Detailed information for compound 183268

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.521 | Formula: C24H31N3O4
  • H donors: 4 H acceptors: 4 LogP: 3.29 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC[C@@H]([C@H](C(=O)N[C@H](C(=O)c1cc[nH]c1)Cc1ccccc1)CC(C)C)C(=O)NO
  • InChi: 1S/C24H31N3O4/c1-4-8-19(24(30)27-31)20(13-16(2)3)23(29)26-21(14-17-9-6-5-7-10-17)22(28)18-11-12-25-15-18/h4-7,9-12,15-16,19-21,25,31H,1,8,13-14H2,2-3H3,(H,26,29)(H,27,30)/t19-,20+,21-/m0/s1
  • InChiKey: LXWSFODDORIHFJ-HBMCJLEFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 7 (matrilysin, uterine) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 7 (matrilysin, uterine) 267 aa 234 aa 41.0 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0219 0.2224 0.3824
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.3481 0.5921
Trypanosoma cruzi protein kinase, putative 0.0219 0.2224 0.5
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Onchocerca volvulus 0.054 0.5815 1
Onchocerca volvulus 0.0219 0.2224 0.3697
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0219 0.2224 0.3799
Echinococcus multilocularis tyrosine protein kinase HCK 0.0219 0.2224 0.2205
Echinococcus multilocularis signal transduction protein lnk realted 0.0321 0.3369 0.3353
Brugia malayi Immunoglobulin I-set domain containing protein 0.0219 0.2224 0.3726
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Trypanosoma brucei Pseudokinase, putative 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Matrixin family protein 0.0213 0.2161 0.3615
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2224 0.5
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0219 0.2224 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0219 0.2224 0.5
Brugia malayi Tensin 0.0321 0.3369 0.5726
Onchocerca volvulus Matrilysin homolog 0.0109 0.0993 0.1537
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0219 0.2224 0.3824
Brugia malayi Guanylyl cyclase protein 23 0.0219 0.2224 0.3726
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0219 0.2224 0.3799
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0219 0.2224 0.2205
Echinococcus multilocularis tyrosine protein kinase Abl 0.054 0.5815 0.5805
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Brugia malayi Hemopexin family protein 0.0104 0.0945 0.1491
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0061 0.0065
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0219 0.2224 0.3799
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.054 0.5815 0.5805
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0219 0.2224 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.054 0.5815 1
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Brugia malayi STAT protein, DNA binding domain containing protein 0.0321 0.3369 0.5726
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0219 0.2224 0.3799
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Schistosoma mansoni ephrin receptor 0.0219 0.2224 0.3799
Trypanosoma brucei protein kinase, putative 0.0219 0.2224 0.5
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Brugia malayi protein-tyrosine kinase 0.054 0.5815 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0219 0.2224 0.3726
Onchocerca volvulus 0.0219 0.2224 0.3697
Loa Loa (eye worm) STAT protein 0.0321 0.3369 0.5793
Schistosoma mansoni bromodomain containing protein 0.0071 0.0575 0.0951
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0219 0.2224 0.3799
Echinococcus granulosus tyrosine protein kinase Srms 0.054 0.5815 1
Echinococcus granulosus tyrosine protein kinase csk 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni nck2/grb4 0.0321 0.3369 0.5775
Echinococcus granulosus suppressor of cytokine signaling 7 0.0321 0.3369 0.5775
Schistosoma mansoni growth factor receptor-bound protein 0.0321 0.3369 0.5775
Echinococcus multilocularis tyrosine protein kinase pr2 0.0219 0.2224 0.2205
Onchocerca volvulus 0.0219 0.2224 0.3697
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0219 0.2224 0.3697
Echinococcus multilocularis natriuretic peptide receptor 1 0.0219 0.2224 0.2205
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Loa Loa (eye worm) TK/INSR protein kinase 0.0219 0.2224 0.3824
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.054 0.5815 0.5805
Echinococcus multilocularis tyrosine protein kinase Blk 0.054 0.5815 0.5805
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0109 0.0993 0.1673
Toxoplasma gondii protein kinase domain-containing protein 0.0219 0.2224 0.5
Toxoplasma gondii protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.054 0.5815 0.5805
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Echinococcus granulosus lamin dm0 0.003 0.0117 0.0161
Brugia malayi hypothetical protein 0.0219 0.2224 0.3726
Onchocerca volvulus 0.0321 0.3369 0.5706
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni tensin 0.0321 0.3369 0.5775
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0219 0.2224 0.2205
