TDR Targets

Basic information

Technical information

TDR Targets ID: 1864344
Name: 6-amino-2-phenylbenzo[h]chromen-4-one
MW: 287.312 | Formula: C19H13NO2
H donors: 1 H acceptors: 1 LogP: 3.75 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc(oc2c1cc(N)c1c2cccc1)c1ccccc1
InChi: 1S/C19H13NO2/c20-16-10-15-17(21)11-18(12-6-2-1-3-7-12)22-19(15)14-9-5-4-8-13(14)16/h1-11H,20H2
InChiKey: RXBUGFGAMQDMSO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-amino-2-phenyl-benzo[h]chromen-4-one
6-amino-2-phenyl-4-benzo[h]chromenone
71601-16-6

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0147	0.1899	0.7076
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0026	0.0173	0.0173
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1105	0.1105
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0173	0.2494
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0341	0.4903
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0682	0.0682
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0173	0.0173
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0682	0.0682
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0026	0.0173	0.0646
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0249
Onchocerca volvulus		0.0038	0.0341	0.0667
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0147	0.1899	0.1899
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0341	0.1034
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0682	0.0682
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0341	0.0391
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0341	0.4903
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0203	0.2684	0.3079
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Brugia malayi	Cell death protein 3 precursor	0.0029	0.0217	0.0809
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Brugia malayi	hypothetical protein	0.0096	0.1164	0.4335
Toxoplasma gondii	ABC1 family protein	0.0038	0.0341	0.5
Plasmodium falciparum	heat shock protein 90	0.0032	0.0261	0.9295
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0026	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus granulosus	endoplasmin	0.0025	0.0169	0.0169
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0341	0.4903
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0173	0.0173
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1105	0.1105
Echinococcus granulosus	jumonji domain containing 1A	0.0017	0.005	0.005
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0341	0.0862
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0261	0.3753
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0071	0.1016
Schistosoma mansoni	caspase-7 (C14 family)	0.0029	0.0217	0.0217
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0341	0.0862
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.0261	0.0299
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0173	0.0173
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0261	0.3753
Schistosoma mansoni	endoplasmin	0.0032	0.0261	0.0261
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0173	0.0173
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0026	0.0173	0.0199
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0249
Brugia malayi	beta-lactamase family protein	0.0038	0.0341	0.1271
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0086	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0341	0.0341
Echinococcus multilocularis		0.0026	0.0173	0.0173
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0169	0.0194
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0026	0.0173	0.0173
Trypanosoma brucei	metacaspase MCA3	0.0029	0.0217	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0017	0.005	0.0188
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0682	0.9806
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0261	0.0299
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0071	0.0071
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Loa Loa (eye worm)	hypothetical protein	0.0017	0.005	0.0188
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0341	0.1271
Leishmania major	metacaspase, putative	0.0029	0.0217	0.3123
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0261	0.3753
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0173	0.0173
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0071	0.0081
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0261	0.3753
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0025	0.0169	0.243
Onchocerca volvulus		0.0203	0.2684	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0017	0.005	0.0724
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0071	0.0071
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0341	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trypanosoma cruzi	heat shock protein 90, putative	0.0025	0.0169	0.243
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Echinococcus granulosus	heat shock protein	0.0032	0.0261	0.0261
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0682	0.2339
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0071	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0629	0.8718	1
Schistosoma mansoni	heat shock protein	0.0032	0.0261	0.0261
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0029	0.0217	0.0217
Schistosoma mansoni	ap endonuclease	0.0018	0.0071	0.0071
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0029	0.0217	0.3185
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0281	0.0322
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0026	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0026	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.005	0.005
Brugia malayi	heat shock protein 90	0.0032	0.0261	0.0972
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0341	0.0341
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.0713	0.2657
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0064	0.0713	0.0713
Toxoplasma gondii	exonuclease III APE	0.0018	0.0071	0.1036
Trypanosoma cruzi	small ubiquitin protein, putative	0.0033	0.0281	0.4037
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0071	0.2072
Brugia malayi	beta-lactamase	0.0038	0.0341	0.1271
