Detailed information for compound 1815615

Basic information

Technical information
  • TDR Targets ID: 1815615
  • Name: (5-methyl-2-propan-2-ylphenyl) 2-[1-(4-chloro benzoyl)-5-methoxy-2-methylindol-3-yl]acetate
  • MW: 489.99 | Formula: C29H28ClNO4
  • H donors: 0 H acceptors: 2 LogP: 7.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(CC(=O)Oc1cc(C)ccc1C(C)C)c(n2C(=O)c1ccc(cc1)Cl)C
  • InChi: 1S/C29H28ClNO4/c1-17(2)23-12-6-18(3)14-27(23)35-28(32)16-24-19(4)31(26-13-11-22(34-5)15-25(24)26)29(33)20-7-9-21(30)10-8-20/h6-15,17H,16H2,1-5H3
  • InChiKey: QJYHEBAGWILBBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-isopropyl-5-methyl-phenyl) 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate
  • 2-[1-[(4-chlorophenyl)-oxomethyl]-5-methoxy-2-methyl-3-indolyl]acetic acid (2-isopropyl-5-methylphenyl) ester
  • 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid (2-isopropyl-5-methyl-phenyl) ester
  • (5-methyl-2-propan-2-yl-phenyl) 2-[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]ethanoate
  • AN-652/14037005
  • Oprea1_240505

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0043 0.0042
Echinococcus multilocularis ubiquitin modifier activating enzyme ATG7 0.0057 0.0291 0.029
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0043 0.014
Echinococcus multilocularis ubiquitin modifier activating enzyme 1 0.0201 0.1227 0.1227
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0051 0.0253 0.0252
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0057 0.0291 0.029
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0384 0.0383
Schistosoma mansoni clathrin coat associated protein ap-50 0.0142 0.084 0.0839
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.037 0.0369
Brugia malayi RNA, U transporter 1 0.0096 0.0545 0.0544
Plasmodium vivax importin-beta 2, putative 0.0034 0.0143 0.0327
Plasmodium vivax SET domain protein, putative 0.0035 0.015 0.0353
Brugia malayi jmjC domain containing protein 0.0018 0.0043 0.0042
Entamoeba histolytica ThiF family protein 0.0097 0.0554 0.0473
Echinococcus granulosus phd:f box containing protein 0.0018 0.0043 0.0042
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0092 0.052 0.1687
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0043 0.0042
Plasmodium falciparum ubiquitin-activating enzyme 0.0057 0.0291 0.0815
Brugia malayi E1-like protein-activating enzyme Gsa7p/Apg7p containing protein 0.0057 0.0291 0.029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0101 0.0023
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0043 0.0042
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.0057 0.0291 0.0289
Plasmodium vivax ubiquitin-activating enzyme, putative 0.0068 0.0366 0.1063
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0057 0.0291 0.0289
Echinococcus granulosus ubiquitin modifier activating enzyme 6 0.0201 0.1227 0.1227
Giardia lamblia Molybdopterin biosynthesis MoeB protein 0.0057 0.0291 0.3078
Trichomonas vaginalis sumo-1-activating enzyme E1a, putative 0.0057 0.0291 0.0289
Brugia malayi jmjC domain containing protein 0.0018 0.0043 0.0042
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.1557 1 1
Toxoplasma gondii ThiF family protein 0.0057 0.0291 0.0249
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0043 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.015 0.015
Plasmodium vivax ubiquitin-activating enzyme E1, putative 0.0057 0.0291 0.0815
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0057 0.0291 0.0815
Toxoplasma gondii ThiF family protein 0.0097 0.0554 0.0513
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0097 0.0554 0.0659
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0104 0.0596 0.1818
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0085 0.0042
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0107 0.0619 0.0618
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0042
Schistosoma mansoni app binding protein 0.0097 0.0554 0.0553
Trichomonas vaginalis set domain proteins, putative 0.0277 0.1718 0.2292
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0097 0.0554 0.0659
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0128 0.0754 0.2337
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0943
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0828 0.0827
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0043 0.0042
Brugia malayi CG1749-PA 0.0057 0.0291 0.029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.036 0.2255 0.2254
Loa Loa (eye worm) hypothetical protein 0.0107 0.0619 0.0618
Toxoplasma gondii ThiF family protein 0.0057 0.0291 0.0249
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.1557 1 1
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0166 0.0998 0.1282
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0043 0.0042
Echinococcus granulosus NEDD8 activating enzyme E1 regulatory subunit 0.0097 0.0554 0.0553
Schistosoma mansoni hypothetical protein 0.0057 0.0291 0.029
Schistosoma mansoni ran 0.0025 0.0085 0.0084
Echinococcus granulosus snurportin 1 0.036 0.2255 0.2254
Onchocerca volvulus 0.0277 0.1718 1
Schistosoma mansoni clathrin coat associated protein ap-50 0.0142 0.084 0.0839
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.037 0.0369
Toxoplasma gondii ThiF family protein 0.0057 0.0291 0.0249
Schistosoma mansoni hypothetical protein 0.036 0.2255 0.2254
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0128 0.0754 0.2444
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0384 0.0383
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0057 0.0291 0.3078
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0057 0.0291 0.0815
Leishmania major importin beta-1 subunit, putative 0.0027 0.0101 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0043 0.0042
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0211 0.1291 0.7515
Echinococcus granulosus microtubule associated protein 2 0.0808 0.5149 0.5149
Echinococcus multilocularis snurportin 1 0.036 0.2255 0.2254
Brugia malayi jmjC domain containing protein 0.0018 0.0043 0.0042
