Detailed information for compound 1796540

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.38 | Formula: C18H14N2O4S
  • H donors: 0 H acceptors: 3 LogP: 2.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)S(=O)(=O)n1ccc2c1c(ncc2)c1ccco1
  • InChi: 1S/C18H14N2O4S/c1-23-14-4-6-15(7-5-14)25(21,22)20-11-9-13-8-10-19-17(18(13)20)16-3-2-12-24-16/h2-12H,1H3
  • InChiKey: IZAAPPPGNNSEMR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 6 class V References
Homo sapiens tubulin, beta 8 class VIII References
Homo sapiens tubulin, beta 4A class IVa References
Homo sapiens tubulin, alpha 1a References
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL References
Homo sapiens tubulin, alpha 3e References
Homo sapiens tubulin, beta 4B class IVb References
Homo sapiens tubulin, alpha 3d References
Homo sapiens tubulin, beta 2A class IIa References
Homo sapiens tubulin, alpha 1b References
Homo sapiens tubulin, alpha 4a References
Homo sapiens tubulin, alpha 1c References
Homo sapiens tubulin, beta 1 class VI References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 8 class VIII 444 aa 438 aa 33.8 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 4B class IVb 445 aa 438 aa 32.9 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 1 class VI 451 aa 438 aa 32.2 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 6 class V 446 aa 438 aa 32.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi valosin containing protein 0.0069 0.1123 0.0888
Echinococcus granulosus tubulin alpha chain 0.021 0.7122 0.6814
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0065 0.0967 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 1 1
Schistosoma mansoni tubulin subunit alpha 0.021 0.7122 0.7046
Echinococcus multilocularis tubulin alpha chain 0.021 0.7122 0.7046
Echinococcus granulosus beta tubulin 0.0278 1 1
Brugia malayi tubulin alpha-2 chain 0.021 0.7122 0.7046
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Loa Loa (eye worm) hypothetical protein 0.0145 0.4344 0.4194
Loa Loa (eye worm) alpha-tubulin 0.021 0.7122 0.7046
Toxoplasma gondii beta-1 tubulin, putative 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0151 0.4588 0.4445
Schistosoma mansoni tubulin subunit beta 0.0278 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.7122 0.7046
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.181 0.0932
Echinococcus granulosus Tubulin beta 2C chain 0.0278 1 1
Plasmodium vivax tubulin epsilon chain, putative 0.0151 0.4588 0.4588
Echinococcus granulosus tubulin beta 1 chain 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.7122 0.6814
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0071 0.1183 0.0238
Echinococcus granulosus beta tubulin 0.0278 1 1
Giardia lamblia Gamma tubulin 0.0151 0.4588 0.4008
Trypanosoma brucei epsilon tubulin 0.0151 0.4588 0.4008
Echinococcus granulosus tubulin epsilon chain 0.0151 0.4588 0.4008
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.7122 0.6814
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0125 0.3501 0.2805
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.7122 0.6814
Echinococcus multilocularis tubulin beta 1 chain 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.4344 0.4194
Leishmania major beta tubulin 0.0278 1 1
Echinococcus multilocularis tubulin alpha chain 0.021 0.7122 0.7046
Echinococcus multilocularis tubulin alpha chain 0.021 0.7122 0.7046
Giardia lamblia AAA family ATPase 0.0071 0.1183 0.0238
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.7122 0.7046
Echinococcus multilocularis tubulin alpha chain 0.021 0.7122 0.7046
Schistosoma mansoni alpha tubulin 0.021 0.7122 0.7046
Leishmania major beta tubulin 0.0278 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.7122 0.6814
Echinococcus multilocularis hypothetical protein 0.021 0.7122 0.7046
Trypanosoma brucei beta tubulin 0.0278 1 1
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Loa Loa (eye worm) hypothetical protein 0.021 0.7122 0.7046
Loa Loa (eye worm) tubulin beta-1 chain 0.0278 1 1
Entamoeba histolytica tubulin gamma chain 0.0151 0.4588 0.2341