Toxoplasma gondii STE kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Loa Loa (eye worm) matrixin family protein 0.0241 0.2474 0.4254
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0219 0.2224 0.3824
Schistosoma mansoni hypothetical protein 0.0023 0.0037 0.0023
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0219 0.2224 0.2205
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0219 0.2224 0.5
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus integrin linked protein kinase 0.0219 0.2224 0.3799
Brugia malayi RhoGAP domain containing protein 0.0321 0.3369 0.5726
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.053 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2224 0.5
Echinococcus multilocularis receptor type guanylyl cyclase 0.0219 0.2224 0.2205
Giardia lamblia Kinase, NEK 0.0219 0.2224 0.5
Echinococcus multilocularis integrin linked protein kinase 0.0219 0.2224 0.2205
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Echinococcus granulosus tyrosine protein kinase csk 0.0219 0.2224 0.3799
Echinococcus multilocularis tyrosine protein kinase Srms 0.054 0.5815 0.5805
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0321 0.3369 0.5706
Leishmania major protein kinase, putative 0.0219 0.2224 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.054 0.5815 1
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Schistosoma mansoni signal transduction protein lnk-related 0.0321 0.3369 0.5775
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.3481 0.5985
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Brugia malayi Protein kinase domain containing protein 0.054 0.5815 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0219 0.2224 0.3799
Brugia malayi Variant SH3 domain containing protein 0.0321 0.3369 0.5726
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.023 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Onchocerca volvulus Matrilysin homolog 0.0241 0.2474 0.4135
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Schistosoma mansoni GTPase activating protein 0.0321 0.3369 0.5775
Brugia malayi Raf kinase 0.0219 0.2224 0.3726
Onchocerca volvulus 0.054 0.5815 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Echinococcus multilocularis protein tyrosine kinase 0.0219 0.2224 0.2205
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0219 0.2224 0.3799
Loa Loa (eye worm) RGC/RGC protein kinase 0.0219 0.2224 0.3824
Echinococcus multilocularis SH2 domain containing protein 7 0.0321 0.3369 0.3353
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.054 0.5815 0.5805
Echinococcus granulosus activated cdc42 kinase 1 0.0219 0.2224 0.3799
Echinococcus multilocularis neuropeptide receptor A26 0.0522 0.5607 0.5596
Brugia malayi Protein kinase domain containing protein 0.054 0.5815 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0321 0.3369 0.5793
Brugia malayi Bromodomain containing protein 0.0085 0.0723 0.1103
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Echinococcus granulosus tyrosine protein kinase Blk 0.054 0.5815 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0219 0.2224 0.3824
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0219 0.2224 0.3726
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Schistosoma mansoni lamin 0.003 0.0117 0.0161
Brugia malayi SH2 domain containing protein 0.0321 0.3369 0.5726
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0219 0.2224 0.3726
Brugia malayi Tyrosine-protein kinase abl-1 0.054 0.5815 1
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0219 0.2224 0.2205
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0331 0.3481 0.3465
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0395 0.4196 0.4182
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus SH2 motif 0.0321 0.3369 0.5775
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0219 0.2224 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.054 0.5815 0.5805
Echinococcus multilocularis tensin 0.0321 0.3369 0.3353
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Plasmodium falciparum protein kinase, putative 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0291 0.05
Loa Loa (eye worm) intermediate filament protein 0.003 0.0117 0.0202
Echinococcus granulosus hypothetical protein 0.0321 0.3369 0.5775
Brugia malayi tRNA modification GTPase TrmE family protein 0.0321 0.3369 0.5726
Echinococcus granulosus tensin 0.0321 0.3369 0.5775
Loa Loa (eye worm) TK/FER protein kinase 0.0219 0.2224 0.3824
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0321 0.3369 0.5793
Loa Loa (eye worm) TK/Met protein kinase 0.0219 0.2224 0.3824
Echinococcus multilocularis tyrosine protein kinase Fgr 0.054 0.5815 0.5805
Schistosoma mansoni tyrosine kinase 0.054 0.5815 1
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0219 0.2224 0.3799
Echinococcus multilocularis tyrosine protein kinase Fyn 0.054 0.5815 0.5805
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Echinococcus granulosus insulin receptor 0.0219 0.2224 0.3799
