Detailed information for compound 1794034

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 268.334 | Formula: C15H12N2OS
  • H donors: 1 H acceptors: 0 LogP: 2.99 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)c1ccc(cc1)c1ccc(o1)c1cccs1
  • InChi: 1S/C15H12N2OS/c16-15(17)11-5-3-10(4-6-11)12-7-8-13(18-12)14-2-1-9-19-14/h1-9H,(H3,16,17)
  • InChiKey: JMZXONZXMMRWAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0008 0.0009
Schistosoma mansoni lamin 0.0026 0.009 0.0111
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0115 0.0141
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0146 0.0847 0.0968
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0129 0.1078
Trichomonas vaginalis set domain proteins, putative 0.02 0.1194 1
Schistosoma mansoni hypothetical protein 0.003 0.0115 0.0141
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.013 0.0596
Trypanosoma cruzi UDP-galactopyranose mutase 0.0338 0.2066 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0166 0.0975 0.1202
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0129 0.1078
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0338 0.2066 1
Echinococcus multilocularis microtubule associated protein 2 0.0579 0.3592 0.4426
Leishmania major UDP-galactopyranose mutase 0.0338 0.2066 1
Plasmodium vivax SET domain protein, putative 0.0027 0.0093 0.0415
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0008 0.0004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0033 0.013 0.5
Entamoeba histolytica hypothetical protein 0.003 0.0115 0.2032
Schistosoma mansoni cpg binding protein 0.0082 0.0445 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0565 0.4737
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0008 0.0009
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0338 0.2066 1
Entamoeba histolytica hypothetical protein 0.0101 0.0565 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0008 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0138 0.0667
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0129 0.0623
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0129 0.0154
Brugia malayi SWIRM domain containing protein 0.1393 0.8752 1
Brugia malayi beta-lactamase 0.0034 0.0138 0.0157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.01
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0101 0.0565 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.0989 0.8288
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.009 0.0103
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0052 0.0064
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0033 0.013 0.0149
Brugia malayi exodeoxyribonuclease III family protein 0.0033 0.013 0.0149
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.0008 0.0037
Trichomonas vaginalis helicase, putative 0.0018 0.0035 0.0296
Onchocerca volvulus 0.02 0.1194 0.1364
Echinococcus multilocularis lysosomal alpha glucosidase 0.0146 0.0847 0.104
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0082 0.0096
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0129 0.0147
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0033 0.013 0.0156
Toxoplasma gondii histone lysine-specific demethylase 0.0338 0.2066 0.9856
Onchocerca volvulus 0.0034 0.0138 0.0157
Loa Loa (eye worm) beta-lactamase 0.0034 0.0138 0.0157
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0129 0.0154
Echinococcus multilocularis Tolloid protein 1 0.0035 0.0145 0.0173
Schistosoma mansoni ap endonuclease 0.0033 0.013 0.016
Echinococcus multilocularis musashi 0.0026 0.009 0.0106
Echinococcus multilocularis lamin 0.0026 0.009 0.0106
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0173 0.1019 0.1164
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0008 0.0009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0052 0.0059
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0008 0.0555
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0138 0.0165
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0129 0.2275
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0268 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0138 0.1154
Echinococcus multilocularis dnaJ subfamily B 0.0742 0.4624 0.5699
Mycobacterium ulcerans lipase LipD 0.0034 0.0138 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0138 0.017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0106
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0008 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0189 0.0216
Loa Loa (eye worm) hypothetical protein 0.0042 0.0189 0.0216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0296
Echinococcus granulosus dnaJ subfamily B 0.0742 0.4624 0.5699
Schistosoma mansoni amine oxidase 0.0338 0.2066 0.2547
Schistosoma mansoni ap endonuclease 0.0033 0.013 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0296
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0439 0.2708 0.3094
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0008 0.0004
Brugia malayi SWIRM domain containing protein 0.0101 0.0565 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0129 0.1078
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.013 0.1091
Chlamydia trachomatis protoporphyrinogen oxidase 0.0338 0.2066 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0105 0.012
Loa Loa (eye worm) hypothetical protein 0.0338 0.2066 0.2361
Echinococcus granulosus Tolloid protein 1 0.0035 0.0145 0.0173
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0054 0.0268 0.0326
Schistosoma mansoni Lysine-specific histone demethylase 1 0.1292 0.8111 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0338 0.2066 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0077 0.0089
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0008 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0008 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0296
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0189 0.0216
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0033 0.013 0.0156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0138 0.017
Entamoeba histolytica hypothetical protein 0.003 0.0115 0.2032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0129 0.0147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0138 0.0008
Loa Loa (eye worm) histone methyltransferase 0.0025 0.0082 0.0094
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.013 0.1091
