Detailed information for compound 1860074

Basic information

Technical information
  • TDR Targets ID: 1860074
  • Name: 3-(3,4-dimethylphenyl)-N-[(4-methoxyphenyl)me thylideneamino]-4-oxophthalazine-1-carboxamid e
  • MW: 426.467 | Formula: C25H22N4O3
  • H donors: 1 H acceptors: 2 LogP: 4.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=N/NC(=O)c1nn(c2ccc(c(c2)C)C)c(=O)c2c1cccc2
  • InChi: 1S/C25H22N4O3/c1-16-8-11-19(14-17(16)2)29-25(31)22-7-5-4-6-21(22)23(28-29)24(30)27-26-15-18-9-12-20(32-3)13-10-18/h4-15H,1-3H3,(H,27,30)/b26-15+
  • InChiKey: PXXBROVSCOXZDO-CVKSISIWSA-N  


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Synonyms

  • 3-(3,4-dimethylphenyl)-N-[(4-methoxyphenyl)methyleneamino]-4-oxo-phthalazine-1-carboxamide
  • 3-(3,4-dimethylphenyl)-N-[(4-methoxyphenyl)methyleneamino]-4-oxo-1-phthalazinecarboxamide
  • 3-(3,4-dimethylphenyl)-4-keto-N-[(4-methoxybenzylidene)amino]phthalazine-1-carboxamide
  • 3-(3,4-dimethylphenyl)-N-[(4-methoxyphenyl)methylideneamino]-4-oxo-phthalazine-1-carboxamide
  • 4P-664S
  • 3-(3,4-dimethylphenyl)-N'-[(E)-(4-methoxyphenyl)methylidene]-4-oxo-3,4-dihydro-1-phthalazinecarbohydrazide
  • MLS000326940
  • SMR000179440

