TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 593.672 | Formula: C34H35N5O5
H donors: 1 H acceptors: 5 LogP: 5.8 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: O=C([C@H](N(C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-])C)Cc1ccc2c(c1)cccc2)N(Cc1ccccc1)C
InChi: 1S/C34H35N5O5/c1-36(23-24-11-4-3-5-12-24)32(40)31(22-25-18-19-26-13-6-7-14-27(26)21-25)37(2)33(41)30-17-10-20-38(30)34(42)35-28-15-8-9-16-29(28)39(43)44/h3-9,11-16,18-19,21,30-31H,10,17,20,22-23H2,1-2H3,(H,35,42)/t30-,31-/m1/s1
InChiKey: JTAYLPLPEXUFKU-FIRIVFDPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lozenge	0.0067	0.0534	0.056
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0182	0.028
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0034	0.0174	0.9563
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Plasmodium vivax	heat shock protein 86, putative	0.0034	0.0174	0.8692
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0458	0.0474
Brugia malayi	G protein-coupled receptor	0.006	0.0458	0.0703
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0195	0.0177
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.0458	0.0474
Echinococcus granulosus	7tm_1 domain containing protein	0.006	0.0458	0.0474
Echinococcus granulosus	epidermal growth factor receptor	0.015	0.1437	0.1579
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.0458	0.0421
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0034	0.0174	0.0211
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0174	0.0211
Schistosoma mansoni	tyrosine kinase	0.0077	0.0647	0.0687
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.8901	0.8897
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.0458	0.0474
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0034	0.0174	0.9563
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	myosin xvIII	0.006	0.0458	0.0474
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0382	0.0346
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0034	0.0174	0.9563
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0614	0.6508	0.6495
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.0458	0.0421
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0034	0.0174	1
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0034	0.0174	0.9563
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0174	0.1702
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0229	0.0663
Echinococcus granulosus	neuropeptide s receptor	0.059	0.6244	0.7002
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	acetylcholinesterase	0.0206	0.2055	0.2276
Schistosoma mansoni	cell adhesion molecule	0.0033	0.0165	0.0143
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0206	0.2055	0.2276
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	twitchin	0.0033	0.0167	0.0146
Echinococcus multilocularis	chromobox protein 1	0.007	0.0564	0.0529
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0034	0.0174	0.9563
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0034	0.0174	0.9563
Plasmodium falciparum	DNA gyrase subunit B	0.0034	0.0174	1
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	0.0029	0.0123	0.0131
Loa Loa (eye worm)	acetylcholinesterase 1	0.0206	0.2055	0.3158
Mycobacterium leprae	Probable two-component sensor kinase	0.0034	0.0174	0.5
Echinococcus granulosus	neuropeptide receptor	0.006	0.0458	0.0474
Mycobacterium ulcerans	two component sensor kinase MprB	0.0034	0.0174	0.9563
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0195	0.0158
Trichomonas vaginalis	sensor histidine kinase, putative	0.0034	0.0174	0.0473
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.0174	0.0211
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0034	0.0174	0.0473
Brugia malayi	GnHR receptor homolog	0.006	0.0458	0.0703
Echinococcus granulosus	fmrfamide receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	insulin receptor	0.0051	0.0355	0.0318
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.006	0.0458	0.0421
Giardia lamblia	Pms1-like protein	0.0034	0.0174	1
Toxoplasma gondii	exonuclease III APE	0.0022	0.0038	0.0134
Toxoplasma gondii	heat shock protein HSP90	0.0034	0.0174	0.0677
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Onchocerca volvulus		0.006	0.0458	0.0583
Onchocerca volvulus		0.006	0.0458	0.0583
Onchocerca volvulus		0.006	0.0458	0.0583
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.8901	1
Brugia malayi	neuropeptide F receptor	0.006	0.0458	0.0703
Brugia malayi	Endoplasmin precursor	0.0034	0.0174	0.0268
Onchocerca volvulus	Neuropeptide F receptor homolog	0.006	0.0458	0.0583
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.0458	0.0474
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	sex peptide receptor	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0535	0.5642	0.8669
Trichomonas vaginalis	receptor histidine kinase, putative	0.0034	0.0174	0.0473
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0312	0.0275
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.0458	0.0474
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0312	0.0309
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.0458	0.0421
