Detailed information for compound 1852222

Basic information

Technical information
  • TDR Targets ID: 1852222
  • Name: ST5334250
  • MW: 111.145 | Formula: C5H9N3
  • H donors: 1 H acceptors: 1 LogP: 0.19 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1ccc(n1)N
  • InChi: 1S/C5H9N3/c1-2-8-4-3-5(6)7-8/h3-4H,2H2,1H3,(H2,6,7)
  • InChiKey: PZJGLURDALTFPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.009 0.5697
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0722 0.077
Schistosoma mansoni ran 0.0018 0.0016 0.0011
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.003 0.0064 0.2889
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0094
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0108 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.021 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0009 0.0003
Brugia malayi hypothetical protein 0.0219 0.0839 0.0908
Mycobacterium ulcerans lipase LipD 0.0036 0.009 0.4573
Echinococcus granulosus snurportin 1 0.0268 0.1042 0.112
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0145 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0192 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0145 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.0108 0.0114
Echinococcus multilocularis transfer RNA-Lys 0.0047 0.0132 0.0116
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0145 0.3551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0025 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0025 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0143 0.0152
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0041 0.0108 0.0111
Brugia malayi CXXC zinc finger family protein 0.0031 0.0067 0.0067
Trypanosoma brucei RNA helicase, putative 0.0107 0.0381 1
Echinococcus multilocularis microtubule associated protein 2 0.0738 0.2973 0.2962
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.225 0.918 1
Leishmania major protein kinase, putative 0.0038 0.0095 0.4467
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.0108 0.0114
Onchocerca volvulus 0.0078 0.0262 0.028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.009 0.1001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0023
Leishmania major ribonuclease H1, putative 0.0029 0.0058 0.2356
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0046 0.0046
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0129 0.0134
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0145 0.0536 0.058
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.225 0.918 0.9179
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.009 0.1001
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0108 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.009 0.0091
Onchocerca volvulus 0.0138 0.0507 0.0547
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0019 0.0019 0.0071
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0041 0.0108 0.0111
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0029 0.0058 0.5
Loa Loa (eye worm) hypoxia-induced factor 1 0.0195 0.0742 0.0805
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0166 0.0174
Schistosoma mansoni phosphoglucomutase 0.0029 0.0058 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0025 0.0505
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0024 0.0597
Echinococcus multilocularis lamin 0.0048 0.0138 0.0122
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0145 0.0536 0.0578
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0166 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.009 0.008
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0192 0.0176
Treponema pallidum ribonuclease H (rnhA) 0.0029 0.0058 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0064 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.009 0.5697
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0025 0.1137
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0003 0.0039
Schistosoma mansoni hypothetical protein 0.0441 0.1753 0.1904
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0064 0.0063
Loa Loa (eye worm) MBCTL1 0.0055 0.0166 0.0177
Echinococcus multilocularis lamin dm0 0.0048 0.0138 0.0122
Echinococcus granulosus GPCR family 2 0.0046 0.0129 0.0123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0192 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0025 0.0505
Trichomonas vaginalis CAMK family protein kinase 0.225 0.918 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0036 0.0021
Schistosoma mansoni importin beta-1 0.0025 0.0043 0.0041
Schistosoma mansoni phosphoglucomutase 0.0029 0.0058 0.0056
Mycobacterium tuberculosis Conserved protein 0.0036 0.009 0.1001
Trichomonas vaginalis sucrase-isomaltase, putative 0.003 0.0064 0.0052
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0181 1
Brugia malayi beta-lactamase 0.0036 0.009 0.0091
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0094
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.009 0.1001
Schistosoma mansoni alpha-glucosidase 0.0117 0.042 0.0451
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.0108 0.7083
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0095 0.608
Schistosoma mansoni hypothetical protein 0.0046 0.0129 0.0134
Echinococcus granulosus importin subunit beta 1 0.0025 0.0043 0.003
Echinococcus granulosus aryl hydrocarbon receptor 0.0039 0.0102 0.0093
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0048 0.0138 0.0146
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0041 0.0108 0.4438
Toxoplasma gondii ribonuclease HI protein 0.0029 0.0058 0.2513
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0064 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0003
