TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 573.994 | Formula: C28H27ClF3N5O3
H donors: 0 H acceptors: 4 LogP: 4.22 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)OC1(CCCN(C1)C(=O)c1cnccc1C(F)(F)F)C(=O)N1CCN(CC1)c1ccccn1
InChi: 1S/C28H27ClF3N5O3/c29-20-5-7-21(8-6-20)40-27(26(39)36-16-14-35(15-17-36)24-4-1-2-11-34-24)10-3-13-37(19-27)25(38)22-18-33-12-9-23(22)28(30,31)32/h1-2,4-9,11-12,18H,3,10,13-17,19H2
InChiKey: DLRIEDHBJGWWTG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin B precursor	0.0118	0.1342	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Giardia lamblia	Cathepsin B precursor	0.0024	0.0183	0.1336
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Schistosoma mansoni	hypothetical protein	0.0149	0.1714	0.4357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0023	0.0178	0.0444
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0009	0.0004	0.001
Onchocerca volvulus		0.0061	0.0639	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0024	0.0183	0.1336
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0183	0.0465
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0826	1	1
Giardia lamblia	Cathepsin L precursor	0.0024	0.0183	0.1336
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0768	0.9288	1
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0183	0.2322
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0024	0.0183	0.1336
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0058	0.0605	0.153
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0013	0.0051	0.012
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0169	0.0431
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0024	0.0183	0.1336
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751
Giardia lamblia	Hypothetical protein	0.0024	0.0183	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0099	0.0253
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0267	0.316	0.8038
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0079	0.0854	0.6352
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Trypanosoma cruzi	cruzipain precursor, putative	0.0061	0.0639	0.1619
Schistosoma mansoni	hypothetical protein	0.0013	0.0051	0.012
Loa Loa (eye worm)	TK/FAK protein kinase	0.0009	0.0004	0.001
Mycobacterium ulcerans	oxidoreductase	0.0058	0.0605	0.051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0061	0.0639	0.4751
Giardia lamblia	Cathepsin B precursor	0.0024	0.0183	0.1336
Giardia lamblia	Cathepsin B precursor	0.0024	0.0183	0.1336
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0024	0.0183	0.2103
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0432	0.1091
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0024	0.0183	0.0465
Plasmodium falciparum	histone acetyltransferase GCN5	0.0072	0.0774	1
Onchocerca volvulus		0.0061	0.0639	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.0639	0.8257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0061	0.0639	0.4751
Entamoeba histolytica	cysteine protease, putative	0.0061	0.0639	0.8257
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0169	0.0071
Echinococcus multilocularis	cysteine protease	0.0061	0.0639	0.1619
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0024	0.0183	0.2103
Plasmodium vivax	unspecified product	0.0024	0.0183	0.2103
Giardia lamblia	Cathepsin B precursor	0.0024	0.0183	0.1336
Plasmodium vivax	vivapain-1	0.0024	0.0183	0.2103
Trypanosoma cruzi	major cysteine proteinase, putative	0.0024	0.0183	0.0455
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0009	0.0004	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0169	0.0071
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0183	0.0455
Echinococcus granulosus	cathepsin b	0.033	0.393	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0024	0.0183	0.0455
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0024	0.0183	0.1336
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0099	0.0012
Echinococcus multilocularis	cathepsin L cysteine protease	0.0061	0.0639	0.1619
Toxoplasma gondii	cathepsin B	0.0118	0.1342	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Schistosoma mansoni	tyrosine kinase	0.0013	0.0056	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Trichomonas vaginalis	chaperonin, putative	0.0023	0.0178	0.1303
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0169	0.0421
Echinococcus multilocularis	roundabout 2	0.0012	0.0037	0.0085
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0061	0.0639	0.1619
Plasmodium vivax	vivapain-2	0.0061	0.0639	0.7479
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0023	0.0178	0.1303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0183	0.1336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0024	0.0183	0.1336
Entamoeba histolytica	cysteine proteinase 2	0.0024	0.0183	0.2322
Onchocerca volvulus		0.0058	0.0605	0.9453
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0432	0.1091
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0058	0.0605	1
Giardia lamblia	Cathepsin L precursor	0.0024	0.0183	0.1336
Echinococcus multilocularis	cathepsin b	0.033	0.393	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0169	0.2149
Plasmodium falciparum	serine repeat antigen 5	0.0024	0.0183	0.2322
Echinococcus granulosus	cathepsin L cysteine protease	0.0024	0.0183	0.0455
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0605	0.707
Onchocerca volvulus		0.0061	0.0639	1
Giardia lamblia	Cathepsin B precursor	0.0024	0.0183	0.1336
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.033	0.393	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0024	0.0183	0.0455
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0061	0.0639	0.1619
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	ctsf protein	0.0061	0.0639	0.1627
Loa Loa (eye worm)	cysteine protease	0.0061	0.0639	0.1627