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0038	0.0058
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus multilocularis	neuropeptide receptor	0.006	0.0458	0.0421
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Echinococcus multilocularis	heat shock protein	0.0034	0.0174	0.0137
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.0458	0.0474
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0034	0.0174	0.9563
Brugia malayi	Carboxylesterase family protein	0.0206	0.2055	0.3158
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.006	0.0458	0.0421
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0458	0.0474
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Schistosoma mansoni	biogenic amine receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0229	0.0663
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0034	0.0174	0.5
Schistosoma mansoni	opsin-like receptor	0.006	0.0458	0.0474
Schistosoma mansoni	pyruvate dehydrogenase	0.0614	0.6508	0.73
Onchocerca volvulus		0.0286	0.2925	0.5064
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0195	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.0184
Onchocerca volvulus		0.0535	0.5642	1
Schistosoma mansoni	pyruvate dehydrogenase	0.058	0.6135	0.6879
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0174	0.0268
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0035	0.0182	0.0145
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	hypothetical protein	0.0035	0.0182	0.028
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0174	0.8692
Entamoeba histolytica	DNA topoisomerase II, putative	0.0034	0.0174	0.1702
Echinococcus multilocularis	neuropeptide receptor A26	0.059	0.6244	0.6229
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.0458	0.0703
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.0458	0.0421
Onchocerca volvulus		0.006	0.0458	0.0583
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0095	0.084	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.0184
Echinococcus multilocularis	dro:myosuppressin receptor	0.006	0.0458	0.0421
Onchocerca volvulus		0.006	0.0458	0.0583
Onchocerca volvulus		0.0047	0.0312	0.0318
Mycobacterium ulcerans	carboxylesterase, LipT	0.0035	0.0182	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus multilocularis	Immunoglobulin	0.0029	0.012	0.0083
Echinococcus granulosus	neuropeptide FF receptor 2	0.006	0.0458	0.0474
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0215	0.2146	0.3258
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.006	0.0458	0.0421
Trypanosoma brucei	DNA topoisomerase ii	0.0034	0.0174	0.0211
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Schistosoma mansoni	nephrin	0.0033	0.0167	0.0146
Plasmodium vivax	SET domain protein, putative	0.0036	0.0195	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.006	0.0458	0.0421
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Onchocerca volvulus		0.0035	0.0182	0.0083
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0034	0.0174	0.9563
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0458	0.0474
Schistosoma mansoni	tyrosine kinase	0.0077	0.0647	0.0687
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0195	0.0759
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0034	0.0174	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0206	0.2055	0.3158
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0035	0.0182	0.0163
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0312	0.0318
Schistosoma mansoni	endoplasmin	0.0034	0.0174	0.0154
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0312	0.0309
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	neuropeptide receptor	0.006	0.0458	0.0474
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	orexin receptor type 2	0.006	0.0458	0.0474
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0195	0.0177
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0038	0.198
Schistosoma mansoni	tyrosine kinase	0.015	0.1437	0.1579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Echinococcus granulosus	chromobox protein 1	0.007	0.0564	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0174	0.0268
Echinococcus multilocularis	orexin receptor type 2	0.006	0.0458	0.0421
Schistosoma mansoni	DNA topoisomerase II	0.0034	0.0174	0.0154
Entamoeba histolytica	transitional endoplasmic reticulum ATPase, putative	0.0029	0.0123	0.1059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Brugia malayi	follicle stimulating hormone receptor	0.006	0.0458	0.0703
Brugia malayi	larval opioid receptor	0.006	0.0458	0.0703
Schistosoma mansoni	amine GPCR	0.006	0.0458	0.0474
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0035	0.0182	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0034	0.0174	0.0677
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0034	0.0174	0.9563
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0104	0.023
Entamoeba histolytica	cdc48-like protein, putative	0.0029	0.0123	0.1059
Brugia malayi	Serotonin receptor	0.006	0.0458	0.0703
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0034	0.0174	0.0473
