Detailed information for compound 1870166

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1011.29 | Formula: C56H86N2O14
  • H donors: 2 H acceptors: 6 LogP: 8.69 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=O)CCC([C@H]1CC[C@@H]2[C@]1(C)[C@@H](OC(=O)C)C[C@H]1[C@H]2[C@H](OC(=O)C)C[C@H]2[C@]1(C)CC[C@]1(C2)OO[C@@]2(OO1)CC[C@]1([C@@H](C2)C[C@H]([C@@H]2[C@@H]1C[C@H](OC(=O)C)[C@]1([C@H]2CC[C@@H]1C(CCC(=O)N)C)C)OC(=O)C)C)C
  • InChi: 1S/C56H86N2O14/c1-29(11-17-47(57)63)37-13-15-39-49-41(25-45(53(37,39)9)67-33(5)61)51(7)19-21-55(27-35(51)23-43(49)65-31(3)59)69-71-56(72-70-55)22-20-52(8)36(28-56)24-44(66-32(4)60)50-40-16-14-38(30(2)12-18-48(58)64)54(40,10)46(26-42(50)52)68-34(6)62/h29-30,35-46,49-50H,11-28H2,1-10H3,(H2,57,63)(H2,58,64)/t29?,30?,35-,36-,37-,38-,39+,40+,41+,42+,43-,44-,45+,46+,49+,50+,51+,52+,53-,54-,55-,56+/m1/s1
  • InChiKey: HBVUCHMMQPBKJZ-WYWYXUOMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 0.00622437 0.0227247 0.0225066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Loa Loa (eye worm) hypothetical protein 0.00209891 0.00096819 0.000863231
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.00622437 0.0227247 0.0666955
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131952 0.0594866 0.134618
Entamoeba histolytica cysteine proteinase, putative 0.00238453 0.00247446 0.042073
Trypanosoma cruzi p450 reductase, putative 0.00208768 0.000908983 0.000728629
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0854352 0.440459 1
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi Serotonin receptor 0.00658834 0.0246441 0.0554726
Toxoplasma gondii aspartyl protease ASP3 0.0153583 0.0708944 0.211829
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00858828 0.0351912 0.105842
Loa Loa (eye worm) hypothetical protein 0.0142467 0.0650319 0.146506
Echinococcus multilocularis metabotropic glutamate receptor 2 0.00336442 0.00764213 0.0212524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Echinococcus granulosus Mastin 0.00209891 0.00096819 0.00114405
Echinococcus granulosus somatostatin receptor 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00658834 0.0246441 0.0724787
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00658834 0.0246441 0.0244265
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00658834 0.0246441 0.0244265
Echinococcus granulosus laminin 0.0041538 0.0118051 0.0337952
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.00208768 0.000908983 0.000728629
Echinococcus granulosus thyroid hormone receptor alpha 0.00622437 0.0227247 0.0666955
Brugia malayi RE15519p 0.00658834 0.0246441 0.0554726
Brugia malayi Nuclear hormone receptor E75 0.00622437 0.0227247 0.0511126
Brugia malayi Fibulin-1 precursor 0.0041538 0.0118051 0.0263087
Echinococcus granulosus Niemann Pick C1 protein 0.0145315 0.0665337 0.198691
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.0056584 0.0197399 0.0435388
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00658834 0.0246441 0.0244265
Brugia malayi Cathepsin L-like precursor 0.00356214 0.00868485 0.0192211
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.00697082 0.0266612 0.0592736
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.000745312
Echinococcus granulosus neuropeptides capa receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus biogenic amine 5HT receptor 0.00658834 0.0246441 0.0724787
Echinococcus granulosus neuropeptide FF receptor 2 0.0240206 0.116577 0.349468
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0546667 0.278195 0.631109
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00658834 0.0246441 0.0724787
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus granulosus rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.00209891 0.00096819 0.00114405
Trypanosoma cruzi cysteine peptidase, putative 0.00356214 0.00868485 0.0184063
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0546667 0.278195 0.836418
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00858828 0.0351912 0.105842
Brugia malayi acyl-CoA desaturase 0.0854352 0.440459 1
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) hypothetical protein 0.00209891 0.00096819 0.000863231
Plasmodium falciparum cysteine repeat modular protein 1 0.00957014 0.0403692 0.0897742
Echinococcus multilocularis G protein coupled receptor 139 0.0221087 0.106494 0.319089
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.00350084 0.00836157 0.0983333
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0164588 0.076698 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0131952 0.0594866 0.133899
Echinococcus multilocularis cysteine protease 0.00356214 0.00868485 0.0243941
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.00332471 0.0074327 0.0148418
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0131952 0.0594866 0.134618
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00622437 0.0227247 0.0495038
Loa Loa (eye worm) TYRA-2 protein 0.00658834 0.0246441 0.0546879
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.00208768 0.000908983 0.000728629
