Detailed information for compound 1791246

Basic information

Technical information
  • TDR Targets ID: 1791246
  • Name: AN-689/41741150
  • MW: 283.347 | Formula: C12H17N3O3S
  • H donors: 2 H acceptors: 0 LogP: 1.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)/C(=N\NC(=S)N)/C
  • InChi: 1S/C12H17N3O3S/c1-7(14-15-12(13)19)8-5-9(16-2)11(18-4)10(6-8)17-3/h5-6H,1-4H3,(H3,13,15,19)/b14-7-
  • InChiKey: MAUDBTSCSBAQQG-AUWJEWJLSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0151 0.1488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0151 0.1488
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0216 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Brugia malayi hypothetical protein 0.0229 0.0975 0.0975
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0235 0.0999 0.0999
Plasmodium vivax vivapain-3 0.001 0.002 0.1111
Brugia malayi Papain family cysteine protease containing protein 0.001 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0975 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0063
Schistosoma mansoni regulator of G protein signaling 0.0229 0.0975 0.0975
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0063 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.0975 0.0975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.002 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Leishmania major cathepsin L-like protease 0.0077 0.0311 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0028 0.0031
Brugia malayi hypothetical protein 0.0006 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0063 0.007
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.002 0.053
Entamoeba histolytica cysteine protease, putative 0.002 0.0063 0.0448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Echinococcus granulosus axis inhibition protein axin 0.0229 0.0975 0.1083
Echinococcus multilocularis expressed protein 0.0229 0.0975 0.1083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0028 0.0028
Loa Loa (eye worm) PXA domain-containing protein 0.0229 0.0975 0.0975
Brugia malayi nuclear receptor RXR 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Echinococcus multilocularis regulator of G protein signaling 3 0.0229 0.0975 0.1083
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.001 0.0011
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2067 0.9 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0975 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0229 0.0975 0.0975
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0151 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0216 0.024
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0229 0.0975 0.1083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0272 0.0272
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0229 0.0975 0.1083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0028 0.0031
Echinococcus multilocularis Regulator of G protein signaling 20 0.0229 0.0975 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0028 0.0028
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0151 0.0167
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0239 0.7656
Mycobacterium ulcerans lipase LipD 0.004 0.0151 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0151 0.4775
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.002 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0229 0.0975 0.0975
Echinococcus granulosus axis inhibition protein axin 0.0229 0.0975 0.1083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0028 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0028 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0028 0.0031
Entamoeba histolytica hypothetical protein 0.0229 0.0975 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2297 1 1
Echinococcus multilocularis muscleblind protein 0.0167 0.0704 0.0783
Onchocerca volvulus 0.002 0.0063 0.1017
Onchocerca volvulus 0.002 0.0063 0.1017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2067 0.9 0.9
Schistosoma mansoni cathepsin s 0.0007 0.0004 0.0004
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0063 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0063
Schistosoma mansoni regulator of G protein signaling 0.0229 0.0975 0.0975
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Onchocerca volvulus 0.002 0.0063 0.1017
Leishmania major cathepsin L-like protease 0.0077 0.0311 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0311 1
Schistosoma mansoni regulator of G protein signaling 0.0229 0.0975 0.0975
Echinococcus multilocularis beta adrenergic receptor kinase 0.0235 0.0999 0.111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.0621 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0063 0.007
Mycobacterium leprae conserved hypothetical protein 0.004 0.0151 0.5
Loa Loa (eye worm) ctsf protein 0.002 0.0063 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0034
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0063 0.1924
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0229 0.0975 0.0975
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0028 0.0031
Echinococcus multilocularis cysteine protease 0.002 0.0063 0.007
Loa Loa (eye worm) histone methyltransferase 0.001 0.0018 0.0018
Loa Loa (eye worm) RGS-3 protein 0.0229 0.0975 0.0975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0216 0.0216
Echinococcus multilocularis regulator of G protein signaling 7 0.0229 0.0975 0.1083
Leishmania major hypothetical protein, conserved 0.004 0.0151 0.353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.002 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0034 0.0282
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0216 0.024
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0063 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0151
Echinococcus granulosus regulator of G protein signaling 7 0.0229 0.0975 0.1083
Echinococcus granulosus Regulator of G protein signaling 20 0.0229 0.0975 0.1083
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0028 0.0031
Echinococcus granulosus muscleblind protein 0.0167 0.0704 0.0783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0028 0.0028
Echinococcus granulosus cathepsin l1 0.002 0.0063 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0034 0.0282
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0028 0.0028
