Detailed information for compound 182759

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.435 | Formula: C22H24N2O8
  • H donors: 6 H acceptors: 8 LogP: 0.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN([C@@H]1C(=O)C(=C([C@@]2([C@H]1[C@@H](O)C1[C@@H](C)c3cccc(c3C(=O)C1=C2O)O)O)O)C(=O)N)C
  • InChi: 1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27,29-30,32H,1-3H3,(H2,23,31)/t7-,10?,14+,15-,17-,22-/m0/s1
  • InChiKey: YDUGFTMNXJLIFF-WWVHYTOUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0145 0.0405 0.0415
Loa Loa (eye worm) hypothetical protein 0.1647 0.5662 0.5988
Schistosoma mansoni thyroid hormone receptor 0.0038 0.003 0.0018
Brugia malayi nuclear hormone receptor 0.0038 0.003 0.0032
Trypanosoma brucei poly(adp-ribose) polymerase 0.008 0.0176 0.0186
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.1647 0.5662 0.5988
Schistosoma mansoni poly [ADP-ribose] polymerase 0.008 0.0176 0.0164
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0232 0.0708 0.0735
Trichomonas vaginalis CAMK family protein kinase 0.1091 0.3716 0.3909
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.003 0.0032
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1647 0.5662 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.003 0.0032
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0052 0.008 0.0071
Echinococcus granulosus WGR domain containing protein 0.0045 0.0055 0.0026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.008 0.0176 0.0186
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 0.0717
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Echinococcus granulosus roundabout 2 0.0077 0.0167 0.0145
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0039 0.0032 0.0056
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.003 0.0032
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5988
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 0.0748
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0089
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0232 0.0708 0.0719
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.008 0.0176 0.0186
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Trypanosoma cruzi polo-like protein kinase, putative 0.273 0.9454 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.003 0.0032
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.003 0.0032
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.003 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Loa Loa (eye worm) hypothetical protein 0.0422 0.1373 0.1452
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Onchocerca volvulus Serine\/threonine kinase homolog 0.273 0.9454 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.003 0.0032
Echinococcus granulosus Immunoglobulin 0.0052 0.008 0.0053
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Entamoeba histolytica serine/threonine protein kinase, putative 0.273 0.9454 1
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.008 0.0176 0.0172
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.003 0.0032
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0475 0.156 0.1638
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0053 0.0084 0.0089
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.003 0.0032
Echinococcus granulosus serine:threonine protein kinase PLK1 0.273 0.9454 1
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0032 0.0056
Trypanosoma cruzi polo-like protein kinase, putative 0.273 0.9454 1
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5988
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0053 0.0084 0.0071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0129 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.008 0.0085
Brugia malayi Cytochrome P450 family protein 0.0062 0.0115 0.0121
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Brugia malayi hypothetical protein 0.0052 0.008 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0017 0.0018
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0232 0.0708 0.12
Echinococcus multilocularis Immunoglobulin 0.0052 0.008 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0708 0.0717
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Echinococcus granulosus synaptic glycoprotein sc2 0.0232 0.0708 0.0719
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0035 0.0021 0.0022
Schistosoma mansoni nuclear hormone receptor 0.0038 0.003 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.003 0.0018
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0053 0.0084 0.0071
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.008 0.0176 0.0186
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.003 0.0018
Echinococcus multilocularis roundabout 2 0.0077 0.0167 0.0163
Entamoeba histolytica hypothetical protein 0.0232 0.0708 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.1091 0.3716 0.3909
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.273 0.9454 1
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.1647 0.5662 0.5988
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0039 0.0032 0.5
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Echinococcus granulosus neuroglian 0.0063 0.0118 0.0093
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0053 0.0084 0.0089
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0475 0.156 0.165
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0572 0.19 0.2009
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0053 0.0084 0.0089
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Plasmodium falciparum polyprenol reductase, putative 0.0232 0.0708 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0167 0.0177
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.1247 0.4261 0.4499
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0232 0.0708 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.003 0.0032
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0032 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0708 0.0717
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.003 0.0018
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5975
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.003 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Brugia malayi Fibronectin type III domain containing protein 0.0052 0.008 0.0085
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0053 0.0084 0.0089
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0053 0.0084 0.0089
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0232 0.0708 0.0717
Mycobacterium ulcerans hypothetical protein 0.1647 0.5662 1
Plasmodium vivax polyprenol reductase, putative 0.0232 0.0708 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0232 0.0708 0.12
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.003 0.0032
Trypanosoma brucei polo-like protein kinase 0.273 0.9454 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus multilocularis synaptic glycoprotein sc2 0.0232 0.0708 0.0735
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Giardia lamblia Kinase, PLK 0.273 0.9454 1
Echinococcus granulosus twitchin 0.0074 0.0155 0.0133
Loa Loa (eye worm) hypothetical protein 0.046 0.1508 0.1595
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.273 0.9454 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0073 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.003 0.0032
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0057 0.0097 0.0103
