Detailed information for compound 1845388

Basic information

Technical information
  • TDR Targets ID: 1845388
  • Name: (E)-3-(3-hydroxyphenyl)-1-pyridin-2-ylprop-2- en-1-one
  • MW: 225.243 | Formula: C14H11NO2
  • H donors: 1 H acceptors: 3 LogP: 2.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)/C=C/C(=O)c1ccccn1
  • InChi: 1S/C14H11NO2/c16-12-5-3-4-11(10-12)7-8-14(17)13-6-1-2-9-15-13/h1-10,16H/b8-7+
  • InChiKey: PXWUCIBTVVNVMI-BQYQJAHWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(3-hydroxyphenyl)-1-(2-pyridyl)prop-2-en-1-one
  • (E)-3-(3-hydroxyphenyl)-1-pyridin-2-yl-prop-2-en-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Leishmania major hypothetical protein, conserved 0.0058 0.0842 0.0941
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Onchocerca volvulus 0.0512 0.8955 1
Entamoeba histolytica tyrosin kinase, putative 0.0512 0.8955 0.8859
Trypanosoma brucei dual specificity protein phosphatase, putative 0.0058 0.0842 0.0941
Onchocerca volvulus 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trypanosoma cruzi leucine-rich repeat protein, putative 0.0058 0.0842 0.0941
Leishmania major dual specificity protein phosphatase, putative 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) TK/FAK protein kinase 0.0512 0.8955 1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0842 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1206 0.0448
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0512 0.8955 1
Plasmodium falciparum protein kinase, putative 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0512 0.8955 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0512 0.8955 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0512 0.8955 1
Trypanosoma brucei leucine-rich repeat protein (LRRP), putative 0.0058 0.0842 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.8955 1
Trypanosoma brucei phosphatase, putative 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Echinococcus granulosus c src tyrosine kinase 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0303 0.5211 0.5385
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) serine/threonine protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0512 0.8955 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0512 0.8955 1
Brugia malayi Phospholipase A2 family protein 0.0073 0.1097 0.1225
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Echinococcus granulosus tyrosine protein kinase 0.0512 0.8955 1
Trichomonas vaginalis protein kinase atn1, putative 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Echinococcus granulosus raf serine:threonine protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0512 0.8955 1
Echinococcus granulosus epidermal growth factor receptor 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0842 0.0941
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Echinococcus multilocularis epidermal growth factor receptor 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Schistosoma mansoni serine/threonine protein kinase 0.0512 0.8955 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0512 0.8955 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Brugia malayi EGF-like domain containing protein 0.0058 0.0842 0.0941
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0512 0.8955 1
Trypanosoma brucei leucine-rich repeat protein (LRRP), putative 0.0058 0.0842 0.0941
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Brugia malayi SH2 domain containing protein 0.0512 0.8955 1
Schistosoma mansoni ephrin receptor 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0512 0.8955 1
Leishmania major hypothetical protein, conserved 0.0058 0.0842 0.0941
Echinococcus multilocularis transfer RNA-Thr 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0512 0.8955 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0512 0.8955 1
Onchocerca volvulus Tyrosine kinase homolog 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0512 0.8955 1
Brugia malayi Furin-like cysteine rich region family protein 0.0512 0.8955 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trypanosoma brucei Basal body protein 0.0058 0.0842 0.0941
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0058 0.0842 0.0941
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Entamoeba histolytica ankyrin repeat protein 0.0512 0.8955 0.8859
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Onchocerca volvulus Phospholipase A2 homolog 0.0073 0.1097 0.0314
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase csk 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0512 0.8955 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Brugia malayi CCR4 0.0058 0.0842 0.0941
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Schistosoma mansoni serine/threonine protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0512 0.8955 1
Trypanosoma brucei protein kinase, putative 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.0842 0.0941
Leishmania major hypothetical protein, conserved 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0512 0.8955 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0512 0.8955 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1206 0.0448
Leishmania major hypothetical protein, conserved 0.0058 0.0842 0.0941
Echinococcus multilocularis kinase suppressor of Ras 1 0.0512 0.8955 1
Brugia malayi ras-binding protein SUR-8 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0512 0.8955 1
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Onchocerca volvulus 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Echinococcus multilocularis protein kinase 0.0512 0.8955 1
Onchocerca volvulus Phospholipase A2 homolog 0.0073 0.1097 0.0314
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trypanosoma cruzi phopshatase, putative 0.0058 0.0842 0.0941
