TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 685.632 | Formula: C30H41FN3O12P
H donors: 6 H acceptors: 9 LogP: -2.44 Rotable bonds: 8
Rule of 5 violations (Lipinski): 3
SMILES: O=C1CC[C@]2(C(=C1)CC[C@@H]1[C@]2(F)[C@@H](O)C[C@]2([C@H]1CC[C@]2(O)C(=O)COP(=O)(OC[C@H]1O[C@H]([C@H]([C@@H]1O)O)n1ccc(nc1=O)N)O)C)C
InChi: 1S/C30H41FN3O12P/c1-27-8-5-16(35)11-15(27)3-4-18-17-6-9-29(41,28(17,2)12-20(36)30(18,27)31)21(37)14-45-47(42,43)44-13-19-23(38)24(39)25(46-19)34-10-7-22(32)33-26(34)40/h7,10-11,17-20,23-25,36,38-39,41H,3-6,8-9,12-14H2,1-2H3,(H,42,43)(H2,32,33,40)/t17-,18-,19+,20-,23+,24-,25+,27-,28-,29-,30-/m0/s1
InChiKey: GPOIBWMJGUUYFG-JVUZGPMKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0141	0.5
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0071	0.0141	0.0141
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0071	0.0141	0.0141
Brugia malayi	Animal haem peroxidase family protein	0.0859	0.4599	1
Schistosoma mansoni	loxhd1	0.0147	0.0575	0.0575
Trypanosoma cruzi	Diacylglycerol kinase catalytic domain containing protein, putative	0.0071	0.0141	0.5
Leishmania major	diacylglycerol kinase, putative	0.0071	0.0141	0.5
Onchocerca volvulus		0.0859	0.4599	1
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Brugia malayi	hypothetical protein	0.0071	0.0141	0.0306
Plasmodium vivax	multidomain scavenger receptor, putative	0.0147	0.0575	1
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.07	0.5268
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0071	0.0141	0.0141
Schistosoma mansoni	lipoxygenase	0.0882	0.4728	0.4728
Trypanosoma brucei	Diacylglycerol kinase catalytic domain containing protein, putative	0.0071	0.0141	0.5
Schistosoma mansoni	polycystin 1-related	0.0147	0.0575	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Schistosoma mansoni	notch	0.0088	0.0236	0.0236
Schistosoma mansoni	septate junction protein	0.0088	0.0236	0.0236
Schistosoma mansoni	rab6-interacting	0.0147	0.0575	0.0575
Toxoplasma gondii	EGF family domain-containing protein	0.0088	0.0236	1
Schistosoma mansoni	notch	0.0088	0.0236	0.0236
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0071	0.0141	0.0141
Onchocerca volvulus	Neurogenic locus notch homolog	0.0088	0.0236	0.0214
Echinococcus multilocularis	neurogenic locus protein delta	0.0088	0.0236	0.0236
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0882	0.4728	0.4728
Loa Loa (eye worm)	animal heme peroxidase	0.0859	0.4599	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0088	0.0236	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus granulosus	RUN	0.0147	0.0575	0.0575
Leishmania major	diacylglycerol kinase-like protein	0.0071	0.0141	0.5
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Schistosoma mansoni	diacylglycerol kinase theta	0.0071	0.0141	0.0141
Trypanosoma cruzi	Sphingosine kinase	0.0071	0.0141	0.5
Echinococcus granulosus	peroxidasin	0.0859	0.4599	0.4599
Brugia malayi	Animal haem peroxidase family protein	0.0859	0.4599	1
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.07	0.5268
Onchocerca volvulus	Peroxidase homolog	0.0859	0.4599	1
Schistosoma mansoni	slit	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Leishmania major	sphingosine kinase A, B, putative	0.0071	0.0141	0.5
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Schistosoma mansoni	laminin gamma-3 chain	0.0088	0.0236	0.0236
Echinococcus multilocularis	neural cadherin	0.0088	0.0236	0.0236
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0071	0.0141	0.5
Schistosoma mansoni	notch	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Brugia malayi	Muscle positioning protein 4	0.0088	0.0236	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Brugia malayi	hypothetical protein	0.0147	0.0575	0.125
Schistosoma mansoni	notch	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Onchocerca volvulus	Dual oxidase homolog	0.0859	0.4599	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.07	0.5268
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Echinococcus granulosus	slit 2 protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus multilocularis	ceramide kinase	0.0071	0.0141	0.0141
