Detailed information for compound 183980

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.876 | Formula: C20H24ClN3O2
  • H donors: 2 H acceptors: 1 LogP: 3.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(N)c(cc1C(=O)N[C@H]1CCCN(C1)Cc1ccccc1)Cl
  • InChi: 1S/C20H24ClN3O2/c1-26-19-11-18(22)17(21)10-16(19)20(25)23-15-8-5-9-24(13-15)12-14-6-3-2-4-7-14/h2-4,6-7,10-11,15H,5,8-9,12-13,22H2,1H3,(H,23,25)/t15-/m0/s1
  • InChiKey: NKNTXYMZEFEUNK-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Dopamine D1 receptor Starlite/ChEMBL References
Homo sapiens dopamine receptor D4 Starlite/ChEMBL References
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 371 aa 34.5 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 27.1 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 359 aa 21.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 393 aa 32.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 398 aa 33.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0121 0.0607 0.1108
Echinococcus granulosus histone deacetylase 3 0.0195 0.1086 0.198
Schistosoma mansoni zinc finger protein 0.0312 0.1838 0.3333
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0192 0.1062 0.1914
Brugia malayi nuclear hormone receptor family member nhr-6 0.009 0.0409 0.0746
Echinococcus granulosus ring and YY1 binding protein 0.0312 0.1838 0.3353
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0148 0.0779 0.142
Echinococcus multilocularis histone deacetylase 7 0.0151 0.0797 0.1455
Toxoplasma gondii histone deacetylase HDAC1 0.0151 0.0797 0.1362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0192 0.1062 0.1937
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0148 0.0779 0.142
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0062 0.0229 0.0418
Brugia malayi hypothetical protein 0.0051 0.0157 0.0286
Echinococcus multilocularis histone deacetylase 3 0.0195 0.1086 0.198
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0213 0.0388
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0312 0.1838 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Onchocerca volvulus 0.0233 0.133 0.2395
Echinococcus granulosus neuropeptide receptor A26 0.006 0.0213 0.0388
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0877 0.5482 1
Schistosoma mansoni hypothetical protein 0.0877 0.5482 1
Onchocerca volvulus 0.0286 0.1671 0.302
Trypanosoma cruzi histone deacetylase, putative 0.0078 0.0329 0.1168
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Brugia malayi Dopamine receptor protein 1 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 6 0.0151 0.0797 0.1455
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0192 0.1062 0.1914
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.013 0.0237
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0312 0.1838 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0312 0.1838 0.3353
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0229 0.0418
Brugia malayi nuclear hormone receptor 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0273 0.0499
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0192 0.1062 0.1914
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0779 0.142
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0229 0.0418
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0213 0.0388
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0877 0.5482 1
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0148 0.0779 0.142
Loa Loa (eye worm) glutathione reductase 0.0047 0.013 0.0237
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0148 0.0779 0.142
Brugia malayi neuropeptide F receptor 0.006 0.0213 0.0388
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0213 0.036
Echinococcus multilocularis SWI:SNF matrix associated 0.0877 0.5482 1
Loa Loa (eye worm) histone deacetylase 0.0151 0.0797 0.1455
Brugia malayi dihydrofolate reductase family protein 0.0044 0.011 0.02
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0192 0.1062 0.1937
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi putative neuropeptide receptor 0.006 0.0213 0.0388
Schistosoma mansoni histone deacetylase hda2 0.0151 0.0797 0.143
Onchocerca volvulus Histone deacetylase 10 homolog 0.0078 0.0329 0.0562
Brugia malayi chromobox protein homolog 3 0.0039 0.0077 0.014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0213 0.036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0192 0.1062 0.1937
Brugia malayi Thioredoxin reductase 0.0047 0.013 0.0237
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0148 0.0779 0.1395
Brugia malayi Nuclear hormone receptor E75 0.009 0.0409 0.0746
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Loa Loa (eye worm) nuclear receptor NHR-67 0.009 0.0409 0.0746
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Trypanosoma cruzi histone deacetylase, putative 0.0151 0.0797 0.3909
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0195 0.1086 0.1975
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0132 0.0212
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Brugia malayi nuclear receptor RXR 0.0101 0.0479 0.0874
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0213 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0312 0.1838 1
Schistosoma mansoni tyrosine kinase 0.0068 0.0265 0.0456