Schistosoma mansoni	pyruvate dehydrogenase	0.058	0.6135	0.6879
Brugia malayi	Carboxylesterase family protein	0.0035	0.0182	0.028
Plasmodium vivax	endoplasmin, putative	0.0034	0.0174	0.8692
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0262	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.0184
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Schistosoma mansoni	hypothetical protein	0.006	0.0458	0.0474
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.2546	0.3911
Echinococcus granulosus	insulin receptor	0.0051	0.0355	0.0358
Echinococcus granulosus	neuroglian	0.0033	0.0167	0.0146
Schistosoma mansoni	tyrosine kinase	0.0082	0.0701	0.0749
Leishmania major	hypothetical protein, conserved	0.0034	0.0174	0.0211
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Onchocerca volvulus		0.0035	0.0182	0.0083
Schistosoma mansoni	tyrosine kinase	0.0082	0.0701	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0182	0.028
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0038	0.1894
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0034	0.0174	0.0154
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0249	0.2519	1
Echinococcus multilocularis	neuroglian	0.0033	0.0167	0.013
Onchocerca volvulus		0.006	0.0458	0.0583
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Loa Loa (eye worm)	carboxylesterase	0.0206	0.2055	0.3158
Echinococcus granulosus	BC026374 protein S09 family	0.0035	0.0182	0.0163
Brugia malayi	Probable DNA topoisomerase II	0.0034	0.0174	0.0268
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0564	0.0867
Echinococcus granulosus	hypothetical protein	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0182	0.028
Echinococcus multilocularis	allatostatin A receptor	0.006	0.0458	0.0421
Mycobacterium ulcerans	DNA gyrase subunit B	0.0034	0.0174	0.9563
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.0458	0.0474
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Toxoplasma gondii	cell division protein CDC48CY	0.0031	0.014	0.0541
Echinococcus multilocularis	g protein coupled receptor	0.006	0.0458	0.0421
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.0458	0.0421
Echinococcus granulosus	g protein coupled receptor	0.006	0.0458	0.0474
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.006	0.0458	0.0703
Plasmodium vivax	DNA topoisomerase II, putative	0.0034	0.0174	0.8692
Echinococcus granulosus	alpha 1A adrenergic receptor	0.006	0.0458	0.0474
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0458	0.0474
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	hypothetical protein	0.0535	0.5642	0.8669
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	heat shock protein	0.0034	0.0174	0.0154
Schistosoma mansoni	neuropeptide receptor	0.006	0.0458	0.0474
Brugia malayi	Fibronectin type III domain containing protein	0.0029	0.012	0.0184
Trypanosoma cruzi	Heat shock protein 83, putative	0.0034	0.0174	0.0211
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0174	0.0211
Schistosoma mansoni	vesicular amine transporter	0.0029	0.012	0.0093
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0035	0.0182	0.0163
Brugia malayi	mbt repeat family protein	0.0047	0.0312	0.0479
Schistosoma mansoni	acetylcholinesterase	0.0035	0.0182	0.0163
Plasmodium falciparum	endoplasmin, putative	0.0034	0.0174	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	amine GPCR	0.006	0.0458	0.0474
Schistosoma mansoni	gliotactin	0.0035	0.0182	0.0163
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.006	0.0458	0.0703
Brugia malayi	Dopamine receptor	0.006	0.0458	0.0703
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0034	0.0174	0.0473
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.0458	0.0474
Onchocerca volvulus		0.006	0.0458	0.0583
Mycobacterium tuberculosis	Conserved protein	0.0034	0.0174	0.9563
Brugia malayi	Dopamine receptor protein 1	0.006	0.0458	0.0703
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0038	0.1894
Echinococcus multilocularis	epidermal growth factor receptor	0.0082	0.0701	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0182	0.028
Echinococcus granulosus	neuropeptide receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0051	0.0355	0.0318
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0034	0.0174	0.9563
Schistosoma mansoni	BC026374 protein (S09 family)	0.0035	0.0182	0.0163
Onchocerca volvulus		0.0047	0.032	0.0333
Schistosoma mansoni	growth hormone secretagogue receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.0458	0.0421
Echinococcus multilocularis	Protein lozenge	0.0067	0.0534	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0229	0.0352
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0031	0.014	0.0115
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	tyrosine kinase	0.0051	0.0355	0.0358
Schistosoma mansoni	endoplasmin	0.0034	0.0174	0.0154
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0034	0.0174	0.5
Schistosoma mansoni	tyrosine kinase	0.0077	0.0647	0.0687
Echinococcus multilocularis	G-protein coupled receptor, putative	0.006	0.0458	0.0421
Onchocerca volvulus		0.006	0.0458	0.0583