Onchocerca volvulus 0.0321 0.3369 0.5706
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2224 0.3799
Echinococcus granulosus suppressor of cytokine signaling 6 0.0321 0.3369 0.5775
Schistosoma mansoni tyrosine kinase 0.054 0.5815 1
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.0993 0.1708
Schistosoma mansoni hypothetical protein 0.0104 0.0945 0.159
Echinococcus multilocularis FL cytokine receptor 0.0219 0.2224 0.2205
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Onchocerca volvulus Matrix metalloproteinase homolog 0.0241 0.2474 0.4135
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Furin-like cysteine rich region family protein 0.0219 0.2224 0.3726
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Onchocerca volvulus 0.0219 0.2224 0.3697
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2224 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Trichomonas vaginalis protein tyrosine kinase, putative 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus tyrosine kinase 0.054 0.5815 1
Schistosoma mansoni survival motor neuron protein 0.0054 0.0385 0.0624
Plasmodium falciparum protein kinase, putative 0.0219 0.2224 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0219 0.2224 0.3824
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.2758 0.2741
Loa Loa (eye worm) TK/EGFR protein kinase 0.0219 0.2224 0.3824
Loa Loa (eye worm) TK/FER protein kinase 0.0219 0.2224 0.3824
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Loa Loa (eye worm) hypothetical protein 0.008 0.0669 0.115
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.1258 0.2163
Loa Loa (eye worm) TK/EPH protein kinase 0.0219 0.2224 0.3824
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0321 0.3369 0.3353
Brugia malayi Variant SH3 domain containing protein 0.0321 0.3369 0.5726
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Onchocerca volvulus 0.054 0.5815 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0219 0.2224 0.5
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0219 0.2224 0.3799
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0219 0.2224 0.3824
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0321 0.3369 0.3353
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Onchocerca volvulus 0.0219 0.2224 0.3697
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Mycobacterium leprae PROBABLE HYDROLASE 0.0132 0.1258 0.5
Brugia malayi SH2 domain containing protein 0.0321 0.3369 0.5726
Entamoeba histolytica SH2 domain containing protein 0.0321 0.3369 0.3188
Echinococcus granulosus fibroblast growth factor receptor 4 0.0219 0.2224 0.3799
Brugia malayi bone morphogenetic protein type 1 receptor 0.0219 0.2224 0.3726
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Echinococcus granulosus tyrosine protein kinase Lyn 0.054 0.5815 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0219 0.2224 0.3799
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0321 0.3369 0.5793
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni serine/threonine RGC 0.0219 0.2224 0.3799
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.054 0.5815 1
Loa Loa (eye worm) TK/FER protein kinase 0.0219 0.2224 0.3824
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Protein kinase domain containing protein 0.054 0.5815 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0219 0.2224 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0331 0.3481 0.3465
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0395 0.4196 0.7215
Echinococcus multilocularis tyrosine kinase 0.054 0.5815 0.5805
Schistosoma mansoni hypothetical protein 0.0321 0.3369 0.5775
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Plasmodium vivax tyrosine kinase-like protein, putative 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi cytokine inducible SH2-containing protein 5 0.0321 0.3369 0.5726
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Mycobacterium ulcerans hydrolase 0.0132 0.1258 0.5
Brugia malayi SH2 domain containing protein 0.0321 0.3369 0.5726
Echinococcus granulosus NCK adaptor protein 0.0321 0.3369 0.5775
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Brugia malayi C-terminal src kinase protein 1 0.0219 0.2224 0.3726
Loa Loa (eye worm) SRC-1 0.054 0.5815 1
Echinococcus multilocularis N chimaerin 0.0321 0.3369 0.3353
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus neuropeptide s receptor 0.0522 0.5607 0.964
Echinococcus granulosus SH2 domain containing protein 7 0.0321 0.3369 0.5775
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0346 0.3641 0.6246
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Schistosoma mansoni hypothetical protein 0.0219 0.2224 0.3799
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Brugia malayi Matrixin family protein 0.0109 0.0993 0.1575
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0321 0.3369 0.3188
