Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.1445 | 0.1264 | 1 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.1445 | 0.1264 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.331 | 0.3831 | 0.3831 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.1445 | 0.1264 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.331 | 0.3831 | 0.3831 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.1445 | 0.1264 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.331 | 0.3831 | 1 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.1445 | 0.1264 | 0.1264 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.7793 | 1 | 1 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.7793 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.331 | 0.3831 | 0.3831 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.7793 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0527 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0527 | 0 | 0.5 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.1445 | 0.1264 | 0.1264 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.1445 | 0.1264 | 1 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.7793 | 1 | 1 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.1445 | 0.1264 | 0.5 |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.1445 | 0.1264 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0527 | 0 | 0.5 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.1445 | 0.1264 | 0.5 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.1445 | 0.1264 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.331 | 0.3831 | 0.3831 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0527 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.331 | 0.3831 | 0.3831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 65 nM | Displacement of [3H]citalopram from SERT in rat brain | ChEMBL. | 19896846 |
Ki (binding) | = 172 nM | Displacement of [3H]WIN-35428 from DAT in rat brain | ChEMBL. | 19896846 |
Ki (binding) | = 1718 nM | Displacement of [3H]nisoxetine from NET in rat brain | ChEMBL. | 19896846 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.