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0192 0.1062 0.1937
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Loa Loa (eye worm) nuclear receptor nhr-7B 0.009 0.0409 0.0746
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.009 0.0409 0.0746
Brugia malayi ORL1-like opioid receptor 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.1577 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.0213 0.0388
Toxoplasma gondii thioredoxin reductase 0.0047 0.013 0.0131
Onchocerca volvulus 0.006 0.0213 0.0348
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0096 0.0168
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Brugia malayi orphan nuclear receptor NR2E1 0.009 0.0409 0.0746
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0213 0.0388
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus granulosus histone deacetylase 0.0151 0.0797 0.1455
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus granulosus hypothetical protein 0.0466 0.2833 0.5168
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.009 0.0409 0.0719
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0779 0.1395
Echinococcus multilocularis zinc finger protein Ran binding 0.0312 0.1838 0.3353
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1447 0.264
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Giardia lamblia Histone deacetylase 0.0195 0.1086 0.5
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0233 0.133 0.2404
Brugia malayi histone deacetylase 3 (HD3) 0.0195 0.1086 0.198
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0101 0.0479 0.0874
Schistosoma mansoni biogenic amine receptor 0.006 0.0213 0.036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0108 0.0521 0.0416
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0148 0.0779 0.142
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.0779 0.142
Onchocerca volvulus 0.009 0.0409 0.0708
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni nuclear hormone receptor 0.009 0.0409 0.0719
Echinococcus multilocularis sex peptide receptor 0.006 0.0213 0.0388
Schistosoma mansoni nuclear receptor nhr-48 0.009 0.0409 0.0719
Echinococcus multilocularis insulin receptor 0.0041 0.009 0.0165
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.3953
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 7 0.0151 0.0797 0.1455
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0213 0.0348
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Echinococcus granulosus insulin receptor 0.0041 0.009 0.0165
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0062 0.0229 0.0418
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.006 0.0213 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Onchocerca volvulus 0.006 0.0213 0.0348
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0148 0.0779 0.142
Echinococcus multilocularis orexin receptor type 2 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis thymidylate synthase 0.0108 0.0521 0.0951
Brugia malayi hypothetical protein 0.0101 0.0479 0.0874
Trypanosoma cruzi histone deacetylase 1, putative 0.0195 0.1086 0.5596
Onchocerca volvulus 0.006 0.0213 0.0348
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0062 0.0229 0.0418
Schistosoma mansoni histone deacetylase hda2 0.0078 0.0329 0.0573
Brugia malayi SWIB/MDM2 domain containing protein 0.0877 0.5482 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus Zinc finger RanBP2 type 0.0312 0.1838 0.3353
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.0779 0.142
Echinococcus granulosus dihydrofolate reductase 0.0044 0.011 0.02
Plasmodium vivax histone deacetylase 1, putative 0.0195 0.1086 0.1894
Schistosoma mansoni hypothetical protein 0.0877 0.5482 1
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.0779 0.142
Brugia malayi Cytochrome P450 family protein 0.0066 0.0255 0.0465
Loa Loa (eye worm) DR-78 0.009 0.0409 0.0746
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0213 0.036
Echinococcus multilocularis histone deacetylase 0.0151 0.0797 0.1455
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0518 0.0413
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0877 0.5482 1
Leishmania major histone deacetylase, putative 0.0151 0.0797 0.3909
Loa Loa (eye worm) TK/INSR protein kinase 0.0041 0.009 0.0165
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus granulosus neuropeptide receptor 0.006 0.0213 0.0388
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0213 0.036
Echinococcus granulosus serotonin receptor 0.006 0.0213 0.0388
Schistosoma mansoni TRABID protein (C64 family) 0.0312 0.1838 0.3333
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.0409 0.0708
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0255 0.0465
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.0479 0.0847
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0213 0.0388
Mycobacterium ulcerans isocitrate lyase AceAb 0.1577 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0148 0.0779 0.142
Echinococcus multilocularis histone deacetylase 6 0.0151 0.0797 0.1455
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0073 0.0294 0.0537
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Brugia malayi Pre-SET motif family protein 0.0251 0.1447 0.264
