Detailed information for compound 1842395

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 375.427 | Formula: C22H24F3NO
  • H donors: 0 H acceptors: 0 LogP: 6.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCc1ccc(c(c1)F)C1COC(=N1)c1c(F)cccc1F
  • InChi: 1S/C22H24F3NO/c1-2-3-4-5-6-8-15-11-12-16(19(25)13-15)20-14-27-22(26-20)21-17(23)9-7-10-18(21)24/h7,9-13,20H,2-6,8,14H2,1H3
  • InChiKey: RIFVBVNDPQBXJC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0045 0.0987 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0045 0.0987 0.0987
Echinococcus granulosus cathepsin L 0.0023 0.0073 0.0073
Echinococcus granulosus tubulin alpha chain 0.0039 0.0716 0.0716
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0044 0.0928 0.0928
Giardia lamblia Alpha-tubulin 0.0039 0.0716 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0044 0.0928 0.0928
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Brugia malayi Cathepsin L-like precursor 0.0044 0.0928 0.0928
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0045 0.0987 0.0987
Loa Loa (eye worm) tubulin alpha 2 0.003 0.0354 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Schistosoma mansoni sterol O-acyltransferase 1 0.0045 0.0987 0.0987
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0073 0.0745
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.027 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0029 0.0345 0.3501
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0928 0.9408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0044 0.0923 0.0923
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Loa Loa (eye worm) hypothetical protein 0.0045 0.0987 0.0987
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Trypanosoma brucei alpha tubulin 0.0039 0.0716 0.7258
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0023 0.0073 0.0745
Echinococcus multilocularis cysteine protease 0.0044 0.0928 0.0928
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.027 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0044 0.0928 0.0928
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0073 0.0745
Echinococcus granulosus tubulin alpha chain 0.0039 0.0716 0.0716
Echinococcus multilocularis hypothetical protein 0.0039 0.0716 0.0716
Onchocerca volvulus 0.0044 0.0928 0.909
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Trypanosoma cruzi cysteine protease, putative 0.0023 0.0073 0.0745
Echinococcus multilocularis tubulin alpha chain 0.0039 0.0716 0.0716
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0928 0.9408
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0073 0.0073
Echinococcus multilocularis tubulin alpha 1C chain 0.0039 0.0716 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0987 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0044 0.0928 0.0928
Loa Loa (eye worm) tubulin alpha 2 0.003 0.0354 0.0354
Echinococcus granulosus cathepsin l1 0.0029 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0045 0.0987 0.0987
Echinococcus granulosus peroxisome assembly protein 26 0.0039 0.0716 0.0716
Trichomonas vaginalis tubulin beta chain, putative 0.0039 0.0716 0.7258
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0073 0.0745
Loa Loa (eye worm) hypothetical protein 0.0224 0.8179 0.8179
Toxoplasma gondii alpha-tubulin I, putative 0.0039 0.0716 0.0716
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0073 0.0745
Plasmodium falciparum cysteine proteinase falcipain 1 0.0023 0.0073 0.0073
Trypanosoma cruzi GUP1, putative 0.0045 0.0987 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0039 0.0716 0.0716
Loa Loa (eye worm) alpha-tubulin 0.0039 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Brugia malayi Cathepsin L-like precursor 0.0044 0.0928 0.0928
Leishmania major glycerol uptake protein, putative 0.0045 0.0987 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0044 0.0928 0.0928
Loa Loa (eye worm) tubulin alpha-2 chain 0.0039 0.0716 0.0716
Echinococcus granulosus o acyltransferase membrane bound domain 0.0045 0.0987 0.0987
Schistosoma mansoni alpha tubulin 0.0039 0.0716 0.0716
Brugia malayi alpha-tubulin 0.0039 0.0716 0.0716
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0045 0.0987 1
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0045 0.0987 0.0987
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Trypanosoma cruzi glycerol uptake protein, putative 0.0045 0.0987 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Echinococcus multilocularis sterol O acyltransferase 1 0.0045 0.0987 0.0987