Echinococcus granulosus	neurogenic locus notch protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0141	0.0141
Brugia malayi	GCC2 and GCC3 family protein	0.0088	0.0236	0.0514
Brugia malayi	Animal haem peroxidase family protein	0.0859	0.4599	1
Brugia malayi	Cadherin domain containing protein	0.0088	0.0236	0.0514
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.07	0.5268
Echinococcus granulosus	lipoxygenase domain containing protein	0.0147	0.0575	0.0575
Echinococcus granulosus	fibropellin Ia	0.0088	0.0236	0.0236
Brugia malayi	Delta serrate ligand family protein	0.0088	0.0236	0.0514
Schistosoma mansoni	hypothetical protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Mycobacterium tuberculosis	Conserved protein	0.1814	1	1
Echinococcus granulosus	neural cadherin	0.0088	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0088	0.0236	0.0236
Onchocerca volvulus	Glucosylceramidase homolog	0.017	0.07	0.1256
Trypanosoma brucei	Sphingosine kinase	0.0071	0.0141	0.5
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0147	0.0575	0.0575
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0071	0.0141	0.5
Plasmodium falciparum	LCCL domain-containing protein	0.0147	0.0575	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0259	0.1203	0.1203
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0882	0.4728	0.4728
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus granulosus	protein jagged 1	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Brugia malayi	Calcium binding EGF domain containing protein	0.0088	0.0236	0.0514
Schistosoma mansoni	diacylglycerol kinase zeta iota	0.0071	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Schistosoma mansoni	notch	0.0088	0.0236	0.0236
Echinococcus multilocularis	Polycystic kidney disease protein	0.0147	0.0575	0.0575
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0088	0.0236	0.0236
Brugia malayi	Eye-specific diacylglycerol kinase	0.0071	0.0141	0.0306
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0071	0.0141	0.0141
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0088	0.0236	0.0214
Leishmania major	hypothetical protein, conserved	0.0071	0.0141	0.5
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0071	0.0141	0.0141
Brugia malayi	EGF-like domain containing protein	0.0088	0.0236	0.0514
Echinococcus granulosus	protein jagged 1	0.0088	0.0236	0.0236
Schistosoma mansoni	diacylglycerol kinase theta	0.0071	0.0141	0.0141
Brugia malayi	Doublecortin family protein	0.0147	0.0575	0.125
Loa Loa (eye worm)	blistered cuticle protein 3	0.0859	0.4599	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus multilocularis	protein jagged 2	0.0088	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0088	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus granulosus	Polycystic kidney disease protein	0.0147	0.0575	0.0575
Onchocerca volvulus		0.0147	0.0575	0.0974
Brugia malayi	Blistered cuticle protein 3	0.0859	0.4599	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Echinococcus multilocularis	neurogenic locus protein delta	0.0088	0.0236	0.0236
Schistosoma mansoni	sphingosine kinase A B	0.1814	1	1
Echinococcus granulosus	protein jagged 2	0.0088	0.0236	0.0236
Onchocerca volvulus	Slit protein homolog	0.0088	0.0236	0.0214
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.1203	1
Echinococcus multilocularis	RUN	0.0147	0.0575	0.0575
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0071	0.0141	0.5
Brugia malayi	hypothetical protein	0.0147	0.0575	0.125
Schistosoma mansoni	peroxidasin	0.0859	0.4599	0.4599
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0088	0.0236	0.0236
Brugia malayi	Animal haem peroxidase family protein	0.0859	0.4599	1
Echinococcus granulosus	protein jagged 2	0.0088	0.0236	0.0236
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.0141	0.5
Echinococcus multilocularis	protein jagged 1	0.0088	0.0236	0.0236
Schistosoma mansoni	sphingoid long chain base kinase	0.1814	1	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0259	0.1203	0.2616
Echinococcus multilocularis	slit 2 protein	0.0088	0.0236	0.0236
Brugia malayi	Animal haem peroxidase family protein	0.0859	0.4599	1