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0023	0.0178	0.2265
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0024	0.0183	0.1336
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0079	0.0854	0.6352
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0024	0.0183	0.2103
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Brugia malayi	amine oxidase, flavin-containing family protein	0.0058	0.0605	0.153
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Echinococcus multilocularis	cathepsin L cysteine protease	0.0061	0.0639	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Schistosoma mansoni	cathepsin C	0.0024	0.0183	0.0455
Plasmodium vivax	serine-repeat antigen (SERA)	0.0024	0.0183	0.2103
Onchocerca volvulus		0.0061	0.0639	1
Onchocerca volvulus		0.0013	0.0051	0.0742
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0024	0.0183	0.2322
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0169	0.0421
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0058	0.0605	1
Onchocerca volvulus	Cathepsin L homolog	0.0061	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0169	0.0431
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0024	0.0183	0.1336
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0058	0.0605	0.707
Entamoeba histolytica	hypothetical protein	0.001	0.0019	0.0192
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0024	0.0183	0.0455
Schistosoma mansoni	hypothetical protein	0.0149	0.1714	0.4357
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0183	0.1336
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0058	0.0605	0.7806
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0058	0.0605	0.153
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0183	0.2322
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.0639	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Schistosoma mansoni	hypothetical protein	0.0013	0.0051	0.012
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Toxoplasma gondii	cathepsin CPC1	0.0024	0.0183	0.1336
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0058	0.0605	0.153
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Plasmodium vivax	vivapain-2	0.0061	0.0639	0.7479
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0024	0.0183	0.2103
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0009	0.0004	0.001
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0058	0.0605	0.7806
Plasmodium falciparum	serine repeat antigen 1	0.0024	0.0183	0.2322
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0118	0.1342	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0169	0.0071
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.0639	0.1619
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.033	0.393	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0013	0.0051	0.0613
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0056	0.0142
Plasmodium vivax	vivapain-3	0.0024	0.0183	0.2103
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0432	0.11
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0061	0.0639	0.8257
Giardia lamblia	Cathepsin L precursor	0.0024	0.0183	0.1336
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Echinococcus multilocularis	SWI:SNF matrix associated	0.0013	0.0051	0.012
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0058	0.0605	0.153
Giardia lamblia	Cysteine protease	0.0024	0.0183	0.1336
Entamoeba histolytica	cysteine proteinase 1, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0183	0.0465
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0024	0.0183	0.2322
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0605	0.1539
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0432	0.1091
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0432	0.1091
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0259	0.3068	0.7805
Brugia malayi	cathepsin L precursor	0.0024	0.0183	0.0455
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0013	0.0051	0.013
Plasmodium falciparum	serine repeat antigen 7	0.0024	0.0183	0.2322
Loa Loa (eye worm)	TK/RYK protein kinase	0.0009	0.0004	0.001
Loa Loa (eye worm)	TK/INSR protein kinase	0.0009	0.0004	0.001
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0051	0.0555
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Echinococcus granulosus	roundabout 2	0.0012	0.0037	0.0085
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0639	0.1619
Brugia malayi	T-complex protein 1, beta subunit	0.0023	0.0178	0.0444
Echinococcus multilocularis	cathepsin L	0.0024	0.0183	0.0455
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0023	0.0178	0.2052
Plasmodium vivax	serine-repeat antigen (SERA)	0.0024	0.0183	0.2103
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0024	0.0183	0.0455
Giardia lamblia	Hypothetical protein	0.0024	0.0183	0.1336
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0024	0.0183	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Loa Loa (eye worm)	TK/ALK protein kinase	0.0009	0.0004	0.001
Brugia malayi	EGF-like domain containing protein	0.0029	0.0243	0.061
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0099	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0037	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0024	0.0183	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0169	0.0431
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0024	0.0183	0.0465
Trypanosoma cruzi	cysteine proteinase, putative	0.0024	0.0183	0.0455
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0024	0.0183	0.0455
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0024	0.0183	0.2103
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.0639	0.8257
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0024	0.0183	0.0455
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0023	0.0178	0.0444