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0115 0.0137
Echinococcus granulosus lamin dm0 0.0026 0.009 0.0106
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.288 0.3547
Mycobacterium tuberculosis Conserved protein 0.0034 0.0138 0.0166
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0129 0.2275
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0155
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0129 0.1078
Loa Loa (eye worm) hypothetical protein 0.1292 0.8111 0.9267
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0138 0.1154
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0338 0.2066 0.1962
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0129 0.1078
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0216 0.1292 0.1636
Mycobacterium tuberculosis Conserved protein 0.0034 0.0138 0.0166
Loa Loa (eye worm) CXXC zinc finger family protein 0.0078 0.0417 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Onchocerca volvulus 0.0084 0.0458 0.0523
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0138 0.0166
Brugia malayi Pre-SET motif family protein 0.0027 0.0093 0.0106
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.013 0.0596
Brugia malayi amine oxidase, flavin-containing family protein 0.0439 0.2708 0.3094
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.159 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0138 0.1154
Schistosoma mansoni alpha-glucosidase 0.0125 0.0719 0.0886
Brugia malayi hypothetical protein 0.0338 0.2066 0.2361
Echinococcus multilocularis lysine specific histone demethylase 1A 0.1292 0.8111 1
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0101 0.0565 0.0692
Onchocerca volvulus 0.0026 0.009 0.0103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0008 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0033 0.013 0.063
Echinococcus multilocularis 0.0338 0.2066 0.2544
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0008 0.0009
Mycobacterium ulcerans beta-lactamase 0.0034 0.0138 0.0008
Echinococcus granulosus lysine specific histone demethylase 1A 0.1292 0.8111 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0093 0.0115
Toxoplasma gondii ABC1 family protein 0.0034 0.0138 0.0623
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.1292 0.8111 0.9267
Echinococcus multilocularis geminin 0.0307 0.1871 0.2303
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0138 0.0166
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0338 0.2066 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0008 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0129 0.1078
Echinococcus granulosus intermediate filament protein 0.0026 0.009 0.0106
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1252 0.7857 1
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0138 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0054 0.0268 0.1297
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0338 0.2066 0.2547
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0296
Schistosoma mansoni cpg binding protein 0.0078 0.0417 0.0513
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0268 0.0139
Entamoeba histolytica SWIRM domain protein 0.0101 0.0565 1
Mycobacterium ulcerans dehydrogenase 0.0338 0.2066 0.1962
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0013 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0338 0.2066 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0027 0.0093 0.011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.0296
Onchocerca volvulus 0.1393 0.8752 1
Trypanosoma brucei glucosidase, putative 0.0032 0.0129 0.9338
Mycobacterium ulcerans oxidoreductase 0.0338 0.2066 0.1962
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0008 0.0037
Brugia malayi hypothetical protein 0.003 0.0115 0.0131
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.0157
Schistosoma mansoni SWI/SNF complex-related 0.0101 0.0565 0.0697
Leishmania major hypothetical protein, conserved 0.0034 0.0138 0.0667
Toxoplasma gondii SWIRM domain-containing protein 0.0101 0.0565 0.267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0033 0.013 0.063
Echinococcus granulosus lamin 0.0026 0.009 0.0106
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.0157
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.0157
Trypanosoma cruzi UDP-galactopyranose mutase 0.0338 0.2066 1
Echinococcus granulosus geminin 0.0307 0.1871 0.2303
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0052 0.0059
Onchocerca volvulus 0.0026 0.009 0.0103
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0054 0.0268 0.0332
Plasmodium vivax hypothetical protein, conserved 0.0338 0.2066 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0129 0.1078
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0138 0.0632
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0268 0.033
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0138 0.0166
Onchocerca volvulus 0.0034 0.0138 0.0157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0176 0.1041 0.1189
Mycobacterium tuberculosis Conserved hypothetical protein 0.0338 0.2066 0.2622
Schistosoma mansoni alpha glucosidase 0.0032 0.0129 0.0158
Toxoplasma gondii histone lysine methyltransferase SET1 0.0148 0.0863 0.4097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.0296
Toxoplasma gondii aldehyde dehydrogenase 0.0054 0.0268 0.1246
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0115 0.0137
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0035 0.0145 0.0165
Schistosoma mansoni microtubule-associated protein tau 0.0579 0.3592 0.4429
Loa Loa (eye worm) intermediate filament protein 0.0026 0.009 0.0103
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0103
Entamoeba histolytica hypothetical protein 0.003 0.0115 0.2032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0008 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0027 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.1393 0.8752 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Schistosoma mansoni hypothetical protein 0.0307 0.1871 0.2307
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0138 0.1154
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Mycobacterium tuberculosis Conserved protein 0.0034 0.0138 0.0166
Entamoeba histolytica hypothetical protein 0.003 0.0115 0.2032
Mycobacterium tuberculosis Possible oxidoreductase 0.0338 0.2066 0.2622
Brugia malayi intermediate filament protein 0.0026 0.009 0.0103