Brugia malayi Cathepsin L-like precursor 0.0044 0.0928 0.0928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Echinococcus granulosus o acyltransferase membrane bound domain 0.0045 0.0987 0.0987
Trichomonas vaginalis tubulin epsilon chain, putative 0.0039 0.0716 0.7258
Echinococcus granulosus sodium channel protein 0.0044 0.0923 0.0923
Loa Loa (eye worm) diacylglycerol acyltransferase 0.027 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Giardia lamblia Alpha-tubulin 0.0039 0.0716 1
Onchocerca volvulus Cathepsin F homolog 0.0044 0.0928 0.909
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0073 0.0745
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0073 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0073 0.0745
Loa Loa (eye worm) hypothetical protein 0.0029 0.0345 0.0345
Loa Loa (eye worm) MBOAT family protein 0.0045 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0345 0.3501
Trichomonas vaginalis tubulin beta chain, putative 0.0039 0.0716 0.7258
Trichomonas vaginalis tubulin beta chain, putative 0.0039 0.0716 0.7258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Trypanosoma brucei alpha tubulin 0.0039 0.0716 0.7258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Trichomonas vaginalis tubulin epsilon chain, putative 0.0039 0.0716 0.7258
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0045 0.0987 0.0987
Schistosoma mansoni alpha tubulin 0.0039 0.0716 0.0716
Schistosoma mansoni hypothetical protein 0.0045 0.0987 0.0987
Loa Loa (eye worm) alpha-tubulin 0.0039 0.0716 0.0716
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0045 0.0987 0.0987
Entamoeba histolytica tubulin alpha chain, putative 0.0039 0.0716 0.7258
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0044 0.0928 0.9408
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0928 0.909
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Trichomonas vaginalis tubulin beta chain, putative 0.0039 0.0716 0.7258
Loa Loa (eye worm) tubulin alpha chain 0.0039 0.0716 0.0716
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0045 0.0987 1
Echinococcus granulosus cysteine protease 0.0023 0.0073 0.0073
Loa Loa (eye worm) cysteine protease 0.0044 0.0928 0.0928
Onchocerca volvulus 0.0044 0.0928 0.909
Entamoeba histolytica vacuolar protein sorting 26 0.0045 0.0987 1
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0928 0.9408
Loa Loa (eye worm) fibroinase 0.0044 0.0928 0.0928
Onchocerca volvulus 0.0044 0.0928 0.909
Brugia malayi Tubulin alpha-2 chain 0.0039 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Echinococcus multilocularis peroxisome assembly protein 26 0.0039 0.0716 0.0716
Toxoplasma gondii alpha tubulin TUBA1 0.0039 0.0716 0.0716
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0345 0.0345
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Trypanosoma cruzi GUP1, putative 0.0045 0.0987 1
Brugia malayi MBOAT family protein 0.0045 0.0987 0.0987
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Brugia malayi Tubulin alpha-2 chain 0.0039 0.0716 0.0716
Echinococcus multilocularis tubulin alpha chain 0.0039 0.0716 0.0716
Echinococcus granulosus cathepsin L cysteine proteinase 0.0044 0.0928 0.0928
Brugia malayi Hhat protein 0.0045 0.0987 0.0987
Onchocerca volvulus 0.0044 0.0928 0.909
Echinococcus multilocularis cysteine protease 0.0044 0.0928 0.0928
Trichomonas vaginalis transmembrane protein nessy, putative 0.0045 0.0987 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0045 0.0987 1
Plasmodium vivax vivapain-3 0.0023 0.0073 0.0073
Leishmania major glycerol uptake protein, putative 0.0045 0.0987 1
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Onchocerca volvulus 0.0044 0.0928 0.909
Brugia malayi Cathepsin L-like precursor 0.0044 0.0928 0.0928
Loa Loa (eye worm) hhat protein 0.0045 0.0987 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0987 1
Toxoplasma gondii cathepsin CPL 0.0044 0.0928 0.0928
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0928 0.9408
Trypanosoma cruzi alpha tubulin, putative 0.0039 0.0716 0.7258
Schistosoma mansoni tubulin subunit alpha 0.0039 0.0716 0.0716
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.027 1 1
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0045 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0044 0.0928 0.0928
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0045 0.0987 0.0987
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0073 0.0073
Echinococcus multilocularis cathepsin L 0.0023 0.0073 0.0073
Echinococcus granulosus cathepsin L cysteine protease 0.0023 0.0073 0.0073
Brugia malayi Cathepsin L-like precursor 0.0044 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0244
Schistosoma mansoni alpha tubulin 0.0039 0.0716 0.0716
