Detailed information for compound 178272

Basic information

Technical information
  • TDR Targets ID: 178272
  • Name: (2R)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naph thalen-2-yl-1-oxopropan-2-yl]-1-N-(2-nitrophe nyl)pyrrolidine-1,2-dicarboxamide
  • MW: 579.646 | Formula: C33H33N5O5
  • H donors: 2 H acceptors: 5 LogP: 5.62 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@@H](NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-])Cc1ccc2c(c1)cccc2)N(Cc1ccccc1)C
  • InChi: 1S/C33H33N5O5/c1-36(22-23-10-3-2-4-11-23)32(40)28(21-24-17-18-25-12-5-6-13-26(25)20-24)34-31(39)30-16-9-19-37(30)33(41)35-27-14-7-8-15-29(27)38(42)43/h2-8,10-15,17-18,20,28,30H,9,16,19,21-22H2,1H3,(H,34,39)(H,35,41)/t28-,30+/m0/s1
  • InChiKey: PCVSIMQAFWRUEC-MFMCTBQISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-N2-[(1S)-2-[benzyl(methyl)amino]-1-(2-naphthylmethyl)-2-oxo-ethyl]-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N2-[(1S)-2-[benzyl(methyl)amino]-1-(2-naphthalenylmethyl)-2-oxoethyl]-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N2-[(2S)-1-[methyl(phenylmethyl)amino]-3-naphthalen-2-yl-1-oxo-propan-2-yl]-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N'-[(1S)-2-[benzyl(methyl)amino]-2-keto-1-(2-naphthylmethyl)ethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N'-[(2S)-1-(methyl-(phenylmethyl)amino)-3-naphthalen-2-yl-1-oxopropan-2-yl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N'-[(1S)-2-(methyl-(phenylmethyl)amino)-1-(2-naphthylmethyl)-2-oxo-ethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N'-[(1S)-2-(methyl-(phenylmethyl)amino)-1-(2-naphthylmethyl)-2-oxoethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N'-[(1S)-2-(benzyl-methyl-amino)-2-keto-1-(2-naphthylmethyl)ethyl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
  • (2R)-N'-[(2S)-1-(methyl-(phenylmethyl)amino)-3-naphthalen-2-yl-1-oxo-propan-2-yl]-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0458 0.0474
Brugia malayi Serotonin receptor 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0031 0.014 0.0103
Echinococcus granulosus neuroligin 0.0035 0.0182 0.0163
Brugia malayi Carboxylesterase family protein 0.0206 0.2055 0.3158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Schistosoma mansoni opsin-like receptor 0.006 0.0458 0.0474
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.0182 0.0145
Brugia malayi Melatonin receptor type 1A 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0034 0.0174 0.0473
Echinococcus multilocularis 0.0045 0.0294 0.0257
Onchocerca volvulus 0.006 0.0458 0.0583
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis serotonin receptor 0.006 0.0458 0.0421
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0614 0.6508 0.6495
Echinococcus multilocularis neuroligin 0.0035 0.0182 0.0145
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0458 0.0474
Echinococcus granulosus chromobox protein 1 0.007 0.0564 0.0594
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0174 0.0473
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0458 0.0474
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0034 0.0174 0.9563
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0614 0.6508 0.73
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0458 0.0474
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0038 0.0058
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0458 0.0474
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0034 0.0174 0.9563
Brugia malayi hypothetical protein 0.0029 0.012 0.0184
Toxoplasma gondii DNA topoisomerase 2, putative 0.0034 0.0174 0.0677
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Leishmania major mitochondrial DNA topoisomerase II 0.0034 0.0174 0.0211
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0382 0.0389
Brugia malayi ORL1-like opioid receptor 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0262 0.0775
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0421
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0458 0.0703
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0355 0.0358
Schistosoma mansoni hypothetical protein 0.0289 0.2952 0.3288
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.0182 0.0163
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2925 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0312 0.0309
Brugia malayi AKH receptor 0.006 0.0458 0.0703
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0474
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0034 0.0174 0.9563
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0034 0.0174 0.9563
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.1861 0.2057
Echinococcus granulosus somatostatin receptor 0.006 0.0458 0.0474
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0034 0.0174 0.9563
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0029 0.012 0.0093
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trichomonas vaginalis chromobox protein, putative 0.007 0.0564 0.1824
Mycobacterium tuberculosis Carboxylesterase LipT 0.0035 0.0182 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0458 0.0474
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Loa Loa (eye worm) TK/EGFR protein kinase 0.015 0.1437 0.2208
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0034 0.0174 0.0473
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.012 0.0184
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0458 0.0421
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0458 0.0474
Schistosoma mansoni chromobox protein 0.007 0.0564 0.0594
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0034 0.0174 0.0211
Trypanosoma brucei Valosin-containing protein 0.0029 0.0123 0.0131
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0458 0.0474
Onchocerca volvulus 0.006 0.0458 0.0583