Echinococcus multilocularis serotonin receptor 0.006 0.0213 0.0388
Echinococcus multilocularis histone deacetylase 6 0.0151 0.0797 0.1455
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0192 0.1062 0.1914
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0059 0.0107
Schistosoma mansoni dihydrofolate reductase 0.0044 0.011 0.0171
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0229 0.0418
Brugia malayi Furin-like cysteine rich region family protein 0.0128 0.0652 0.119
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0069 0.027 0.0493
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Brugia malayi GnHR receptor homolog 0.006 0.0213 0.0388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi YY1-associated factor 2 0.0312 0.1838 0.3353
Brugia malayi nuclear hormone receptor 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) brahma associated protein 0.0877 0.5482 1
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0213 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Onchocerca volvulus Bile acid receptor homolog 0.0192 0.1062 0.1904
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Schistosoma mansoni fusion 0.0312 0.1838 0.3333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0059 0.0078
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0213 0.0388
Brugia malayi brahma associated protein 60 kDa 0.0877 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0229 0.0418
Schistosoma mansoni histone deacetylase 4 5 0.0151 0.0797 0.143
Schistosoma mansoni nAChR subunit 0.0062 0.0229 0.039
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0157 0.0048
Echinococcus granulosus somatostatin receptor 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0108 0.0521 0.0925
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0101 0.0479 0.0847
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0213 0.036
Echinococcus multilocularis fmrfamide receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0192 0.1062 0.1937
Schistosoma mansoni hypothetical protein 0.0877 0.5482 1
Toxoplasma gondii histone deacetylase HDAC4 0.0078 0.0329 0.0499
Onchocerca volvulus 0.0312 0.1838 0.3325
Chlamydia trachomatis SWIB complex protein 0.0877 0.5482 1
Schistosoma mansoni histone deacetylase 0.0195 0.1086 0.1957
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0779 0.142
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0148 0.0779 0.142
Brugia malayi Histone deacetylase 1 0.0195 0.1086 0.198
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0375 0.0685
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0213 0.0388
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Toxoplasma gondii histone deacetylase HDAC2 0.0195 0.1086 0.1894
Echinococcus multilocularis epidermal growth factor receptor 0.0128 0.0652 0.119
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0213 0.0388
Schistosoma mansoni nuclear receptor 0.009 0.0409 0.0719
Schistosoma mansoni biogenic amine receptor 0.006 0.0213 0.036
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0085 0.0375 0.0658
Brugia malayi Serotonin receptor 0.0331 0.1959 0.3574
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.1577 1 1
Echinococcus granulosus histone deacetylase 6 0.0151 0.0797 0.1455
Toxoplasma gondii histone deacetylase HDAC5 0.0078 0.0329 0.0499
Schistosoma mansoni tyrosine kinase 0.0068 0.0265 0.0456
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0213 0.0388
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0134
Loa Loa (eye worm) histone deacetylase 3 0.0195 0.1086 0.198
Brugia malayi follicle stimulating hormone receptor 0.006 0.0213 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0134
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0101 0.0479 0.0874
Brugia malayi hypothetical protein 0.009 0.0409 0.0746
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Brugia malayi steroid hormone receptor 0.0192 0.1062 0.1937
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0192 0.1062 0.1904
Onchocerca volvulus 0.0148 0.0779 0.1385
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0062 0.0229 0.0418
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0192 0.1062 0.1937
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0312 0.1838 1
Echinococcus multilocularis histone deacetylase 8 0.0078 0.0329 0.0601
Schistosoma mansoni nuclear hormone receptor 0.0192 0.1062 0.1914
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.006 0.0213 0.0348
Schistosoma mansoni acetylcholine receptor-related 0.0062 0.0229 0.039
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.013 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0192 0.1062 0.1937
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Echinococcus granulosus SWI:SNF matrix associated 0.0877 0.5482 1
Brugia malayi G protein-coupled receptor 0.006 0.0213 0.0388
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Echinococcus multilocularis dihydrofolate reductase 0.0044 0.011 0.02
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis g protein coupled receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0312 0.1838 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.1577 1 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0779 0.1395
Schistosoma mansoni tyrosine kinase 0.0069 0.027 0.0465