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0382	0.0389
Loa Loa (eye worm)	heat shock protein 90	0.0034	0.0174	0.0268
Echinococcus multilocularis	Immunoglobulin	0.0029	0.012	0.0083
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0034	0.0174	1
Schistosoma mansoni	hypothetical protein	0.006	0.0458	0.0474
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0215	0.2146	0.3258
Brugia malayi	Heterochromatin protein 1	0.007	0.0564	0.0867
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.006	0.0458	0.0703
Echinococcus granulosus	g protein coupled receptor	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0382	0.0588
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0382	0.0346
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0034	0.0174	0.9563
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.006	0.0458	0.0474
Toxoplasma gondii	cell division protein CDC48AP	0.0019	0.0004	0.0000019203
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0165	0.0253
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0035	0.0182	0.0163
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0312	0.0309
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0034	0.0174	0.0137
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0034	0.0174	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0312	0.0275
Schistosoma mansoni	hypothetical protein	0.006	0.0458	0.0474
Trichomonas vaginalis	spermatogenesis associated factor, putative	0.0031	0.014	0.0355
Brugia malayi	putative neuropeptide receptor	0.006	0.0458	0.0703
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0215	0.2146	0.8517
Echinococcus granulosus	dro:myosuppressin receptor	0.006	0.0458	0.0474
Schistosoma mansoni	histamine h1 receptor	0.006	0.0458	0.0474
Plasmodium falciparum	heat shock protein 90	0.0034	0.0174	1
Brugia malayi	G-protein coupled receptor	0.006	0.0458	0.0703
Onchocerca volvulus		0.006	0.0458	0.0583
Schistosoma mansoni	biogenic amine receptor	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0535	0.5642	0.8669
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0229	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	para nitrobenzyl esterase	0.0035	0.0182	0.0163
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0382	0.0389
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.0184
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0034	0.0174	0.0211
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0174	0.0211
Loa Loa (eye worm)	MBCTL1	0.0053	0.0382	0.0588
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0195	0.0177
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0034	0.0174	0.9563
Brugia malayi	chromobox protein homolog 3	0.0039	0.0229	0.0352
Echinococcus multilocularis	chromobox protein 1	0.007	0.0564	0.0529
Schistosoma mansoni	tyrosine kinase	0.0051	0.0355	0.0358
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0174	0.1702
Trypanosoma cruzi	Valosin-containing protein, putative	0.0029	0.0123	0.0131
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.006	0.0458	0.0583
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	opsin-like receptor	0.006	0.0458	0.0474
Schistosoma mansoni	neuropeptide receptor	0.006	0.0458	0.0474
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0034	0.0174	0.0211
Brugia malayi	Pre-SET motif family protein	0.0036	0.0195	0.0299
Plasmodium vivax	cell division cycle protein 48 homologue, putative	0.0029	0.0123	0.5406
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.0458	0.0703
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0355	0.0546
Brugia malayi	Pre-SET motif family protein	0.0251	0.2546	0.3911
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0034	0.0174	0.9563
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0312	0.0479
Schistosoma mansoni	adenoreceptor	0.006	0.0458	0.0474
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.0184
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	putative neuropeptide receptor NPR1	0.006	0.0458	0.0703
Brugia malayi	G-protein coupled receptor	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0614	0.6508	1
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.0458	0.0474
Toxoplasma gondii	heat shock protein 90, putative	0.0034	0.0174	0.0677
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0564	0.1824
Plasmodium falciparum	DNA topoisomerase 2	0.0034	0.0174	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.0174	0.0211
Onchocerca volvulus		0.0035	0.0182	0.0083
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0182	0.028
Echinococcus multilocularis	sex peptide receptor	0.006	0.0458	0.0421
Echinococcus multilocularis	acetylcholinesterase	0.0206	0.2055	0.2025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.006	0.0458	0.0703
Echinococcus multilocularis	acetylcholinesterase	0.0206	0.2055	0.2025
Loa Loa (eye worm)	endoplasmin	0.0034	0.0174	0.0268
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.0174	0.0473
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.006	0.0458	0.0421
Onchocerca volvulus		0.006	0.0458	0.0583
Echinococcus multilocularis	epidermal growth factor receptor	0.015	0.1437	0.1405