Loa Loa (eye worm) MBOAT family protein 0.0045 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0073 0.0745
Trichomonas vaginalis porcupine, putative 0.0045 0.0987 1
Plasmodium vivax unspecified product 0.0023 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0039 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Schistosoma mansoni zinc finger protein 0.0045 0.0987 0.0987
Onchocerca volvulus 0.0044 0.0928 0.909
Echinococcus granulosus tubulin alpha 3 chain 0.0039 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0044 0.0928 0.0928
Echinococcus granulosus tubulin alpha chain 0.0039 0.0716 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0027 0.0244 0.2472
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0073 0.0073
Schistosoma mansoni tubulin subunit alpha 0.0039 0.0716 0.0716
Loa Loa (eye worm) ctsf protein 0.0044 0.0928 0.0928
Leishmania major glycerol uptake protein, putative 0.0045 0.0987 1
Plasmodium vivax tubulin alpha chain, putative 0.0039 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Echinococcus granulosus tubulin alpha 3 chain 0.0039 0.0716 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Entamoeba histolytica cysteine proteinase 1, putative 0.0023 0.0073 0.0745
Loa Loa (eye worm) hypothetical protein 0.0045 0.0987 0.0987
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Echinococcus granulosus cathepsin l1 0.0044 0.0928 0.0928
Plasmodium vivax vivapain-1 0.0023 0.0073 0.0073
Trypanosoma brucei alpha tubulin 0.0039 0.0716 0.7258
Loa Loa (eye worm) hypothetical protein 0.0045 0.0987 0.0987
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0045 0.0987 0.0987
Trichomonas vaginalis tubulin beta chain, putative 0.0039 0.0716 0.7258
Plasmodium vivax tubulin alpha chain, putative 0.0039 0.0716 0.0716
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0073 0.0073
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0045 0.0987 0.0987
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0039 0.0716 0.7258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Entamoeba histolytica cysteine protease, putative 0.0044 0.0928 0.9408
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0928 0.909
Leishmania major cysteine peptidase A (CPA) 0.0044 0.0928 0.9408
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0928 0.9408
Brugia malayi MBOAT family protein 0.0045 0.0987 0.0987
Echinococcus multilocularis tubulin alpha 3 chain 0.0039 0.0716 0.0716
Brugia malayi MBOAT family protein 0.0045 0.0987 0.0987
Echinococcus multilocularis tubulin alpha chain 0.0039 0.0716 0.0716
Toxoplasma gondii hypothetical protein 0.0045 0.0987 0.0987
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Echinococcus multilocularis sodium channel protein 0.0044 0.0923 0.0923
Plasmodium falciparum alpha tubulin 1 0.0039 0.0716 0.0716
Echinococcus multilocularis cathepsin L cysteine protease 0.0044 0.0928 0.0928
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0045 0.0987 0.0987
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0073 0.0745
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0073 0.0745
Leishmania major glycerol uptake protein, putative 0.0045 0.0987 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0044 0.0928 0.0928
Brugia malayi tubulin alpha-2 chain 0.0039 0.0716 0.0716
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0045 0.0987 0.0987
Brugia malayi Tubulin alpha chain 0.0039 0.0716 0.0716
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0928 0.0928
Schistosoma mansoni tubulin subunit alpha 0.0039 0.0716 0.0716
Echinococcus multilocularis Tubulin alpha 1 chain 0.0039 0.0716 0.0716
Loa Loa (eye worm) alpha-tubulin isotype 2 0.003 0.0354 0.0354
Echinococcus multilocularis tubulin alpha chain 0.0039 0.0716 0.0716
Onchocerca volvulus 0.0044 0.0928 0.909
Entamoeba histolytica cysteine proteinase 2 0.0023 0.0073 0.0745
Echinococcus granulosus tubulin alpha 1C chain 0.0039 0.0716 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0987 1
Loa Loa (eye worm) MBOAT family protein 0.0045 0.0987 0.0987
Entamoeba histolytica tubulin alpha-1 chain 0.0039 0.0716 0.7258
Trichomonas vaginalis tubulin beta chain, putative 0.0039 0.0716 0.7258
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.0987 1
Brugia malayi MBOAT family protein 0.0045 0.0987 0.0987
Echinococcus multilocularis Tubulin alpha 1 chain 0.0039 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0029 0.0345 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Brugia malayi MBOAT family protein 0.0045 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0073 0.0745