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.054 0.5815 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0219 0.2224 0.3726
Schistosoma mansoni shc transforming protein 0.0321 0.3369 0.5775
Schistosoma mansoni growth factor receptor-bound protein 0.0321 0.3369 0.5775
Echinococcus multilocularis c src tyrosine kinase 0.054 0.5815 0.5805
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0219 0.2224 0.3799
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0219 0.2224 0.3799
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Trichomonas vaginalis AGC family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0321 0.3369 0.3353
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0331 0.3481 0.5969
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0219 0.2224 0.2205
Loa Loa (eye worm) TK/FER protein kinase 0.0219 0.2224 0.3824
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2224 0.3799
Echinococcus multilocularis 0.0321 0.3369 0.3353
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0219 0.2224 0.5
Echinococcus granulosus lamin 0.003 0.0117 0.0161
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0385 0.0514
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Brugia malayi Matrixin family protein 0.0109 0.0993 0.1575
Schistosoma mansoni tensin-related 0.0321 0.3369 0.5775
Schistosoma mansoni hypothetical protein 0.0054 0.0385 0.0624
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi ephrin receptor 1 precursor 0.0219 0.2224 0.3726
Echinococcus multilocularis raf serine:threonine protein kinase 0.0219 0.2224 0.2205
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Echinococcus granulosus tyrosine protein kinase Fyn 0.054 0.5815 1
Echinococcus multilocularis NCK adaptor protein 0.0321 0.3369 0.3353
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0061 0.0065
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0321 0.3369 0.3353
Echinococcus multilocularis tyrosine protein kinase Fyn 0.054 0.5815 0.5805
Brugia malayi SH2 domain containing protein 0.054 0.5815 1
Echinococcus multilocularis SH2 motif 0.0321 0.3369 0.3353
Loa Loa (eye worm) TK/DDR protein kinase 0.0219 0.2224 0.3824
Onchocerca volvulus 0.054 0.5815 1
Loa Loa (eye worm) TK protein kinase 0.054 0.5815 1
Schistosoma mansoni tyrosine kinase 0.054 0.5815 1
Echinococcus multilocularis tensin 0.0321 0.3369 0.3353
Echinococcus multilocularis SHC transforming protein 3 0.0321 0.3369 0.3353
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TK family protein kinase 0.0219 0.2224 0.5
Brugia malayi Tyrosine-protein kinase PR2 0.0219 0.2224 0.3726
Echinococcus granulosus tyrosine protein kinase Fyn 0.054 0.5815 1
Echinococcus granulosus tyrosine kinase 0.0219 0.2224 0.3799
Schistosoma mansoni tensin 0.0321 0.3369 0.5775
Plasmodium falciparum tyrosine kinase-like protein 0.0219 0.2224 0.5
Brugia malayi Protein kinase domain containing protein 0.054 0.5815 1
Onchocerca volvulus 0.0321 0.3369 0.5706
Brugia malayi Sex muscle abnormal protein 5 0.0321 0.3369 0.5726
Giardia lamblia Protein 21.1 0.0219 0.2224 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0321 0.3369 0.5775
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0522 0.5607 0.964
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0321 0.3369 0.5775
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0321 0.3369 0.5793
Echinococcus granulosus tyrosine kinase 0.054 0.5815 1
Brugia malayi SH2 domain containing protein 0.0321 0.3369 0.5726
Brugia malayi hypothetical protein 0.0219 0.2224 0.3726
Schistosoma mansoni SH2A 0.0321 0.3369 0.5775
Onchocerca volvulus 0.0104 0.0945 0.1453
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi SH2 domain containing protein 0.0321 0.3369 0.5726
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0219 0.2224 0.3726
Schistosoma mansoni ephrin receptor 0.0219 0.2224 0.3799
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) protein kinase domain-containing protein 0.0219 0.2224 0.3824
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Onchocerca volvulus 0.0321 0.3369 0.5706
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Loa Loa (eye worm) TK/CSK protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus tyrosine protein kinase Fps85D 0.054 0.5815 1
Schistosoma mansoni intermediate filament proteins 0.003 0.0117 0.0161
Echinococcus granulosus tyrosine protein kinase pr2 0.0219 0.2224 0.3799
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.023 0.0207
Echinococcus granulosus epidermal growth factor receptor 0.0219 0.2224 0.3799
Echinococcus multilocularis activated cdc42 kinase 1 0.0219 0.2224 0.2205
Echinococcus multilocularis tyrosine protein kinase csk 0.0219 0.2224 0.2205
Onchocerca volvulus 0.0219 0.2224 0.3697
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus c src tyrosine kinase 0.054 0.5815 1
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Onchocerca volvulus 0.0321 0.3369 0.5706
Brugia malayi Matrixin family protein 0.0109 0.0993 0.1575