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0039 0.0102 0.0107
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0166 0.015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.009 0.0091
Loa Loa (eye worm) hypothetical protein 0.0145 0.0536 0.058
Brugia malayi RNA, U transporter 1 0.0071 0.0234 0.0248
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0041 0.0108 0.2515
Trichomonas vaginalis esterase, putative 0.0036 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0129 0.0136
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0138 0.0144
Leishmania major protein kinase, putative 0.0038 0.0095 0.4467
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0023
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0138 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0025 0.1137
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0166 0.0163
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.1753 0.1739
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.009 0.008
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0023 0.0036 0.1517
Brugia malayi bHLH-PAS transcription factor 0.0047 0.0132 0.0137
Brugia malayi Glycosyl hydrolases family 31 protein 0.0136 0.0497 0.0536
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.009 0.2023
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0064 0.0052
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0192 0.0203
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0064 0.0052
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0016 0.0014
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0031 0.0067 0.1412
Echinococcus granulosus single minded 2 0.0047 0.0132 0.0126
Schistosoma mansoni phosphoglucomutase 0.0029 0.0058 0.0056
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0023 0.0035 0.0021
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.003 0.0064 0.0066
Trichomonas vaginalis importin beta-1, putative 0.002 0.0024 0.0008
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0041 0.0108 0.0092
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0038 0.0095 0.608
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0025 0.1137
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0016 0.0011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0268 0.1042 0.1132
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0094
Leishmania major alpha glucosidase II subunit, putative 0.003 0.0064 0.2709
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0067 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0025 0.0431
Mycobacterium tuberculosis Conserved protein 0.0036 0.009 0.1001
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0043 0.0748
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0023 0.0036 0.002
Trypanosoma cruzi ribonuclease H1, putative 0.0029 0.0058 0.3206
Schistosoma mansoni intermediate filament proteins 0.0048 0.0138 0.0144
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0064 0.231
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0025 0.0021
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0041 0.0108 0.0111
Leishmania major hypothetical protein, conserved 0.005 0.0145 0.7348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0003
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0138 0.0134
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0016 0.0884
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.009 0.008
Onchocerca volvulus 0.0036 0.009 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0036 0.009 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.0108 0.7083
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0023 0.0036 0.0021
Echinococcus multilocularis lysosomal alpha glucosidase 0.0136 0.0497 0.0482
Brugia malayi Calcitonin receptor-like protein seb-1 0.0145 0.0536 0.0578
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0064 0.231
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.009 0.008
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0043 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.009 0.008
Mycobacterium ulcerans hypothetical protein 0.0021 0.0025 0.1137
Echinococcus granulosus microtubule associated protein 2 0.0738 0.2973 0.3227
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0032 0.0016
Trypanosoma cruzi ribonuclease H1, putative 0.0029 0.0058 0.3206
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0067 0.1412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0143 0.0149
Brugia malayi hypothetical protein 0.0235 0.0903 0.0978
Trypanosoma brucei ribonuclease H1 0.0029 0.0058 0.1138
Schistosoma mansoni single-minded 0.007 0.0227 0.0241
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0064 0.0052
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0138 0.0144
Echinococcus granulosus lamin dm0 0.0048 0.0138 0.0133
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0129 0.0123
Brugia malayi PAS domain containing protein 0.007 0.0227 0.0241
Echinococcus multilocularis cpg binding protein 0.0033 0.0075 0.0059
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.009 0.4573
Schistosoma mansoni cpg binding protein 0.0033 0.0075 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0145 1
Echinococcus multilocularis ribonuclease H1 0.0029 0.0058 0.0042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0136 0.0497 0.0538
Brugia malayi mbt repeat family protein 0.0048 0.0138 0.0144
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0025 0.1137
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0032 0.0018
Schistosoma mansoni aryl hydrocarbon receptor 0.007 0.0227 0.0241
