Detailed information for compound 1851756

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.393 | Formula: C17H18N5O7PS
  • H donors: 3 H acceptors: 6 LogP: -0.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Sc1nc2c(n1[C@@H]1O[C@H]3[C@H]([C@H]1O)OP(=O)(OC3)O)ncnc2N
  • InChi: 1S/C17H18N5O7PS/c1-26-8-2-4-9(5-3-8)31-17-21-11-14(18)19-7-20-15(11)22(17)16-12(23)13-10(28-16)6-27-30(24,25)29-13/h2-5,7,10,12-13,16,23H,6H2,1H3,(H,24,25)(H2,18,19,20)/t10-,12-,13-,16-/m1/s1
  • InChiKey: VQNRSRXBMBFUOR-XNIJJKJLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0048
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0123 0.1405 0.4232
Trichomonas vaginalis alpha-glucosidase, putative 0.0123 0.1405 0.4232
Echinococcus multilocularis peptidase Clp (S14 family) 0.0061 0.0624 0.0622
Echinococcus granulosus geminin 0.0373 0.4575 0.4687
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0046 0.0428 0.0931
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0016 0.0133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0083 0.0083
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0332 0.0982
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0083 0.0081
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0102 0.0284
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0276 0.0643
Trichomonas vaginalis rotamase, putative 0.0039 0.0338 0.1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0879 0.0899
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0348 0.4258 0.4364
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0428 0.1274
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0102 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.0781 0.9757 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0037 0.0038
Onchocerca volvulus Alhambra homolog 0.0034 0.0276 0.0275
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0016 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0016 0.0016
Onchocerca volvulus 0.0043 0.0398 0.04
Brugia malayi Probable ClpP-like protease 0.0093 0.1032 0.1056
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0002 0.0002
Echinococcus granulosus neutral alpha glucosidase AB 0.0123 0.1405 0.1438
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0013 0.0008 0.0006
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0326 0.0656
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0326 0.228
Onchocerca volvulus 0.0013 0.0016 0.0008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0209 0.0212
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0016 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Entamoeba histolytica hypothetical protein 0.0013 0.0016 0.0056
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0049 0.0048
Leishmania major mitochondrial DNA polymerase beta 0.031 0.3787 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0348 0.4258 0.4257
Echinococcus multilocularis peregrin 0.0034 0.0276 0.0274
Echinococcus multilocularis neutral alpha glucosidase AB 0.0123 0.1405 0.1403
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.1247 0.1245
Brugia malayi PHD-finger family protein 0.0034 0.0276 0.0281
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0013 0.0008 0.0006
Brugia malayi Bromodomain containing protein 0.0034 0.0276 0.0281
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0016 0.0042
Trypanosoma brucei glycosyl hydrolase-like protein 0.0046 0.0428 0.0931
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0061 0.0624 0.2941
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0464 0.1382
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0421 0.0423
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0366 0.0364
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0024
Brugia malayi CXXC zinc finger family protein 0.003 0.0229 0.0232
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0008 0.0006
Plasmodium falciparum phd finger protein, putative 0.0034 0.0276 0.2657
Mycobacterium ulcerans hypothetical protein 0.0164 0.1923 0.5703
Schistosoma mansoni alpha glucosidase 0.0123 0.1405 0.144
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0008 0.0006
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0014
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0781 0.9757 1
Echinococcus granulosus dnaJ subfamily B 0.0426 0.5257 0.5387
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0016 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0102 0.0284
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0016 0.0042
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0008 0.0008
Brugia malayi glutaminase DH11.1 0.0273 0.3309 0.339
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0016 0.0014
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0008 0.0006
Brugia malayi CHD4 protein 0.0015 0.0037 0.0036
Schistosoma mansoni hypothetical protein 0.0034 0.028 0.0287
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0013 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0254 0.0745
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0008 0.0006
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0232 0.2789 0.2858
Echinococcus granulosus neuroglian 0.0015 0.004 0.0039
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0123 0.1405 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.2789 0.2857
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0184 0.1691
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0008 0.0008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0403 0.0862
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0348 0.4258 0.4257
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0257 0.1824
Brugia malayi Melibiase family protein 0.0232 0.2789 0.2857
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0015 0.004 0.0041
Brugia malayi hypothetical protein 0.0013 0.0016 0.0014
Toxoplasma gondii hypothetical protein 0.0032 0.0257 0.0598
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.048 0.049
Onchocerca volvulus 0.003 0.0229 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0002 0.0002
Giardia lamblia PHD finger protein 15 0.0034 0.0276 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0257 0.247
Echinococcus granulosus Chromobox protein 3 0.0013 0.0016 0.0014
Mycobacterium ulcerans glutaminase 0.0273 0.3309 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0254 0.0745
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1923 1
Onchocerca volvulus 0.0234 0.2822 0.2887
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0781 0.9757 1
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.5257 0.5256
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0093 0.1032 0.1056
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0348 0.4258 0.4364
Loa Loa (eye worm) helicase 0.0013 0.0016 0.0014
Schistosoma mansoni rotamase 0.0039 0.0338 0.0346
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0016 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2462 0.2522
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0016 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0102 0.0284
