Detailed information for compound 1802549

Basic information

Technical information
  • TDR Targets ID: 1802549
  • Name: (5-methyl-2-propan-2-ylphenyl) 2-[(2,3-dimeth ylphenyl)amino]benzoate
  • MW: 373.487 | Formula: C25H27NO2
  • H donors: 1 H acceptors: 1 LogP: 7.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)OC(=O)c1ccccc1Nc1cccc(c1C)C)C(C)C
  • InChi: 1S/C25H27NO2/c1-16(2)20-14-13-17(3)15-24(20)28-25(27)21-10-6-7-11-23(21)26-22-12-8-9-18(4)19(22)5/h6-16,26H,1-5H3
  • InChiKey: NDNGOGWAXNHSCK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-isopropyl-5-methyl-phenyl) 2-[(2,3-dimethylphenyl)amino]benzoate
  • 2-[(2,3-dimethylphenyl)amino]benzoic acid (2-isopropyl-5-methylphenyl) ester
  • 2-[(2,3-dimethylphenyl)amino]benzoic acid (2-isopropyl-5-methyl-phenyl) ester
  • (5-methyl-2-propan-2-yl-phenyl) 2-[(2,3-dimethylphenyl)amino]benzoate
  • 20724-12-3
  • Anthranilic acid, N-2,3-xylyl-, thymyl ester
  • BRN 3009051
  • SAS 557
  • Thymyl N-2,3-xylylanthranilate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.0037 0.0093
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0092 0.014
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0092 0.014
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0098
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.7454 1
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0244 0.0873
Echinococcus multilocularis lysine specific demethylase 5A 0.0053 0.0362 0.0486
Brugia malayi Telomerase reverse transcriptase 0.088 0.7246 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0092 0.1184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0092 0.1184
Brugia malayi hypothetical protein 0.0011 0.001 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0012 0.0151
Echinococcus multilocularis phd:f box containing protein 0.0014 0.0037 0.0049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0092 0.0127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0092 0.014
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0092 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0092 0.0127
Plasmodium falciparum ABC transporter G family member 2 0.002 0.0089 0.0197
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0777 0.5
Brugia malayi Cytochrome P450 family protein 0.0039 0.0244 0.0337
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0483 0.1769
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0777 0.1179
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Echinococcus granulosus ATP binding cassette sub family G 0.002 0.0089 0.0134
Echinococcus multilocularis GPCR, family 2 0.0018 0.0065 0.0087
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0037 0.0469
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0092 0.0092
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0777 1
Brugia malayi ecdysone receptor 0.001 0.0001 0.0001
Brugia malayi hypothetical protein 0.0011 0.001 0.0014
Brugia malayi tailless protein 0.001 0.0001 0.0001
Schistosoma mansoni protein phosphatase 2C 0.0014 0.0037 0.0055
Loa Loa (eye worm) hypothetical protein 0.0056 0.0382 0.4912
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.0037 0.0055
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0185 0.2382
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0053 0.0362 0.055
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0052 0.0069
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0092 0.014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.001 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0092 0.014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0065 0.0098
Trypanosoma brucei ATP-binding cassette protein, putative 0.002 0.0089 0.0288
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0127
Onchocerca volvulus 0.0057 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0031 0.0174 0.2237
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0053 0.0362 0.0486
Brugia malayi CXXC zinc finger family protein 0.0032 0.0185 0.0256
Schistosoma mansoni jumonji/arid domain-containing protein 0.0055 0.0378 0.0573
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0532 0.1954
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0532 0.1954
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.0037 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0092 0.0123
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0777 0.2874
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0483 0.0733
Echinococcus multilocularis ATP binding cassette sub family G 0.002 0.0089 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0235 0.0325
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0065 0.009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0065 0.0098
Mycobacterium leprae putative cytochrome p450 0.0011 0.0012 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0235 0.3023
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0092 0.014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0092 0.0127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0485 0.0735
Plasmodium vivax telomerase reverse transcriptase, putative 0.0331 0.2672 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0777 0.1041
Echinococcus multilocularis musashi 0.0031 0.0179 0.0239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0382 0.0527
Trypanosoma cruzi ATP-binding cassette protein, putative 0.002 0.0089 0.0288
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0037 0.0469
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0532 0.1954
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0179 0.0247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0092 0.0123
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0098
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0092 0.014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0092 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0127
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0058 0.008
Loa Loa (eye worm) histone methyltransferase 0.001 0.0001 0.0007
Echinococcus multilocularis lamin 0.0031 0.0179 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0092 0.1184
Brugia malayi jmjC domain containing protein 0.0014 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0396 0.5097
Brugia malayi MAP kinase sur-1 0.0103 0.0777 0.1072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0092 0.0127
Schistosoma mansoni hypothetical protein 0.0457 0.372 0.565
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0092 0.0123
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0017 0.0061 0.1033
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0001 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0092 0.1184
Echinococcus granulosus dnaJ subfamily B 0.0457 0.372 0.565
