	0.0685	0.069
Onchocerca volvulus		0.0356	0.0685	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0049	0.0077	0.095
Schistosoma mansoni	hypothetical protein	0.0016	0.001	0.0129
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0001	0.0007
Brugia malayi	Muscleblind-like protein	0.0153	0.0283	0.4137
Schistosoma mansoni	tyrosine kinase	0.0082	0.0142	0.1747
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0034	0.0047	0.0693
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0001	0.0008
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.0127	0.0086
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Onchocerca volvulus		0.0092	0.0162	0.2363
Toxoplasma gondii	ABC1 family protein	0.0075	0.0127	0.185
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0356	0.0685	0.2175
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0007
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.0162	0.2363
Loa Loa (eye worm)	patched family protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Echinococcus granulosus	insulin receptor	0.0049	0.0077	0.095
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Brugia malayi	RNA recognition motif domain containing protein	0.0129	0.0235	0.3426
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0001	0.0007
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0252	0.0479	0.6989
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0479	1
Echinococcus multilocularis		0.0048	0.0074	0.0446
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0001	0.0008
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0001	0.0003
Giardia lamblia	Pyruvate kinase	0.0034	0.0047	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0001	0.0007
Schistosoma mansoni	tyrosine kinase	0.0083	0.0143	0.1769
Echinococcus multilocularis	GPCR, family 2	0.0016	0.001	0.0063
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0356	0.0685	0.2175
Brugia malayi	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	tyrosinase 1	0.0092	0.0162	0.2363
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0356	0.0685	0.8457
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0479	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.0162	0.2363
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0127	0.1859
Plasmodium vivax	patched family protein, putative	0.0012	0.0004	0.0012
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0001	0.0008
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0001	0.0008
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Onchocerca volvulus		0.0092	0.0162	0.2363
Giardia lamblia	Pyruvate kinase	0.0018	0.0014	0.3042
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0038	0.0554
Echinococcus multilocularis	epidermal growth factor receptor	0.0083	0.0143	0.0864
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.000000057572	0.00000034704
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.0127	0.1859
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0077	0.1126
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0001	0.0007
Trichomonas vaginalis	esterase, putative	0.0075	0.0127	0.266
Echinococcus granulosus	tar DNA binding protein	0.0129	0.0235	0.2898
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0047	0.0693
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0014	0.0087
Mycobacterium ulcerans	lipase LipD	0.0075	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0685	1
Echinococcus multilocularis	expressed conserved protein	0.0188	0.0352	0.2123
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.000000057572	0.0000012021
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0127	0.0086
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0001	0.0007
Schistosoma mansoni	tyrosine kinase	0.0082	0.0142	0.1747
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.001	0.0129
Brugia malayi	SWIRM domain containing protein	0.0356	0.0685	1
Brugia malayi	beta-lactamase	0.0075	0.0127	0.1859
Treponema pallidum	DNA ligase (lig)	0.001	0	0.5
Echinococcus multilocularis	muscleblind protein 1	0.0153	0.0283	0.1709
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.0127	0.0127
Echinococcus multilocularis	protein patched	0.0086	0.015	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0162	0.2363
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0001	0.0008
Brugia malayi	hypothetical protein	0.0012	0.0004	0.0053
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.0307	0.4483
Schistosoma mansoni	tyrosine kinase	0.0082	0.0142	0.1747
Plasmodium vivax	hypothetical protein, conserved	0.0356	0.0685	0.2175
Onchocerca volvulus	Protein patched homolog	0.0012	0.0004	0.0053
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0046	0.0676
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0479	1
Schistosoma mansoni	tyrosine kinase	0.0154	0.0284	0.3509
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0047	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0046	0.0676
Schistosoma mansoni	hypothetical protein	0.0083	0.0144	0.1773
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0001	0.0008
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0086	0.015	0.2186
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Echinococcus granulosus	pyruvate kinase	0.0018	0.0014	0.0178
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0047	0.0693
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.0325	0.6783
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.0127	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0127	0.1859
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0307	0.6415
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0001	0.0007
Onchocerca volvulus		0.0092	0.0162	0.2363
Echinococcus granulosus	sterol regulatory element binding protein	0.0086	0.015	0.1849
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0283	0.4137
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0154	0.0284	0.4149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0003
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0014	0.0087
Brugia malayi	Common central domain of tyrosinase family protein	0.0092	0.0162	0.2363
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.001	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0356	0.0685	1
Brugia malayi	ecdysteroid receptor	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0685	1
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Brugia malayi	protein C24B5.3	0.0012	0.0004	0.0053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0001	0.0008
Echinococcus granulosus	expressed conserved protein	0.0188	0.0352	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0685	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0046	0.0572
Echinococcus granulosus	pyruvate kinase	0.0034	0.0047	0.0586
Brugia malayi	Patched related family protein 12	0.0012	0.0004	0.0053