Echinococcus multilocularis	cathepsin L	0.0024	0.0183	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0013	0.0051	0.012
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0058	0.0605	0.153
Entamoeba histolytica	hypothetical protein	0.0024	0.0183	0.2322
Loa Loa (eye worm)	brahma associated protein	0.0013	0.0051	0.013
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Schistosoma mansoni	brg-1 associated factor	0.0013	0.0051	0.012
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0079	0.0854	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0024	0.0183	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0099	0.0253
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0024	0.0183	0.0455
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0061	0.0639	0.1619
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0169	0.0088
Brugia malayi	T-complex protein 1, beta subunit	0.0023	0.0178	0.0444
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0061	0.0639	0.8257
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0024	0.0183	0.2322
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0183	0.0455
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0118	0.1342	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0024	0.0183	0.1336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0024	0.0183	0.2103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Brugia malayi	brahma associated protein 60 kDa	0.0013	0.0051	0.012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Loa Loa (eye worm)	hypothetical protein	0.033	0.393	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0061	0.0639	0.8257
Giardia lamblia	Cysteine protease	0.0024	0.0183	0.1336
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.001	0.0019	0.0192
Entamoeba histolytica	hypothetical protein	0.001	0.0019	0.0192
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TK/CSK protein kinase	0.0009	0.0004	0.001
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0058	0.0605	0.153
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0009	0.0004	0.001
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0169	0.0421
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0099	0.1241
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0432	0.1091
Giardia lamblia	Cathepsin L precursor	0.0024	0.0183	0.1336
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0013	0.0056	0.0132
Brugia malayi	fibroinase precursor	0.0024	0.0183	0.0455
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0058	0.0605	0.153
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0605	0.1539
Plasmodium falciparum	protoporphyrinogen oxidase	0.0058	0.0605	0.7806
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0183	0.0455
Onchocerca volvulus		0.0027	0.0228	0.3533
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.0639	0.8257
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0013	0.0056	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0169	0.0071
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0432	0.1091
Onchocerca volvulus	Cathepsin L homolog	0.0061	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0099	0.0253
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0009	0.0004	0.001
Schistosoma mansoni	cathepsin B (C01 family)	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0017	0.0096	0.0245
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0639	0.1627
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0169	0.1237
Brugia malayi	hypothetical protein	0.0058	0.0605	0.153
Toxoplasma gondii	cathepsin CPC2	0.0024	0.0183	0.1336
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Echinococcus multilocularis	neuroglian	0.0012	0.0037	0.0085
Schistosoma mansoni	cathepsin F (C01 family)	0.0061	0.0639	0.1619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Onchocerca volvulus		0.0023	0.0169	0.2603
Mycobacterium ulcerans	dehydrogenase	0.0058	0.0605	0.051
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0009	0.0004	0.001
Giardia lamblia	Histone acetyltransferase GCN5	0.0072	0.0774	0.5753
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Onchocerca volvulus	Slit protein homolog	0.0029	0.0243	0.3766
Leishmania major	T-complex protein 1, beta subunit, putative	0.0023	0.0178	0.1303
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0024	0.0183	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Schistosoma mansoni	amine oxidase	0.0058	0.0605	0.153
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0061	0.0639	0.1619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Echinococcus granulosus	cysteine protease	0.0024	0.0183	0.0455
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0058	0.0605	0.707
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	TK/Met protein kinase	0.0009	0.0004	0.001
Entamoeba histolytica	hypothetical protein	0.001	0.0019	0.0192
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0061	0.0639	0.1627
Entamoeba histolytica	acetyltransferase, GNAT family	0.0072	0.0774	1
Echinococcus granulosus	slit 2 protein	0.0029	0.0243	0.061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0183	0.0465
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0024	0.0183	0.2103
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0183	0.0465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0024	0.0183	0.1336
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0061	0.0639	0.1619
Giardia lamblia	Cathepsin L precursor	0.0024	0.0183	0.1336
Plasmodium vivax	unspecified product	0.0024	0.0183	0.2103
Echinococcus multilocularis	SWI:SNF matrix associated	0.0013	0.0051	0.012
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0024	0.0183	0.0455
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0058	0.0605	0.051
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0118	0.1342	1