Plasmodium vivax tubulin alpha chain, putative 0.021 0.7122 0.7122
Giardia lamblia Beta tubulin 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Echinococcus multilocularis peroxisome assembly protein 26 0.021 0.7122 0.7046
Leishmania major beta tubulin 0.0278 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.7122 0.6814
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.7122 0.6814
Entamoeba histolytica tubulin alpha-1 chain 0.021 0.7122 0.5927
Leishmania major beta tubulin 0.0278 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.7122 0.7046
Echinococcus granulosus Tubulin beta 2C chain 0.0278 1 1
Echinococcus granulosus tubulin alpha 0.0151 0.4588 0.4008
Echinococcus multilocularis tubulin epsilon chain 0.0151 0.4588 0.4445
Echinococcus multilocularis tubulin alpha chain 0.021 0.7122 0.7046
Trichomonas vaginalis tubulin gamma chain, putative 0.0151 0.4588 0.4008
Echinococcus multilocularis tubulin subunit TubB 0.021 0.7122 0.7046
Plasmodium vivax tubulin gamma chain, putative 0.0151 0.4588 0.4588
Plasmodium falciparum alpha tubulin 2 0.021 0.7122 0.6814
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.181 0.0932
Toxoplasma gondii alpha tubulin TUBA1 0.021 0.7122 0.6814
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0112 0.2934 0.2177
Giardia lamblia Alpha-tubulin 0.021 0.7122 0.6814
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.7122 0.6814
Loa Loa (eye worm) tubulin beta-4 chain 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Trypanosoma brucei beta tubulin 0.0151 0.4588 0.4008
Brugia malayi Tubulin gamma chain 0.0151 0.4588 0.4445
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.7122 0.7046
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0118 0.3191 0.3011
Trypanosoma brucei tubulin gamma chain 0.0151 0.4588 0.4008
Trypanosoma brucei beta tubulin 0.0278 1 1
Brugia malayi Tubulin alpha chain 0.021 0.7122 0.7046
Echinococcus multilocularis beta tubulin 0.0278 1 1
Echinococcus granulosus tubulin alpha chain 0.021 0.7122 0.6814
Loa Loa (eye worm) tubulin beta chain 0.0065 0.0967 0.0728
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.7122 0.6814
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 1 1
Schistosoma mansoni tubulin subunit alpha 0.021 0.7122 0.7046
Toxoplasma gondii alpha-tubulin I, putative 0.021 0.7122 0.6814
Leishmania major beta tubulin 0.0278 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.7122 0.6814
Loa Loa (eye worm) BEN-1 protein 0.0278 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.181 0.0932
Toxoplasma gondii beta tubulin 0.0278 1 1
Echinococcus granulosus tubulin gamma 1 chain 0.0151 0.4588 0.4008
Trichomonas vaginalis tubulin gamma chain, putative 0.0151 0.4588 0.4008
Plasmodium falciparum alpha tubulin 1 0.021 0.7122 0.6814
Echinococcus multilocularis tubulin alpha 0.0151 0.4588 0.4445
Plasmodium vivax tubulin beta chain, putative 0.0278 1 1
Echinococcus multilocularis beta tubulin 0.0278 1 1
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Echinococcus granulosus tubulin beta 4A class IVa 0.0278 1 1
Schistosoma mansoni tubulin subunit epsilon 0.0151 0.4588 0.4445
Brugia malayi Tubulin beta chain 0.0085 0.181 0.1593
Trichomonas vaginalis tubulin alpha chain, putative 0.0151 0.4588 0.4008
Brugia malayi tubulin alpha chain - mouse 0.021 0.7122 0.7046
Schistosoma mansoni tubulin subunit beta 0.0278 1 1
Entamoeba histolytica tubulin alpha chain, putative 0.021 0.7122 0.5927
Leishmania major epsilon tubulin, putative 0.0151 0.4588 0.4008
Mycobacterium tuberculosis Putative conserved ATPase 0.0071 0.1183 1
Echinococcus multilocularis tubulin subunit beta 0.0278 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 1 1
Giardia lamblia Alpha-tubulin 0.021 0.7122 0.6814
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.7122 0.6814
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0085 0.181 0.0932
Schistosoma mansoni tubulin subunit beta 0.0278 1 1
Loa Loa (eye worm) BEN-1 protein 0.0278 1 1
Brugia malayi vesicle-fusing ATPase 0.0069 0.1123 0.0888
Leishmania major gamma-tubulin 0.0151 0.4588 0.4008