Trypanosoma cruzi cysteine peptidase, putative 0.00356214 0.00868485 0.0184063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0131952 0.0594866 0.177458
Schistosoma mansoni biogenic amine receptor 0.00658834 0.0246441 0.0244265
Brugia malayi nuclear hormone receptor family member odr-7 0.00622437 0.0227247 0.0511126
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0131952 0.0594866 0.0592768
Loa Loa (eye worm) IMP dehydrogenase 1 0.00350084 0.00836157 0.0176713
Leishmania major inosine-5-monophosphate dehydrogenase 0.00350084 0.00836157 0.0189838
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.00350084 0.00836157 0.0176713
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.00622437 0.0227247 0.0225066
Brugia malayi CHE-14 protein 0.00400457 0.0110181 0.0245211
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0131952 0.0594866 0.177458
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00322768 0.00692101 0.0208159
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0153583 0.0708944 0.211829
Plasmodium vivax aspartyl protease, putative 0.0153583 0.0708944 0.160956
Loa Loa (eye worm) hypothetical protein 0.00204278 0.000672206 0.000190341
Brugia malayi orphan nuclear receptor NR2E1 0.00622437 0.0227247 0.0511126
Echinococcus multilocularis neuropeptide Y receptor 0.00658834 0.0246441 0.0724787
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.00350084 0.00836157 0.0234201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus multilocularis neuroendocrine convertase 2 0.00888609 0.0367617 0.108989
Schistosoma mansoni hypothetical protein 0.00957014 0.0403692 0.0401551
Loa Loa (eye worm) hypothetical protein 0.00536278 0.0181809 0.0399945
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Plasmodium falciparum plasmepsin IX 0.0153583 0.0708944 0.159221
Echinococcus multilocularis Tolloid protein 1 0.0041538 0.0118051 0.0337952
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.000745312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Plasmodium falciparum stearoyl-CoA desaturase 0.0854352 0.440459 1
Echinococcus multilocularis sex peptide receptor 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus multilocularis fmrfamide receptor 0.00658834 0.0246441 0.0724787
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.00456676 0.0139829 0.0137629
Echinococcus multilocularis 0.0114562 0.0503159 0.149827
Loa Loa (eye worm) G-protein coupled receptor 0.00658834 0.0246441 0.0546879
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.00332471 0.0074327 0.0860772
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00356214 0.00868485 0.0243941
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00573204 0.0201282 0.0605383
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Schistosoma mansoni amine GPCR 0.00658834 0.0246441 0.0244265
Brugia malayi proprotein convertase 2 0.00888609 0.0367617 0.082998
Echinococcus granulosus furin 0.0142467 0.0650319 0.194166
Echinococcus multilocularis Niemann Pick C1 protein 0.0105269 0.0454148 0.13506
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049444 0.0159744 0.0463574
Brugia malayi hypothetical protein 0.00209891 0.00096819 0.00169261
Loa Loa (eye worm) hypothetical protein 0.00209891 0.00096819 0.000863231
Toxoplasma gondii cathepsin CPL 0.00356214 0.00868485 0.0243941
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.00350084 0.00836157 0.0176713
Brugia malayi G protein-coupled receptor 0.00658834 0.0246441 0.0554726
Schistosoma mansoni amine GPCR 0.00658834 0.0246441 0.0244265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus multilocularis expressed conserved protein 0.0101752 0.04356 0.129472
Loa Loa (eye worm) hypothetical protein 0.00957014 0.0403692 0.0904374
Loa Loa (eye worm) ctsf protein 0.00356214 0.00868485 0.0184063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Plasmodium vivax aspartyl proteinase, putative 0.0649616 0.332487 0.754866
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.00622437 0.0227247 0.0511126
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.00202691 0.000588481 0.000365518
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00658834 0.0246441 0.0554726
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis G-protein coupled receptor, putative 0.00658834 0.0246441 0.0724787
Schistosoma mansoni myosin xvIII 0.00658834 0.0246441 0.0244265
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.00622437 0.0227247 0.0225066
Loa Loa (eye worm) hypothetical protein 0.0049444 0.0159744 0.0349784
Trypanosoma cruzi cytochrome P450 reductase, putative 0.00208768 0.000908983 0.000728629
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0110584 0.048218 0.143506
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Echinococcus granulosus transmembrane protease serine 3 0.00209891 0.00096819 0.00114405
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.000745312
Brugia malayi Cathepsin L-like precursor 0.00356214 0.00868485 0.0192211
Schistosoma mansoni amine GPCR 0.00658834 0.0246441 0.0244265
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00658834 0.0246441 0.0724787