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0193 0.4562
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0423 0.5972
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.028 0.0257
Loa Loa (eye worm) hypothetical protein 0.0037 0.0589 0.1663
Echinococcus multilocularis geminin 0.0205 0.3903 1
Leishmania major glucose transporter, lmgt3 0.0037 0.0598 0.8587
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0693 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0598 0.2586
Mycobacterium ulcerans sugar transporter 0.0017 0.0193 0.4247
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Brugia malayi Sugar transporter family protein 0.0121 0.2247 0.654
Brugia malayi lysyl-tRNA synthetase 0.0027 0.039 0.108
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0193 0.0764
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0589 0.0567
Loa Loa (eye worm) sugar transporter 0.0017 0.0193 0.0499
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0423 0.7069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0439 0.1224
Echinococcus multilocularis General substrate transporter 0.0104 0.1911 0.4866
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0589 0.0567
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0423 0.7069
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0693 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0764
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.031 0.7328
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.039 0.0947
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Plasmodium falciparum hexose transporter 0.0121 0.2247 0.2229
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Brugia malayi Sugar transporter family protein 0.0017 0.0193 0.0499
Loa Loa (eye worm) hypothetical protein 0.0027 0.039 0.108
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0423 1
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0438
Loa Loa (eye worm) hypothetical protein 0.0029 0.0423 0.1176
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 0.5732
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0193 0.4247
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0423 0.5972
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0589 0.2544
Schistosoma mansoni glucose transport protein 0.0121 0.2247 0.5732
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Echinococcus granulosus geminin 0.0205 0.3903 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0589 0.1663
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0193 0.0499
Onchocerca volvulus 0.0017 0.0193 0.4247
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 0.5732
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.039 0.1651
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.039 0.6668
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0023 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0257 0.6071
Plasmodium falciparum mitogen-activated protein kinase 2 0.0195 0.3719 0.3704
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0693 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0423 1
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0193 0.0258
Entamoeba histolytica protein kinase, putative 0.0037 0.0589 1
Plasmodium falciparum protein kinase 7 0.0342 0.6609 0.6601
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0023 0.0546
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0755
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0589 0.0567
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.1458
Onchocerca volvulus 0.0017 0.0193 0.4247
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.028 0.6421
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0598 0.8587
Entamoeba histolytica protein kinase, putative 0.0037 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0574 0.162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0598 0.2586
Schistosoma mansoni glucose transport protein 0.0121 0.2247 0.5732
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.1458
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.031 0.7328
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0423 0.726
Schistosoma mansoni glucose transport protein 0.0121 0.2247 0.5732
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.039 0.5485
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0589 0.1458
Onchocerca volvulus 0.0017 0.0193 0.4247
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0589 0.0859
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0589 0.1663
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.028 0.0257
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Onchocerca volvulus 0.0029 0.0423 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0574 0.162
Onchocerca volvulus 0.0017 0.0193 0.4247
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0438
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0023 0.0546
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0598 0.8587
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0574 0.9738
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Onchocerca volvulus 0.0017 0.0193 0.4247
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.028 0.6617
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0755
Plasmodium vivax CDK-related protein kinase 6, putative 0.0513 1 1
Onchocerca volvulus Putative transporter 0.0017 0.0193 0.4247
Plasmodium vivax hexose transporter 0.0121 0.2247 0.2229
Onchocerca volvulus 0.0017 0.0193 0.4247
Plasmodium vivax sugar transporter, putative 0.0017 0.0193 0.017
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Loa Loa (eye worm) hypothetical protein 0.018 0.3423 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Onchocerca volvulus 0.0017 0.0193 0.4247
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0598 0.2586
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0121 0.2247 0.5732
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0193 0.4247
Brugia malayi major facilitator superfamily protein 0.0017 0.0193 0.0499
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0438
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0438
Brugia malayi hypothetical protein 0.0017 0.0193 0.0499
Echinococcus granulosus muscleblind protein 0.018 0.3423 0.8765
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0423 1
Brugia malayi Cam kinase protein 1 0.0037 0.0589 0.1663
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0193 0.4247
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Entamoeba histolytica hypothetical protein 0.0027 0.039 0.6493
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.039 0.0368
Onchocerca volvulus 0.0017 0.0193 0.4247
Schistosoma mansoni glucose transporter 0.0017 0.0193 0.0438
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0423 0.1176
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0438
Schistosoma mansoni hypothetical protein 0.0205 0.3903 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0589 0.0859
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0438
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0598 0.2586
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.1458
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Schistosoma mansoni protein kinase 0.0037 0.0589 0.1458
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.039 0.5182
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0193 0.0438
Brugia malayi Muscleblind-like protein 0.018 0.3423 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0023 0.0546
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Trypanosoma cruzi hexose transporter, putative 0.002 0.0262 0.3568
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0423 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0574 0.142
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0257 0.6071
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Toxoplasma gondii facilitative glucose transporter GT1 0.0121 0.2247 0.3376
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0764
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0023 0.0546
Schistosoma mansoni hypothetical protein 0.0121 0.2247 0.5732
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.039 0.0947
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0589 0.0567
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0574 0.142
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0598 0.8587
Schistosoma mansoni hypothetical protein 0.0205 0.3903 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0589 0.0567
Brugia malayi major facilitator superfamily protein 0.0017 0.0193 0.0499