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0229 0.0418
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0213 0.036
Brugia malayi nuclear receptor NHR-88 0.009 0.0409 0.0746
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0213 0.0388
Leishmania major histone deacetylase, putative 0.0151 0.0797 0.3909
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Echinococcus granulosus thyroid hormone receptor alpha 0.009 0.0409 0.0746
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) GABA receptor subunit 0.0085 0.0375 0.0685
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0213 0.0388
Toxoplasma gondii histone deacetylase HDAC3 0.0195 0.1086 0.1894
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0213 0.0388
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0195 0.1086 0.1975
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 1 0.0195 0.1086 0.198
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.013 0.0237
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Trypanosoma cruzi histone deacetylase, putative 0.0151 0.0797 0.3909
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0213 0.036
Plasmodium vivax histone deacetylase, putative 0.0151 0.0797 0.1362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0192 0.1062 0.1937
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0213 0.0348
Onchocerca volvulus 0.0192 0.1062 0.1904
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi nuclear receptor NHR-88 0.0192 0.1062 0.1937
Leishmania major histone deacetylase, putative 0.0195 0.1086 0.5596
Onchocerca volvulus 0.0148 0.0779 0.1385
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0213 0.036
Loa Loa (eye worm) LGC-31 protein 0.0148 0.0779 0.142
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Trypanosoma cruzi WLM domain containing protein, putative 0.0312 0.1838 1
Brugia malayi Steroid receptor seven-up type 2 0.0192 0.1062 0.1937
Schistosoma mansoni neurotransmitter gated ion channel 0.0085 0.0375 0.0658
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0312 0.1838 0.3192
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0195 0.1086 0.198
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0312 0.1838 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0148 0.0779 0.142
Brugia malayi Pre-SET motif family protein 0.0036 0.0059 0.0107
Trypanosoma cruzi WLM domain containing protein, putative 0.0312 0.1838 1
Chlamydia trachomatis DNA topoisomerase I 0.0877 0.5482 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0877 0.5482 1
Echinococcus granulosus thymidylate synthase 0.0108 0.0521 0.0951
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0518 0.0413
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0312 0.1838 0.3281
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.0409 0.0708
Onchocerca volvulus 0.0062 0.0229 0.0379
Echinococcus multilocularis SWI:SNF matrix associated 0.0877 0.5482 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0059 0.0078
Schistosoma mansoni histone deacetylase 1 2 3 0.0078 0.0329 0.0573
Echinococcus multilocularis nuclear receptor nhr 48 0.009 0.0409 0.0746
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.0409 0.0746
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0213 0.0388
Schistosoma mansoni opsin-like receptor 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0192 0.1062 0.1937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0192 0.1062 0.1937
Brugia malayi nuclear receptor RXR 0.009 0.0409 0.0746
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0213 0.0388
Brugia malayi nuclear hormone receptor family member odr-7 0.009 0.0409 0.0746
Echinococcus granulosus g protein coupled receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni hypothetical protein 0.0051 0.0158 0.026
Echinococcus granulosus allatostatin A receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0192 0.1062 0.1937
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Onchocerca volvulus 0.006 0.0213 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0877 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0273 0.0492
Echinococcus multilocularis ecdysone induced protein 78C 0.0192 0.1062 0.1937
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0085 0.0375 0.0685
Plasmodium falciparum histone deacetylase 2 0.0151 0.0797 0.1248
Trypanosoma brucei histone deacetylase 4 0.0151 0.0797 0.3909
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0596 0.0491
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.0779 0.142
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Cation transporter family protein 0.0233 0.133 0.2426
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis nAChR subunit 0.0148 0.0779 0.142
Schistosoma mansoni tyrosine kinase 0.0069 0.027 0.0465
Trypanosoma brucei hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Schistosoma mansoni opsin-like receptor 0.006 0.0213 0.036
Schistosoma mansoni zinc finger protein 0.009 0.0409 0.0719
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0213 0.0388
Brugia malayi Histone deacetylase family protein 0.0151 0.0797 0.1455
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0273 0.0492
Loa Loa (eye worm) acetylcholine receptor protein 0.0062 0.0229 0.0418
Echinococcus granulosus chromobox protein 1 0.0069 0.0273 0.0499