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0358	0.0689	1
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0014	0.0087
Plasmodium falciparum	pyruvate kinase	0.0034	0.0047	0.0151
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0356	0.0685	0.8457
Brugia malayi	RNA binding protein	0.0129	0.0235	0.3426
Echinococcus granulosus	dnaJ subfamily B	0.0419	0.081	1
Brugia malayi	hypothetical protein	0.0012	0.0004	0.0053
Mycobacterium ulcerans	beta-lactamase	0.0075	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0162	0.2363
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0001	0.0008
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0307	0.6415
Schistosoma mansoni	cpg binding protein	0.0031	0.0041	0.0509
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0235	0.2898
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.0127	0.0404
Entamoeba histolytica	fatty acid elongase, putative	0.0208	0.0391	1
Brugia malayi	steroid hormone receptor	0.0011	0.0001	0.0008
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0003
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.16	0.315	0.315
Schistosoma mansoni	cpg binding protein	0.0031	0.0041	0.0509
Brugia malayi	nuclear hormone receptor	0.0011	0.0001	0.0008
Brugia malayi	CHE-14 protein	0.0086	0.015	0.2186
Toxoplasma gondii	patched family protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0307	0.6415
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0007
Toxoplasma gondii	patched family protein	0.0012	0.0004	0.0053
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0307	0.6415
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0001	0.0008
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.4702	0.9294	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.02	0.0376	0.549
Echinococcus granulosus	Niemann Pick C1 protein	0.02	0.0376	0.4643
Toxoplasma gondii	pyruvate kinase PyKII	0.0018	0.0014	0.021
Onchocerca volvulus		0.0012	0.0004	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0001	0.0008
Schistosoma mansoni	hypothetical protein	0.0016	0.001	0.0129
Schistosoma mansoni	hypothetical protein	0.0083	0.0144	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0127	0.1859
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0235	0.2898
Echinococcus multilocularis	insulin receptor	0.0049	0.0077	0.0464
Echinococcus granulosus	cpg binding protein	0.0031	0.0041	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Echinococcus granulosus	GPCR family 2	0.0016	0.001	0.0129
Loa Loa (eye worm)	patched family protein	0.0012	0.0004	0.0053
Toxoplasma gondii	histone lysine-specific demethylase	0.0356	0.0685	0.9948
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0077	0.1126
Schistosoma mansoni	tyrosine kinase	0.0083	0.0143	0.1769
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.16	0.315	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0307	0.6415
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0001	0.0008
Loa Loa (eye worm)	beta-lactamase	0.0075	0.0127	0.1859
Brugia malayi	Myosin head containing protein	0.0012	0.0004	0.0053
Schistosoma mansoni	hypothetical protein	0.0177	0.0331	0.4079
Schistosoma mansoni	hypothetical protein	0.0419	0.081	1
Echinococcus multilocularis		0.0356	0.0685	0.4131
Echinococcus multilocularis	Niemann Pick C1 protein	0.0286	0.0546	0.3294
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0356	0.0685	0.8457
Toxoplasma gondii	pyruvate kinase PyK1	0.0034	0.0047	0.0689
Loa Loa (eye worm)	patched family protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0047	0.0693
Plasmodium falciparum	lipid/sterol:H+ symporter	0.0012	0.0004	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0001	0.0008
Loa Loa (eye worm)	patched family protein	0.0012	0.0004	0.0053
Brugia malayi	hypothetical protein	0.0356	0.0685	1
Brugia malayi	Patched related family protein 4	0.0012	0.0004	0.0053
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.000000057572	0.0000012021
Mycobacterium ulcerans	oxidoreductase	0.0356	0.0685	0.0685
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.16	0.315	0.3355
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0047	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0685	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0001	0.0007
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.0127	0.0086
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0127	0.0127
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.001	0	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0235	0.2898
Plasmodium vivax	hypothetical protein, conserved	0.0356	0.0685	0.2175
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0479	1
Toxoplasma gondii	patched family protein	0.0012	0.0004	0.0053
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Schistosoma mansoni	hypothetical protein	0.0177	0.0331	0.4079
Trypanosoma brucei	pyruvate kinase 1, putative	0.0034	0.0047	0.3726
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0127	0.1572
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.001	0.0129
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.0127	0.1572
Echinococcus granulosus	pyruvate kinase	0.0018	0.0014	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0283	0.4137
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0685	1
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.0127	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Mycobacterium ulcerans	monoamine oxidase	0.0356	0.0685	0.0685
Leishmania major	UDP-galactopyranose mutase	0.0356	0.0685	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0047	0.0693
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0307	0.6415
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0001	0.0007
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0001	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0001	0.0008
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0356	0.0685	0.4131
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Schistosoma mansoni	pyruvate kinase	0.0018	0.0014	0.0178
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0038	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0188	0.2745
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.02	0.0376	0.9613
Echinococcus multilocularis	protein dispatched 1	0.0098	0.0174	0.1048
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0356	0.0685	0.2175
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0127	0.266
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0479	1
Brugia malayi	Patched protein homolog 1	0.0012	0.0004	0.0053
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0356	0.0685	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0103	0.1275
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0127	0.1859