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1291
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0031 0.014 0.0115
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0355 0.0546
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Leishmania major DNA topoisomerase ii 0.0034 0.0174 0.0211
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0312 0.0309
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0458 0.0421
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0034 0.0174 0.9563
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi Furin-like cysteine rich region family protein 0.015 0.1437 0.2208
Loa Loa (eye worm) hypothetical protein 0.0038 0.0211 0.0325
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0458 0.0474
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.0182 0.05
Trypanosoma cruzi DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Trichomonas vaginalis receptor histidine kinase, putative 0.0034 0.0174 0.0473
Brugia malayi kinase, mitochondrial precursor 0.0614 0.6508 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0219 0.0337
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0174 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Echinococcus granulosus g-protein coupled receptor 0.006 0.0458 0.0474
Brugia malayi sulfakinin receptor protein 0.006 0.0458 0.0703
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0034 0.0174 0.9563
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0458 0.0703
Schistosoma mansoni chromobox protein 0.007 0.0564 0.0594
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0174 0.5
Onchocerca volvulus 0.0035 0.0182 0.0083
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0458 0.0474
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0034 0.0174 1
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0215 0.2146 0.3258
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0095 0.084 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0034 0.0174 0.0068
Echinococcus multilocularis neuropeptide s receptor 0.059 0.6244 0.6229
Trypanosoma brucei developmentally regulated phosphoprotein 0.0614 0.6508 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.0182 0.05
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus epidermal growth factor receptor 0.0082 0.0701 0.0749
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus roundabout 2 0.0038 0.0211 0.0196
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0262 0.0775
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0458 0.0474
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0034 0.0174 0.9563
Echinococcus multilocularis serotonin receptor 0.006 0.0458 0.0421
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0458 0.0474
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0458 0.0474
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0029 0.0123 0.0096
Loa Loa (eye worm) hypothetical protein 0.0614 0.6508 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus acetylcholinesterase 0.0206 0.2055 0.2276
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0458 0.0703
Echinococcus granulosus allatostatin A receptor 0.006 0.0458 0.0474
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.032 0.0318
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0034 0.0174 0.0677
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0034 0.0174 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0104 0.023
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0036 0.0195 0.0299
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0458 0.0474
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0174 0.0211
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0458 0.0703
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0034 0.0174 1
Echinococcus multilocularis roundabout 2 0.0038 0.0211 0.0174
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0034 0.0174 0.0068
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Brugia malayi neuropeptide F receptor 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0458 0.0474
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0458 0.0421
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8901 1
Echinococcus multilocularis g protein coupled receptor 0.006 0.0458 0.0421
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0458 0.0474
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0458 0.0421
Echinococcus multilocularis g protein coupled receptor 0.006 0.0458 0.0421
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0458 0.0703
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0182 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0458 0.0703
Plasmodium vivax DNA gyrase subunit B, putative 0.0034 0.0174 0.8692
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0195 0.0158
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0034 0.0174 1
Echinococcus multilocularis fmrfamide receptor 0.006 0.0458 0.0421
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0031 0.014 0.0006
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0034 0.0174 0.0473
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0458 0.0474
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0174 0.0211
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0174 0.0211
Echinococcus multilocularis fmrfamide receptor 0.006 0.0458 0.0421
Echinococcus granulosus defective proboscis extension response 0.0029 0.012 0.0093
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0038 0.0219 0.0337
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Brugia malayi mbt repeat family protein 0.0047 0.0312 0.0479
Onchocerca volvulus 0.0035 0.0182 0.0083
Leishmania major developmentally regulated phosphoprotein-like protein 0.0614 0.6508 1
Onchocerca volvulus 0.006 0.0458 0.0583
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0458 0.0421