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus 0.006 0.0213 0.0348
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0096 0.0168
Brugia malayi photoreceptor-specific nuclear receptor 0.0192 0.1062 0.1937
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Onchocerca volvulus 0.0062 0.0229 0.0379
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0192 0.1062 0.1937
Echinococcus granulosus nAChR subunit 0.0085 0.0375 0.0685
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0041
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Echinococcus multilocularis 0.004 0.0082 0.0149
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0108 0.0521 0.0416
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0213 0.0388
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1671 0.3044
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0157 0.016
Schistosoma mansoni histone deacetylase 0.0195 0.1086 0.1957
Brugia malayi excitatory GABA receptor EXP-1A 0.0148 0.0779 0.142
Brugia malayi Dopamine receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus granulosus fmrfamide receptor 0.006 0.0213 0.0388
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0229 0.039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0518 0.0413
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis neuropeptide receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0171 0.0927 0.1691
Trypanosoma brucei histone deacetylase 3 0.0151 0.0797 0.3909
Brugia malayi sulfakinin receptor protein 0.006 0.0213 0.0388
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0192 0.1062 0.1937
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0779 0.1395
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Schistosoma mansoni acetylcholine receptor subunit beta 0.0062 0.0229 0.039
Schistosoma mansoni coup transcription factor 0.0192 0.1062 0.1914
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 6 0.0151 0.0797 0.1455
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus granulosus nuclear receptor nhr 48 0.009 0.0409 0.0746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0192 0.1062 0.1937
Trypanosoma cruzi histone deacetylase 1, putative 0.0195 0.1086 0.5596
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0192 0.1062 0.1937
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0213 0.0388
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Plasmodium falciparum histone deacetylase, putative 0.0151 0.0797 0.1248
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0192 0.1062 0.1937
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis chromobox protein 1 0.0069 0.0273 0.0499
Schistosoma mansoni tyrosine kinase 0.0128 0.0652 0.1165
Schistosoma mansoni nuclear receptor 0.009 0.0409 0.0719
Schistosoma mansoni chromobox protein 0.0069 0.0273 0.0471
Trypanosoma cruzi histone deacetylase, putative 0.0078 0.0329 0.1168
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.027 0.0493
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.3953
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0233 0.133 0.2404
Brugia malayi AKH receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.0312 0.1838 0.3325
Onchocerca volvulus 0.0047 0.0132 0.02
Onchocerca volvulus 0.0877 0.5482 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Echinococcus granulosus epidermal growth factor receptor 0.0128 0.0652 0.119
Schistosoma mansoni steroid hormone receptor ad4bp 0.0192 0.1062 0.1914
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0213 0.0388
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0229 0.039
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0213 0.036
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0148 0.0779 0.142
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0213 0.0388
Echinococcus multilocularis conserved hypothetical protein 0.0406 0.2446 0.4462
Mycobacterium ulcerans isocitrate lyase Icl 0.1577 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0152 0.0805 0.1376
Onchocerca volvulus 0.0312 0.1838 0.3325
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0059 0.0107
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0148 0.0779 0.142
Echinococcus multilocularis ring and YY1 binding protein 0.0312 0.1838 0.3353
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Trypanosoma cruzi histone deacetylase, putative 0.0151 0.0797 0.3909
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Mycobacterium tuberculosis Probable reductase 0.0107 0.0518 0.0413
Trypanosoma brucei histone deacetylase, putative 0.0151 0.0797 0.3909
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.009 0.0409 0.0746
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.0233 0.133 0.2395
Loa Loa (eye worm) hypothetical protein 0.0233 0.133 0.2426
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Dihydrofolate reductase 0.0044 0.011 0.02
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.027 0.0493
Onchocerca volvulus 0.006 0.0213 0.0348
Onchocerca volvulus 0.0062 0.0229 0.0379
Echinococcus granulosus chromobox protein 1 0.0069 0.0273 0.0499
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0213 0.0388
Brugia malayi ecdysteroid receptor 0.0192 0.1062 0.1937
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0213 0.0388