Trichomonas vaginalis tubulin gamma chain, putative 0.0278 1 1
Treponema pallidum cell division protein FtsZ 0.0065 0.0967 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.1123 0.0888
Brugia malayi Tubulin beta chain 0.0065 0.0967 0.0728
Leishmania major beta tubulin 0.0278 1 1
Trypanosoma cruzi tubulin gamma chain 0.0151 0.4588 0.4008
Loa Loa (eye worm) vesicle-fusing ATPase 0.0069 0.1123 0.0888
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0112 0.2934 0.2177
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Brugia malayi Cell division protein ftsZ 0.0065 0.0967 0.0728
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0118 0.3191 0.2462
Trichomonas vaginalis tubulin beta chain, putative 0.0278 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.7122 0.6814
Schistosoma mansoni tubulin subunit alpha 0.021 0.7122 0.7046
Trypanosoma brucei alpha tubulin 0.021 0.7122 0.6814
Trypanosoma brucei alpha tubulin, putative 0.0085 0.181 0.0932
Trypanosoma cruzi beta tubulin, putative 0.0278 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0085 0.181 0.0932
Mycobacterium ulcerans ATPase 0.0071 0.1183 1
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Echinococcus granulosus tubulin alpha chain 0.021 0.7122 0.6814
Loa Loa (eye worm) tubulin alpha chain 0.021 0.7122 0.7046
Echinococcus granulosus Tubulin beta 2C chain 0.0278 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.7122 0.7046
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Leishmania major beta tubulin 0.0278 1 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0112 0.2934 0.2747
Plasmodium falciparum tubulin gamma chain 0.0151 0.4588 0.4008
Loa Loa (eye worm) tubulin alpha-2 chain 0.021 0.7122 0.7046
Trypanosoma brucei beta tubulin 0.0278 1 1
Brugia malayi Tubulin alpha chain 0.0065 0.0967 0.0728
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.7122 0.6814
Leishmania major beta tubulin 0.0278 1 1
Trypanosoma brucei epsilon tubulin 0.0151 0.4588 0.4008
Schistosoma mansoni tubulin subunit delta 0.0065 0.0967 0.0728
Echinococcus multilocularis tubulin delta chain 0.0065 0.0967 0.0728
Trichomonas vaginalis tubulin, putative 0.0278 1 1
Entamoeba histolytica tubulin family protein 0.0278 1 1
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Trypanosoma cruzi epsilon tubulin, putative 0.0151 0.4588 0.4008
Plasmodium falciparum tubulin epsilon chain, putative 0.0151 0.4588 0.4008
Schistosoma mansoni tubulin subunit beta 0.0278 1 1
Giardia lamblia Beta tubulin 0.0278 1 1
Trichomonas vaginalis tubulin, putative 0.0085 0.181 0.0932
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0118 0.3191 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.3501 0.333
Trypanosoma brucei alpha tubulin 0.021 0.7122 0.6814
Trypanosoma brucei alpha tubulin 0.021 0.7122 0.6814
Giardia lamblia Beta tubulin 0.0278 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.7122 0.7046
Plasmodium vivax tubulin alpha chain, putative 0.021 0.7122 0.7122
Loa Loa (eye worm) tubulin gamma chain 0.0151 0.4588 0.4445
Plasmodium falciparum tubulin beta chain 0.0278 1 1
Loa Loa (eye worm) beta-tubulin 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Trypanosoma cruzi alpha tubulin, putative 0.021 0.7122 0.6814
Schistosoma mansoni tubulin subunit beta 0.0065 0.0967 0.0728
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0151 0.4588 0.4008
Echinococcus granulosus tubulin subunit beta 0.0278 1 1
Echinococcus granulosus tubulin subunit TubB 0.021 0.7122 0.6814
Echinococcus granulosus alpha tubulin 0.021 0.7122 0.6814
Mycobacterium leprae cell division protein FtsZ 0.0065 0.0967 0.5
Trichomonas vaginalis tubulin alpha chain, putative 0.0278 1 1
Brugia malayi alpha-tubulin 0.021 0.7122 0.7046
Loa Loa (eye worm) tubulin alpha chain 0.021 0.7122 0.7046
Echinococcus granulosus peroxisome assembly protein 26 0.021 0.7122 0.6814
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0118 0.3191 0.3011
Schistosoma mansoni alpha tubulin 0.021 0.7122 0.7046
Schistosoma mansoni tubulin subunit alpha 0.0065 0.0967 0.0728
Brugia malayi Tubulin alpha-2 chain 0.021 0.7122 0.7046