Echinococcus multilocularis chromobox protein 1 0.008 0.0869 0.0867
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0184 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0231 0.0237
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0056 0.0145
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0008 0.0008
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0061 0.0624 0.4744
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0039 0.0037
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0039 0.004
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0008 0.0006
Brugia malayi Pre-SET motif family protein 0.003 0.0231 0.0234
Echinococcus multilocularis chromobox protein 1 0.008 0.0869 0.0867
Schistosoma mansoni hypothetical protein 0.0373 0.4575 0.4689
Schistosoma mansoni cpg binding protein 0.0032 0.025 0.0256
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0013 0.0008 0.0006
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0093 0.1032 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0231 0.0537
Brugia malayi G-protein alpha subunit 0.0013 0.0008 0.0006
Brugia malayi hypothetical protein 0.0349 0.4275 0.438
Brugia malayi SET domain containing protein 0.0015 0.0038 0.0037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0083 0.0215
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1713 0.4519
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0016 0.0014
Echinococcus multilocularis roundabout 2 0.0015 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0014
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0008 0.0008
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0006
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0046 0.0428 0.0431
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.073 0.0747
Onchocerca volvulus 0.0349 0.4275 0.4377
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0015 0.004 0.0041
Echinococcus granulosus roundabout 2 0.0015 0.004 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0016 0.0024
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0012 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0102 0.0284
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1713 0.4399
Loa Loa (eye worm) G protein alpha subunit 3 0.0013 0.0008 0.0006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0083 0.0083
Brugia malayi Glycosyl hydrolases family 31 protein 0.0123 0.1405 0.1438
Loa Loa (eye worm) glutaminase 2 0.0273 0.3309 0.339
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0093 0.1032 0.5
Entamoeba histolytica hypothetical protein 0.0013 0.0016 0.0056
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0229 0.0232
Echinococcus multilocularis Immunoglobulin 0.0015 0.004 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0524 0.1189
Echinococcus multilocularis Immunoglobulin 0.0015 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0038
Trypanosoma brucei glucosidase, putative 0.0123 0.1405 0.3568
Echinococcus multilocularis expressed protein 0.0039 0.0338 0.0336
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0057 0.0056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0668 0.0685
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0123 0.1405 0.1438
Schistosoma mansoni glutaminase 0.0273 0.3309 0.3392
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0008 0.0006
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1713 0.4399
Leishmania major hypothetical protein, conserved 0.0026 0.0184 0.0481
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0037 0.0035
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Echinococcus granulosus peregrin 0.0034 0.0276 0.0281
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.048 0.049
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0348 0.4258 0.4364
Schistosoma mansoni chromobox protein 0.008 0.0869 0.0891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.3554 0.3642
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0048
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0016 0.0133
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0093 0.1032 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0039 0.004
Echinococcus granulosus expressed protein 0.0013 0.0008 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0123 0.1405 0.4232
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0102 0.0284
Trichomonas vaginalis sucrase-isomaltase, putative 0.0123 0.1405 0.4232
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0083 0.0229
Brugia malayi PHD-finger family protein 0.0013 0.001 0.0008
Schistosoma mansoni jumonji domain containing protein 0.0088 0.096 0.0984
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.1405 0.3568
Echinococcus granulosus Immunoglobulin 0.0015 0.004 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0292 0.3554 0.3553
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0056
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0326 0.0656
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1597 0.1635
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0093 0.1032 0.242
Loa Loa (eye worm) hypothetical protein 0.0034 0.0276 0.0281
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0332 0.0982
Loa Loa (eye worm) hypothetical protein 0.005 0.048 0.049
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0039 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0083 0.0229
Schistosoma mansoni chromobox protein 0.008 0.0869 0.0891
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0348 0.4258 0.4363
Schistosoma mansoni peptidase Clp (S14 family) 0.0093 0.1032 0.1058
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.022 0.2641 0.27
Brugia malayi jmjC domain containing protein 0.0042 0.0387 0.0395
Loa Loa (eye worm) hypothetical protein 0.0058 0.0581 0.0593
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0083 0.0705
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0046 0.0428 0.1274
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0243 0.0247
Schistosoma mansoni cell adhesion molecule 0.0015 0.004 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0048
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0083 0.079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0297 0.0303
Echinococcus granulosus GPCR family 2 0.0016 0.0049 0.0048
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0062 0.0164
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0231 0.0229
Schistosoma mansoni chromobox protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0231 0.0234
Trichomonas vaginalis alpha-glucosidase, putative 0.0123 0.1405 0.4232
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0443 0.0452
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0231 0.0237
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0013 0.0008 0.0006
Schistosoma mansoni ap endonuclease 0.0018 0.0083 0.0086
Toxoplasma gondii hypothetical protein 0.005 0.0484 0.1132
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0582 0.1363
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0781 0.9757 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0037 0.0036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0553 0.6862 0.7032