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0193 0.0438
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0755
Trypanosoma brucei sugar transporter, putative 0.0017 0.0193 0.2536
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0598 0.8587
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 0.5732
Loa Loa (eye worm) hypothetical protein 0.0036 0.0574 0.162
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0598 0.8587
Schistosoma mansoni protein kinase 0.0037 0.0589 0.1458
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0151 0.0377
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0589 0.8447
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0574 0.142
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0598 0.2586
Trypanosoma brucei glucose transporter 2A 0.0037 0.0598 0.8587
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0023 0.0546
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2247 0.5732
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0589 0.0567
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0598 0.8587
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Onchocerca volvulus 0.0017 0.0193 0.4247
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2247 1
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0438
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0257 0.6071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0423 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0023 0.0546
Brugia malayi Sugar transporter family protein 0.0017 0.0193 0.0499
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0257 0.6071
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0423 0.1176
Loa Loa (eye worm) sugar transporter 0.0121 0.2247 0.654
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0193 0.2536
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0574 0.142
Echinococcus multilocularis muscleblind protein 0.018 0.3423 0.8765
Trypanosoma brucei glucose transporter 1E 0.0037 0.0598 0.8587
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0193 0.0438
Onchocerca volvulus 0.0017 0.0193 0.4247
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.1458
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0598 0.2586
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0195 0.3719 0.5611
Toxoplasma gondii protein kinase, putative 0.0342 0.6609 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0589 0.0567
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0193 0.0499
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.011 0.5
Brugia malayi hypothetical protein 0.0017 0.0193 0.0499
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0693 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0693 0.0671
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0193 0.0764
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2247 0.5732
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0195 0.3719 0.3704
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0193 0.0438
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.039 0.5485
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Schistosoma mansoni protein kinase 0.0037 0.0589 0.1458
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0543 0.1341
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.039 0.9184
Echinococcus granulosus solute carrier family 22 0.0017 0.0193 0.0438
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0193 0.0438
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0589 0.1458
Loa Loa (eye worm) hypothetical protein 0.018 0.3423 1
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0598 0.8587
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.1458
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.039 1
Leishmania major hypothetical protein, conserved 0.0017 0.0193 0.2536
Loa Loa (eye worm) hypothetical protein 0.0029 0.0423 0.1176
Echinococcus multilocularis muscleblind protein 1 0.018 0.3423 0.8765
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0423 1
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0438
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0193 0.0499
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.028 0.6057
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0574 0.2477
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0423 0.1176
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0574 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0423 0.726
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.011 0.2177
Leishmania major glucose transporter, lmgt2 0.0037 0.0598 0.8587
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0193 0.2536
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0423 0.1176
Onchocerca volvulus 0.0017 0.0193 0.4247
Onchocerca volvulus 0.0017 0.0193 0.4247
Brugia malayi hypothetical protein 0.0017 0.0193 0.0499
Leishmania major protein kinase, putative 0.0037 0.0589 0.8447
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0023 0.0546
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.039 0.0558
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0193 0.5
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0693 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.031 0.5208
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0193 0.2536
Leishmania major glucose transporter, lmgt1 0.0037 0.0598 0.8587
Trypanosoma brucei glucose transporter, putative 0.0037 0.0598 0.8587
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2247 0.5732
Toxoplasma gondii sugar transporter ST1 0.0017 0.0193 0.0258
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.039 0.0947
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0589 0.1663
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0193 0.0764
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.039 0.0368
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.039 0.9184
Onchocerca volvulus 0.0017 0.0193 0.4247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0574 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0589 0.0567
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.1458
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0693 1
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0543 0.1341
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0438
Loa Loa (eye worm) hypothetical protein 0.0017 0.0193 0.0499
Toxoplasma gondii sugar transporter ST3 0.0017 0.0193 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Echinococcus granulosus General substrate transporter 0.0104 0.1911 0.4866
Onchocerca volvulus 0.0017 0.0193 0.4247
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0193 0.0499
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0423 0.7069
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0423 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0193 0.017
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0755
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0193 0.2536
Mycobacterium ulcerans hypothetical protein 0.0029 0.0423 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0589 0.0859
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0193 0.2536
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0193 0.4562
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0589 0.0567
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0755
Toxoplasma gondii sugar transporter ST2 0.0017 0.0193 0.0258
Onchocerca volvulus 0.0017 0.0193 0.4247
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2247 0.5732
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0693 0.0671
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0193 0.0764
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0574 0.162
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0598 0.2586
Echinococcus multilocularis solute carrier family 22 0.0017 0.0193 0.0438
Trypanosoma cruzi hexose transporter 0.0037 0.0598 0.8587
Onchocerca volvulus 0.0017 0.0193 0.4247
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.039 0.5485
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0423 0.5972
Schistosoma mansoni sugar transporter 0.0017 0.0193 0.0438
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0589 0.1458
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.039 0.0947
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0325 0.1356
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0193 0.0499

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.0131 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) 6.3096 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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