Plasmodium falciparum	serine repeat antigen 6	0.0024	0.0183	0.2322
Entamoeba histolytica	protein kinase, putative	0.001	0.0019	0.0192
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.0183	0.1336
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0183	0.2322
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.0639	0.1619
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.0639	0.1619
Schistosoma mansoni	hypothetical protein	0.0013	0.0051	0.012
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0013	0.0051	0.0352
Loa Loa (eye worm)	TK/ACK protein kinase	0.0009	0.0004	0.001
Echinococcus multilocularis	cysteine protease	0.0061	0.0639	0.1619
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0183	0.0465
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Schistosoma mansoni	cathepsin F (C01 family)	0.0061	0.0639	0.1619
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0605	0.707
Plasmodium falciparum	serine repeat antigen 4	0.0024	0.0183	0.2322
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0024	0.0183	0.1336
Mycobacterium tuberculosis	Possible oxidoreductase	0.0058	0.0605	0.0561
Brugia malayi	SWIB/MDM2 domain containing protein	0.0013	0.0051	0.012
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0267	0.316	0.8038
Giardia lamblia	Cysteine protease	0.0024	0.0183	0.1336
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0061	0.0639	0.1627
Toxoplasma gondii	t-complex protein beta subunit	0.0023	0.0178	0.1303
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0183	0.1336
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.033	0.393	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Onchocerca volvulus		0.0061	0.0639	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0024	0.0183	0.2322
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0024	0.0183	0.2103
Schistosoma mansoni	amine oxidase	0.0058	0.0605	0.153
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Loa Loa (eye worm)	serine/threonine protein kinase	0.0009	0.0004	0.001
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0009	0.0004	0.001
Brugia malayi	SWIRM domain containing protein	0.0058	0.0605	0.153
Giardia lamblia	Cysteine protease	0.0024	0.0183	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Echinococcus granulosus	geminin	0.0149	0.1714	0.4357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.0183	0.1336
Brugia malayi	Cathepsin L-like precursor	0.0061	0.0639	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0605	0.1539
Loa Loa (eye worm)	fibroinase	0.0061	0.0639	0.1627
Echinococcus granulosus	SWI:SNF matrix associated	0.0013	0.0051	0.012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Onchocerca volvulus		0.0061	0.0639	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0009	0.0004	0.001
Giardia lamblia	Cathepsin L-like protease	0.0024	0.0183	0.1336
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0024	0.0183	0.0455
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0079	0.0854	0.6352
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0099	0.1124
Echinococcus granulosus	cathepsin b	0.033	0.393	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0013	0.0056	0.0817
Loa Loa (eye worm)	TK protein kinase	0.0009	0.0004	0.001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0169	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0009	0.0004	0.001
Loa Loa (eye worm)	acetyltransferase	0.0267	0.316	0.804
Plasmodium falciparum	serine repeat antigen 8	0.0024	0.0183	0.2322
Toxoplasma gondii	histone lysine-specific demethylase	0.0058	0.0605	0.4491
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Onchocerca volvulus		0.0061	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0037	0.0094
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0169	0.0071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Trypanosoma cruzi	cysteine protease, putative	0.0024	0.0183	0.0455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0024	0.0183	0.1336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0024	0.0183	0.2322
Brugia malayi	cathepsin B-like cysteine proteinase	0.033	0.393	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Echinococcus granulosus	cathepsin l1	0.0061	0.0639	0.1619
Giardia lamblia	Cathepsin L-like protease	0.0024	0.0183	0.1336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Loa Loa (eye worm)	SRC-1	0.0009	0.0004	0.001
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0058	0.0605	0.4491
Leishmania major	UDP-galactopyranose mutase	0.0058	0.0605	0.4491
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0013	0.0056	0.0132
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TK/DDR protein kinase	0.0009	0.0004	0.001
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0024	0.0183	0.2103
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0079	0.0854	0.6352
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.0183	0.2812
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0013	0.0051	0.0613
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0009	0.0004	0.001
Brugia malayi	cathepsin F-like cysteine proteinase	0.0024	0.0183	0.0455
Echinococcus multilocularis		0.0058	0.0605	0.153
Echinococcus granulosus	neuroglian	0.0012	0.0037	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0639	0.1627
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0058	0.0605	0.153
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0079	0.0854	0.2164
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0024	0.0183	0.2103
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0024	0.0183	0.0455
Schistosoma mansoni	nephrin	0.0012	0.0037	0.0085
Echinococcus multilocularis	geminin	0.0149	0.1714	0.4357
Loa Loa (eye worm)	TK/ROR protein kinase	0.0013	0.0056	0.0142
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0183	0.1336