Giardia lamblia	Grp94/Hsp90	0.0025	0.0169	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus multilocularis	heat shock protein	0.0032	0.0261	0.0261
Onchocerca volvulus		0.0038	0.0341	0.0667
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0203	0.2684	0.3079
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0025	0.0169	0.0314
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0026	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0017	0.005	0.1793
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Treponema pallidum	fructose-bisphosphate aldolase	0.0287	0.3871	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0033	0.0281	0.8234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0017	0.005	0.0188
Leishmania major	hypothetical protein, conserved	0.0038	0.0341	0.4903
Treponema pallidum	heat shock protein 90	0.0025	0.0169	0.0259
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0629	0.8718	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Echinococcus multilocularis	jumonji domain containing 1A	0.0017	0.005	0.005
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0071	0.1016
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0086	0.0099
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0071	0.1016
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0147	0.1899	0.1899
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0071	0.0263
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0341	0.1271
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Brugia malayi	jmjC domain containing protein	0.0017	0.005	0.0188
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.0713	0.0713
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0026	0.0173	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0341	0.1271
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0203	0.2684	0.3079
Echinococcus granulosus	lysine specific demethylase 5A	0.0064	0.0713	0.0713
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Trypanosoma brucei	metacaspase MCA2	0.0029	0.0217	0.3123
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0032	0.0261	0.0674
Echinococcus granulosus	Small ubiquitin modifier 2	0.0033	0.0281	0.0281
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0203	0.2684	0.3079
Echinococcus multilocularis	lysine specific demethylase 6a	0.0017	0.005	0.005
Echinococcus granulosus	caspase	0.0029	0.0217	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0341	0.1271
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0203	0.2684	0.6934
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trypanosoma cruzi	metacaspase 5, putative	0.0029	0.0217	0.3123
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.005	0.0188
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0063	0.0695	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0026	0.0173	0.0173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0026	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0026	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0026	0.0173	0.0173
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0173	0.0173
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.1793	0.5494
Brugia malayi	jmjC domain containing protein	0.0017	0.005	0.0188
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0682	0.2339
Trypanosoma brucei	Heat shock protein 83, putative	0.0032	0.0261	0.3753
Giardia lamblia	Fructose-bisphosphate aldolase	0.0287	0.3871	1
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0217	0.637
Trypanosoma brucei	metacaspase 5, putative	0.0029	0.0217	0.3123
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0203	0.2684	0.3079
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0026	0.0173	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trypanosoma brucei	Metacaspase-4	0.0029	0.0217	0.3123
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0203	0.2684	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0063	0.0695	0.0798
Brugia malayi	jmjC domain containing protein	0.0017	0.005	0.0188
Mycobacterium ulcerans	heat shock protein 90	0.0025	0.0169	0.0376
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0033	0.0281	0.0281
Plasmodium vivax	JmjC domain containing protein	0.0017	0.005	0.1476
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0695	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0026	0.0173	0.0199
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.1105	0.4116
Brugia malayi	Endoplasmin precursor	0.0032	0.0261	0.0972
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0173	0.2494
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1105	0.1105
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0203	0.2684	1
Plasmodium falciparum	small ubiquitin-related modifier	0.0033	0.0281	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0026	0.0173	0.0173
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0017	0.005	0.0724
Schistosoma mansoni	eyes absent homolog	0.0096	0.1164	0.1164
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0173	0.0173
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0071	0.0081
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0169	0.0194
Schistosoma mansoni	protein phosphatase 2C	0.0017	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Schistosoma mansoni	endoplasmin	0.0032	0.0261	0.0261
Plasmodium falciparum	metacaspase-like protein	0.0029	0.0217	0.7736
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trypanosoma cruzi	metacaspase, putative	0.0029	0.0217	0.3123
Plasmodium vivax	heat shock protein 86, putative	0.0032	0.0261	0.7654
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0026	0.0173	0.0646
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0063	0.0695	0.0798
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0026	0.0173	0.0173
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.005	0.0188
Echinococcus multilocularis	caspase 8	0.0029	0.0217	0.0217
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0173	0.0173
Trypanosoma cruzi	heat shock protein 90, putative	0.0032	0.0261	0.3753
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0341	0.0341
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Plasmodium falciparum	endoplasmin, putative	0.002	0.0086	0.3076