Schistosoma mansoni heat shock protein 0.0034 0.0174 0.0154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0458 0.0421
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0082 0.0701 0.0749
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0033 0.0165 0.0143
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0458 0.0421
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus granulosus neuropeptide receptor A26 0.059 0.6244 0.7002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0458 0.0703
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0034 0.0174 0.5
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Onchocerca volvulus 0.006 0.0458 0.0583
Echinococcus multilocularis carboxylesterase 5A 0.0206 0.2055 0.2025
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) TOPoisomerase family member 0.0034 0.0174 0.0268
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni biogenic amine receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) carboxylesterase 0.0035 0.0182 0.028
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0458 0.0474
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.1861 0.183
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0029 0.012 0.0083
Echinococcus granulosus Immunoglobulin 0.0029 0.012 0.0093
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0034 0.0174 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) carboxylesterase 0.0035 0.0182 0.028
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Mycobacterium ulcerans putative regultory protein 0.0034 0.0174 0.9563
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0034 0.0174 1
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0174 0.5
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0034 0.0174 0.0211
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0382 0.0588
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0458 0.0703
Echinococcus granulosus carboxylesterase 5A 0.0206 0.2055 0.2276
Echinococcus multilocularis sex peptide receptor 0.006 0.0458 0.0421
Echinococcus multilocularis acetylcholinesterase 0.0206 0.2055 0.2025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0458 0.0703
Echinococcus multilocularis acetylcholinesterase 0.0206 0.2055 0.2025
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0458 0.0421
Onchocerca volvulus 0.006 0.0458 0.0583
Loa Loa (eye worm) endoplasmin 0.0034 0.0174 0.0268
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0174 0.0473
Echinococcus multilocularis heat shock protein 90 0.0034 0.0174 0.0137
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.1437 0.1405
Brugia malayi vesicle-fusing ATPase 0.0018 0.00000048294 0.00000074207
Brugia malayi heat shock protein 90 0.0034 0.0174 0.0268
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0614 0.6508 1
Brugia malayi G-protein coupled receptor 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0458 0.0474
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Trichomonas vaginalis chromobox protein, putative 0.007 0.0564 0.1824
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0174 0.0677
Plasmodium falciparum DNA topoisomerase 2 0.0034 0.0174 1
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus 0.0035 0.0182 0.0083
Brugia malayi Pre-SET motif family protein 0.0251 0.2546 0.3911
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0312 0.0479
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0034 0.0174 0.9563
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Schistosoma mansoni adenoreceptor 0.006 0.0458 0.0474
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni opsin-like receptor 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Brugia malayi Pre-SET motif family protein 0.0036 0.0195 0.0299
Trypanosoma cruzi DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0029 0.0123 0.5406
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0458 0.0703
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Brugia malayi Protein kinase domain containing protein 0.0051 0.0355 0.0546
Brugia malayi Dopamine receptor protein 2 0.006 0.0458 0.0703
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Onchocerca volvulus 0.006 0.0458 0.0583
Loa Loa (eye worm) hypothetical protein 0.0047 0.0312 0.0479
Echinococcus multilocularis somatostatin receptor 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.0206 0.2055 0.3158
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0029 0.0123 0.6219
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0458 0.0703
Echinococcus granulosus g protein coupled receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0458 0.0421
Echinococcus granulosus serotonin receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.0038 0.0211 0.0325
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.0458 0.0703
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0174 0.0473
Echinococcus multilocularis neuropeptide receptor 0.006 0.0458 0.0421
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0458 0.0474
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0182 0.0163
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0458 0.0474
Loa Loa (eye worm) runx1 0.0067 0.0534 0.082
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.0182 0.0145
Schistosoma mansoni heat shock protein 0.0034 0.0174 0.0154
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus heat shock protein 90 0.0034 0.0174 0.0154
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0034 0.0174 0.9563
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0029 0.012 0.0093
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0034 0.0174 0.0268
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Brugia malayi RE15519p 0.006 0.0458 0.0703
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.018 0.0161
Schistosoma mansoni tyrosine kinase 0.0077 0.0647 0.0687