Onchocerca volvulus 0.00622437 0.0227247 0.0495038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00622437 0.0227247 0.0666955
Brugia malayi follicle stimulating hormone receptor 0.00658834 0.0246441 0.0554726
Schistosoma mansoni RAR-like nuclear receptor 0.0131952 0.0594866 0.0592768
Schistosoma mansoni hypothetical protein 0.00658834 0.0246441 0.0244265
Brugia malayi hypothetical protein 0.0153583 0.0708944 0.160531
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Brugia malayi nuclear receptor RXR 0.00697082 0.0266612 0.0600545
Echinococcus granulosus hypothetical protein 0.00658834 0.0246441 0.0724787
Echinococcus granulosus rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Onchocerca volvulus Cathepsin F homolog 0.00356214 0.00868485 0.0175582
Echinococcus multilocularis g-protein coupled receptor 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus multilocularis Niemann Pick C1 protein 0.0145315 0.0665337 0.198691
Schistosoma mansoni cathepsin F (C01 family) 0.00238453 0.00247446 0.00225191
Plasmodium vivax plasmepsin IV, putative 0.0649616 0.332487 0.754866
Brugia malayi celfurPC protein 0.0114562 0.0503159 0.113787
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00624851 0.0228519 0.0670791
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00204278 0.000672206 0.000252262
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Brugia malayi Kringle domain containing protein 0.00957014 0.0403692 0.0911924
Onchocerca volvulus 0.00356214 0.00868485 0.0175582
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00622437 0.0227247 0.0666955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Echinococcus multilocularis tissue type plasminogen activator 0.00957014 0.0403692 0.119858
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Echinococcus multilocularis allatostatin A receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00209891 0.00096819 0.000863231
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0131952 0.0594866 0.177458
Echinococcus granulosus tm gpcr rhodopsin 0.00658834 0.0246441 0.0724787
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00204278 0.000672206 0.000252262
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.032383 0.160677 0.482342
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Onchocerca volvulus 0.0153583 0.0708944 0.159108
Giardia lamblia High cysteine membrane protein Group 2 0.00536059 0.0181693 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00658834 0.0246441 0.0244265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus granulosus tm gpcr rhodopsin 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0131952 0.0594866 0.0592768
Echinococcus multilocularis dro:myosuppressin receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Brugia malayi Tachykinin-like peptides receptor 99D 0.0240206 0.116577 0.264298
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.00697082 0.0266612 0.0785561
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0131952 0.0594866 0.134618
Entamoeba histolytica cysteine proteinase, putative 0.00356214 0.00868485 0.180616
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Toxoplasma gondii kringle domain-containing protein 0.00957014 0.0403692 0.119858
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0131952 0.0594866 0.133899
Schistosoma mansoni hypothetical protein 0.00541424 0.0184522 0.0182333
Brugia malayi Cathepsin L-like precursor 0.00238453 0.00247446 0.00511411
Trypanosoma cruzi cysteine peptidase, putative 0.00356214 0.00868485 0.0184063
Schistosoma mansoni neuropeptide receptor 0.00658834 0.0246441 0.0244265
Brugia malayi Nuclear hormone receptor-like 1 0.00697082 0.0266612 0.0600545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Toxoplasma gondii calcium binding egf domain-containing protein 0.0041538 0.0118051 0.0337952
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.000745312
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0131952 0.0594866 0.177458
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00622437 0.0227247 0.0666955
Echinococcus granulosus 7TM GPCR rhodopsin 0.00658834 0.0246441 0.0724787
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0131952 0.0594866 0.177458
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Plasmodium vivax vivapain-2 0.00356214 0.00868485 0.0197177
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.00858828 0.0351912 0.104257
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00658834 0.0246441 0.0244265
Brugia malayi Trypsin family protein 0.00209891 0.00096819 0.00169261
Schistosoma mansoni voltage-gated potassium channel 0.00204278 0.000672206 0.000449262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Loa Loa (eye worm) hypothetical protein 0.00238453 0.00247446 0.00428757
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) neuropeptide F receptor 0.00658834 0.0246441 0.0546879
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00322768 0.00692101 0.0208159
Brugia malayi Serotonin receptor 0.00658834 0.0246441 0.0554726
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Loa Loa (eye worm) endoprotease bli-4 0.0142467 0.0650319 0.146506