Echinococcus granulosus	phd:f box containing protein	0.0017	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0026	0.0173	0.0173
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0695	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0071	0.1016
Schistosoma mansoni	heat shock protein	0.0032	0.0261	0.0261
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0682	1
Schistosoma mansoni	microtubule-associated protein tau	0.0719	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1105	0.1105
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0173	0.0173
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0173	0.0173
Echinococcus multilocularis	endoplasmin	0.0025	0.0169	0.0169
Echinococcus multilocularis	heat shock protein 90	0.0025	0.0169	0.0169
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0341	0.1059
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0076	0.1092
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Trypanosoma cruzi	metacaspase, putative	0.0029	0.0217	0.3123
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0026	0.0173	0.0646
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0173	0.0173
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0341	0.0391
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.3206	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0341	0.0391
Echinococcus multilocularis	heat shock protein 90	0.0032	0.0261	0.0261
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1105	0.1105
Schistosoma mansoni	jumonji domain containing protein	0.0064	0.0713	0.0713
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Leishmania major	tyrosine specific protein phosphatase, putative	0.0026	0.0173	0.2494
Loa Loa (eye worm)	SMO-1 protein	0.0033	0.0281	0.1046
Schistosoma mansoni	jumonji domain containing protein	0.0017	0.005	0.005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0026	0.0173	0.0173
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0341	0.1034
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0026	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1164	0.4335
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0341	0.0862
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0033	0.0281	0.4117
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0341	0.1034
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0071	0.0263
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0064	0.0713	0.0713
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0173	0.0173
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0026	0.0173	0.0173
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0341	0.0862
Schistosoma mansoni	ap endonuclease	0.0018	0.0071	0.0071
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.005	0.005
Echinococcus multilocularis	caspase	0.0029	0.0217	0.0217
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0026	0.0173	0.0173
Brugia malayi	hypothetical protein	0.0026	0.0173	0.0646
Onchocerca volvulus	Cell death protein 3 homolog	0.0029	0.0217	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0341	0.0862
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0025	0.0169	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1105	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0147	0.1899	0.1899
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0026	0.0173	0.2494
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trypanosoma cruzi	metacaspase, putative	0.0029	0.0217	0.3123
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0147	0.1899	0.1899
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0651	0.9039	0.9039
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Brugia malayi	Protein-tyrosine phosphatase 1	0.0026	0.0173	0.0646
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0026	0.0173	0.0199
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0026	0.0173	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Echinococcus multilocularis	lysine specific demethylase 5A	0.0064	0.0713	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0341	0.1271
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0341	0.1059
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0341	0.0862
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0341	0.0862
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0029	0.0217	0.0809
Brugia malayi	jmjC domain containing protein	0.0064	0.0713	0.2657
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0026	0.0173	0.0173
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0071	0.2517
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1164	0.4335
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0173	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0147	0.1899	0.7076
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0071	0.0081
Brugia malayi	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus granulosus	JmjC domain containing protein 4	0.0017	0.005	0.005
Brugia malayi	hypothetical protein	0.0026	0.0173	0.0646
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0029	0.0217	0.3185
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0341	0.1271
Giardia lamblia	Protein tyrosine phosphatase	0.0026	0.0173	0.0448
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0026	0.0173	0.0173
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0025	0.0169	0.0169
Echinococcus multilocularis	phd:f box containing protein	0.0017	0.005	0.005
Echinococcus granulosus	lysine specific demethylase 6a	0.0017	0.005	0.005
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0017	0.005	0.0738
Brugia malayi	jmjC domain containing protein	0.0064	0.0713	0.2657
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0341	0.0862
Toxoplasma gondii	heat shock protein HSP90	0.0032	0.0261	0.3827
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0025	0.0169	0.0437
Trypanosoma cruzi	small ubiquitin protein, putative	0.0033	0.0281	0.4037
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0682	0.2339
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Echinococcus multilocularis	microtubule associated protein 2	0.0719	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1105	0.1105
Brugia malayi	Protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Plasmodium vivax	metacaspase 1, putative	0.0029	0.0217	0.637