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0458 0.0421
Echinococcus multilocularis Immunoglobulin 0.0029 0.012 0.0083
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0034 0.0174 1
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0174 0.0268
Onchocerca volvulus 0.006 0.0458 0.0583
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0382 0.0389
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0215 0.2146 0.3258
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0458 0.0703
Brugia malayi Heterochromatin protein 1 0.007 0.0564 0.0867
Loa Loa (eye worm) hypothetical protein 0.0053 0.0382 0.0588
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus g protein coupled receptor 0.006 0.0458 0.0474
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0031 0.014 0.0115
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0352
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni tyrosine kinase 0.0051 0.0355 0.0358
Schistosoma mansoni endoplasmin 0.0034 0.0174 0.0154
Mycobacterium leprae Probable two component sensor kinase MprB 0.0034 0.0174 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0038 0.1894
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Echinococcus multilocularis epidermal growth factor receptor 0.0082 0.0701 0.0666
Echinococcus granulosus neuropeptide receptor 0.006 0.0458 0.0474
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0355 0.0318
Mycobacterium tuberculosis Probable two component sensor kinase 0.0034 0.0174 0.9563
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0458 0.0474
Onchocerca volvulus 0.0047 0.032 0.0333
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.0182 0.0163
Echinococcus multilocularis Protein lozenge 0.0067 0.0534 0.0498
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0458 0.0421
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Schistosoma mansoni gliotactin 0.0035 0.0182 0.0163
Brugia malayi Dopamine receptor 0.006 0.0458 0.0703
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0458 0.0703
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0034 0.0174 0.0473
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0458 0.0474
Onchocerca volvulus 0.006 0.0458 0.0583
Mycobacterium tuberculosis Conserved protein 0.0034 0.0174 0.9563
Brugia malayi Dopamine receptor protein 1 0.006 0.0458 0.0703
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0034 0.0174 0.0211
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0174 0.0211
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0458 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Loa Loa (eye worm) MBCTL1 0.0053 0.0382 0.0588
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0034 0.0174 0.9563
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0195 0.0177
Brugia malayi chromobox protein homolog 3 0.0039 0.0229 0.0352
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0174 0.1702
Schistosoma mansoni tyrosine kinase 0.0051 0.0355 0.0358
Echinococcus multilocularis chromobox protein 1 0.007 0.0564 0.0529
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0458 0.0583
Trypanosoma cruzi Valosin-containing protein, putative 0.0029 0.0123 0.0131
Schistosoma mansoni biogenic amine receptor 0.006 0.0458 0.0474
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0229 0.0168
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.0535 0.5642 0.8669
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.0182 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0382 0.0389
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0031 0.014 0.0355
Brugia malayi putative neuropeptide receptor 0.006 0.0458 0.0703
Schistosoma mansoni histamine h1 receptor 0.006 0.0458 0.0474
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0458 0.0474
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0215 0.2146 0.8517
Plasmodium falciparum heat shock protein 90 0.0034 0.0174 1
Brugia malayi G-protein coupled receptor 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Mycobacterium tuberculosis Possible two component sensor kinase 0.0034 0.0174 0.9563
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0382 0.0346
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0253
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Toxoplasma gondii cell division protein CDC48AP 0.0019 0.0004 0.0000019203
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.0182 0.0163
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0312 0.0309
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0034 0.0174 0.0137
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0034 0.0174 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0312 0.0275
Schistosoma mansoni hypothetical protein 0.006 0.0458 0.0474
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2546 0.3911
Schistosoma mansoni tyrosine kinase 0.0082 0.0701 0.0749
Echinococcus granulosus neuroglian 0.0033 0.0167 0.0146
Echinococcus granulosus insulin receptor 0.0051 0.0355 0.0358
Leishmania major hypothetical protein, conserved 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni tyrosine kinase 0.0082 0.0701 0.0749
Onchocerca volvulus 0.0035 0.0182 0.0083
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0038 0.1894
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0104 0.023
Entamoeba histolytica cdc48-like protein, putative 0.0029 0.0123 0.1059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Brugia malayi Serotonin receptor 0.006 0.0458 0.0703
Schistosoma mansoni pyruvate dehydrogenase 0.058 0.6135 0.6879
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0034 0.0174 0.0473
Brugia malayi Carboxylesterase family protein 0.0035 0.0182 0.028
Plasmodium vivax endoplasmin, putative 0.0034 0.0174 0.8692
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0262 0.0227