Schistosoma mansoni vav2 0.0321 0.3369 0.5775
Loa Loa (eye worm) TK/ALK protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.2758 0.4721
Echinococcus multilocularis tyrosine protein kinase ABL1 0.054 0.5815 0.5805
Loa Loa (eye worm) hypothetical protein 0.0267 0.2758 0.4743
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0321 0.3369 0.3353
Onchocerca volvulus 0.0321 0.3369 0.5706
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0219 0.2224 0.2205
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0395 0.4196 0.7203
Echinococcus multilocularis tyrosine protein kinase Src64B 0.054 0.5815 0.5805
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.054 0.5815 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0219 0.2224 0.2205
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0061 0.0037
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni protein tyrosine kinase 0.0219 0.2224 0.3799
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Echinococcus granulosus tyrosine protein kinase Btk29A 0.054 0.5815 1
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi SH2 domain containing protein 0.0321 0.3369 0.5726
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0321 0.3369 0.5706
Loa Loa (eye worm) SH2 domain-containing protein 0.0321 0.3369 0.5793
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0321 0.3369 0.3353
Onchocerca volvulus 0.0219 0.2224 0.3697
Echinococcus multilocularis tyrosine protein kinase csk 0.0219 0.2224 0.2205
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0219 0.2224 0.3824
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Entamoeba histolytica protein kinase, putative 0.0321 0.3369 0.3188
Echinococcus multilocularis lamin 0.003 0.0117 0.0093
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0321 0.3369 0.5775
Brugia malayi hypothetical protein 0.0321 0.3369 0.5726
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0219 0.2224 0.2205
Echinococcus multilocularis transfer RNA-Thr 0.0219 0.2224 0.2205
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Onchocerca volvulus 0.0219 0.2224 0.3697
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0219 0.2224 0.3799
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0219 0.2224 0.3697
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0321 0.3369 0.5793
Echinococcus granulosus tyrosine protein kinase shark 0.054 0.5815 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0219 0.2224 0.3799
Trichomonas vaginalis protein kinase atn1, putative 0.0219 0.2224 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0395 0.4196 0.717
Loa Loa (eye worm) TK/FAK protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus expressed conserved protein 0.0321 0.3369 0.5775
Leishmania major hypothetical protein, conserved 0.0219 0.2224 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0219 0.2224 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0219 0.2224 0.3799
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0321 0.3369 0.5775
Schistosoma mansoni lamin 0.003 0.0117 0.0161
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0219 0.2224 0.2205
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0132 0.1258 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Echinococcus granulosus signal transduction protein lnk realted 0.0321 0.3369 0.5775
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Echinococcus multilocularis tyrosine kinase 0.0219 0.2224 0.2205
Echinococcus granulosus receptor type guanylyl cyclase 0.0219 0.2224 0.3799
Schistosoma mansoni tensin 0.0321 0.3369 0.5775
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0449
Brugia malayi Variant SH3 domain containing protein 0.0321 0.3369 0.5726
Loa Loa (eye worm) TK/FER protein kinase 0.0219 0.2224 0.3824
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0219 0.2224 0.3824
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0219 0.2224 0.2205
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0219 0.2224 0.2205
Echinococcus granulosus ephrin type A receptor 4 A 0.0219 0.2224 0.3799
Giardia lamblia Kinase 0.0219 0.2224 0.5
Echinococcus multilocularis insulin receptor 0.0219 0.2224 0.2205
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Loa Loa (eye worm) TK/FER protein kinase 0.0219 0.2224 0.3824
Brugia malayi Protein kinase domain containing protein 0.054 0.5815 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0219 0.2224 0.3799
Echinococcus multilocularis heat shock protein 70 0.0219 0.2224 0.2205
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0219 0.2224 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0219 0.2224 0.2205
Echinococcus multilocularis neuropeptide s receptor 0.0522 0.5607 0.5596
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Giardia lamblia Kinase, NEK 0.0219 0.2224 0.5
Brugia malayi SH2 domain containing protein 0.0321 0.3369 0.5726
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.054 0.5815 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0219 0.2224 0.2205