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.16	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Echinococcus multilocularis	sterol regulatory element binding protein	0.0086	0.015	0.0903
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0127	0.266
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0047	0.0286
Loa Loa (eye worm)	pyruvate kinase-PB	0.0024	0.0027	0.0393
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0127	0.266
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Schistosoma mansoni	pyruvate kinase	0.0034	0.0047	0.0586
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0047	0.0286
Echinococcus granulosus	pyruvate kinase	0.0034	0.0047	0.0586
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0001	0.0007
Onchocerca volvulus		0.0012	0.0004	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0127	0.266
Schistosoma mansoni	hypothetical protein	0.0016	0.001	0.0129
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0356	0.0685	0.069
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.0325	0.6783
Chlamydia trachomatis	pyruvate kinase	0.0034	0.0047	0.0151
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.0127	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Toxoplasma gondii	patched family protein	0.0012	0.0004	0.0053
Entamoeba histolytica	fatty acid elongase, putative	0.0208	0.0391	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0047	0.0991
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Mycobacterium leprae	Probable lipase LipE	0.0075	0.0127	0.1859
Brugia malayi	beta-lactamase family protein	0.0075	0.0127	0.1859
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.0127	0.0086
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0252	0.0479	0.6989
Brugia malayi	beta-lactamase family protein	0.0075	0.0127	0.1859
Brugia malayi	protein C24B5.3	0.0012	0.0004	0.0053
Schistosoma mansoni	pyruvate kinase	0.0034	0.0047	0.0586
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0356	0.0685	0.8457
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.001	0.0063
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0001	0.0007
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.16	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0077	0.1126
Echinococcus multilocularis	dnaJ subfamily B	0.0419	0.081	0.4884
Echinococcus granulosus	Niemann Pick C1 protein	0.0286	0.0546	0.6743
Echinococcus multilocularis	Niemann Pick C1 protein	0.02	0.0376	0.2268
Schistosoma mansoni	patched 1	0.0086	0.015	0.1849
Schistosoma mansoni	hypothetical protein	0.0016	0.001	0.0129
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0307	0.6415
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.16	0.315	1
Mycobacterium ulcerans	pyruvate kinase	0.0034	0.0047	0.0047
Schistosoma mansoni	amine oxidase	0.0356	0.0685	0.8457
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.001	0.0153
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.0162	0.2363
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0127	0.0086
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0001	0.0007
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0001	0.0008
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0356	0.0685	0.2175
Entamoeba histolytica	fatty acid elongase, putative	0.0208	0.0391	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.0162	0.2363
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0092	0.0162	0.2363
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0129	0.0235	0.3426
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0047	0.0991
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Onchocerca volvulus		0.0012	0.0004	0.0053
Onchocerca volvulus		0.0012	0.0004	0.0053
Echinococcus multilocularis	epidermal growth factor receptor	0.0154	0.0284	0.1714
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0077	0.1126
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0001	0.0007
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0127	0.1572
Onchocerca volvulus		0.0012	0.0004	0.0053
Brugia malayi	TAR-binding protein	0.0129	0.0235	0.3426
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0477	0.0924	0.0948
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0001	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0127	0.1859
Onchocerca volvulus		0.0075	0.0127	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Loa Loa (eye worm)	TK/INSR protein kinase	0.0049	0.0077	0.1123
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0001	0.0007
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0127	0.266
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0235	0.2898
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.000000057572	0.0000012021
Loa Loa (eye worm)	RNA binding protein	0.0129	0.0235	0.3426
Schistosoma mansoni	hypothetical protein	0.0083	0.0144	0.1773
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0001	0.0008
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.0162	0.2363
Echinococcus granulosus	epidermal growth factor receptor	0.0154	0.0284	0.3509
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.0235	0.2898
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0356	0.0685	0.0685
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0077	0.1123
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.009	0.1308
Echinococcus granulosus	pyruvate kinase	0.0018	0.0014	0.0178
Brugia malayi	Patched related family protein 10	0.0012	0.0004	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0053
Schistosoma mansoni	amine oxidase	0.0356	0.0685	0.8457
Onchocerca volvulus		0.0011	0.0001	0.0008
Brugia malayi	Furin-like cysteine rich region family protein	0.0154	0.0284	0.4149
Brugia malayi	Niemann-Pick C1 protein precursor	0.02	0.0376	0.549
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0001	0.0007
Mycobacterium ulcerans	dehydrogenase	0.0356	0.0685	0.0685
Onchocerca volvulus		0.0012	0.0004	0.0053
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0049	0.0077	0.0464
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.015	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0047	0.0693
Onchocerca volvulus		0.0092	0.0162	0.2363
Brugia malayi	Patched family protein	0.0012	0.0004	0.0053
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0356	0.0685	0.4131
Onchocerca volvulus		0.0029	0.0038	0.0554
Schistosoma mansoni	tyrosine kinase	0.0049	0.0077	0.095
Toxoplasma gondii	hypothetical protein	0.0012	0.0004	0.0053
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0001	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0001	0.0008
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.0479	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0008
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0001	0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2386139

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1782215