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0003
Brugia malayi beta-lactamase family protein 0.0036 0.009 0.0091
Echinococcus granulosus cpg binding protein 0.0033 0.0075 0.0064
Mycobacterium tuberculosis Conserved protein 0.0036 0.009 0.1001
Brugia malayi RNase H family protein 0.0029 0.0058 0.0056
Onchocerca volvulus 0.0036 0.009 0.0091
Brugia malayi hypothetical protein 0.0138 0.0507 0.0547
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0025 0.1137
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.225 0.918 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0143 0.0127
Echinococcus multilocularis lysosomal alpha glucosidase 0.0136 0.0497 0.0482
Schistosoma mansoni hypothetical protein 0.0099 0.0347 0.0372
Mycobacterium ulcerans beta-lactamase 0.0036 0.009 0.4573
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0023 0.0036 0.0021
Mycobacterium ulcerans hypothetical protein 0.0036 0.009 0.4573
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0897 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0145 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0041 0.0108 0.5552
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0129 0.0123
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0043 0.165
Brugia malayi Protein kinase domain containing protein 0.225 0.918 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0069 0.0223 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.009 0.1001
Onchocerca volvulus Ribonuclease H1 homolog 0.0029 0.0058 0.0056
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0023 0.0035 0.002
Onchocerca volvulus 0.0048 0.0138 0.0144
Schistosoma mansoni hypothetical protein 0.0046 0.0129 0.0134
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0129 0.0134
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.0108 0.7341
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0064 0.3686
Loa Loa (eye worm) hypothetical protein 0.0069 0.0223 0.0239
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0023 0.0036 0.0021
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0041 0.0108 0.5205
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.009 0.1001
Onchocerca volvulus 0.0048 0.0138 0.0144
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0025 0.1137
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0046 0.0044
Brugia malayi RNase H family protein 0.0029 0.0058 0.0056
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0023 0.0036 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.009 0.0091
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0041 0.0108 0.01
Leishmania major hypothetical protein, conserved 0.0036 0.009 0.4186
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0094
Trichomonas vaginalis guanylate cyclase, putative 0.0023 0.0036 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.009 0.008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0129 0.0113
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0016 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0138 0.0146
Schistosoma mansoni hypothetical protein 0.0046 0.0129 0.0134
Echinococcus granulosus lysosomal alpha glucosidase 0.0136 0.0497 0.0525
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0038 0.0095 0.608
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.009 0.4573
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0138 0.0123
Echinococcus multilocularis snurportin 1 0.0268 0.1042 0.1028
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0025 0.0278
Onchocerca volvulus Huntingtin homolog 0.0219 0.0839 0.0908
Giardia lamblia Ribonuclease H 0.0029 0.0058 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0143 0.0149
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0722 0.0707
Onchocerca volvulus 0.0021 0.0025 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0145 0.7838
Brugia malayi beta-lactamase family protein 0.0036 0.009 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0023
Leishmania major importin beta-1 subunit, putative 0.002 0.0024 0.0439
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0067 0.1412
Echinococcus granulosus neutral alpha glucosidase AB 0.003 0.0064 0.0052
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0138 0.0144
Echinococcus multilocularis neutral alpha glucosidase AB 0.003 0.0064 0.0048
Mycobacterium leprae Probable lipase LipE 0.0036 0.009 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0036 0.0021
Schistosoma mansoni hypothetical protein 0.0046 0.0129 0.0134
Echinococcus granulosus intermediate filament protein 0.0048 0.0138 0.0133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0143 0.0138
Brugia malayi latrophilin 2 splice variant baaae 0.0099 0.0347 0.0372
Onchocerca volvulus 0.0048 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.005 0.0145 0.0155
Loa Loa (eye worm) hypothetical protein 0.0138 0.0507 0.0549
Plasmodium vivax hypothetical protein, conserved 0.0036 0.009 0.6077
Mycobacterium leprae Possible regulatory protein 0.0023 0.0036 0.1656
Echinococcus granulosus ribonuclease H1 0.0029 0.0058 0.0045
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0192 0.2143
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0024 0.0008
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0138 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0031
Schistosoma mansoni hypothetical protein 0.0022 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0441 0.1753 0.1895
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0166 0.0163
Onchocerca volvulus 0.0031 0.0067 0.0067
Brugia malayi hypoxia-induced factor 1 0.0195 0.0742 0.0802