Echinococcus multilocularis protein kinase 0.0219 0.2224 0.2205
Schistosoma mansoni tyrosine protein kinase 0.0219 0.2224 0.3799
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Brugia malayi SRC-1 0.054 0.5815 1
Onchocerca volvulus 0.0219 0.2224 0.3697
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0219 0.2224 0.3799
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0331 0.3481 0.5969
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni tensin-related 0.0321 0.3369 0.5775
Leishmania major protein kinase, putative 0.0219 0.2224 0.5
Echinococcus multilocularis protein KINase family member (kin 25) 0.0219 0.2224 0.2205
Echinococcus granulosus SH2 domain containing adapter protein F 0.0321 0.3369 0.5775
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Loa Loa (eye worm) TK/FER protein kinase 0.054 0.5815 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0219 0.2224 0.3799
Schistosoma mansoni tyrosine kinase 0.054 0.5815 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.054 0.5815 0.5805
Echinococcus granulosus SHC transforming protein 3 0.0321 0.3369 0.5775
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0219 0.2224 0.3824
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0219 0.2224 0.2205
Echinococcus multilocularis SH2 motif 0.0321 0.3369 0.3353
Echinococcus multilocularis lamin dm0 0.003 0.0117 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2224 0.3799
Plasmodium vivax protein kinase, putative 0.0219 0.2224 0.5
Trypanosoma cruzi protein kinase, putative 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.0993 0.1708
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0219 0.2224 0.3799
Loa Loa (eye worm) SH2 domain-containing protein 0.0321 0.3369 0.5793
Echinococcus granulosus growth factor receptor bound protein 2 0.0321 0.3369 0.5775
Echinococcus granulosus protein tyrosine kinase 0.0219 0.2224 0.3799
Plasmodium falciparum tyrosine kinase-like protein 0.0219 0.2224 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0219 0.2224 0.3824
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus granulosus N chimaerin 0.0321 0.3369 0.5775
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.053 0.0873
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.054 0.5815 1
Schistosoma mansoni suppressor of cytokine signaling 0.0321 0.3369 0.5775
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Echinococcus granulosus tyrosine protein kinase ABL1 0.054 0.5815 1
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2224 0.5
Brugia malayi hypothetical protein 0.0267 0.2758 0.4659
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis SH2 motif 0.0321 0.3369 0.3353
Brugia malayi Bromodomain containing protein 0.0043 0.026 0.0295
Loa Loa (eye worm) TK/RYK protein kinase 0.0219 0.2224 0.3824
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Trichomonas vaginalis STE family protein kinase 0.0219 0.2224 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.054 0.5815 0.5805
Loa Loa (eye worm) SH2 domain-containing protein 0.0321 0.3369 0.5793
Schistosoma mansoni suppressor of cytokine signaling 0.0321 0.3369 0.5775
Plasmodium falciparum protein kinase, putative 0.0219 0.2224 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0117 0.0202
Echinococcus multilocularis epidermal growth factor receptor 0.0219 0.2224 0.2205
Schistosoma mansoni tyrosine kinase 0.054 0.5815 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0117 0.0045
Schistosoma mansoni hypothetical protein 0.0321 0.3369 0.5775
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0219 0.2224 0.2205
Echinococcus multilocularis tyrosine protein kinase 0.0219 0.2224 0.2205
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0346 0.3641 0.3626
Brugia malayi intermediate filament protein 0.003 0.0117 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0219 0.2224 0.3824
Brugia malayi integrin-linked kinase 0.0219 0.2224 0.3726
Echinococcus granulosus activated cdc42 kinase 1 0.0219 0.2224 0.3799
Echinococcus multilocularis protein kinase 0.0219 0.2224 0.2205
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Echinococcus granulosus raf serine:threonine protein kinase 0.0219 0.2224 0.3799
Echinococcus granulosus tyrosine protein kinase Fyn 0.054 0.5815 1
Echinococcus granulosus tyrosine protein kinase 0.0219 0.2224 0.3799
Onchocerca volvulus 0.0109 0.0993 0.1537
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0321 0.3369 0.5775
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Receptor family ligand binding region containing protein 0.0219 0.2224 0.3726
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0321 0.3369 0.3353
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Loa Loa (eye worm) RGC/RGC protein kinase 0.0219 0.2224 0.3824
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0219 0.2224 0.3824
Loa Loa (eye worm) matrix metalloproteinase 0.0109 0.0993 0.1708
Schistosoma mansoni adapter molecule crk 0.0321 0.3369 0.5775
