TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.554 | Formula: C30H28N2O4
H donors: 2 H acceptors: 2 LogP: 5.97 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(/C=N/c2ccc(cc2)CCc2ccc(cc2)/N=C/c2ccc(c(c2)OC)O)ccc1O
InChi: 1S/C30H28N2O4/c1-35-29-17-23(9-15-27(29)33)19-31-25-11-5-21(6-12-25)3-4-22-7-13-26(14-8-22)32-20-24-10-16-28(34)30(18-24)36-2/h5-20,33-34H,3-4H2,1-2H3/b31-19+,32-20+
InChiKey: GAZNSLYPSMMSST-GKTLAHRSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0012	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Trypanosoma cruzi	heat shock protein, putative	0.0012	0.0005	0.0031
Leishmania major	glycerol uptake protein, putative	0.044	0.1646	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0027	0.006	0.006
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0024	0.0049	0.3472
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0033	0.0199
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0292	0.1774
Trypanosoma brucei	Heat shock protein 83, putative	0.003	0.0073	0.0443
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0127	0.0127
Trypanosoma cruzi	heat shock protein 85, putative	0.0024	0.0049	0.0301
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.044	0.1646	0.1646
Trypanosoma cruzi	heat shock protein 90, putative	0.003	0.0073	0.0443
Brugia malayi	MBOAT family protein	0.044	0.1646	0.1646
Echinococcus granulosus	o acyltransferase membrane bound domain	0.044	0.1646	0.1646
Echinococcus multilocularis	heat shock protein	0.003	0.0073	0.0073
Brugia malayi	MBOAT family protein	0.044	0.1646	0.1646
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0336	0.1247	0.7578
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0012	0.0005	0.0005
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.2617	1	1
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Onchocerca volvulus		0.044	0.1646	1
Brugia malayi	Hsp90 protein	0.0012	0.0005	0.0005
Echinococcus granulosus	muscleblind protein	0.0166	0.0596	0.0596
Trichomonas vaginalis	heat shock protein, putative	0.0012	0.0005	0.0031
Onchocerca volvulus		0.0014	0.0012	0.0074
Trypanosoma cruzi	heat shock protein 90, putative	0.0018	0.0026	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0096	0.0096
Brugia malayi	CXXC zinc finger family protein	0.0086	0.0288	0.0288
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0087	0.0292	0.1774
Treponema pallidum	heat shock protein 90	0.0024	0.0049	0.0301
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0021	0.004	0.004
Toxoplasma gondii	heat shock protein 90, putative	0.003	0.0073	0.0073
Schistosoma mansoni	endoplasmin	0.003	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0096	0.0096
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0014	0.0012	0.0853
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Trypanosoma cruzi	heat shock protein 85, putative	0.003	0.0073	0.0443
Trypanosoma cruzi	GUP1, putative	0.044	0.1646	1
Loa Loa (eye worm)	histone methyltransferase	0.0027	0.006	0.006
Trypanosoma cruzi	glycerol uptake protein, putative	0.044	0.1646	1
Schistosoma mansoni	hypothetical protein	0.0319	0.1182	0.1182
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.044	0.1646	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0087	0.0292	0.1774
Entamoeba histolytica	vacuolar protein sorting 26	0.044	0.1646	1
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Schistosoma mansoni	cpg binding protein	0.0091	0.0307	0.0307
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0292	0.1774
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0142	0.2237
Entamoeba histolytica	hypothetical protein, conserved	0.044	0.1646	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0096	0.1505
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0014	0.0012	0.0012
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0014	0.0012	0.0191
Giardia lamblia	Kinase, PLK	0.0087	0.0292	1
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	0.0012	0.0004	0.0023
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0004	0.0023
Echinococcus multilocularis	muscleblind protein	0.0166	0.0596	0.0596
Trichomonas vaginalis	conserved hypothetical protein	0.044	0.1646	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0047	0.0139	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0596	0.0596
Leishmania major	heat shock protein, putative	0.0012	0.0005	0.0008
Loa Loa (eye worm)	hypothetical protein	0.044	0.1646	0.1646
Entamoeba histolytica	heat shock protein 90, putative	0.003	0.0073	0.0443
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Toxoplasma gondii	heat shock protein 75, putative	0.0012	0.0005	0.0005
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0142	0.0866
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0142	0.2237
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.2617	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0142	0.2237
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.044	0.1646	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0142	0.0845
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0292	0.1774
Schistosoma mansoni	kinase	0.0044	0.0128	0.0128
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0014	0.0012	0.0191
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0139	0.0846
Entamoeba histolytica	hypothetical protein	0.044	0.1646	1
Trypanosoma cruzi	GUP1, putative	0.044	0.1646	1
Echinococcus granulosus	cpg binding protein	0.0091	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.044	0.1646	0.1646
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0014	0.0012	0.0191
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0012	0.0012
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	0.0012	0.0004	0.0004
Loa Loa (eye worm)	MBOAT family protein	0.044	0.1646	0.1646
Mycobacterium ulcerans	hypothetical protein	0.0177	0.0637	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0142	0.0142
Trypanosoma cruzi	heat shock protein 85, putative	0.003	0.0073	0.0443
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0012	0.0012
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0033	0.0199
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0012	0.0012
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0014	0.0012	0.0191
Echinococcus granulosus	sterol O acyltransferase 1	0.044	0.1646	0.1646