Echinococcus multilocularis	heat shock protein 90	0.0034	0.0174	0.0137
Brugia malayi	vesicle-fusing ATPase	0.0018	0.00000048294	0.00000074207
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.0458	0.0474
Brugia malayi	heat shock protein 90	0.0034	0.0174	0.0268
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	heat shock protein 90	0.0034	0.0174	0.0154
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0034	0.0174	0.9563
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0034	0.0174	0.0268
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0029	0.012	0.0093
Schistosoma mansoni	amine GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.018	0.0161
Brugia malayi	Carboxylesterase family protein	0.0035	0.0182	0.028
Brugia malayi	RE15519p	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0325
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.0174	0.0473
Echinococcus multilocularis	neuropeptide receptor	0.006	0.0458	0.0421
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.006	0.0458	0.0703
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.0458	0.0474
Echinococcus granulosus	peptide allatostatin:somatostatin	0.006	0.0458	0.0474
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0035	0.0182	0.0163
Loa Loa (eye worm)	runx1	0.0067	0.0534	0.082
Echinococcus multilocularis	para nitrobenzyl esterase	0.0035	0.0182	0.0145
Schistosoma mansoni	heat shock protein	0.0034	0.0174	0.0154
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	0.0029	0.0123	0.6219
Echinococcus granulosus	g protein coupled receptor	0.006	0.0458	0.0474
Brugia malayi	G protein-coupled receptor F59B2.13	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	serotonin receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.006	0.0458	0.0421
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Brugia malayi	Dopamine receptor protein 2	0.006	0.0458	0.0703
Onchocerca volvulus		0.006	0.0458	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0206	0.2055	0.3158
Echinococcus multilocularis	somatostatin receptor	0.006	0.0458	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0312	0.0479
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.0174	0.0211
Trypanosoma brucei	Heat shock protein 83, putative	0.0034	0.0174	0.0211
Schistosoma mansoni	neuropeptide receptor	0.006	0.0458	0.0474
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0038	0.0219	0.0337
Echinococcus multilocularis	fmrfamide receptor	0.006	0.0458	0.0421
Echinococcus granulosus	defective proboscis extension response	0.0029	0.012	0.0093
Brugia malayi	mbt repeat family protein	0.0047	0.0312	0.0479
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0614	0.6508	1
Onchocerca volvulus		0.0035	0.0182	0.0083
Echinococcus multilocularis	G protein coupled receptor 139	0.006	0.0458	0.0421
Onchocerca volvulus		0.006	0.0458	0.0583
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0034	0.0174	1
Echinococcus multilocularis	fmrfamide receptor	0.006	0.0458	0.0421
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	0.0031	0.014	0.0006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0034	0.0174	0.0473
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.006	0.0458	0.0421
Echinococcus multilocularis	g protein coupled receptor	0.006	0.0458	0.0421
Brugia malayi	Tachykinin-like peptides receptor 99D	0.006	0.0458	0.0703
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0035	0.0182	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.006	0.0458	0.0703
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Plasmodium vivax	DNA gyrase subunit B, putative	0.0034	0.0174	0.8692
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0195	0.0158
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0182	0.028
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	neuropeptide F receptor	0.006	0.0458	0.0703
Echinococcus multilocularis	g-protein coupled receptor	0.006	0.0458	0.0421
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.0458	0.0474
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.8901	1
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	g protein coupled receptor	0.006	0.0458	0.0421
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0458	0.0474
Mycobacterium ulcerans	putative regultory protein	0.0034	0.0174	0.9563
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0034	0.0174	0.0211
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0034	0.0174	1
Chlamydia trachomatis	DNA gyrase subunit B	0.0034	0.0174	0.5
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0382	0.0588
Echinococcus granulosus	carboxylesterase 5A	0.0206	0.2055	0.2276
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.0458	0.0474
Loa Loa (eye worm)	carboxylesterase	0.0035	0.0182	0.028
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0029	0.012	0.0083
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0189	0.1861	0.183
Echinococcus granulosus	Immunoglobulin	0.0029	0.012	0.0093
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0034	0.0174	0.5
Loa Loa (eye worm)	carboxylesterase	0.0035	0.0182	0.028
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.006	0.0458	0.0474