Echinococcus granulosus kinase suppressor of Ras 1 0.0219 0.2224 0.3799
Echinococcus granulosus intermediate filament protein 0.003 0.0117 0.0161
Onchocerca volvulus 0.054 0.5815 1
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus retinal guanylyl cyclase 2 0.0219 0.2224 0.3799
Brugia malayi hypothetical protein 0.054 0.5815 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.054 0.5815 0.5805
Schistosoma mansoni protein kinase 0.0219 0.2224 0.3799
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0132 0.1258 0.2038
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0219 0.2224 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0321 0.3369 0.5775
Echinococcus multilocularis musashi 0.003 0.0117 0.0093
Brugia malayi Matrixin family protein 0.0109 0.0993 0.1575
Echinococcus granulosus SH2 motif 0.0321 0.3369 0.5775
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0219 0.2224 0.3726
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2224 0.5
Echinococcus granulosus natriuretic peptide receptor 1 0.0219 0.2224 0.3799
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0321 0.3369 0.3353
Echinococcus granulosus tyrosine protein kinase Src64B 0.054 0.5815 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0321 0.3369 0.5775
Echinococcus multilocularis tyrosine protein kinase csk 0.0219 0.2224 0.2205
Onchocerca volvulus 0.054 0.5815 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0395 0.4196 0.7203
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0219 0.2224 0.3824
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.0321 0.3369 0.5793
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0219 0.2224 0.3799
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0219 0.2224 0.3799
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0219 0.2224 0.2205
Schistosoma mansoni tyrosine kinase 0.054 0.5815 1
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2224 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0111 0.0191
Echinococcus granulosus protein kinase 0.0219 0.2224 0.3799
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0219 0.2224 0.2205
Echinococcus multilocularis activin receptor type 0.0219 0.2224 0.2205
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Protein kinase domain containing protein 0.0219 0.2224 0.3726
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Echinococcus granulosus retinal guanylyl cyclase 2 0.0219 0.2224 0.3799
Loa Loa (eye worm) TK protein kinase 0.0219 0.2224 0.3824
Loa Loa (eye worm) hypothetical protein 0.0109 0.0993 0.1708
Loa Loa (eye worm) TK/ABL protein kinase 0.054 0.5815 1
Echinococcus granulosus activin receptor type 0.0219 0.2224 0.3799
Onchocerca volvulus 0.0054 0.0385 0.047
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0331 0.3481 0.5969
Loa Loa (eye worm) matrixin family protein 0.0213 0.2161 0.3715
Onchocerca volvulus Tyrosine kinase homolog 0.0219 0.2224 0.3697
Loa Loa (eye worm) hypothetical protein 0.0048 0.0315 0.0542
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0219 0.2224 0.3799
Brugia malayi SH2 domain containing protein 0.054 0.5815 1
Brugia malayi Variant SH3 domain containing protein 0.0321 0.3369 0.5726
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.005 0.0336 0.0539
Echinococcus multilocularis tyrosine protein kinase Fyn 0.054 0.5815 0.5805
Echinococcus multilocularis ephrin type A receptor 4 A 0.0219 0.2224 0.2205
Trichomonas vaginalis TKL family protein kinase 0.0219 0.2224 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0219 0.2224 0.3726
Schistosoma mansoni tyrosine kinase 0.0219 0.2224 0.3799
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0321 0.3369 0.5775

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.7 nM In vitro inhibitory activity against matrix metalloproteinase 2 isolated from human HT-1080 fibrosarcoma cells induced with TNF ChEMBL. 9873712
IC50 (binding) = 2.7 nM In vitro inhibitory activity against matrix metalloproteinase 2 isolated from human HT-1080 fibrosarcoma cells induced with TNF ChEMBL. 9873712
IC50 (binding) = 6.2 nM In vitro inhibitory activity against matrix metalloproteinase 1 isolated from the culture medium of human skin fibroblasts induced with PMA ChEMBL. 9873712
IC50 (binding) = 6.2 nM In vitro inhibitory activity against matrix metalloproteinase 1 isolated from the culture medium of human skin fibroblasts induced with PMA ChEMBL. 9873712
IC50 (binding) = 6.6 nM In vitro inhibitory activity against human recombinant matrix metalloproteinase 3 ChEMBL. 9873712
IC50 (binding) = 6.6 nM In vitro inhibitory activity against human recombinant matrix metalloproteinase 3 ChEMBL. 9873712
IC50 (binding) = 8 nM In vitro inhibitory activity against human recombinant matrix metalloproteinase 7 ChEMBL. 9873712
IC50 (binding) = 8 nM In vitro inhibitory activity against human recombinant matrix metalloproteinase 7 ChEMBL. 9873712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.