Schistosoma mansoni protein tyrosine kinase 0.0512 0.8955 1
Trypanosoma brucei Outer row dynein-assembly protein 7 0.0058 0.0842 0.0941
Onchocerca volvulus 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0512 0.8955 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) protein kinase domain-containing protein 0.0512 0.8955 1
Trypanosoma brucei leucine-rich repeat protein (LRRP), putative 0.0058 0.0842 0.0941
Loa Loa (eye worm) TK/ACK protein kinase 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Echinococcus granulosus tyrosine protein kinase Src42A 0.0512 0.8955 1
Leishmania major leucine-rich repeat protein, putative 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Echinococcus granulosus tyrosine kinase 0.0512 0.8955 1
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis Regulatory protein uhpC, putative 0.0079 0.1206 0.0448
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trypanosoma cruzi protein phosphatase 1, regulatory subunit, putative 0.0058 0.0842 0.0941
Chlamydia trachomatis hexose phosphate transporter 0.0079 0.1206 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Entamoeba histolytica serine/threonine kinase, putative 0.0512 0.8955 0.8859
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0512 0.8955 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0512 0.8955 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0303 0.5211 0.5385
Giardia lamblia Protein 21.1 0.0512 0.8955 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0512 0.8955 1
Echinococcus multilocularis FL cytokine receptor 0.0512 0.8955 1
Leishmania major hypothetical protein, conserved 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0842 0.0941
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Trichomonas vaginalis CAMK family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0512 0.8955 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0512 0.8955 1
Giardia lamblia Kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Leishmania major protein kinase, putative 0.0512 0.8955 1
Trypanosoma brucei Pseudokinase, putative 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Trichomonas vaginalis glucose-6-phosphate translocase, putative 0.0079 0.1206 0.0448
Onchocerca volvulus 0.0512 0.8955 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0512 0.8955 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus granulosus insulin receptor 0.0512 0.8955 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Leishmania major proteophosphoglycan ppg3, putative 0.0058 0.0842 0.0941
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0512 0.8955 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Loa Loa (eye worm) TK/CSK protein kinase 0.0512 0.8955 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Leishmania major hypothetical protein, conserved 0.0058 0.0842 0.0941
Brugia malayi Guanylyl cyclase protein 23 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1206 0.0448
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0512 0.8955 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0512 0.8955 1
Entamoeba histolytica serine/threonine kinase, putative 0.0512 0.8955 0.8859
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0 0.5
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) TK/Met protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Toxoplasma gondii protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Entamoeba histolytica receptor protein kinase, putative 0.0512 0.8955 0.8859
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi hypothetical protein 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus multilocularis epidermal growth factor receptor 0.0512 0.8955 1
Trypanosoma cruzi leucine-rich repeat protein, putative 0.0058 0.0842 0.0941
Echinococcus granulosus epidermal growth factor receptor 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0512 0.8955 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0512 0.8955 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0512 0.8955 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0512 0.8955 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0512 0.8955 1
Trichomonas vaginalis Hexuronate transporter, putative 0.0079 0.1206 0.0448
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Brugia malayi Raf kinase 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1206 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1206 0.0448
Echinococcus multilocularis tyrosine protein kinase csk 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Trichomonas vaginalis TK family protein kinase 0.0512 0.8955 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Echinococcus granulosus tyrosine protein kinase Srms 0.0512 0.8955 1
Trypanosoma cruzi Calcium/calmodulin-dependent protein kinase kinase, putative 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Brugia malayi hypothetical protein 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Echinococcus granulosus tyrosine protein kinase Lyn 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Plasmodium falciparum protein kinase, putative 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Onchocerca volvulus 0.0512 0.8955 1
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Echinococcus multilocularis insulin receptor 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Brugia malayi integrin-linked kinase 0.0512 0.8955 1
Trypanosoma cruzi kinatase, putative 0.0058 0.0842 0.0941
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0303 0.5211 0.5819
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Echinococcus granulosus integrin linked protein kinase 0.0512 0.8955 1
Trichomonas vaginalis glucarate, hexuronate transporter, putative 0.0079 0.1206 0.0448
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1206 0.0448