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Brugia malayi larval opioid receptor 0.006 0.0458 0.0703
Brugia malayi follicle stimulating hormone receptor 0.006 0.0458 0.0703
Schistosoma mansoni amine GPCR 0.006 0.0458 0.0474
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0182 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0034 0.0174 0.0677
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0034 0.0174 0.9563
Echinococcus granulosus chromobox protein 1 0.007 0.0564 0.0594
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Schistosoma mansoni tyrosine kinase 0.015 0.1437 0.1579
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0268
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0029 0.0123 0.1059
Echinococcus multilocularis orexin receptor type 2 0.006 0.0458 0.0421
Schistosoma mansoni DNA topoisomerase II 0.0034 0.0174 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni vesicular amine transporter 0.0029 0.012 0.0093
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0174 0.0211
Brugia malayi mbt repeat family protein 0.0047 0.0312 0.0479
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0182 0.0163
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Schistosoma mansoni acetylcholinesterase 0.0035 0.0182 0.0163
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Plasmodium falciparum endoplasmin, putative 0.0034 0.0174 1
Toxoplasma gondii cell division protein CDC48CY 0.0031 0.014 0.0541
Echinococcus granulosus g protein coupled receptor 0.006 0.0458 0.0474
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0458 0.0421
Echinococcus multilocularis g protein coupled receptor 0.006 0.0458 0.0421
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0458 0.0703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.0535 0.5642 0.8669
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0458 0.0474
Plasmodium vivax DNA topoisomerase II, putative 0.0034 0.0174 0.8692
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Echinococcus granulosus heat shock protein 0.0034 0.0174 0.0154
Brugia malayi Fibronectin type III domain containing protein 0.0029 0.012 0.0184
Echinococcus granulosus hypothetical protein 0.006 0.0458 0.0474
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0564 0.0867
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0458 0.0474
Mycobacterium ulcerans DNA gyrase subunit B 0.0034 0.0174 0.9563
Echinococcus multilocularis allatostatin A receptor 0.006 0.0458 0.0421
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0458 0.0703
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0034 0.0174 0.0154
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0249 0.2519 1
Echinococcus multilocularis neuroglian 0.0033 0.0167 0.013
Onchocerca volvulus 0.006 0.0458 0.0583
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Loa Loa (eye worm) carboxylesterase 0.0206 0.2055 0.3158
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.0182 0.0163
Brugia malayi Probable DNA topoisomerase II 0.0034 0.0174 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0174 0.8692
Entamoeba histolytica DNA topoisomerase II, putative 0.0034 0.0174 0.1702
Echinococcus multilocularis neuropeptide receptor A26 0.059 0.6244 0.6229
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0458 0.0421
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0458 0.0703
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0095 0.084 1
Onchocerca volvulus 0.006 0.0458 0.0583
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Onchocerca volvulus 0.0535 0.5642 1
Schistosoma mansoni pyruvate dehydrogenase 0.058 0.6135 0.6879
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.0182 0.0145
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0268
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Brugia malayi hypothetical protein 0.0035 0.0182 0.028
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0458 0.0421
Brugia malayi Carboxylesterase family protein 0.0206 0.2055 0.3158
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0034 0.0174 0.9563
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0458 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Schistosoma mansoni biogenic amine receptor 0.006 0.0458 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0229 0.0663
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0458 0.0421
Onchocerca volvulus 0.0286 0.2925 0.5064
Schistosoma mansoni opsin-like receptor 0.006 0.0458 0.0474
Schistosoma mansoni pyruvate dehydrogenase 0.0614 0.6508 0.73
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0034 0.0174 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0195 0.0177
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0184
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0458 0.0421
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0038 0.0058
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0312 0.0309
Echinococcus multilocularis neuropeptide receptor 0.006 0.0458 0.0421
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Echinococcus multilocularis heat shock protein 0.0034 0.0174 0.0137
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0458 0.0474
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0182 0.0163
Loa Loa (eye worm) hypothetical protein 0.0206 0.2055 0.3158
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0312 0.0318
Schistosoma mansoni endoplasmin 0.0034 0.0174 0.0154
Schistosoma mansoni neuropeptide receptor 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0312 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0195 0.0177
Echinococcus granulosus orexin receptor type 2 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0038 0.198
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0034 0.0174 0.9563
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Schistosoma mansoni tyrosine kinase 0.0077 0.0647 0.0687