Leishmania major ubiquitin-activating enzyme-like protein 0.0057 0.0291 0.0815
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.0128 0.0754 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0085 0.0276
Trypanosoma cruzi Ubiquitin-like modifier-activating enzyme ATG7, putative 0.0057 0.0291 0.0943
Echinococcus granulosus adenylyltransferase and sulfurtransferase 0.0057 0.0291 0.029
Brugia malayi Pre-SET motif family protein 0.0244 0.15 0.1499
Plasmodium falciparum importin beta, putative 0.0034 0.0143 0.0327
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.037 0.0369
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0143 0.01
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0101 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0042
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0085 0.0084
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0143 0.0327
Plasmodium falciparum autophagy-related protein 7, putative 0.0057 0.0291 0.0815
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0057 0.0291 0.029
Trichomonas vaginalis ubiquitin-activating enzyme E1b, putative 0.0057 0.0291 0.0289
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.015
Echinococcus multilocularis microtubule associated protein 2 0.0808 0.5149 0.5149
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.1557 1 1
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.1557 1 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0085 0.0084
Trichomonas vaginalis ubiquitin-activating enzyme E1 X, putative 0.0099 0.0565 0.0673
Leishmania major ubiquitin activating enzyme, putative 0.0057 0.0291 0.0815
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0085 0.0138
Brugia malayi ThiF family protein 0.0057 0.0291 0.029
Entamoeba histolytica HesA/MoeB/ThiF family protein, putative 0.0057 0.0291 0.0208
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0208
Giardia lamblia Molybdopterin biosynthesis MoeB protein 0.0057 0.0291 0.3078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0042
Toxoplasma gondii ThiF family protein 0.0068 0.0366 0.0325
Schistosoma mansoni microtubule-associated protein tau 0.0808 0.5149 0.5149
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0043 0.014
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.0488 0.3084 1
Leishmania major ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0815
Loa Loa (eye worm) ube1-prov protein 0.0201 0.1227 0.1227
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.1557 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0828 0.0827
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0384 0.0342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.015 0.015
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0068 0.0366 0.0395
Brugia malayi jmjC domain containing protein 0.0018 0.0043 0.0042
Brugia malayi ThiF family protein 0.0097 0.0554 0.0553
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0107 0.0619 0.1895
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0057 0.0291 0.029
Echinococcus granulosus ubiquitin modifier activating enzyme ATG7 0.0057 0.0291 0.029
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0201 0.1227 0.1152
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0384 1
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.1557 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.037 0.0369
Brugia malayi ube1-prov protein 0.0201 0.1227 0.1227
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.15 0.1499
Brugia malayi MH2 domain containing protein 0.014 0.0828 0.0827
Echinococcus multilocularis ubiquitin modifier activating enzyme 5 0.0057 0.0291 0.029
Trypanosoma cruzi Ubiquitin-like modifier-activating enzyme ATG7, putative 0.0057 0.0291 0.0943
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0085 0.0138
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0143 0.0142
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0043 0.0042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.015 0.015
Leishmania major hypothetical protein, conserved 0.0097 0.0554 0.1681
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0101 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.015 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.015 0.015
Trypanosoma brucei ubiquitin activating enzyme, putative 0.0057 0.0291 0.0815
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0107 0.0619 0.0618
Echinococcus granulosus ubiquitin modifier activating enzyme 1 0.0201 0.1227 0.1227
Trypanosoma brucei molybdopterin synthase sulphurylase protein, putative 0.0057 0.0291 0.0815
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0085 0.0276
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0488 0.3084 1
Brugia malayi jmjC domain containing protein 0.0069 0.037 0.0369
Brugia malayi N-terminal motif family protein 0.0211 0.1291 0.129
Trypanosoma brucei ubiquitin activating enzyme, putative 0.0057 0.0291 0.0815
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0068 0.0366 0.0395
Onchocerca volvulus 0.0035 0.015 0.0871
Schistosoma mansoni importin beta-1 0.0034 0.0143 0.0142
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0384 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.037 0.0369
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.037 0.0369
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0488 0.3084 1
Leishmania major ubiquitin-activating enzyme e1, putative 0.0104 0.0596 0.1818
Echinococcus multilocularis adenylyltransferase and sulfurtransferase 0.0057 0.0291 0.029
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0384 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0043 0.0042
Brugia malayi Importin beta-1 subunit 0.0034 0.0143 0.0142
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.0488 0.3084 1
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0057 0.0291 0.0289
Brugia malayi Pre-SET motif family protein 0.0035 0.015 0.015
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.0057 0.0291 0.3078
Brugia malayi jmjC domain containing protein 0.0069 0.037 0.0369