Trypanosoma cruzi	heat shock protein 85, putative	0.0025	0.0169	0.243
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0026	0.0173	0.0173
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.1105	0.4116
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0203	0.2684	1
Trypanosoma brucei	small ubiquitin-related modifier	0.0033	0.0281	0.4037
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0341	0.1271
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0026	0.0173	0.0173
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0341	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus multilocularis	caspase 2	0.0029	0.0217	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0033	0.0281	0.0281
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Brugia malayi	Protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Schistosoma mansoni	caspase-3 (C14 family)	0.0029	0.0217	0.0217
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0261	0.3753
Schistosoma mansoni	pcd6 interacting protein-related	0.0026	0.0173	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0249
Entamoeba histolytica	ubiquitin like protein	0.0033	0.0281	0.0322
Schistosoma mansoni	phosphatidylserine receptor	0.0017	0.005	0.005
Toxoplasma gondii	heat shock protein 90, putative	0.0032	0.0261	0.3827
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0341	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Schistosoma mansoni	caspase-7 (C14 family)	0.0029	0.0217	0.0217
Plasmodium vivax	endoplasmin, putative	0.0032	0.0261	0.7654
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0026	0.0173	0.2494
Echinococcus multilocularis	hypothetical protein	0.0026	0.0173	0.0173
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0017	0.005	0.005
Plasmodium falciparum	metacaspase 1	0.0029	0.0217	0.7736
Brugia malayi	hypothetical protein	0.0026	0.0173	0.0646
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0341	0.0391
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.1793	0.6592
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0026	0.0173	0.0646
Leishmania major	small ubiquitin protein, putative	0.0033	0.0281	0.4037
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0026	0.0173	0.2494
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0203	0.2684	0.3079
Loa Loa (eye worm)	endoplasmin	0.0032	0.0261	0.0972
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0017	0.005	0.0738
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0026	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0809
Trypanosoma cruzi	Heat shock protein 83, putative	0.0032	0.0261	0.3753
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0249
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.005	0.0188
Echinococcus granulosus	heat shock protein 90	0.0025	0.0169	0.0169
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Mycobacterium ulcerans	lipase LipD	0.0038	0.0341	0.1034
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0029	0.0217	0.0217
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0682	0.0682
Giardia lamblia	Sentrin	0.0033	0.0281	0.0725
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.014	0.1798	0.5508
Leishmania major	hypothetical protein, conserved	0.0063	0.0695	1
Brugia malayi	jmjC domain containing protein	0.0017	0.005	0.0188
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Trypanosoma brucei	metacaspase	0.0029	0.0217	0.3123
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0017	0.005	0.0724
Trypanosoma cruzi	metacaspase 5, putative	0.0029	0.0217	0.3123
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0203	0.2684	0.3079
Brugia malayi	hypothetical protein	0.0026	0.0173	0.0646
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.0713	0.0713
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0261	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Trichomonas vaginalis	esterase, putative	0.0038	0.0341	0.0391
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0173	0.0173
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0029	0.0217	0.0217
Echinococcus granulosus	caspase 2	0.0029	0.0217	0.0217
Echinococcus granulosus	caspase 8	0.0029	0.0217	0.0217
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.3871	0.444
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0341	0.1271
Brugia malayi	beta-lactamase family protein	0.0038	0.0341	0.1271
Leishmania major	hypothetical protein, conserved	0.0017	0.005	0.0724
Trypanosoma cruzi	metacaspase, putative	0.0029	0.0217	0.3123
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0341	0.1034
Schistosoma mansoni	phd/f-box containing protein	0.0017	0.005	0.005
Loa Loa (eye worm)	heat shock protein 90	0.0032	0.0261	0.0972
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0026	0.0173	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0682	0.195
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0261	0.3753
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0173	0.0173
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0029	0.0217	0.0249
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.014	0.1793	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0173	0.0646
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0029	0.0217	0.3185
Leishmania major	heat shock protein 83-1	0.0032	0.0261	0.3753
Echinococcus granulosus	heat shock protein 90	0.0032	0.0261	0.0261
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0341	0.0862
Schistosoma mansoni	protein tyrosine phosphatase	0.0026	0.0173	0.0173
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0169	0.0194
Brugia malayi	Ubiquitin-like protein SMT3	0.0033	0.0281	0.1046
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0026	0.0173	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0026	0.0173	0.0173
Trichomonas vaginalis	pten, drome, putative	0.0026	0.0173	0.0199
Onchocerca volvulus		0.0038	0.0341	0.0667
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0203	0.2684	0.3079
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0147	0.1899	0.1899
Echinococcus multilocularis	JmjC domain containing protein 4	0.0017	0.005	0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3230196

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1864344