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0004	0.0004
Toxoplasma gondii	hypothetical protein	0.044	0.1646	0.1646
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0012	0.0119
Trypanosoma cruzi	polo-like protein kinase, putative	0.0087	0.0292	0.1774
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0024	0.0049	0.1695
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.044	0.1646	0.1646
Schistosoma mansoni	cpg binding protein	0.0091	0.0307	0.0307
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0163	0.0583	0.0583
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Echinococcus granulosus	o acyltransferase membrane bound domain	0.044	0.1646	0.1646
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0012	0.0051
Leishmania major	acetyl-CoA synthetase, putative	0.0014	0.0012	0.0051
Loa Loa (eye worm)	heat shock protein 75	0.0012	0.0005	0.0005
Toxoplasma gondii	Hsp90 domain-containing protein	0.0012	0.0005	0.0005
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0012	0.0004	0.0004
Plasmodium falciparum	heat shock protein 90, putative	0.0012	0.0005	0.0005
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0014	0.0012	0.0191
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0142	0.0142
Trypanosoma brucei	glycerol uptake protein, putative	0.044	0.1646	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0142	0.2237
Echinococcus multilocularis	heat shock protein 90	0.0024	0.0049	0.0049
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.044	0.1646	0.1646
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0096	0.0096
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.2617	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0033	0.0199
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0142	0.0845
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0033	0.0199
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	0.0012	0.0004	0.0023
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0142	0.2237
Echinococcus multilocularis	endoplasmin	0.0024	0.0049	0.0049
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.044	0.1646	0.1646
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0012	0.0119
Echinococcus granulosus	dnaJ subfamily B	0.1225	0.4658	0.4658
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0142	0.0142
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0012	0.0012
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0159	0.0568	0.3452
Trypanosoma cruzi	Heat shock protein 83, putative	0.003	0.0073	0.0443
Trichomonas vaginalis	CAMK family protein kinase	0.0043	0.0123	0.0749
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Schistosoma mansoni	acetyl-CoA synthetase	0.0014	0.0012	0.0012
Onchocerca volvulus		0.0014	0.0012	0.0074
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0004	0.0004
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0014	0.0012	0.0191
Schistosoma mansoni	heat shock protein	0.003	0.0073	0.0073
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Toxoplasma gondii	propionate-CoA ligase	0.0014	0.0012	0.0012
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.0292	0.0292
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0004	0.0023
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0012	0.0119
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0012	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0012
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0142	0.0866
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Echinococcus granulosus	heat shock protein	0.003	0.0073	0.0073
Leishmania major	mitochondrial DNA polymerase beta	0.0336	0.1247	0.7572
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0088	0.1323
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0014	0.0012	0.0191
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.044	0.1646	0.1646
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0159	0.0568	0.3452
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0014	0.0012	0.0853
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	0.0012	0.0004	0.0127
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.2617	1	1
Trichomonas vaginalis	endoplasmin, putative	0.0018	0.0028	0.0173
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0127	0.0127
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0014	0.0012	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0003	0.0003
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0012
Schistosoma mansoni	heat shock protein	0.0012	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.2177	0.8312	0.8312
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0012	0.0119
Trichomonas vaginalis	heat shock protein, putative	0.0018	0.0028	0.0173
Loa Loa (eye worm)	hhat protein	0.044	0.1646	0.1646
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0096	0.0096
Giardia lamblia	Grp94/Hsp90	0.0024	0.0049	0.1695
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0047	0.0139	0.0846
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0086	0.0288	0.0288
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0012	0.0012
Trypanosoma brucei	polo-like protein kinase	0.0087	0.0292	0.1774
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0012	0.0119
Echinococcus multilocularis		0.0012	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.044	0.1646	0.1646
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0021	0.004	0.004
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0021	0.004	0.004
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0012	0.0074
Echinococcus multilocularis	geminin	0.0319	0.1182	0.1182
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Loa Loa (eye worm)	hhat protein	0.044	0.1646	0.1646
Loa Loa (eye worm)	heat shock protein 90	0.003	0.0073	0.0073
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0012	0.0012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0127	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.044	0.1646	1
Plasmodium vivax	heat shock protein, putative	0.0012	0.0005	0.0005
Trichomonas vaginalis	porcupine, putative	0.044	0.1646	1
Loa Loa (eye worm)	hypothetical protein	0.044	0.1646	0.1646
Trichomonas vaginalis	CAMK family protein kinase	0.0043	0.0123	0.0749
Onchocerca volvulus		0.0048	0.0142	0.0866