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0312 0.1838 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0059 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0229 0.0418
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0213 0.036
Schistosoma mansoni histamine h1 receptor 0.006 0.0213 0.036
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Schistosoma mansoni thyroid hormone receptor 0.0192 0.1062 0.1914
Brugia malayi Melatonin receptor type 1A 0.006 0.0213 0.0388
Echinococcus multilocularis nAChR subunit 0.0085 0.0375 0.0685
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Loa Loa (eye worm) dihydrofolate reductase 0.0044 0.011 0.02
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0192 0.1062 0.1937
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Echinococcus granulosus neuropeptide receptor 0.006 0.0213 0.0388
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0479 0.0874
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0192 0.1062 0.1937
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0312 0.1838 0.3353
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0312 0.1838 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0192 0.1062 0.1937
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.0779 0.142
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0213 0.036
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0213 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0877 0.5482 1
Schistosoma mansoni opsin-like receptor 0.006 0.0213 0.036
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0518 0.0413
Echinococcus multilocularis somatostatin receptor 0.006 0.0213 0.0388
Brugia malayi Cation transporter family protein 0.0148 0.0779 0.142
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) hypothetical protein 0.0233 0.133 0.2426
Brugia malayi Histone deacetylase family protein 0.0151 0.0797 0.1455
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi ecdysone receptor 0.009 0.0409 0.0746
Loa Loa (eye worm) steroid hormone receptor 0.0192 0.1062 0.1937
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0192 0.1062 0.1937
Echinococcus multilocularis allatostatin A receptor 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Schistosoma mansoni tyrosine kinase 0.0041 0.009 0.0136
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0062 0.0229 0.0418
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0148 0.0779 0.142
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0312 0.1838 0.3325
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0077 0.0099
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni retinoic acid receptor RXR 0.0192 0.1062 0.1914
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0041 0.009 0.0165
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0148 0.0779 0.142
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0213 0.0388
Schistosoma mansoni histone deacetylase 4 5 0.0151 0.0797 0.143
Trypanosoma brucei hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0101 0.0479 0.0874
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0213 0.0388
Echinococcus granulosus g protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0213 0.0388
Plasmodium vivax histone deacetylase, putative 0.0078 0.0329 0.0499
Schistosoma mansoni nuclear hormone receptor 0.009 0.0409 0.0719
Brugia malayi Cation transporter family protein 0.0148 0.0779 0.142
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0192 0.1062 0.1914
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0213 0.0388
Schistosoma mansoni RNA binding protein 0.0312 0.1838 0.3333
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Loa Loa (eye worm) hypothetical protein 0.0078 0.0329 0.0601
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0192 0.1062 0.1937
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Onchocerca volvulus 0.0085 0.0375 0.0646
Brugia malayi G-protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi histone deacetylase 11 0.0078 0.0329 0.0601
Onchocerca volvulus 0.0312 0.1838 0.3325
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Schistosoma mansoni myosin xvIII 0.006 0.0213 0.036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0213 0.0388
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.0779 0.142
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.0779 0.142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.005 0.0091
Onchocerca volvulus Protein ultraspiracle homolog 0.0192 0.1062 0.1904
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Trypanosoma cruzi hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0213 0.0388
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis g protein coupled receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus 0.0148 0.0779 0.1385
Brugia malayi thymidylate synthase 0.0108 0.0521 0.0951
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.013 0.0131
Plasmodium vivax glutathione reductase, putative 0.0047 0.013 0.0131
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0213 0.036
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.0409 0.0746
Schistosoma mansoni thyroid hormone receptor 0.0192 0.1062 0.1914
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Loa Loa (eye worm) ACC-1 protein 0.0148 0.0779 0.142
Onchocerca volvulus 0.0108 0.0521 0.0914