Plasmodium falciparum alpha tubulin 2 0.0039 0.0716 0.0716
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0928 0.9408
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Trypanosoma brucei glycerol uptake protein, putative 0.0045 0.0987 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0045 0.0987 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Onchocerca volvulus 0.0045 0.0987 1
Brugia malayi Cathepsin L-like precursor 0.0029 0.0345 0.0345
Echinococcus granulosus sterol O acyltransferase 1 0.0045 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Echinococcus granulosus Tubulin alpha 1 chain 0.0039 0.0716 0.0716
Plasmodium vivax vivapain-2 0.0044 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.003 0.0354 0.0354
Brugia malayi Cathepsin L-like precursor 0.0029 0.0345 0.0345
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.027 1 1
Echinococcus granulosus tubulin alpha chain 0.0039 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0045 0.0987 0.0987
Loa Loa (eye worm) tubulin alpha chain 0.0039 0.0716 0.0716
Trypanosoma brucei glycerol uptake protein, putative 0.0045 0.0987 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0045 0.0987 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Loa Loa (eye worm) tubulin alpha-3 chain 0.0027 0.0244 0.0244
Echinococcus multilocularis Tubulin alpha 1 chain 0.0039 0.0716 0.0716
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Loa Loa (eye worm) hhat protein 0.0045 0.0987 0.0987
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0044 0.0923 0.936
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.003 0.0354 0.3585
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0044 0.0928 0.0928
Echinococcus multilocularis tubulin alpha 1C chain 0.0039 0.0716 0.0716
Leishmania major hypothetical protein, conserved 0.0045 0.0987 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Leishmania major alpha tubulin 0.0039 0.0716 0.7258
Plasmodium vivax vivapain-2 0.0044 0.0928 0.0928
Echinococcus granulosus tubulin alpha chain 0.0039 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0345 0.3501
Echinococcus multilocularis tubulin alpha 3 chain 0.0039 0.0716 0.0716
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.027 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0928 0.9408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0044 0.0928 0.0928
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0045 0.0987 0.0987
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0928 0.9408
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0045 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0044 0.0928 0.9408
Loa Loa (eye worm) hypothetical protein 0.0029 0.0345 0.0345
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0045 0.0987 0.0987
Echinococcus multilocularis tubulin subunit TubB 0.0039 0.0716 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0073 0.0745
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0928 0.9408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0345 0.3501
Echinococcus granulosus alpha tubulin 0.0039 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Echinococcus granulosus tubulin alpha 1C chain 0.0039 0.0716 0.0716
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0045 0.0987 0.0987
Leishmania major cathepsin L-like protease 0.0044 0.0928 0.9408
Leishmania major glycerol uptake protein, putative 0.0045 0.0987 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0029 0.0345 0.0345
Plasmodium falciparum diacylglycerol O-acyltransferase 0.027 1 1
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0045 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0928 0.9408
Brugia malayi tubulin alpha chain - mouse 0.0039 0.0716 0.0716
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.027 1 1
Echinococcus granulosus tubulin subunit TubB 0.0039 0.0716 0.0716
Brugia malayi Cathepsin L-like precursor 0.0044 0.0928 0.0928
Echinococcus multilocularis tubulin alpha chain 0.0039 0.0716 0.0716
Echinococcus granulosus o acyltransferase membrane bound domain 0.0045 0.0987 0.0987
Brugia malayi cathepsin L-like precursor 0.0029 0.0345 0.0345
Entamoeba histolytica cysteine protease, putative 0.0023 0.0073 0.0745
Entamoeba histolytica hypothetical protein 0.0045 0.0987 1
Trypanosoma brucei alpha tubulin 0.0039 0.0716 0.7258
Echinococcus granulosus Tubulin alpha 1 chain 0.0039 0.0716 0.0716
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0928 0.0928
Schistosoma mansoni cathepsin F (C01 family) 0.0044 0.0928 0.0928

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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