Schistosoma mansoni cpg binding protein 0.0032 0.0185 0.0281
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.001 0.0127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0092 0.0123
Brugia malayi Nuclear hormone receptor E75 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0501
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0483 0.0647
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0092 0.014
Echinococcus granulosus tumor protein p63 0.0392 0.3182 0.4833
Schistosoma mansoni hypothetical protein 0.0017 0.0061 0.0092
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.0037 0.0093
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0092 0.014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0092 0.014
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0014 0.0037 0.0093
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0044 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0092 0.1184
Brugia malayi conserved hypotetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0382 0.4912
Trypanosoma brucei telomerase reverse transcriptase 0.0331 0.2672 1
Echinococcus multilocularis ATP binding cassette sub family G 0.002 0.0089 0.0118
Loa Loa (eye worm) ABC transporter 0.0017 0.0063 0.0803
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0092 0.0092
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0274 0.0366
Brugia malayi jmjC domain containing protein 0.0014 0.0037 0.0051
Brugia malayi jmjC domain containing protein 0.0055 0.0378 0.0521
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0092 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0483 0.0733
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0092 0.0127
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0777 0.2874
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0065 0.0087
Echinococcus granulosus cpg binding protein 0.0034 0.0201 0.0304
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0483 1
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.372 0.499
Echinococcus multilocularis 0.0011 0.0012 0.0016
Echinococcus granulosus lamin 0.0031 0.0179 0.0271
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0362 0.055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0092 0.014
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0532 0.0807
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.0037 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0092 0.0123
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0244 0.0873
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0331 0.2672 1
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0777 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0244 0.4934
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0065 0.0832
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.0378 0.4859
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0562
Brugia malayi ABC transporter family protein 0.0017 0.0063 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0092 0.0123
Echinococcus granulosus intermediate filament protein 0.0031 0.0179 0.0271
Brugia malayi nuclear hormone receptor 0.001 0.0001 0.0001
Schistosoma mansoni phd/f-box containing protein 0.0014 0.0037 0.0055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0179 0.2298
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0092 0.0127
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0014
Brugia malayi jmjC domain containing protein 0.0053 0.0362 0.05
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0065 0.0087
Brugia malayi Cytochrome P450 family protein 0.0011 0.0012 0.0017
Onchocerca volvulus 0.0031 0.0179 0.0178
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0014
Echinococcus granulosus phd:f box containing protein 0.0014 0.0037 0.0055
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0092 0.1184
Giardia lamblia Telomerase catalytic subunit 0.0331 0.2672 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0092 0.0127
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0396 0.0601
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0092 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0832
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0777 0.2874
Brugia malayi nuclear receptor RXR 0.0011 0.001 0.0014
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0777 0.1041
Echinococcus multilocularis tumor protein p63 0.0392 0.3182 0.4268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.001 0.0015
Brugia malayi Cytochrome P450 family protein 0.0039 0.0244 0.0337
Echinococcus multilocularis cpg binding protein 0.0034 0.0201 0.0268
Brugia malayi jmjC domain containing protein 0.0014 0.0037 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0092 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0501
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0532 1
Trypanosoma brucei ABC transporter, putative 0.002 0.0089 0.0288
Brugia malayi intermediate filament protein 0.0031 0.0179 0.0247
Toxoplasma gondii RNA-directed DNA polymerase 0.0331 0.2672 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0092 0.014
Echinococcus granulosus GPCR family 2 0.0018 0.0065 0.0098
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0058 0.0741
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.002 0.0089 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0777 0.5
Echinococcus granulosus ATP binding cassette sub family G 0.002 0.0089 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0014 0.0037 0.0093
Echinococcus granulosus microtubule associated protein 2 0.0801 0.6583 1
Schistosoma mansoni microtubule-associated protein tau 0.0801 0.6583 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0777 0.2874
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0532 0.6847
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0777 0.2668
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0018
Schistosoma mansoni cpg binding protein 0.0034 0.0201 0.0304
Brugia malayi nuclear receptor RXR 0.001 0.0001 0.0001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0092 0.014
Onchocerca volvulus 0.0031 0.0179 0.0178
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0179 0.2298
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0777 0.2874
Schistosoma mansoni hypothetical protein 0.0038 0.0235 0.0357
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.001 0.0015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0532 0.1954
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0092 0.0092
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0424 0.1548
Onchocerca volvulus 0.0021 0.0092 0.0092
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0244 0.3143
