TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.888 | Formula: C18H20ClN3O2S
H donors: 2 H acceptors: 2 LogP: 4.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CNC(=O)c1sc2c(c1N)c(C)cc(n2)C.Cl
InChi: 1S/C18H19N3O2S.ClH/c1-10-8-11(2)21-18-14(10)15(19)16(24-18)17(22)20-9-12-4-6-13(23-3)7-5-12;/h4-8H,9,19H2,1-3H3,(H,20,22);1H
InChiKey: YBJIEYPPSOBSKN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, muscarinic 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Entamoeba histolytica	hypothetical protein	0.006	0.1364	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Brugia malayi	hypothetical protein	0.0013	0.0186	0.0111
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Echinococcus granulosus	histone lysine methyltransferase setb	0.0026	0.0498	0.0631
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Onchocerca volvulus		0.0026	0.0516	0.0336
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0013	0.0186	0.0211
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0302	0.7462	0.7442
Loa Loa (eye worm)	hypothetical protein	0.0174	0.4244	0.4199
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0013	0.0186	0.0111
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Trypanosoma brucei	DNA polymerase IV, putative	0.0016	0.0246	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.0246	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0013	0.0186	0.0211
Schistosoma mansoni	hypothetical protein	0.006	0.1364	0.1796
Echinococcus granulosus	survival motor neuron protein 1	0.0206	0.504	0.6742
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0016	0.0246	0.0292
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0302	0.7462	1
Mycobacterium ulcerans	DNA polymerase IV	0.0016	0.0246	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0016	0.0246	0.0292
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Schistosoma mansoni	cpg binding protein	0.0026	0.0516	0.0654
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Leishmania major	DNA polymerase kappa, putative	0.0016	0.0246	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0026	0.0498	0.0631
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Trichomonas vaginalis	set domain proteins, putative	0.02	0.4897	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0246	0.0171
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.006	0.1364	0.1796
Schistosoma mansoni	protein tyrosine phosphatase	0.0013	0.0186	0.0211
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0013	0.0186	0.0211
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0016	0.0246	1
Echinococcus granulosus	dna polymerase eta	0.0016	0.0246	0.0292
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0007	0.0029	0.5
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0302	0.7462	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Onchocerca volvulus		0.0403	1	1
Brugia malayi	CXXC zinc finger family protein	0.0026	0.0516	0.0443
Trypanosoma brucei	DNA polymerase IV, putative	0.0016	0.0246	1
Trypanosoma brucei	unspecified product	0.0016	0.0246	1
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0013	0.0186	0.0211
Brugia malayi	hypothetical protein	0.0013	0.0186	0.0111
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0013	0.0186	0.0211
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0186	0.0211
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0186	0.0211
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0016	0.0246	0.0292
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Brugia malayi	hypothetical protein	0.0174	0.4244	0.42
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0013	0.0186	0.0211
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0024	0.046	0.058
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Entamoeba histolytica	hypothetical protein	0.006	0.1364	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0038	0.0012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Giardia lamblia	DINP protein human, muc B family	0.0016	0.0246	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0013	0.0186	0.0211
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0016	0.0246	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Trichomonas vaginalis	pten, drome, putative	0.0013	0.0186	0.0379
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Brugia malayi	hypothetical protein	0.006	0.1364	0.1298
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0042	0.0908	0.0838
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0016	0.0246	0.0502
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0013	0.0186	0.0108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0498	0.0631
Onchocerca volvulus		0.02	0.4897	0.4801
Echinococcus multilocularis	dna polymerase kappa	0.0016	0.0246	0.0292
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0013	0.0186	0.0211
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0206	0.504	0.6742
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0013	0.0186	0.5102
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0246	0.0169
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Onchocerca volvulus		0.0174	0.4244	0.4135
Onchocerca volvulus		0.0403	1	1
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0013	0.0186	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0013	0.0186	0.0211
Echinococcus multilocularis	cpg binding protein	0.0028	0.0554	0.0706
Brugia malayi	Pre-SET motif family protein	0.0176	0.4286	0.4243
Leishmania major	DNA polymerase eta, putative	0.0016	0.0246	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0498	0.0631
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0013	0.0186	0.0211
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.006	0.1364	0.1796
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0016	0.0246	0.0169
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0038	0.0012
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0013	0.0186	0.0211
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0026	0.0498	0.0631
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0206	0.504	0.5001
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Brugia malayi	Protein-tyrosine phosphatase	0.0013	0.0186	0.0111