Brugia malayi	EGF-like domain containing protein	0.0088	0.0236	0.0514
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0071	0.0141	0.0141
Echinococcus granulosus	neurogenic locus notch protein 4	0.0088	0.0236	0.0236
Giardia lamblia	High cysteine protein	0.0088	0.0236	0.5
Echinococcus multilocularis	protein jagged 1	0.0088	0.0236	0.0236
Onchocerca volvulus		0.0859	0.4599	1
Schistosoma mansoni	peroxidasin	0.0859	0.4599	0.4599
Echinococcus granulosus	neurogenic locus protein delta	0.0088	0.0236	0.0236
Brugia malayi	Cadherin domain containing protein	0.0088	0.0236	0.0514
Echinococcus granulosus	notch	0.0088	0.0236	0.0236
Echinococcus multilocularis	neurogenic locus notch protein	0.0088	0.0236	0.0236
Onchocerca volvulus		0.0088	0.0236	0.0214
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.1203	1
Entamoeba histolytica	hypothetical protein, conserved	0.1814	1	1
Schistosoma mansoni	hypothetical protein	0.0147	0.0575	0.0575
Mycobacterium ulcerans	hypothetical protein	0.1814	1	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.07	0.5268
Schistosoma mansoni	notch	0.0088	0.0236	0.0236
Onchocerca volvulus	Chorion peroxidase homolog	0.0859	0.4599	1
Brugia malayi	diacylglycerol kinase	0.0071	0.0141	0.0306
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0071	0.0141	0.0141
Echinococcus granulosus	neurogenic locus notch protein	0.0088	0.0236	0.0236
Schistosoma mansoni	cell polarity protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0141	0.0141
Echinococcus granulosus	lipoxygenase domain containing protein	0.0147	0.0575	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus multilocularis	peroxidasin	0.0859	0.4599	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Brugia malayi	Diacylglycerol kinase protein 2	0.0071	0.0141	0.0306
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0752	0.5755
Brugia malayi	EGF-like domain containing protein	0.0088	0.0236	0.0514
Echinococcus multilocularis	sphingosine kinase 1	0.1814	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.07	0.5268
Echinococcus granulosus	delta-like protein 1	0.0088	0.0236	0.0236
Loa Loa (eye worm)	doublecortin family protein	0.0147	0.0575	0.0575
Loa Loa (eye worm)	animal heme peroxidase	0.0859	0.4599	0.4599
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0088	0.0236	0.0236
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.1203	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0575	0.0575
Onchocerca volvulus		0.0088	0.0236	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus multilocularis	neurogenic locus notch protein	0.0088	0.0236	0.0236
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.1203	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0088	0.0236	0.0514
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.1203	1
Brugia malayi	EGF-like domain containing protein	0.0088	0.0236	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0141	0.0141
Onchocerca volvulus	Putative cubilin	0.0088	0.0236	0.0214
Schistosoma mansoni	hypothetical protein	0.0088	0.0236	0.0236
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.07	0.5268
Loa Loa (eye worm)	hypothetical protein	0.1814	1	1
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0071	0.0141	0.5
Loa Loa (eye worm)	ceramide kinase	0.0071	0.0141	0.0141
Schistosoma mansoni	lipoxygenase	0.0617	0.3228	0.3228
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0752	0.5755
Onchocerca volvulus	Peroxidase homolog	0.0859	0.4599	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.1203	1
Onchocerca volvulus		0.0088	0.0236	0.0214
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0147	0.0575	0.0575
Brugia malayi	Peroxidasin	0.0859	0.4599	1
Onchocerca volvulus		0.0088	0.0236	0.0214
Echinococcus multilocularis	fibropellin Ia	0.0088	0.0236	0.0236
Brugia malayi	Ceramide kinase	0.0071	0.0141	0.0306
Onchocerca volvulus		0.0859	0.4599	1
Brugia malayi	diacylglycerol kinase	0.0071	0.0141	0.0306
Brugia malayi	EGF-like domain containing protein	0.0088	0.0236	0.0514
Trypanosoma cruzi	Sphingosine kinase	0.0071	0.0141	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0859	0.4599	1