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0428 0.1274
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0024
Entamoeba histolytica hypothetical protein 0.0013 0.0016 0.0056
Brugia malayi MH2 domain containing protein 0.0138 0.1597 0.1635
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0232 0.2789 0.8424
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0184 0.0272
Echinococcus granulosus chromobox protein 1 0.008 0.0869 0.0889
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0014
Echinococcus multilocularis cpg binding protein 0.0032 0.025 0.0248
Trichomonas vaginalis chromobox protein, putative 0.008 0.0869 0.2609
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0049 0.0473 0.0485
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0464 0.0468
Loa Loa (eye worm) hypothetical protein 0.0093 0.1032 0.1056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0123 0.1405 0.4232
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0879 0.6236
Trichomonas vaginalis rotamase, putative 0.0038 0.0326 0.0965
Brugia malayi Protein kinase domain containing protein 0.0781 0.9757 1
Schistosoma mansoni cpg binding protein 0.003 0.0229 0.0234
Echinococcus granulosus expressed protein 0.0039 0.0338 0.0344
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0123 0.1405 1
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0118 0.0119
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.005
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0879 0.6236
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Brugia malayi hypothetical protein 0.0015 0.004 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0292 0.3554 0.3553
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0403 0.0862
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.004 0.0038
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0093 0.1032 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0096 0.0099
Brugia malayi Heterochromatin protein 1 0.008 0.0869 0.0889
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0039 0.0037
Schistosoma mansoni hypothetical protein 0.0373 0.4575 0.4689
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0008 0.0008
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0037 0.0036
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Onchocerca volvulus 0.032 0.3905 0.3997
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.3554 0.3642
Trichomonas vaginalis maltase-glucoamylase, putative 0.0046 0.0428 0.1274
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1597 0.1635
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0008 0.0008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0032 0.0257 0.24
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0276 0.0281
Brugia malayi hypothetical protein 0.0013 0.0008 0.0006
Schistosoma mansoni alpha-glucosidase 0.0476 0.5885 0.6032
Echinococcus multilocularis chromobox protein 2 0.0013 0.0016 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0013 0.0008 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0123 0.1405 0.4232
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.3787 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0184 0.0272
Toxoplasma gondii Alpha-galactosidase 0.0049 0.0473 0.1106
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0008 0.0006
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0093 0.1032 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0016 0.0014
Echinococcus granulosus cpg binding protein 0.0032 0.025 0.0254
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0428 0.1274
Brugia malayi hypothetical protein 0.0017 0.0065 0.0065
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0013 0.0008 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0231 0.0229
Brugia malayi Pre-SET motif family protein 0.0206 0.2462 0.2522
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0008 0.0008
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0061 0.0624 0.2941
Trichomonas vaginalis chromobox protein, putative 0.008 0.0869 0.2609
Loa Loa (eye worm) hypothetical protein 0.022 0.2641 0.2705
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0326 0.0857
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0049 0.0048
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0781 0.9757 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0553 0.6862 0.6861
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0184 0.0272
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.0032 0.025 0.0256
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0387 0.0395
Echinococcus multilocularis lysosomal alpha glucosidase 0.0553 0.6862 0.6861
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0285
Onchocerca volvulus 0.0035 0.0297 0.0297
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0403 0.0862
Echinococcus multilocularis neuroglian 0.0015 0.004 0.0038
Loa Loa (eye worm) glutaminase 0.0273 0.3309 0.339
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0013 0.0008 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.004 0.0039
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0008 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0421 0.125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0292 0.3554 0.3641
Loa Loa (eye worm) hypothetical protein 0.0045 0.0421 0.0429
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.1405 0.3568
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.3787 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0093 0.1032 0.242
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0039 0.0038
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0013 0.0008 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0102 0.0284
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0428 0.1274
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0184 0.1767
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0013 0.0008 0.0006
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0016 0.0014
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0123 0.1405 0.3297
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Toxoplasma gondii exonuclease III APE 0.0018 0.0083 0.0191
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0016 0.0057 0.0056
Schistosoma mansoni nephrin 0.0015 0.004 0.0041
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0276 0.0281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0102 0.0284
Schistosoma mansoni ap endonuclease 0.0018 0.0083 0.0086
Schistosoma mansoni chromobox protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0013 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.005
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0362 0.0369
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0348 0.4258 0.4364
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0016 0.0032
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0869 0.0889
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0039 0.0038