Schistosoma mansoni niemann-pick C1 (NPC1) 0.00911721 0.0379806 0.037766
Brugia malayi endoprotease bli-4 precursor 0.0142467 0.0650319 0.147214
Giardia lamblia GTOR 0.00202691 0.000588481 0.0323887
Schistosoma mansoni steroid hormone receptor ad4bp 0.0131952 0.0594866 0.0592768
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.00208768 0.000908983 0.000728629
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.00350084 0.00836157 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Schistosoma mansoni neuropeptide f receptor 76f 0.00658834 0.0246441 0.0244265
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00658834 0.0246441 0.0724787
Brugia malayi Cathepsin L-like cysteine proteinase 0.00238453 0.00247446 0.00511411
Schistosoma mansoni amine GPCR 0.00658834 0.0246441 0.0244265
Brugia malayi Cathepsin L-like precursor 0.00356214 0.00868485 0.0192211
Schistosoma mansoni biogenic amine (5HT) receptor 0.00658834 0.0246441 0.0244265
Echinococcus multilocularis laminin 0.0041538 0.0118051 0.0337952
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0131952 0.0594866 0.134618
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi ecdysteroid receptor 0.0131952 0.0594866 0.134618
Echinococcus granulosus cathepsin L cysteine proteinase 0.00356214 0.00868485 0.0243941
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.00208768 0.000908983 0.000728629
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.00208768 0.000908983 0.000965662
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.057514 0.293211 0.88166
Leishmania major guanosine monophosphate reductase 0.00350084 0.00836157 0.0189838
Schistosoma mansoni hypothetical protein 0.0546667 0.278195 0.278034
Schistosoma mansoni hypothetical protein 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00624851 0.0228519 0.0506137
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.00332471 0.0074327 0.0168749
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0131952 0.0594866 0.134618
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.00209891 0.00096819 0.00114405
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0131952 0.0594866 0.177458
Onchocerca volvulus 0.00957014 0.0403692 0.0896516
Brugia malayi Cathepsin L-like precursor 0.00356214 0.00868485 0.0192211
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Trichomonas vaginalis conserved hypothetical protein 0.00400457 0.0110181 0.0331384
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Brugia malayi AKH receptor 0.00658834 0.0246441 0.0554726
Brugia malayi Steroid receptor seven-up type 2 0.0131952 0.0594866 0.134618
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0041538 0.0118051 0.0254997
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) hypothetical protein 0.0105269 0.0454148 0.101908
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) hypothetical protein 0.00697082 0.0266612 0.0592736
Echinococcus granulosus alpha 1A adrenergic receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Entamoeba histolytica cysteine proteinase, putative 0.00356214 0.00868485 0.180616
Echinococcus granulosus cathepsin l1 0.00356214 0.00868485 0.0243941
Brugia malayi Trypsin family protein 0.00209891 0.00096819 0.00169261
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.00622437 0.0227247 0.0666955
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.00202691 0.000588481 0.00133606
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00658834 0.0246441 0.0724787
Echinococcus granulosus Protein patched homolog 1 0.00400457 0.0110181 0.0314241
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.00350084 0.00836157 0.0234201
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00658834 0.0246441 0.0724787
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Echinococcus multilocularis enteropeptidase 0.00209891 0.00096819 0.00114405
Schistosoma mansoni neuropeptide F-like receptor 0.00658834 0.0246441 0.0244265
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00658834 0.0246441 0.0724787
Echinococcus granulosus g protein coupled receptor 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0131952 0.0594866 0.177458
Echinococcus granulosus neuroendocrine convertase 2 0.00888609 0.0367617 0.108989
Leishmania major hypothetical protein, conserved 0.00957014 0.0403692 0.0916526
Brugia malayi putative neuropeptide receptor 0.00658834 0.0246441 0.0554726
Echinococcus granulosus g protein coupled receptor 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00658834 0.0246441 0.0724787
Brugia malayi ORL1-like opioid receptor 0.00658834 0.0246441 0.0554726
Schistosoma mansoni opsin-like receptor 0.00658834 0.0246441 0.0244265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Schistosoma mansoni biogenic amine receptor 0.00658834 0.0246441 0.0244265
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00624851 0.0228519 0.0514018
Plasmodium falciparum plasmepsin III 0.0153583 0.0708944 0.159221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.00350084 0.00836157 0.0176713
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.00209891 0.00096819 0.00114405