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0014	0.0012	0.0074
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0177	0.0637	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0142	0.2237
Schistosoma mansoni	sterol O-acyltransferase 1	0.044	0.1646	0.1646
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0012	0.0119
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0159	0.0568	0.3437
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0096	0.0096
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0014	0.0012	0.0074
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.044	0.1646	0.1646
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0012	0.0012
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0001	0.0003
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.044	0.1646	0.1646
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0012	0.0119
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0024	0.0049	0.0049
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0027	0.006	0.006
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0012	0.0119
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.2617	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0292	0.1774
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0012	0.0005	0.0005
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Onchocerca volvulus		0.0086	0.0288	0.175
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0004	0.0023
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0012	0.0004	0.0004
Brugia malayi	Hhat protein	0.044	0.1646	0.1646
Toxoplasma gondii	hypothetical protein	0.0054	0.0166	0.0166
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.044	0.1646	0.1646
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0012	0.0074
Brugia malayi	MBOAT family protein	0.044	0.1646	0.1646
Echinococcus multilocularis	sterol O acyltransferase 1	0.044	0.1646	0.1646
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.0139	0.0846
Leishmania major	hypothetical protein, conserved	0.044	0.1646	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Trypanosoma brucei	glycerol uptake protein, putative	0.044	0.1646	1
Mycobacterium ulcerans	heat shock protein 90	0.0024	0.0049	0.0777
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0142	0.0845
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0087	0.0292	0.1755
Trichomonas vaginalis	conserved hypothetical protein	0.044	0.1646	1
Schistosoma mansoni	hypothetical protein	0.0319	0.1182	0.1182
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.044	0.1646	0.1646
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0088	0.1323
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0336	0.1247	0.7578
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0096	0.0096
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0142	0.0142
Trypanosoma cruzi	polo-like protein kinase, putative	0.0087	0.0292	0.1774
Trypanosoma brucei	heat shock protein 90, putative	0.003	0.0073	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Brugia malayi	Endoplasmin precursor	0.003	0.0073	0.0073
Onchocerca volvulus		0.0014	0.0012	0.0074
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0033	0.0199
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Echinococcus granulosus	heat shock protein 90	0.003	0.0073	0.0073
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0012	0.0074
Trypanosoma cruzi	glycerol uptake protein, putative	0.044	0.1646	1
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0014	0.0012	0.0012
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0142	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0021	0.004	0.004
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0033	0.0199
Plasmodium vivax	heat shock protein 90, putative	0.0012	0.0005	0.0005
Trichomonas vaginalis	heat shock protein, putative	0.0024	0.0049	0.0301
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0024	0.0049	0.0709
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0087	0.0292	0.0292
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0142	0.0142
Brugia malayi	MBOAT family protein	0.044	0.1646	0.1646
Leishmania major	glycerol uptake protein, putative	0.044	0.1646	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0012	0.0074
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0142	0.2237
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0058	0.0179	0.1087
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0127	0.0127
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.2617	1	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0096	0.1443
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0127	0.0127
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.044	0.1646	0.1646
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0142	0.0866
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.044	0.1646	1
Leishmania major	glycerol uptake protein, putative	0.044	0.1646	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0033	0.0199
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0336	0.1247	0.7578
Plasmodium falciparum	endoplasmin, putative	0.0018	0.0028	0.0028
Echinococcus multilocularis	heat shock protein 90	0.003	0.0073	0.0073
Trypanosoma brucei	heat shock protein 84, putative	0.0012	0.0005	0.0031
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0142	0.2237
Plasmodium vivax	endoplasmin, putative	0.003	0.0073	0.0073
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.044	0.1646	0.1646
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0014	0.0012	0.0012
Brugia malayi	F/Y-rich N-terminus family protein	0.0026	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0142	0.0142
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0127	0.0127
Brugia malayi	MBOAT family protein	0.044	0.1646	0.1646
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0014	0.0012	0.0012
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.2617	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0033	0.0199
Schistosoma mansoni	cpg binding protein	0.0086	0.0288	0.0288
Treponema pallidum	alginate O-acetylation protein (algI)	0.044	0.1646	1
Echinococcus granulosus	heat shock protein 90	0.0024	0.0049	0.0049
Echinococcus granulosus	CTD small phosphatase protein like	0.0012	0.0004	0.0004