Onchocerca volvulus	Cathepsin F homolog	0.0061	0.0639	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.033	0.393	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0024	0.0183	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0183	0.0465
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0051	0.0352
Loa Loa (eye worm)	cathepsin B	0.0118	0.1342	0.3414
Brugia malayi	acetyltransferase, GNAT family protein	0.0267	0.316	0.8038
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751
Giardia lamblia	Encystation-specific protease	0.0024	0.0183	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0639	0.1627
Trypanosoma cruzi	cysteine proteinase, putative	0.0024	0.0183	0.0455
Echinococcus granulosus	twitchin	0.0012	0.0037	0.0085
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0169	0.2149
Echinococcus multilocularis	SWI:SNF matrix associated	0.0013	0.0051	0.012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0061	0.0639	0.4751
Echinococcus granulosus	cathepsin l1	0.0061	0.0639	0.1619
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0118	0.1342	0.3407
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Onchocerca volvulus		0.0024	0.0183	0.2812
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0023	0.0178	0.0444
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0009	0.0004	0.001
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0169	0.0071
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0432	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0024	0.0183	0.0465
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0169	0.0071
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.0639	0.1619
Echinococcus multilocularis	slit 2 protein	0.0029	0.0243	0.061
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0605	0.1539
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0169	0.0071
Giardia lamblia	Cathepsin B precursor	0.0118	0.1342	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0183	0.1336
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0023	0.0178	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0243	0.0619
Giardia lamblia	Cathepsin B precursor	0.0118	0.1342	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Loa Loa (eye worm)	TK/EPH protein kinase	0.0009	0.0004	0.001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0432	0.1091
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Plasmodium falciparum	serine repeat antigen 2	0.0024	0.0183	0.2322
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0033	0.0295	0.0751
Trypanosoma cruzi	major cysteine proteinase, putative	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Plasmodium falciparum	serine repeat antigen 3	0.0024	0.0183	0.2322
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0169	0.2149
Onchocerca volvulus		0.0061	0.0639	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0061	0.0639	0.1619
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0096	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0099	0.0253
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0033	0.0295	0.0742
Brugia malayi	cathepsin L-like precursor	0.0061	0.0639	0.1619
Toxoplasma gondii	cathepsin CPL	0.0061	0.0639	0.4751
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0024	0.0183	0.2322
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0023	0.0178	0.0444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.0639	0.4751
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0024	0.0183	0.0455
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.033	0.393	1
Echinococcus granulosus	cathepsin L	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0169	0.1237
Loa Loa (eye worm)	TK/ABL protein kinase	0.0009	0.0004	0.001
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0183	0.0455
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0009	0.0004	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0099	0.0253
Giardia lamblia	Cathepsin L precursor	0.0024	0.0183	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0605	0.1539
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0169	0.1237
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0023	0.0178	0.0444
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0023	0.0178	0.2265
Plasmodium falciparum	serine repeat antigen 9	0.0024	0.0183	0.2322
Echinococcus granulosus	cathepsin L	0.0024	0.0183	0.0455
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0013	0.0051	0.0352
Mycobacterium ulcerans	monoamine oxidase	0.0058	0.0605	0.051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0183	0.1336
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0118	0.1342	0.3407
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0023	0.0178	0.1303
Loa Loa (eye worm)	T-complex protein 1	0.0023	0.0178	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0639	0.1627
Echinococcus multilocularis	cathepsin b	0.033	0.393	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0183	0.2322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.0639	0.4751
Leishmania major	cysteine peptidase A (CPA)	0.0061	0.0639	0.4751
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0023	0.0178	0.1303
Brugia malayi	brahma associated protein 60 kDa	0.0013	0.0051	0.012
Loa Loa (eye worm)	TK/FER protein kinase	0.0009	0.0004	0.001
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0013	0.0051	0.0555
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0058	0.0605	0.0561
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0009	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0605	0.1539
Schistosoma mansoni	cathepsin S (C01 family)	0.0024	0.0183	0.0455
Leishmania major	cathepsin L-like protease	0.0061	0.0639	0.4751

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3139631

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1862722