Echinococcus granulosus	ceramide kinase	0.0071	0.0141	0.0141
Brugia malayi	notch-like transmembrane receptor	0.0088	0.0236	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Onchocerca volvulus	Peroxidasin homolog	0.0859	0.4599	1
Schistosoma mansoni	hypothetical protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	notch protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	animal heme peroxidase	0.0859	0.4599	0.4599
Onchocerca volvulus		0.0147	0.0575	0.0974
Brugia malayi	EGF-like domain containing protein	0.0088	0.0236	0.0514
Brugia malayi	Calcium binding EGF domain containing protein	0.0088	0.0236	0.0514
Schistosoma mansoni	rab6-interacting	0.0147	0.0575	0.0575
Onchocerca volvulus		0.0088	0.0236	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Loa Loa (eye worm)	animal heme peroxidase	0.0859	0.4599	0.4599
Brugia malayi	EGF-like domain containing protein	0.0088	0.0236	0.0514
Leishmania major	hypothetical protein, conserved	0.0071	0.0141	0.5
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0575	0.0575
Trypanosoma brucei	diacylglycerol kinase, putative	0.0071	0.0141	0.5
Brugia malayi	hypothetical protein	0.0859	0.4599	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0236	0.0236
Echinococcus multilocularis	notch	0.0088	0.0236	0.0236
Loa Loa (eye worm)	Notch2	0.0088	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599
Schistosoma mansoni	hypothetical protein	0.0071	0.0141	0.0141
Echinococcus granulosus	Diacylglycerol kinase theta	0.0071	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4599	0.4599

Activities

Activity type	Activity value	Assay description	Source	Reference
ED 50 (functional)	= 0.08 uM	In Vitro evaluation of the compound for the antiproliferative activity by observing the growth inhibition of L1210 lymphoid leukemia cells in culture at 72 hour	ChEMBL.	7452687
ILS (functional)	= -36 %	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 100 mg/kg/day x 5 was determined as percentage increase in the life span as compared with control tumor bearers	ChEMBL.	7452687
ILS (functional)	= 65 %	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 25 mg/kg/day x 5 was determined as percentage increase in the life span as compared with control tumor bearers	ChEMBL.	7452687
ILS (functional)	= 68 %	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 50 mg/kg/day x 5 was determined as percentage increase in the life span as compared with control tumor bearers	ChEMBL.	7452687
ILS (functional)	= 84 %	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 75 mg/kg/day x 5 was determined as percentage increase in the life span as compared with control tumor bearers	ChEMBL.	7452687
Survival time (functional)	= 7 day	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 100 mg/kg/day x 5 was determined as Survival time in days; Range is 7-8 days	ChEMBL.	7452687
Survival time (functional)	= 12 day	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 25 mg/kg/day x 5 was determined as Survival time in days; Range is 12-18 days	ChEMBL.	7452687
Survival time (functional)	= 14 day	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 50 mg/kg/day x 5 was determined as Survival time in days; Range is 14-17 days	ChEMBL.	7452687
Survival time (functional)	= 14 day	Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 75 mg/kg/day x 5 was determined as Survival time in days; Range is 14-18 days	ChEMBL.	7452687
Weight change (functional)	= -1.09 g mouse-1	Antitumor activity in mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 25 mg/kg/day x 5 was determined as weight change (g/mouse) on 8th day	ChEMBL.	7452687
Weight change (functional)	= 0.39 g mouse-1	Antitumor activity in mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 50 mg/kg/day x 5 was determined as weight change (g/mouse) on 8th day	ChEMBL.	7452687
Weight change (functional)	= 0.52 g mouse-1	Antitumor activity in mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 75 mg/kg/day x 5 was determined as weight change (g/mouse) on 8th day	ChEMBL.	7452687

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3037847

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1806976