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Echinococcus granulosus tyrosine protein kinase Fyn 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Entamoeba histolytica hypothetical protein 0.057 1 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.8955 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0512 0.8955 1
Echinococcus multilocularis protein tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) PDZ-domain-containing protein scribble 0.0058 0.0842 0.0941
Trypanosoma brucei paraflagellar rod component, putative 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Echinococcus granulosus tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0512 0.8955 1
Entamoeba histolytica tyrosin kinase, putative 0.0512 0.8955 0.8859
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0512 0.8955 1
Trypanosoma brucei protein phosphatase 1, regulatory subunit, putative 0.0058 0.0842 0.0941
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Leishmania major hypothetical protein, conserved 0.0058 0.0842 0.0941
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase, putative 0.057 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase csk 0.0512 0.8955 1
Trypanosoma brucei leucine-rich repeat protein (LRRP), putative 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Giardia lamblia Kinase, NEK 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Leishmania major proteophosphoglycan ppg1 0.0058 0.0842 0.0941
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0512 0.8955 1
Brugia malayi SRC-1 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0512 0.8955 1
Echinococcus granulosus activin receptor type 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Echinococcus granulosus tyrosine protein kinase ABL1 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0842 0.0941
Echinococcus granulosus activated cdc42 kinase 1 0.0512 0.8955 1
Entamoeba histolytica ankyrin repeat protein 0.0512 0.8955 0.8859
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trypanosoma cruzi Outer row dynein-assembly protein 7 0.0058 0.0842 0.0941
Loa Loa (eye worm) RGC/RGC protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Echinococcus multilocularis tyrosine kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0512 0.8955 1
Entamoeba histolytica hypothetical protein, conserved 0.0512 0.8955 0.8859
Echinococcus multilocularis tyrosine protein kinase HCK 0.0512 0.8955 1
Trypanosoma cruzi protein phosphatase 1, regulatory subunit, putative 0.0058 0.0842 0.0941
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Brugia malayi ephrin receptor 1 precursor 0.0512 0.8955 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0303 0.5211 0.5385
Echinococcus granulosus fibroblast growth factor receptor 4 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase 0.0512 0.8955 1
Schistosoma mansoni ephrin receptor 0.0512 0.8955 1
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Brugia malayi Tyrosine-protein kinase abl-1 0.0512 0.8955 1
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Entamoeba histolytica receptor protein kinase, putative 0.0512 0.8955 0.8859
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Onchocerca volvulus 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0512 0.8955 1
Trichomonas vaginalis glucarate, hexuronate transporter, putative 0.0079 0.1206 0.0448
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0512 0.8955 1
Entamoeba histolytica hypothetical protein 0.0512 0.8955 0.8859
Leishmania major hypothetical protein, conserved 0.0058 0.0842 0.0941
Brugia malayi PDZ-domain protein scribble 0.0058 0.0842 0.0941
Loa Loa (eye worm) TK/DDR protein kinase 0.0512 0.8955 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0303 0.5211 0.5819
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Entamoeba histolytica tyrosin kinase, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.8955 1
Echinococcus granulosus tyrosine kinase 0.0512 0.8955 1
Echinococcus multilocularis c src tyrosine kinase 0.0512 0.8955 1
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0058 0.0842 0.0941
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Trichomonas vaginalis STE family protein kinase 0.0512 0.8955 1
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Toxoplasma gondii STE kinase 0.0512 0.8955 1
Entamoeba histolytica serine/threonine kinase, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Trypanosoma cruzi phopshatase, putative 0.0058 0.0842 0.0941
Echinococcus granulosus tyrosine protein kinase pr2 0.0512 0.8955 1
Echinococcus multilocularis protein kinase 0.0512 0.8955 1
Echinococcus granulosus protein tyrosine kinase 0.0512 0.8955 1
Brugia malayi Tyrosine-protein kinase PR2 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Plasmodium falciparum tyrosine kinase-like protein 0.0512 0.8955 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0512 0.8955 1
Echinococcus multilocularis integrin linked protein kinase 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase csk 0.0512 0.8955 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0512 0.8955 1
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0512 0.8955 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Echinococcus granulosus activated cdc42 kinase 1 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Trypanosoma cruzi Calcium/calmodulin-dependent protein kinase kinase, putative 0.0058 0.0842 0.0941
Echinococcus granulosus tyrosine protein kinase shark 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) sur-8-PB 0.0058 0.0842 0.0941
Entamoeba histolytica tyrosin kinase, putative 0.0512 0.8955 0.8859
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0079 0.1206 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0512 0.8955 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Trypanosoma cruzi kinatase, putative 0.0058 0.0842 0.0941