Trypanosoma brucei histone deacetylase 2 0.0078 0.0329 0.1168
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.1262
Echinococcus granulosus FTZ F1 alpha 0.0192 0.1062 0.1937
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Brugia malayi histone deacetylase 1 (HD1) 0.0195 0.1086 0.198
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0213 0.0388
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.3953
Brugia malayi brahma associated protein 60 kDa 0.0877 0.5482 1
Echinococcus multilocularis neuropeptide s receptor 0.006 0.0213 0.0388
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Brugia malayi glutathione reductase 0.0047 0.013 0.0237
Echinococcus granulosus orexin receptor type 2 0.006 0.0213 0.0388
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.0779 0.142
Schistosoma mansoni RAR-like nuclear receptor 0.0192 0.1062 0.1914
Brugia malayi Dopamine receptor protein 2 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 8 0.0078 0.0329 0.0601
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.0085 0.0375 0.0646
Schistosoma mansoni nAChR subunit 0.0062 0.0229 0.039
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0518 0.0413
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0213 0.036
Loa Loa (eye worm) histone deacetylase 7A 0.0151 0.0797 0.1455
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Brugia malayi Protein kinase domain containing protein 0.0041 0.009 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0877 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0192 0.1062 0.1937
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0596 0.0491
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0518 0.0413
Loa Loa (eye worm) nuclear hormone receptor 0.009 0.0409 0.0746
Echinococcus multilocularis neuropeptide receptor 0.006 0.0213 0.0388
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.013 0.0237
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0041 0.009 0.0165
Echinococcus granulosus sex peptide receptor 0.006 0.0213 0.0388
Schistosoma mansoni brg-1 associated factor 0.0877 0.5482 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0213 0.0388
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0192 0.1062 0.1914
Loa Loa (eye worm) ACC-1 protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0375 0.0685
Brugia malayi G-protein coupled receptor 0.006 0.0213 0.0388
Echinococcus granulosus ecdysone induced protein 78C 0.0192 0.1062 0.1937
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0213 0.0388
Echinococcus granulosus neuropeptide s receptor 0.006 0.0213 0.0388
Trypanosoma brucei histone deacetylase 1 0.0195 0.1086 0.5596
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0096 0.0134
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.009 0.0409 0.0719
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0596 0.0491
Brugia malayi tailless protein 0.009 0.0409 0.0746
Onchocerca volvulus 0.0233 0.133 0.2395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0192 0.1062 0.1937
Entamoeba histolytica histone deacetylase, putative 0.0195 0.1086 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Brugia malayi hypothetical protein 0.009 0.0409 0.0746
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0213 0.0388
Brugia malayi RE15519p 0.006 0.0213 0.0388
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Onchocerca volvulus Putative nachr subunit 0.0148 0.0779 0.1385
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.009 0.0409 0.0746
Brugia malayi hypothetical protein 0.0101 0.0479 0.0874
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0213 0.0388
Schistosoma mansoni adenoreceptor 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus 0.009 0.0409 0.0708
Schistosoma mansoni tyrosine kinase 0.0041 0.009 0.0136
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus multilocularis serotonin receptor 0.006 0.0213 0.0388
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0148 0.0779 0.142
Loa Loa (eye worm) TK/EGFR protein kinase 0.0128 0.0652 0.119
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.1376
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0596 0.0491
Echinococcus multilocularis g protein coupled receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Leishmania major histone deacetylase, putative 0.0195 0.1086 0.5596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0192 0.1062 0.1937
Mycobacterium ulcerans thymidylate synthase 0.0108 0.0521 0.0416
Echinococcus multilocularis fmrfamide receptor 0.006 0.0213 0.0388
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0192 0.1062 0.1937
Echinococcus multilocularis chromobox protein 1 0.0069 0.0273 0.0499
Echinococcus granulosus g-protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0213 0.0388
Echinococcus multilocularis thyroid hormone receptor alpha 0.0192 0.1062 0.1937
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0192 0.1062 0.1937
Brugia malayi larval opioid receptor 0.006 0.0213 0.0388
Mycobacterium leprae Isocitrate lyase 0.0739 0.4595 0.4535
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Loa Loa (eye worm) thymidylate synthase 0.0108 0.0521 0.0951
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0213 0.0388
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0375 0.0658