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.2617	1	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0012	0.0074
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0024	0.0049	1
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0012	0.0004	0.0004
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.044	0.1646	0.1646
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0012	0.0005	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0596	0.0596
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0012	0.0012
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0012	0.0004	0.0004
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0012	0.0004	0.0004
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0087	0.0292	0.0292
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0024	0.0049	0.0279
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0127	0.0127
Leishmania major	acetyl-CoA synthetase, putative	0.0014	0.0012	0.0051
Trichomonas vaginalis	heat shock protein, putative	0.0024	0.0049	0.0301
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0127	0.0127
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0014	0.0012	0.0853
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0033	0.0199
Onchocerca volvulus		0.0014	0.0012	0.0074
Plasmodium falciparum	heat shock protein 90	0.003	0.0073	0.0073
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0292	0.1774
Schistosoma mansoni	heat shock protein	0.003	0.0073	0.0073
Brugia malayi	serine/threonine-protein kinase plk-2	0.0087	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0004	0.0004
Echinococcus granulosus	endoplasmin	0.0024	0.0049	0.0049
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.044	0.1646	0.1646
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0012	0.0119
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0012	0.0012
Echinococcus multilocularis	cpg binding protein	0.0091	0.0307	0.0307
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0142	0.218
Loa Loa (eye worm)	MBOAT family protein	0.044	0.1646	0.1646
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0182	0.0658	0.0658
Echinococcus granulosus	geminin	0.0319	0.1182	0.1182
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Schistosoma mansoni	zinc finger protein	0.044	0.1646	0.1646
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0012	0.0119
Giardia lamblia	Heat shock protein HSP 90-alpha	0.003	0.0073	0.2497
Toxoplasma gondii	heat shock protein HSP90	0.003	0.0073	0.0073
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.044	0.1646	0.1646
Loa Loa (eye worm)	hypothetical protein	0.044	0.1646	0.1646
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0012	0.0191
Trichomonas vaginalis	heat shock protein, putative	0.003	0.0073	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0096	0.0096
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0012	0.0012
Trichomonas vaginalis	transmembrane protein nessy, putative	0.044	0.1646	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0096	1
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0292	0.1774
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0088	0.1323
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.044	0.1646	0.1646
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0012	0.0074
Trichomonas vaginalis	helicase, putative	0.0019	0.0033	0.0199
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.044	0.1646	0.1646
Loa Loa (eye worm)	endoplasmin	0.003	0.0073	0.0073
Brugia malayi	Muscleblind-like protein	0.0166	0.0596	0.0596
Schistosoma mansoni	hypothetical protein	0.1225	0.4658	0.4658
Plasmodium falciparum	heat shock protein 90, putative	0.0012	0.0005	0.0005
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0014	0.0012	0.0012
Trypanosoma brucei	heat shock protein, putative	0.003	0.0073	0.0443
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0012	0.0005	0.0031
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0004	0.0023
Echinococcus granulosus	o acyltransferase membrane bound domain	0.044	0.1646	0.1646
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Trypanosoma cruzi	glycerol uptake protein, putative	0.044	0.1646	1
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0004	0.0023
Leishmania major	heat shock protein 83-1	0.003	0.0073	0.0421
Echinococcus multilocularis	muscleblind protein 1	0.0166	0.0596	0.0596
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0004	0.0023
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0088	0.1323
Loa Loa (eye worm)	MBOAT family protein	0.044	0.1646	0.1646
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.044	0.1646	0.1646
Trypanosoma cruzi	heat shock protein 85, putative	0.003	0.0073	0.0443
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0021	0.004	0.004
Leishmania major	glycerol uptake protein, putative	0.044	0.1646	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0127	0.0127
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0142	0.218
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0012	0.0074
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0142	1
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0014	0.0012	0.0191
Entamoeba histolytica	heat shock protein 90, putative	0.003	0.0073	0.0443
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0004	0.0023
Trichomonas vaginalis	CAMK family protein kinase	0.0087	0.0292	0.1774
Trypanosoma brucei	heat shock protein 90, putative	0.003	0.0073	0.0443
Plasmodium vivax	heat shock protein 86, putative	0.003	0.0073	0.0073
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0012	0.0119
Trichomonas vaginalis	heat shock protein, putative	0.0024	0.0049	0.0301
Brugia malayi	heat shock protein 90	0.003	0.0073	0.0073
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0087	0.0292	0.0292
Trypanosoma cruzi	heat shock protein 90, putative	0.0024	0.0049	0.0301
Echinococcus multilocularis	dnaJ subfamily B	0.1225	0.4658	0.4658
Schistosoma mansoni	hypothetical protein	0.0012	0.0003	0.0003
Leishmania major	glycerol uptake protein, putative	0.044	0.1646	1
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0004	0.0023
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0001	0.0003
Schistosoma mansoni	endoplasmin	0.003	0.0073	0.0073

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2268786

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1839826