Brugia malayi nuclear receptor NHR-88 0.0021 0.0092 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0092 0.1184
Echinococcus granulosus lamin dm0 0.0031 0.0179 0.0271
Brugia malayi Nuclear hormone receptor E75 0.001 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0244 0.3143
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0037 0.0469
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0092 0.0127
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0092 0.0123
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0012 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0777 0.2874
Brugia malayi nuclear receptor NHR-67 0.001 0.0001 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0092 0.014
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.002 0.0089 0.0288
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0001 0.0001
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0777 0.1179
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0092 0.014
Trypanosoma brucei protein kinase, putative 0.0103 0.0777 0.2874
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.0037 0.0055
Loa Loa (eye worm) cytochrome P450 0.0011 0.0012 0.0151
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0044 0.0059
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.002 0.0089 0.0288
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0092 0.014
Schistosoma mansoni coup transcription factor 0.0021 0.0092 0.014
Schistosoma mansoni cpg binding protein 0.0034 0.0201 0.0304
Brugia malayi nuclear receptor NHR-88 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.1934
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0098
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.002 0.0089 0.0288
Plasmodium falciparum telomerase reverse transcriptase 0.0331 0.2672 1
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0483 0.1769
Leishmania major hypothetical protein, conserved 0.0014 0.0037 0.0093
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0092 0.014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0092 0.0127
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0089 0.1625
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.0037 0.0049
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0244 0.0873
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0777 0.2874
Echinococcus granulosus lysine specific demethylase 5A 0.0055 0.0378 0.0573
Brugia malayi steroid hormone receptor 0.0021 0.0092 0.0127
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0001 0.0001
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0052 0.0078
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0483 1
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.0037 0.0055
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0777 0.2874
Echinococcus multilocularis microtubule associated protein 2 0.0801 0.6583 0.883
Brugia malayi nuclear hormone receptor 0.0021 0.0092 0.0127
Onchocerca volvulus 0.0032 0.0185 0.0185
Schistosoma mansoni lamin 0.0031 0.0179 0.0271
Schistosoma mansoni jumonji/arid domain-containing protein 0.0055 0.0378 0.0573
Trypanosoma cruzi ABC transporter, putative 0.002 0.0089 0.0288
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0179 0.2298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0092 0.0127
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0532 0.0734
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0014 0.0037 0.0093
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0532 0.0807
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0127
Brugia malayi hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni cytochrome P450 0.0011 0.0012 0.0018
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0012 0.0018
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0089 0.1625
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0469
Echinococcus multilocularis ATP binding cassette sub family G 0.002 0.0089 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0469
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0001 0.0001
Echinococcus granulosus ATP binding cassette sub family G 0.002 0.0089 0.0134
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.0037 0.0049
Brugia malayi cytochrome P450 0.0011 0.0012 0.0017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0092 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0092 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0092 0.0127
Echinococcus multilocularis lamin dm0 0.0031 0.0179 0.0239
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0092 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0092 0.0127
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0089 0.1625
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.0037 0.0055
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0092 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0092 0.1184
Leishmania major telomerase reverse transcriptase, putative 0.0331 0.2672 1
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0274 0.0415
Schistosoma mansoni lamin 0.0031 0.0179 0.0271
Brugia malayi ecdysteroid receptor 0.0021 0.0092 0.0127
Schistosoma mansoni ABC transporter 0.0017 0.0063 0.0095
Leishmania major cytochrome p450-like protein 0.0039 0.0244 0.0873
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0331 0.2672 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0777 0.1179
Schistosoma mansoni jumonji domain containing protein 0.0014 0.0037 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.001 0.0013
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0532 0.0713
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0483 0.0733
Schistosoma mansoni intermediate filament proteins 0.0031 0.0179 0.0271
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0777 0.5
Brugia malayi hypothetical protein 0.001 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0092 0.014
Brugia malayi jmjC domain containing protein 0.0014 0.0037 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0065 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.1184
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0244 0.3143
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0382 0.0527
Plasmodium vivax ABC transporter G family member 2, putative 0.002 0.0089 0.0197

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 52.722 % Analgesic activity in po dosed Mus musculus Swiss albino (mouse) assessed as inhibition of acetic acid-induced writhing administered 1 hr prior to acetic acid challenge measured for 20 min relative to control ChEMBL. No reference
T1/2 (ADMET) = 1.14 hr Half life in Homo sapiens (human) 80% plasma at 10 mg at pH 7.4 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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