Echinococcus multilocularis cpg binding protein 0.0034 0.0123 0.0137
Onchocerca volvulus 0.002 0.0063 0.1017
Schistosoma mansoni regulator of G protein signaling 0.0229 0.0975 0.0975
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0003 0.0003
Brugia malayi A-kinase anchor protein 10, precursor 0.0229 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Echinococcus multilocularis cysteine protease 0.002 0.0063 0.007
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0063
Mycobacterium ulcerans hypothetical protein 0.004 0.0151 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0063
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0007 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0028 0.0028
Onchocerca volvulus 0.0014 0.0034 0.0547
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0063 0.0063
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.002 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0216 0.0216
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0028 0.0031
Echinococcus granulosus regulator of G protein signaling 3 0.0229 0.0975 0.1083
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.1098 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0028 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0028 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0151 0.5
Brugia malayi hypothetical protein 0.0229 0.0975 0.0975
Echinococcus multilocularis cathepsin L 0.001 0.002 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0975 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Onchocerca volvulus 0.0032 0.0115 0.1855
Schistosoma mansoni serine/threonine protein kinase 0.2297 1 1
Brugia malayi Muscleblind-like protein 0.0167 0.0704 0.0704
Loa Loa (eye worm) fibroinase 0.002 0.0063 0.0063
Brugia malayi beta-lactamase family protein 0.004 0.0151 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Mycobacterium ulcerans beta-lactamase 0.004 0.0151 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.0229 0.0975 0.1083
Brugia malayi hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0063 0.0063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0216 0.0216
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0028 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0028 0.0028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0241 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0151 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0028 0.0031
Brugia malayi regulator of G-protein signaling egl-10 0.0229 0.0975 0.0975
Echinococcus granulosus cathepsin l1 0.0014 0.0034 0.0038
Plasmodium vivax hypothetical protein, conserved 0.004 0.0151 1
Toxoplasma gondii ABC1 family protein 0.004 0.0151 0.4935
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0063 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0028 0.0028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0063 0.007
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Brugia malayi Papain family cysteine protease containing protein 0.001 0.002 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0003 0.0003
Onchocerca volvulus 0.004 0.0151 0.2428
Echinococcus multilocularis axis inhibition protein axin 0.0229 0.0975 0.1083
Schistosoma mansoni z-protein (S1r protein) 0.0229 0.0975 0.0975
Leishmania major cathepsin L-like protease 0.0077 0.0311 1
Echinococcus granulosus cathepsin L 0.001 0.002 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Onchocerca volvulus 0.002 0.0063 0.1017
Onchocerca volvulus 0.004 0.0151 0.2428
Echinococcus granulosus cysteine protease 0.001 0.002 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0115 0.0115
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0028 0.0031
Schistosoma mansoni cpg binding protein 0.0034 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0063 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi regulator of G-protein signaling rgs-7 0.0229 0.0975 0.0975
Echinococcus multilocularis regulator of G protein signaling 7 0.0229 0.0975 0.1083
Brugia malayi cathepsin L-like precursor 0.0014 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0148 0.0621 0.0621
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2067 0.9 0.9
Brugia malayi nuclear hormone receptor 0.0012 0.0028 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0151 0.0151
Brugia malayi nuclear receptor NHR-88 0.0012 0.0028 0.0028
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.001 0.0011
Loa Loa (eye worm) cysteine protease 0.002 0.0063 0.0063
Plasmodium vivax vivapain-1 0.001 0.002 0.1111
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0063 0.0063
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0151
Brugia malayi ecdysteroid receptor 0.0012 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.0999 0.0999
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0063 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0115 0.0115
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0028 0.0028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0063 0.007
Brugia malayi Cathepsin L-like precursor 0.0014 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0034
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0151
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.002 0.053
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0028 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0151 0.1488
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0028 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0216 0.0216
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0028 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Onchocerca volvulus Cathepsin L homolog 0.002 0.0063 0.1017
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.002 0.002
Onchocerca volvulus 0.002 0.0063 0.1017
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0004
Onchocerca volvulus Huntingtin homolog 0.0148 0.0621 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0007 0.0004 0.0004
Echinococcus multilocularis muscleblind protein 1 0.0167 0.0704 0.0783
Loa Loa (eye worm) hypothetical protein 0.0167 0.0704 0.0704
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0028 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0975 1
Schistosoma mansoni axis inhibition protein axin 0.0229 0.0975 0.0975
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.0999 0.0999