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Schistosoma mansoni chromobox protein 0.0069 0.0273 0.0471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0148 0.0779 0.142
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0213 0.0388
Echinococcus multilocularis FTZ F1 alpha 0.0192 0.1062 0.1937
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0192 0.1062 0.1937
Loa Loa (eye worm) histone deacetylase 11 0.0078 0.0329 0.0601
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Brugia malayi nuclear receptor NHR-67 0.009 0.0409 0.0746
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0479 0.0874
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0213 0.0388
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0213 0.036
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0107
Loa Loa (eye worm) hypothetical protein 0.0073 0.0294 0.0537
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Echinococcus granulosus zinc finger protein Ran binding 0.0312 0.1838 0.3353
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0213 0.0388
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0312 0.1838 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Schistosoma mansoni tyrosine kinase 0.0068 0.0265 0.0456
Echinococcus granulosus nAChR subunit 0.0148 0.0779 0.142
Plasmodium vivax histone deacetylase 2, putative 0.0151 0.0797 0.1362
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0779 0.142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0059 0.0078
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Brugia malayi conserved hypotetical protein 0.009 0.0409 0.0746
Schistosoma mansoni hypothetical protein 0.0312 0.1838 0.3333
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0213 0.0388
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0195 0.1086 0.1975
Echinococcus multilocularis histone deacetylase 6 0.0151 0.0797 0.1455
Loa Loa (eye worm) histone deacetylase 1 0.0195 0.1086 0.198
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0157 0.028
Plasmodium falciparum histone deacetylase 1 0.0195 0.1086 0.1786
Brugia malayi neuropeptide F receptor 0.006 0.0213 0.0388
Echinococcus granulosus g protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0148 0.0779 0.142
Brugia malayi Heterochromatin protein 1 0.0069 0.0273 0.0499
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0312 0.1838 0.3353
Loa Loa (eye worm) hypothetical protein 0.0316 0.1863 0.3398
Echinococcus multilocularis histone deacetylase 1 0.0195 0.1086 0.198
Brugia malayi Nuclear hormone receptor E75 0.009 0.0409 0.0746
Brugia malayi Serotonin receptor 0.006 0.0213 0.0388
Toxoplasma gondii ran binding protein 0.0312 0.1838 0.3281
Schistosoma mansoni biogenic amine receptor 0.006 0.0213 0.036

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 200 nM Ability to displace [3H]-spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 200 nM Ability to displace [3H]-spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 530 nM Ability to displace [3H]-spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 530 nM Ability to displace [3H]-spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 1100 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 1100 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 1600 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from human recombinant dopamine receptor D2L expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 1600 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from human recombinant dopamine receptor D2L expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 2900 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from recombinant human dopamine receptor D3 expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 2900 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from recombinant human dopamine receptor D3 expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 4200 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 4200 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 7900 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from human recombinant dopamine receptor D2L expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 7900 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from human recombinant dopamine receptor D2L expressed in CHO cells ChEMBL. 12951112
Ki (binding) = 8700 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from recombinant human dopamine receptor D3 expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 8700 nM Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from recombinant human dopamine receptor D3 expressed in CHO cells at 0.5 nM concentration ChEMBL. 12951112
Ki (binding) = 13000 nM Displacement of [3H]-SCH-23,390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes ChEMBL. 12951112
Ki (binding) = 13000 nM Displacement of [3H]-SCH-23,390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes ChEMBL. 12951112
Ki (binding) = 17000 nM Displacement of [3H]-SCH-23,390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes ChEMBL. 12951112
Ki (binding) = 17000 nM Displacement of [3H]-SCH-23,390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes ChEMBL. 12951112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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