Entamoeba histolytica ubiquitin-activating enzyme E1 1, putative 0.0166 0.0998 0.0921
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0057 0.0291 0.029
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.015 0.015
Echinococcus granulosus importin subunit beta 1 0.0034 0.0143 0.0142
Plasmodium vivax autophagy-related protein 7, putative 0.0057 0.0291 0.0815
Leishmania major ubiquitin activating enzyme, putative 0.0488 0.3084 1
Loa Loa (eye worm) ThiF family protein 0.0068 0.0366 0.0366
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0043 0.0042
Toxoplasma gondii autophagy-related protein 7 atg7, putative 0.0057 0.0291 0.0249
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0057 0.0291 0.0815
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0057 0.0291 0.5
Plasmodium falciparum ubiquitin-activating enzyme E1, putative 0.0057 0.0291 0.0815
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.0166 0.0998 0.1282
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0057 0.0291 0.0943
Echinococcus granulosus ubiquitin modifier activating enzyme 5 0.0057 0.0291 0.029
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0384 0.1121
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0085 0.0084
Brugia malayi ThiF family protein 0.0107 0.0619 0.0618
Trypanosoma cruzi E1-like ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0943
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0384 1
Leishmania major ubiquitin activating E1 enzyme, putative 0.0057 0.0291 0.0815
Loa Loa (eye worm) hypothetical protein 0.0211 0.1291 0.129
Trypanosoma cruzi NEDD8-activating enzyme E1 regulatory subunit, putative 0.0097 0.0554 0.1797
Loa Loa (eye worm) hypothetical protein 0.0034 0.0143 0.0142
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0166 0.0998 0.1282
Trypanosoma cruzi molybdopterin synthase sulphurylase-like protein, putative 0.0057 0.0291 0.0943
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0068 0.0366 0.0284
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0384 0.0383
Schistosoma mansoni jumonji domain containing protein 0.0069 0.037 0.0369
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0057 0.0291 0.0943
Plasmodium vivax ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0815
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0488 0.3084 0.421
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0101 0.0329
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0043 0.0042
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0068 0.0366 0.0395
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0085 0.0138
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0068 0.0366 0.1063
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.1126 0.7207 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0043 0.0042
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0107 0.0619 0.0618
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.015 0.015
Trypanosoma brucei E1-like ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0815
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0043 0.0042
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0043 0.0042
Mycobacterium leprae POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY 0.0057 0.0291 0.5
Plasmodium falciparum ubiquitin-activating enzyme E1 0.0201 0.1227 0.3895
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0384 0.0383
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0085 0.0084
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0043 0.0042
Brugia malayi MoeZ/MoeB domain containing protein 0.0057 0.0291 0.029
Loa Loa (eye worm) ubiquitin-activating enzyme 5 0.0057 0.0291 0.029
Plasmodium vivax ubiquitin activating enzyme, putative 0.0107 0.0619 0.1895
Echinococcus multilocularis NEDD8 activating enzyme E1 regulatory subunit 0.0097 0.0554 0.0553
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0128 0.0754 0.2444
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0143 0.0327
Schistosoma mansoni ran 0.0025 0.0085 0.0084
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0043 0.0042
Toxoplasma gondii hypothetical protein 0.0107 0.0619 0.0579
Leishmania major NAD/FAD dependent dehydrogenase, putative 0.0057 0.0291 0.0815
Trypanosoma brucei Ubiquitin-like modifier-activating enzyme ATG7, putative 0.0057 0.0291 0.0815
Loa Loa (eye worm) hypothetical protein 0.0097 0.0554 0.0553
Entamoeba histolytica autophagy protein apg7, putative 0.0057 0.0291 0.0208
Leishmania major ubiquitin-activating enzyme e1, putative 0.0128 0.0754 0.2337
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.0488 0.3084 1
Trichomonas vaginalis autophagy protein, putative 0.0057 0.0291 0.0289
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0142 0.0141
Entamoeba histolytica molybdenum cofactor synthesis protein3, putative 0.0057 0.0291 0.0208
Entamoeba histolytica hypothetical protein 0.0027 0.0101 0.0016
Trypanosoma cruzi E1-like ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0943
Echinococcus multilocularis ubiquitin modifier activating enzyme 6 0.0201 0.1227 0.1227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.037 0.0369
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0057 0.0291 0.0943
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0057 0.0291 0.0943
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0171 0.1029 0.1028
Trypanosoma brucei NEDD8-activating enzyme E1 regulatory subunit, putative 0.0097 0.0554 0.1681
Loa Loa (eye worm) hypothetical protein 0.0057 0.0291 0.029
Loa Loa (eye worm) hypothetical protein 0.0057 0.0291 0.029
Leishmania major GTP-binding protein, putative 0.0025 0.0085 0.0138
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0094 0.0535 0.0632
Plasmodium falciparum ubiquitin-activating enzyme 0.0068 0.0366 0.1063
Schistosoma mansoni ubiquitin-activating enzyme E1-related 0.0057 0.0291 0.029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.015 0.015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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