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.009 0.0103
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0129 0.0623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0093 0.0115
Schistosoma mansoni cpg binding protein 0.0082 0.0445 0.0548
Brugia malayi Pre-SET motif family protein 0.0176 0.1041 0.1189
Echinococcus multilocularis lamin dm0 0.0026 0.009 0.0106
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0035 0.0145 0.0178
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0268 0.033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0093 0.0115
Schistosoma mansoni hypothetical protein 0.0029 0.0105 0.0129
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0027 0.0093 0.011
Echinococcus granulosus neuropeptide s receptor 0.0466 0.288 0.3547
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.288 0.3547
Echinococcus multilocularis protoporphyrinogen oxidase 0.0338 0.2066 0.2544
Echinococcus granulosus lysosomal alpha glucosidase 0.0146 0.0847 0.104
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.0008 0.0555
Brugia malayi beta-lactamase family protein 0.0034 0.0138 0.0157
Brugia malayi beta-lactamase family protein 0.0034 0.0138 0.0157
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0033 0.013 0.063
Trichomonas vaginalis esterase, putative 0.0034 0.0138 0.1154
Treponema pallidum exodeoxyribonuclease (exoA) 0.0033 0.013 0.5
Onchocerca volvulus 0.0027 0.0093 0.0106
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0129 0.0579
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.008 0.0091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0082 0.0096
Schistosoma mansoni amine oxidase 0.0338 0.2066 0.2547
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0138 0.0165
Loa Loa (eye worm) hypothetical protein 0.0338 0.2066 0.2361
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0054 0.0268 0.0326
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0138 0.0166
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0129 0.1078
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0138 0.1154
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0027 0.0093 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0296
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0013 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0138 0.0157
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0033 0.013 0.2304
Echinococcus granulosus microtubule associated protein 2 0.0579 0.3592 0.4426
Echinococcus granulosus lysine specific histone demethylase 1A 0.0338 0.2066 0.2544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0189 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0565 0.4737
Schistosoma mansoni hypothetical protein 0.0742 0.4624 0.5701
Loa Loa (eye worm) hypothetical protein 0.0101 0.0565 0.0646
Onchocerca volvulus 0.0078 0.0417 0.0476
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0173 0.1019 0.1164
Brugia malayi isocitrate dehydrogenase 0.0013 0.0008 0.0009
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0008 0.0009
Toxoplasma gondii exonuclease III APE 0.0033 0.013 0.0587
Echinococcus multilocularis cpg binding protein 0.0082 0.0445 0.0543
Echinococcus multilocularis GPCR, family 2 0.0013 0.0008 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0027 0.0093 0.011
Mycobacterium ulcerans hypothetical protein 0.0034 0.0138 0.0008
Echinococcus granulosus GPCR family 2 0.0013 0.0008 0.0004
Plasmodium falciparum protoporphyrinogen oxidase 0.0338 0.2066 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0268 0.0139
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0138 0.0008
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0052 0.0059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0008 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0138 0.0667
Schistosoma mansoni hypothetical protein 0.0307 0.1871 0.2307
Echinococcus multilocularis lysosomal alpha glucosidase 0.0146 0.0847 0.104
Schistosoma mansoni intermediate filament proteins 0.0026 0.009 0.0111
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0052 0.0059
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.0157
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0033 0.013 0.0156
Entamoeba histolytica SWIRM domain protein 0.0101 0.0565 1
Giardia lamblia hypothetical protein 0.0101 0.0565 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0338 0.2066 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.0157
Echinococcus granulosus cpg binding protein 0.0082 0.0445 0.0543
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0296
Schistosoma mansoni alpha-glucosidase 0.0125 0.0719 0.0886
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0138 0.0166
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0343 0.2096 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0033 0.013 0.9456
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0138 0.0157
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0138 0.0166
Onchocerca volvulus 0.0034 0.0138 0.0157
Schistosoma mansoni lamin 0.0026 0.009 0.0111
Mycobacterium ulcerans monoamine oxidase 0.0338 0.2066 0.1962
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.288 0.3547
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0129 0.1078
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0138 0.0166
Loa Loa (eye worm) AStacin protease 0.0022 0.0062 0.0071
Brugia malayi CXXC zinc finger family protein 0.0078 0.0417 0.0476
Brugia malayi Glycosyl hydrolases family 31 protein 0.0146 0.0847 0.0968
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0129 0.0623

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Induction of Bos taurus (bovine) serum albumin degradation after 1 hr by SDS-PAGE analysis ChEMBL. No reference
IZ (functional) = 9 mm Antimicrobial activity against Escherichia coli at 100 ug after 24 hr by cup diffusion technique ChEMBL. No reference
IZ (functional) = 12 mm Antimicrobial activity against Saccharomyces cerevisiae at 100 ug after 24 hr by cup diffusion technique ChEMBL. No reference
MIC (functional) = 7.5 ug ml-1 Antimicrobial activity against Saccharomyces cerevisiae after 24 hr by CLSI liquid dilution method ChEMBL. No reference
MIC (functional) = 15 ug ml-1 Antimicrobial activity against Escherichia coli after 24 hr by CLSI liquid dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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