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus granulosus defective proboscis extension response 0.0052 0.008 0.0053
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0032 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0038 0.003 0.0018
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0232 0.0708 0.0696
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi ecdysteroid receptor 0.0038 0.003 0.0032
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0151 0.0425 0.0699
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0053 0.0084 0.0075
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0475 0.156 0.1623
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.003 0.0018
Schistosoma mansoni coup transcription factor 0.0038 0.003 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.003 0.0018
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Onchocerca volvulus 0.0232 0.0708 0.0719
Echinococcus multilocularis Immunoglobulin 0.0052 0.008 0.0071
Brugia malayi WGR domain containing protein 0.008 0.0176 0.0186
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.003 0.0032
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi WGR domain containing protein 0.0145 0.0405 0.0429
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0053 0.0084 0.0089
Loa Loa (eye worm) hypothetical protein 0.0232 0.0708 0.0748
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.003 0.0032
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0039 0.0032 0.5
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0052 0.008 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.003 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.003 0.0018
Echinococcus granulosus poly adp ribose polymerase 2 0.008 0.0176 0.0155
Brugia malayi serine/threonine-protein kinase plk-2 0.273 0.9454 1
Echinococcus granulosus poly ADP ribose polymerase 1 0.0145 0.0405 0.0398
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 1
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.003 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0073 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0084 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.003 0.0032
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0232 0.0708 0.0334
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.003 0.0032
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.1247 0.4261 0.4489
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.003 0.0032
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 1
Brugia malayi Synaptic glycoprotein SC2 0.0232 0.0708 0.0748
Schistosoma mansoni vesicular amine transporter 0.0052 0.008 0.0067
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0145 0.0405 0.0393
Schistosoma mansoni cell adhesion molecule 0.0066 0.0129 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0077
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.273 0.9454 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.003 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0073 0.0077
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5975
Onchocerca volvulus 0.0498 0.1638 0.1706
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0052 0.008 0.0067
Brugia malayi Immunoglobulin I-set domain containing protein 0.0572 0.19 0.2009
Schistosoma mansoni amine GPCR 0.0175 0.0508 0.0496
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0069 0.0138 0.0126
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.003 0.0032
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.003 0.0032
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0232 0.0708 0.0717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.003 0.0032
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0232 0.0708 0.0696
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0077 0.0167 0.0177
Brugia malayi steroid hormone receptor 0.0038 0.003 0.0032
Schistosoma mansoni nephrin 0.0063 0.0118 0.0106
Loa Loa (eye worm) hypothetical protein 0.0111 0.0284 0.03
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.003 0.0018
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.003 0.0018
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) hypothetical protein 0.0232 0.0708 0.0748
Onchocerca volvulus Tyrosine kinase homolog 0.0517 0.1706 0.1778
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0053 0.0084 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.003 0.0032
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5975
Entamoeba histolytica steroid 5-alpha reductase, putative 0.1647 0.5662 0.5809
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0005
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.003 0.0032
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.1647 0.5662 0.5988
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.273 0.9454 0.9454
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0066 0.0129 0.0105
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0232 0.0708 0.0717
Echinococcus multilocularis neuroglian 0.0063 0.0118 0.0111
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi nuclear receptor NHR-88 0.0038 0.003 0.0032
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 0.0748
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus granulosus poly (ADP ribose) polymerase 0.0045 0.0055 0.0026
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.003 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0115 0.0121
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.12 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus smith cell lines ChEMBL. 7932547
MIC (functional) = 0.12 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 90-3 sensitive cell lines ChEMBL. 7932547
MIC (functional) = 1 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-5 sensitive cell lines ChEMBL. 7932547
MIC (functional) = 1 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-5 sensitive cell lines ChEMBL. 7932547
MIC (functional) = 8 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 88-7 tet-k(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 8 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 90-1 tet-M(ribosomal protection) cell lines ChEMBL. 7932547
MIC (functional) = 16 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli PRP-1 tet-a(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 16 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-C(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 16 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli PRP-1 tet-a(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 16 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-C(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 32 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 88-1 tet-B(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) > 32 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-D(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) > 32 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-4 tet-M(ribosomal protection) cell lines ChEMBL. 7932547
MIC (functional) = 32 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 88-1 tet-B(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) > 32 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-D(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) > 32 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-4 tet-M(ribosomal protection) cell lines ChEMBL. 7932547

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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