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0013	0.0186	0.0108
Brugia malayi	hypothetical protein	0.0013	0.0186	0.0111
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0016	0.0246	0.0292
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Schistosoma mansoni	transcription factor LCR-F1	0.006	0.1364	0.1796
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0016	0.0246	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Plasmodium vivax	SET domain protein, putative	0.0026	0.0498	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0016	0.0246	0.0512
Onchocerca volvulus		0.0042	0.0908	0.0736
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0016	0.0246	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0013	0.0186	0.0211
Brugia malayi	Pre-SET motif family protein	0.0026	0.0498	0.0425
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0186	0.0211
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0051	0.1135	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Trichomonas vaginalis	DNA polymerase eta, putative	0.0016	0.0246	0.0502
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.0246	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Brugia malayi	Protein-tyrosine phosphatase	0.0013	0.0186	0.0111
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.0246	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0026	0.0516	0.0441
Brugia malayi	hypothetical protein	0.0013	0.0186	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Schistosoma mansoni	cpg binding protein	0.0028	0.0554	0.0706
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0302	0.7462	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0079	0.0066
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0038	0.0012
Entamoeba histolytica	hypothetical protein	0.006	0.1364	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0498	0.0423
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Schistosoma mansoni	hypothetical protein	0.0042	0.0908	0.1182
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0016	0.0246	1
Echinococcus granulosus	dna polymerase kappa	0.0016	0.0246	0.0292
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0026	0.0498	0.0631
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0013	0.0186	0.0211
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0302	0.7462	0.7442
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0013	0.0186	0.0211
Brugia malayi	hypothetical protein	0.0206	0.504	0.5002
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0013	0.0186	0.0211
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0013	0.0186	0.0211
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0013	0.0186	0.0211
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0013	0.0186	0.0111
Schistosoma mansoni	DNA polymerase eta	0.0016	0.0246	0.0292
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0038	0.0012
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0246	1
Trichomonas vaginalis	ferritin, putative	0.0007	0.0029	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.0246	1
Schistosoma mansoni	pcd6 interacting protein-related	0.0013	0.0186	0.0211
Brugia malayi	hypothetical protein	0.0013	0.0186	0.0111
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0186	0.0211
Treponema pallidum	bacterioferrin (TpF1)	0.0007	0.0029	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.0016	0.0246	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0079	0.0066
Echinococcus multilocularis		0.0013	0.0186	0.0211
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0013	0.0186	0.0108
Echinococcus multilocularis	hypothetical protein	0.0013	0.0186	0.0211
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0013	0.0186	0.0108
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0246	0.0171
Schistosoma mansoni	survival motor neuron protein	0.0042	0.0908	0.1182
Echinococcus granulosus	cpg binding protein	0.0028	0.0554	0.0706
Onchocerca volvulus		0.0026	0.0498	0.0318
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0038	0.0012
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0498	0.0631
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0186	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0246	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0013	0.0186	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Schistosoma mansoni	cpg binding protein	0.0028	0.0554	0.0706
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0057	0.1286	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0007	0.0029	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0013	0.0186	0.0111
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0176	0.4286	0.4241
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0108
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0186	0.0211
Schistosoma mansoni	protein tyrosine phosphatase	0.0013	0.0186	0.0211
Brugia malayi	Protein-tyrosine phosphatase 1	0.0013	0.0186	0.0111
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0013	0.0186	0.0211
Echinococcus multilocularis	dna polymerase eta	0.0016	0.0246	0.0292
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0403	1	1
Entamoeba histolytica	hypothetical protein	0.006	0.1364	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 6.89	Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO Flp-In cells assessed as stimulation of acetylcholine-induced ERK1/2 phosphorylation incubated under green light condition by fluorescence assay	ChEMBL.	24074052
EC50 (binding)	= 0.13 uM	Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO Flp-In cells assessed as stimulation of acetylcholine-induced ERK1/2 phosphorylation incubated under green light condition by fluorescence assay	ChEMBL.	24074052
Emax (binding)	= 85 %	Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO Flp-In cells assessed as stimulation of acetylcholine-induced ERK1/2 phosphorylation incubated under green light condition by fluorescence assay relative to control	ChEMBL.	24074052
Kb (binding)	= 1.14 uM	Binding affinity to human muscarinic M4 receptor expressed in CHO Flp-In cells	ChEMBL.	24074052

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2435348

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1787975