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0268 0.1042 0.1129
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0095 0.608
Giardia lamblia Kinase, TTK 0.225 0.918 1
Trichomonas vaginalis guanylate cyclase, putative 0.0023 0.0036 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0143 0.0127
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0099 0.0347 0.0375
Plasmodium vivax importin-beta 2, putative 0.0025 0.0043 0.2804
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.009 0.0094
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0024 0.0008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.009 0.0074
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0023 0.0036 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0143 0.0138
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0043 0.0748
Toxoplasma gondii ABC1 family protein 0.0036 0.009 0.4465
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.0016 0.0884
Brugia malayi RNase H family protein 0.0029 0.0058 0.0056
Plasmodium falciparum importin beta, putative 0.0025 0.0043 0.2804
Schistosoma mansoni hypothetical protein 0.0107 0.0381 0.0408
Trichomonas vaginalis adenylate cyclase, putative 0.0023 0.0036 0.0021
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0175 0.0187
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0138 0.0147
Onchocerca volvulus Huntingtin homolog 0.0219 0.0839 0.0908
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0023 0.0036 0.0021
Schistosoma mansoni cpg binding protein 0.0033 0.0075 0.0075
Schistosoma mansoni lamin 0.0048 0.0138 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0129 0.0113
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0064 0.0052
Onchocerca volvulus 0.0047 0.0132 0.0137
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0025 0.1137
Loa Loa (eye worm) TTK protein kinase 0.225 0.918 1
Onchocerca volvulus 0.0036 0.009 0.0091
Echinococcus multilocularis aryl hydrocarbon receptor 0.0039 0.0102 0.0086
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.0177
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0138 0.0134
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0143 0.0149
Echinococcus granulosus lamin 0.0048 0.0138 0.0133
Schistosoma mansoni microtubule-associated protein tau 0.0738 0.2973 0.3234
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0192 0.0192
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0069 0.0223 1
Echinococcus multilocularis musashi 0.0048 0.0138 0.0122
Brugia malayi Intermediate filament tail domain containing protein 0.0048 0.0138 0.0144
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.0108 0.7341
Schistosoma mansoni ran 0.0018 0.0016 0.0011
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.225 0.918 1
Entamoeba histolytica hypothetical protein 0.002 0.0024 0.0374
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0192 0.0203
Schistosoma mansoni alpha glucosidase 0.003 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.009 0.0094
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0023 0.0036 0.1115
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0067 0.1412
Trypanosoma brucei unspecified product 0.0031 0.0067 0.1412
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0023 0.0036 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0129 0.0136
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0025 0.0431
Entamoeba histolytica acyl-coA synthetase, putative 0.0021 0.0025 0.0431
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.009 0.1001
Mycobacterium ulcerans putative regulatory protein 0.0047 0.0132 0.68
Echinococcus multilocularis GPCR, family 2 0.0046 0.0129 0.0113
Schistosoma mansoni hypothetical protein 0.0294 0.1146 0.1242
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0166 0.015
Schistosoma mansoni alpha-glucosidase 0.0117 0.042 0.0451
Loa Loa (eye worm) beta-lactamase 0.0036 0.009 0.0094
Schistosoma mansoni lamin 0.0048 0.0138 0.0144
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0023 0.0036 0.1517
Loa Loa (eye worm) hypothetical protein 0.0219 0.0839 0.091
Loa Loa (eye worm) hypothetical protein 0.0219 0.0839 0.091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0143 0.0149
Brugia malayi Importin beta-1 subunit 0.0025 0.0043 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0025 0.0505
Loa Loa (eye worm) hypothetical protein 0.0235 0.0903 0.0981
Brugia malayi hypothetical protein 0.005 0.0145 0.0152
Trypanosoma brucei glucosidase, putative 0.003 0.0064 0.1309
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0064 0.3686
Trichomonas vaginalis CAMK family protein kinase 0.225 0.918 1
Brugia malayi mbt repeat family protein 0.0048 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0048 0.0138 0.0147
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0145 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0036 0.0021
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.009 0.1001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0064 0.0052
Trichomonas vaginalis ribonuclease H1, putative 0.0029 0.0058 0.0045
Onchocerca volvulus 0.0039 0.0102 0.0104
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0064 0.0052
Loa Loa (eye worm) intermediate filament protein 0.0048 0.0138 0.0146
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0192 1
Brugia malayi hypothetical protein 0.0032 0.0073 0.0073
Brugia malayi intermediate filament protein 0.0048 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0134 0.0142
Schistosoma mansoni cpg binding protein 0.0031 0.0067 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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