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0512 0.8955 1
Giardia lamblia Kinase, NEK 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0512 0.8955 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0512 0.8955 1
Plasmodium vivax protein kinase, putative 0.0512 0.8955 1
Brugia malayi ras suppressor protein 1 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi hypothetical protein 0.0058 0.0842 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.1206 0.0448
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi Peroxidasin 0.0058 0.0842 0.0941
Brugia malayi hypothetical protein 0.0079 0.1206 0.1346
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0512 0.8955 1
Brugia malayi Receptor family ligand binding region containing protein 0.0512 0.8955 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0058 0.0842 0.0941
Entamoeba histolytica serine/threonine kinase, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1097 0.1225
Entamoeba histolytica hypothetical protein 0.057 1 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Toxoplasma gondii protein kinase domain-containing protein 0.0512 0.8955 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0512 0.8955 1
Trypanosoma brucei kinatase, putative 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Echinococcus granulosus retinal guanylyl cyclase 2 0.0512 0.8955 1
Brugia malayi SH2 domain containing protein 0.0512 0.8955 1
Entamoeba histolytica protein kinase, putative 0.0512 0.8955 0.8859
Trypanosoma cruzi protein kinase, putative 0.0512 0.8955 1
Entamoeba histolytica cysteine surface protein, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Echinococcus multilocularis heat shock protein 70 0.0512 0.8955 1
Echinococcus granulosus protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0512 0.8955 1
Loa Loa (eye worm) TK/FER protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0842 0.0941
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0512 0.8955 0.8859
Schistosoma mansoni serine/threonine RGC 0.0512 0.8955 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0512 0.8955 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0512 0.8955 1
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0512 0.8955 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Schistosoma mansoni serine/threonine protein kinase 0.0512 0.8955 1
Schistosoma mansoni serine/threonine protein kinase 0.0512 0.8955 1
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Entamoeba histolytica serine/threonine kinase, putative 0.0512 0.8955 0.8859
Trichomonas vaginalis Regulatory protein uhpC, putative 0.0079 0.1206 0.0448
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.057 1 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) Ras-binding protein SUR-8 0.0058 0.0842 0.0941
Plasmodium falciparum protein kinase, putative 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0512 0.8955 1
Schistosoma mansoni hypothetical protein 0.0512 0.8955 1
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Brugia malayi hypothetical protein 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0512 0.8955 1
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Echinococcus multilocularis activin receptor type 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0512 0.8955 0.8859
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0512 0.8955 0.8859
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1097 0.1225
Trichomonas vaginalis AGC family protein kinase 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi C-terminal src kinase protein 1 0.0512 0.8955 1
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Entamoeba histolytica protein kinase domain containing protein 0.0512 0.8955 0.8859
Entamoeba histolytica serine/threonine kinase, putative 0.0512 0.8955 0.8859
Entamoeba histolytica tyrosine kinase, putative 0.0512 0.8955 0.8859
Trypanosoma brucei leucine-rich repeat protein (LRRP), putative 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0842 0.0941
Leishmania major protein kinase, putative 0.0512 0.8955 1
Trichomonas vaginalis TKL family protein kinase 0.0512 0.8955 1
Brugia malayi Leucine Rich Repeat family protein 0.0058 0.0842 0.0941
Plasmodium falciparum tyrosine kinase-like protein 0.0512 0.8955 1
Brugia malayi Protein kinase domain containing protein 0.0512 0.8955 1
Onchocerca volvulus 0.0512 0.8955 1
Trypanosoma cruzi leucine-rich repeat protein, putative 0.0058 0.0842 0.0941
Loa Loa (eye worm) TK protein kinase 0.0512 0.8955 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0512 0.8955 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0512 0.8955 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0512 0.8955 1
Giardia lamblia Sugar transport family protein 0.0079 0.1206 0.0448
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Trichomonas vaginalis transport proetin, putative 0.0079 0.1206 0.0448
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0079 0.1206 0.5
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0842 0.0941
Schistosoma mansoni tyrosine kinase 0.0512 0.8955 1
Schistosoma mansoni protein kinase 0.0512 0.8955 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0842 0.0941
Trypanosoma cruzi protein kinase, putative 0.0512 0.8955 1
Loa Loa (eye worm) hypothetical protein 0.0512 0.8955 1
Loa Loa (eye worm) SRC-1 0.0512 0.8955 1
Brugia malayi protein-tyrosine kinase 0.0512 0.8955 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0512 0.8955 1
Trypanosoma brucei leucine-rich repeat protein (LRRP), putative 0.0058 0.0842 0.0941

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 49.51 uM Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced NO production after 17 to 20 hr by Griess assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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