Trichomonas vaginalis glutaminase, putative 0.0273 0.3309 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.028 0.0285
Brugia malayi hypothetical protein 0.0026 0.0184 0.0187
Brugia malayi jmjC domain containing protein 0.011 0.1247 0.1276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0292 0.3554 0.3641
Brugia malayi Protein cec-1. 0.0013 0.0016 0.0014
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0093 0.1032 1
Brugia malayi N-terminal motif family protein 0.022 0.2641 0.2705
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.1247 0.1276
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0014
Schistosoma mansoni alpha-glucosidase 0.0476 0.5885 0.6032
Brugia malayi chromobox protein homolog 3 0.0045 0.0421 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0421 0.125
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0184 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0231 0.0237
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0008 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0464 0.1382
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0232 0.2789 0.2858
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0016 0.0133
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0404 0.0414
Loa Loa (eye worm) hypothetical protein 0.0046 0.0428 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.3554 0.3642
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0008 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.3787 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0006
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0326 0.0656
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0276 0.0283
Echinococcus granulosus chromobox protein 1 0.008 0.0869 0.0889
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.004 0.0039
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0403 0.0862
Toxoplasma gondii melibiase subfamily protein 0.0348 0.4258 1
Plasmodium vivax SET domain protein, putative 0.003 0.0231 0.2149
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0008 0.0008
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0276 0.0274
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0362 0.0369
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0093 0.1032 0.2941
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0093 0.1032 0.103
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0013 0.0008 0.0006
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0008 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0016 0.0024
Trichomonas vaginalis hypothetical protein 0.0013 0.0016 0.0024
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.005
Echinococcus granulosus twitchin 0.0018 0.0074 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0292 0.3554 0.3641
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0276 0.0643
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0008 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0387 0.0395
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.048 0.049
Echinococcus granulosus chromobox protein 2 0.0013 0.0016 0.0014
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0013 0.0008 0.0006
Echinococcus multilocularis Chromo domain 0.0013 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0006
Schistosoma mansoni vesicular amine transporter 0.0017 0.007 0.0072
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0231 0.0234
Echinococcus granulosus Chromo domain 0.0013 0.0016 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0046 0.0428 0.1274
Schistosoma mansoni hypothetical protein 0.0426 0.5257 0.5388
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0338 0.0344
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0387 0.0397
Echinococcus multilocularis geminin 0.0373 0.4575 0.4574
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0781 0.9757 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0083 0.0083
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0338 0.0344
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0276 0.2589
Brugia malayi Glycosyl hydrolases family 31 protein 0.0046 0.0428 0.0437
Trichomonas vaginalis maltase-glucoamylase, putative 0.0123 0.1405 0.4232
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0387 0.0397
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2822 0.8525
Echinococcus granulosus defective proboscis extension response 0.0015 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0039
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0093 0.1032 0.2941
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0553 0.6862 0.7032
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0326 0.0762
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0398 0.0408
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0008
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0443 0.0441
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0404 0.0414
Leishmania major alpha glucosidase II subunit, putative 0.0123 0.1405 0.3707
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0016 0.0014
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0781 0.9757 0.9757
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0062 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0046 0.0428 0.1274
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0013 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0034 0.0276 0.0283
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0016 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0362 0.036
Echinococcus multilocularis expressed protein 0.0013 0.0008 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0362 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0049 0.0048
Onchocerca volvulus 0.0013 0.0016 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0123 0.1405 0.4232
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.004 0.0039
Echinococcus granulosus lysosomal alpha glucosidase 0.0553 0.6862 0.7032
Loa Loa (eye worm) hypothetical protein 0.0349 0.4275 0.438
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0046 0.0428 0.301
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0046 0.0428 0.0931
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0083 0.054
Echinococcus granulosus peptidase Clp S14 family 0.0061 0.0624 0.0638
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0184 0.1767
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0008 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0338 0.1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0292 0.3554 0.3641
Leishmania major glycosyl hydrolase-like protein 0.0046 0.0428 0.1126
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0093 0.1032 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0024

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 27 uM Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 microM ChEMBL. 6245211
IC50 (binding) = 48 uM Inhibition of cAMP phosphodiesterase preparation from rabbit lung at a substrate concentration of 0.14 microM ChEMBL. 6245211

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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