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0034	0.0174	0.5
Onchocerca volvulus		0.006	0.0458	0.0583
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Echinococcus multilocularis	carboxylesterase 5A	0.0206	0.2055	0.2025
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	TOPoisomerase family member	0.0034	0.0174	0.0268
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	biogenic amine receptor	0.006	0.0458	0.0474
Schistosoma mansoni	heat shock protein	0.0034	0.0174	0.0154
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0033	0.0165	0.0143
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.0458	0.0421
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0082	0.0701	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0137	0.021
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.006	0.0458	0.0421
Echinococcus granulosus	neuropeptide receptor A26	0.059	0.6244	0.7002
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.006	0.0458	0.0703
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0034	0.0174	0.0068
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0095	0.084	1
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0614	0.6508	1
Echinococcus multilocularis	neuropeptide s receptor	0.059	0.6244	0.6229
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Trichomonas vaginalis	spcc417.12 protein, putative	0.0035	0.0182	0.05
Echinococcus granulosus	tachykinin peptides receptor 99D	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Echinococcus granulosus	epidermal growth factor receptor	0.0082	0.0701	0.0749
Echinococcus granulosus	roundabout 2	0.0038	0.0211	0.0196
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0458	0.0474
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0174	0.0211
Brugia malayi	sulfakinin receptor protein	0.006	0.0458	0.0703
Echinococcus granulosus	g-protein coupled receptor	0.006	0.0458	0.0474
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0034	0.0174	0.9563
Chlamydia trachomatis	DNA gyrase subunit B	0.0034	0.0174	0.5
Schistosoma mansoni	chromobox protein	0.007	0.0564	0.0594
Onchocerca volvulus		0.0035	0.0182	0.0083
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.0458	0.0703
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0034	0.0174	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.006	0.0458	0.0474
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0215	0.2146	0.3258
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0034	0.0174	0.0211
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0035	0.0182	0.05
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0182	0.028
Trichomonas vaginalis	receptor histidine kinase, putative	0.0034	0.0174	0.0473
Brugia malayi	kinase, mitochondrial precursor	0.0614	0.6508	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.0219	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.0184
Brugia malayi	Carboxylesterase family protein	0.0035	0.0182	0.028
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.0458	0.0421
Leishmania major	DNA topoisomerase ii	0.0034	0.0174	0.0211
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0312	0.0309
Echinococcus multilocularis	neuropeptide FF receptor 2	0.006	0.0458	0.0421
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Brugia malayi	Furin-like cysteine rich region family protein	0.015	0.1437	0.2208
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0034	0.0174	0.9563
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0325
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	roundabout 2	0.0038	0.0211	0.0174
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	Carboxylesterase family protein	0.0035	0.0182	0.028
Schistosoma mansoni	hypothetical protein	0.006	0.0458	0.0474
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0034	0.0174	0.0068
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0174	0.0211
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0104	0.023
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0195	0.0299
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0458	0.0421
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.006	0.0458	0.0474
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0174	0.0211
Loa Loa (eye worm)	TYRA-2 protein	0.006	0.0458	0.0703
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0034	0.0174	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	amine GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	acetylcholinesterase	0.0206	0.2055	0.2276
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.006	0.0458	0.0703
Echinococcus granulosus	allatostatin A receptor	0.006	0.0458	0.0474
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0047	0.032	0.0318
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0034	0.0174	0.0677
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0034	0.0174	0.0268
Schistosoma mansoni	alpha-1 adrenergic receptor	0.006	0.0458	0.0474
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0262	0.0775
Echinococcus multilocularis	serotonin receptor	0.006	0.0458	0.0421
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0034	0.0174	0.9563