Loa Loa (eye worm) tubulin beta-2A chain 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Trypanosoma brucei epsilon tubulin 0.0151 0.4588 0.4008
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0145 0.4344 0.4194
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0278 1 1
Leishmania major alpha tubulin 0.021 0.7122 0.6814
Loa Loa (eye worm) tubulin alpha 2 0.006 0.0723 0.0478
Echinococcus granulosus Tubulin beta 2C chain 0.0278 1 1
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0118 0.3191 0.2462
Trichomonas vaginalis tubulin epsilon chain, putative 0.0278 1 1
Plasmodium vivax delta tubulin, putative 0.0065 0.0967 0.0967
Trypanosoma cruzi Valosin-containing protein, putative 0.0112 0.2934 0.2177
Trypanosoma brucei beta tubulin 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Trypanosoma brucei alpha tubulin 0.021 0.7122 0.6814
Loa Loa (eye worm) tubulin beta chain 0.0278 1 1
Trypanosoma brucei Valosin-containing protein 0.0112 0.2934 0.2177
Schistosoma mansoni tubulin subunit gamma 0.0151 0.4588 0.4445
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.7122 0.6814
Echinococcus granulosus tubulin alpha chain 0.021 0.7122 0.6814
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.021 0.7122 0.6814
Schistosoma mansoni tubulin subunit beta 0.0278 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0278 1 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0125 0.3501 0.333
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.7122 0.6814
Brugia malayi Tubulin alpha-2 chain 0.021 0.7122 0.7046
Toxoplasma gondii cell division protein CDC48CY 0.0118 0.3191 0.2462
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 1 1
Trichomonas vaginalis tubulin, putative 0.0085 0.181 0.0932
Schistosoma mansoni tubulin subunit beta 0.0278 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.4344 0.4194
Brugia malayi beta-tubulin, identical 0.0278 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0278 1 1
Entamoeba histolytica tubulin family protein 0.0278 1 1
Toxoplasma gondii cell division protein CDC48AP 0.0071 0.1183 0.0238
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0145 0.4344 0.3738
Toxoplasma gondii beta-tubulin, putative 0.0278 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 1 1
Leishmania major beta tubulin 0.0278 1 1
Loa Loa (eye worm) alpha-tubulin 0.021 0.7122 0.7046
Schistosoma mansoni alpha tubulin 0.021 0.7122 0.7046
Leishmania major beta tubulin 0.0278 1 1
Echinococcus granulosus tubulin alpha chain 0.021 0.7122 0.6814
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.7122 0.6814
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0112 0.2934 0.2934
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.7122 0.7046
Trypanosoma cruzi epsilon tubulin, putative 0.0151 0.4588 0.4008

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in athymic nude mouse at 50 to 200 mg/kg, po qd ChEMBL. 24106982
Activity (ADMET) Toxicity in athymic nude mouse assessed as change in body weight at 50 to 200 mg/kg, po qd measured daily during first week followed by twice per week ChEMBL. 24106982
IC50 (functional) = 27.5 nM Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay ChEMBL. 24106982
Inhibition (binding) = 63 % Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) at 1 uM after 2 hrs by scintillation proximity assay relative to control ChEMBL. 24106982
Inhibition (binding) = 81 % Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) at 5 uM after 2 hrs by scintillation proximity assay relative to control ChEMBL. 24106982
Ki (binding) = 0.38 uM Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) after 2 hrs by scintillation proximity assay ChEMBL. 24106982
TGI (functional) = 54 % Antitumor activity against human HT-29 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 200 mg/kg, po qd measured twice per week relative to vehicle-treated control ChEMBL. 24106982

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 24106982

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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