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0195 0.0759
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0034 0.0174 0.0068
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Schistosoma mansoni nephrin 0.0033 0.0167 0.0146
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0458 0.0421
Plasmodium vivax SET domain protein, putative 0.0036 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus 0.0035 0.0182 0.0083
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0458 0.0421
Mycobacterium ulcerans carboxylesterase, LipT 0.0035 0.0182 1
Onchocerca volvulus 0.0047 0.0312 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Echinococcus multilocularis Immunoglobulin 0.0029 0.012 0.0083
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0458 0.0474
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0458 0.0421
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0215 0.2146 0.3258
Trypanosoma brucei DNA topoisomerase ii 0.0034 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni myosin xvIII 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0382 0.0346
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0458 0.0421
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0614 0.6508 0.6495
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0034 0.0174 0.9563
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0174 1
Mycobacterium ulcerans two component regulator - sensor kinase 0.0034 0.0174 0.9563
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0174 0.1702
Schistosoma mansoni tyrosine kinase 0.0077 0.0647 0.0687
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8901 0.8897
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0458 0.0474
Trypanosoma brucei heat shock protein, putative 0.0034 0.0174 0.0211
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0034 0.0174 0.9563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0458 0.0474
Echinococcus granulosus epidermal growth factor receptor 0.015 0.1437 0.1579
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0458 0.0474
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0458 0.0421
Brugia malayi hypothetical protein 0.006 0.0458 0.0703
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0174 0.0211
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0034 0.0174 0.0211
Schistosoma mansoni lozenge 0.0067 0.0534 0.056
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0034 0.0174 0.9563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.028
Leishmania major heat shock protein 83-1 0.0034 0.0174 0.0211
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0174 0.8692
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0195 0.0177
Brugia malayi G protein-coupled receptor 0.006 0.0458 0.0703
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0458 0.0474
Echinococcus granulosus sex peptide receptor 0.006 0.0458 0.0474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0458 0.0474
Loa Loa (eye worm) hypothetical protein 0.0535 0.5642 0.8669
Trichomonas vaginalis receptor histidine kinase, putative 0.0034 0.0174 0.0473
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0312 0.0275
Brugia malayi GnHR receptor homolog 0.006 0.0458 0.0703
Trichomonas vaginalis DNA topoisomerase II, putative 0.0034 0.0174 0.0473
Echinococcus multilocularis insulin receptor 0.0051 0.0355 0.0318
Echinococcus granulosus fmrfamide receptor 0.006 0.0458 0.0474
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0458 0.0421
Giardia lamblia Pms1-like protein 0.0034 0.0174 1
Toxoplasma gondii exonuclease III APE 0.0022 0.0038 0.0134
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8901 1
Onchocerca volvulus 0.006 0.0458 0.0583
Onchocerca volvulus 0.006 0.0458 0.0583
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0174 0.0677
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Onchocerca volvulus 0.006 0.0458 0.0583
Brugia malayi neuropeptide F receptor 0.006 0.0458 0.0703
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0458 0.0583
Brugia malayi Endoplasmin precursor 0.0034 0.0174 0.0268
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0458 0.0474
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0029 0.0123 0.0131
Loa Loa (eye worm) acetylcholinesterase 1 0.0206 0.2055 0.3158
Echinococcus granulosus neuropeptide receptor 0.006 0.0458 0.0474
Mycobacterium leprae Probable two-component sensor kinase 0.0034 0.0174 0.5
Mycobacterium ulcerans two component sensor kinase MprB 0.0034 0.0174 0.9563
Trichomonas vaginalis sensor histidine kinase, putative 0.0034 0.0174 0.0473
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0195 0.0158
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0174 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0229 0.0663
Echinococcus granulosus neuropeptide s receptor 0.059 0.6244 0.7002
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Schistosoma mansoni cell adhesion molecule 0.0033 0.0165 0.0143
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0206 0.2055 0.2276
Echinococcus granulosus acetylcholinesterase 0.0206 0.2055 0.2276
Echinococcus multilocularis chromobox protein 1 0.007 0.0564 0.0529
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0703
Echinococcus granulosus twitchin 0.0033 0.0167 0.0146
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0034 0.0174 0.9563
Plasmodium falciparum DNA gyrase subunit B 0.0034 0.0174 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0034 0.0174 0.9563

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.1 uM In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R ChEMBL. 9703462
IC50 (binding) = 7.1 uM In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R ChEMBL. 9703462

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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