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.001 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0151 0.4775
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0148 0.0621 0.0621
Brugia malayi beta-lactamase 0.004 0.0151 0.0151
Schistosoma mansoni regulator of G protein signaling 0.0229 0.0975 0.0975
Echinococcus multilocularis regulator of G protein signaling 0.0229 0.0975 0.1083
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0282 0.905
Loa Loa (eye worm) hypothetical protein 0.0167 0.0704 0.0704
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0028 0.0453
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0063
Onchocerca volvulus 0.004 0.0151 0.2428
Mycobacterium leprae Probable lipase LipE 0.004 0.0151 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0003 0.0003
Onchocerca volvulus 0.002 0.0063 0.1017
Trypanosoma cruzi cysteine protease, putative 0.001 0.002 0.053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0975 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0311 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0028 0.0028
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0028 0.0031
Brugia malayi Cathepsin L-like precursor 0.0014 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0151
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0311 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.0583
Loa Loa (eye worm) beta-lactamase 0.004 0.0151 0.0151
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0028 0.0028
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.002 0.053
Onchocerca volvulus 0.0012 0.0028 0.0453
Entamoeba histolytica hypothetical protein 0.0229 0.0975 1
Echinococcus granulosus expressed protein 0.0229 0.0975 0.1083
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0028 0.0028
Brugia malayi steroid hormone receptor 0.0012 0.0028 0.0028
Echinococcus multilocularis axis inhibition protein axin 0.0229 0.0975 0.1083
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0151
Brugia malayi beta-lactamase family protein 0.004 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0229 0.0975 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0229 0.0975 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0063 0.007
Plasmodium vivax vivapain-2 0.002 0.0063 0.4029
Loa Loa (eye worm) hypothetical protein 0.0229 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Plasmodium vivax unspecified product 0.001 0.002 0.1111
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0028 0.0028
Trichomonas vaginalis esterase, putative 0.004 0.0151 0.1488
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0063 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0151 0.1488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0311 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Brugia malayi hypothetical protein 0.0148 0.0621 0.0621
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0063
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0028 0.0031
Schistosoma mansoni cpg binding protein 0.0032 0.0115 0.0115
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0229 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0229 0.0975 0.0975
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0028 0.0028
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0028 0.0031
Brugia malayi Regulator of G protein signaling domain containing protein 0.0229 0.0975 0.0975
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0028 0.0453
Brugia malayi Regulator of G protein signaling domain containing protein 0.0229 0.0975 0.0975
Schistosoma mansoni coup transcription factor 0.0012 0.0028 0.0028
Echinococcus granulosus regulator of G protein signaling 3 0.0229 0.0975 0.1083
Loa Loa (eye worm) hypothetical protein 0.004 0.0151 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0975 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0003 0.0003
Brugia malayi PXA domain containing protein 0.0229 0.0975 0.0975
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0311 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0229 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0216 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0216 0.024
Brugia malayi PXA domain containing protein 0.0229 0.0975 0.0975
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0063 1
Plasmodium vivax vivapain-2 0.002 0.0063 0.4029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0151 0.0151
Onchocerca volvulus Cathepsin F homolog 0.002 0.0063 0.1017
Echinococcus multilocularis regulator of G protein signaling 3 0.0229 0.0975 0.1083
Echinococcus granulosus cpg binding protein 0.0034 0.0123 0.0137
Onchocerca volvulus Cathepsin L homolog 0.002 0.0063 0.1017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0028 0.0028
Schistosoma mansoni axis inhibition protein axin 0.0229 0.0975 0.0975
Brugia malayi Cathepsin L-like precursor 0.0007 0.0004 0.0004
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0028 0.0028
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0028 0.0453
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0151 0.1488
Echinococcus granulosus beta-adrenergic receptor kinase 0.0235 0.0999 0.111
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0151 0.4482
Brugia malayi cathepsin F-like cysteine proteinase 0.0007 0.0004 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.002
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0063 0.0448
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0028 0.0028
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2067 0.9 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2067 0.9 0.9
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.0583
Loa Loa (eye worm) hypothetical protein 0.0229 0.0975 0.0975
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0229 0.0975 0.0975
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0151 0.0167
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0028 0.0028

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Trypanocidal activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of parasite proliferation after 72 hr by Lilit Alamar Blue method ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 50 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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