Loa Loa (eye worm)	melatonin receptor type 1A	0.006	0.0458	0.0703
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0614	0.6508	1
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0029	0.0123	0.0096
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.006	0.0458	0.0474
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0034	0.0174	0.0677
Leishmania major	mitochondrial DNA topoisomerase II	0.0034	0.0174	0.0211
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0382	0.0389
Brugia malayi	ORL1-like opioid receptor	0.006	0.0458	0.0703
Onchocerca volvulus		0.006	0.0458	0.0583
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.0458	0.0703
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0262	0.0775
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.0458	0.0421
Echinococcus multilocularis	neuroligin	0.0035	0.0182	0.0145
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0614	0.6508	0.6495
Echinococcus multilocularis	serotonin receptor	0.006	0.0458	0.0421
Echinococcus granulosus	chromobox protein 1	0.007	0.0564	0.0594
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.006	0.0458	0.0474
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.0458	0.0474
Trichomonas vaginalis	endoplasmin, putative	0.0034	0.0174	0.0473
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0614	0.6508	0.73
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0034	0.0174	0.9563
Schistosoma mansoni	amine GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.0458	0.0474
Schistosoma mansoni	neuropeptide f receptor 76f	0.006	0.0458	0.0474
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0038	0.0058
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0034	0.0174	0.9563
Brugia malayi	hypothetical protein	0.0029	0.012	0.0184
Schistosoma mansoni	opsin-like receptor	0.006	0.0458	0.0474
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0035	0.0182	0.0145
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Brugia malayi	Melatonin receptor type 1A	0.006	0.0458	0.0703
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0034	0.0174	0.0473
Echinococcus multilocularis		0.0045	0.0294	0.0257
Onchocerca volvulus		0.006	0.0458	0.0583
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.0174	0.0211
Echinococcus granulosus	G protein coupled receptor 139	0.006	0.0458	0.0474
Onchocerca volvulus		0.006	0.0458	0.0583
Brugia malayi	Serotonin receptor	0.006	0.0458	0.0703
Brugia malayi	Carboxylesterase family protein	0.0206	0.2055	0.3158
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0031	0.014	0.0103
Echinococcus granulosus	neuroligin	0.0035	0.0182	0.0163
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.012	0.0184
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0034	0.0174	0.0473
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.006	0.0458	0.0421
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.0458	0.0474
Schistosoma mansoni	chromobox protein	0.007	0.0564	0.0594
Onchocerca volvulus		0.006	0.0458	0.0583
Trypanosoma brucei	Valosin-containing protein	0.0029	0.0123	0.0131
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.006	0.0458	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0095	0.084	0.1291
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0034	0.0174	0.0211
Echinococcus granulosus	transitional endoplasmic reticulum atpase	0.0031	0.014	0.0115
Loa Loa (eye worm)	TK/INSR protein kinase	0.0051	0.0355	0.0546
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0189	0.1861	0.2057
Echinococcus granulosus	somatostatin receptor	0.006	0.0458	0.0474
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0034	0.0174	0.9563
Loa Loa (eye worm)	hypothetical protein	0.006	0.0458	0.0703
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0029	0.012	0.0093
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0035	0.0182	1
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0564	0.1824
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.006	0.0458	0.0474
Leishmania major	heat shock protein 83-1	0.0034	0.0174	0.0211
Loa Loa (eye worm)	TK/EGFR protein kinase	0.015	0.1437	0.2208
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.0458	0.0474
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0034	0.0174	0.9563
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0034	0.0174	0.9563
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0458	0.0474
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0051	0.0355	0.0358
Schistosoma mansoni	hypothetical protein	0.0289	0.2952	0.3288
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0035	0.0182	0.0163
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.2925	1
Brugia malayi	AKH receptor	0.006	0.0458	0.0703
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0312	0.0309
Brugia malayi	hypothetical protein	0.006	0.0458	0.0703

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.14 uM	In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R	ChEMBL.	9703462
IC50 (binding)	= 0.14 uM	In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R	ChEMBL.	9703462

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 180480