Echinococcus granulosus rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Schistosoma mansoni zinc finger protein 0.00622437 0.0227247 0.0225066
Schistosoma mansoni hypothetical protein 0.0546667 0.278195 0.278034
Schistosoma mansoni neuropeptide receptor 0.0221087 0.106494 0.106294
Schistosoma mansoni biogenic amine (5HT) receptor 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.00209891 0.00096819 0.00169261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0131952 0.0594866 0.133899
Leishmania major C-8 sterol isomerase-like protein 0.0397596 0.19958 0.453117
Schistosoma mansoni patched 1 0.00400457 0.0110181 0.0107975
Schistosoma mansoni coup transcription factor 0.0131952 0.0594866 0.0592768
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0131952 0.0594866 0.134618
Echinococcus granulosus neuropeptide Y receptor 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00322768 0.00692101 0.0208159
Brugia malayi sulfakinin receptor protein 0.00658834 0.0246441 0.0554726
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Schistosoma mansoni nuclear hormone receptor 0.00622437 0.0227247 0.0225066
Plasmodium falciparum plasmepsin V 0.0153583 0.0708944 0.159221
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus granulosus rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Schistosoma mansoni egf-like domain protein 0.0041538 0.0118051 0.0115846
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus neuropeptide receptor 0.0221087 0.106494 0.319089
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00658834 0.0246441 0.0546879
Schistosoma mansoni histamine h1 receptor 0.00658834 0.0246441 0.0244265
Schistosoma mansoni thyroid hormone receptor 0.0242536 0.117806 0.117609
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00573204 0.0201282 0.0605383
Loa Loa (eye worm) steroid hormone receptor 0.0131952 0.0594866 0.133899
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Brugia malayi photoreceptor-specific nuclear receptor 0.0131952 0.0594866 0.134618
Echinococcus granulosus neuropeptide Y receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.0204161 0.0975677 0.220472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Leishmania major phosphatidylinositol 3-kinase, putative 0.00202691 0.000588481 0.00133606
Brugia malayi G-protein coupled receptor 0.00658834 0.0246441 0.0554726
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.00697082 0.0266612 0.0592736
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00658834 0.0246441 0.0724787
Plasmodium vivax plasmepsin V, putative 0.0153583 0.0708944 0.160956
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Onchocerca volvulus Cathepsin L homolog 0.00356214 0.00868485 0.0175582
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Echinococcus multilocularis Furin 1 0.00322768 0.00692101 0.0190797
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0131952 0.0594866 0.134618
Onchocerca volvulus Cathepsin L homolog 0.00356214 0.00868485 0.0175582
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.00208768 0.000908983 0.000965662
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00658834 0.0246441 0.0244265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.00322768 0.00692101 0.00669946
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.00202691 0.000588481 0.000365518
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00658834 0.0246441 0.0724787
Brugia malayi nuclear receptor NHR-88 0.0131952 0.0594866 0.134618
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00322768 0.00692101 0.0208159
Echinococcus granulosus allatostatin A receptor 0.00658834 0.0246441 0.0724787
Echinococcus granulosus dro:myosuppressin receptor 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Plasmodium falciparum plasmepsin VI 0.0649616 0.332487 0.754359
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.000745312
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00658834 0.0246441 0.0554726
Plasmodium falciparum plasmepsin X 0.0153583 0.0708944 0.159221
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0131952 0.0594866 0.0592768
Brugia malayi G-protein coupled receptor 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) hypothetical protein 0.0041538 0.0118051 0.0254997
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0649616 0.332487 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.00356214 0.00868485 0.0243941
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Loa Loa (eye worm) nuclear receptor nhr-7B 0.00622437 0.0227247 0.0503243
Brugia malayi Metabotropic glutamate receptor precursor. 0.0040163 0.0110799 0.0246616
Brugia malayi Nuclear hormone receptor-like 1 0.0131952 0.0594866 0.134618
Plasmodium falciparum cysteine proteinase falcipain 2b 0.00356214 0.00868485 0.0176905
Loa Loa (eye worm) hypothetical protein 0.00697082 0.0266612 0.0592736
Schistosoma mansoni opsin-like receptor 0.00658834 0.0246441 0.0244265
Brugia malayi hypothetical protein 0.00697082 0.0266612 0.0600545
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0131952 0.0594866 0.177458
Brugia malayi Papain family cysteine protease containing protein 0.00356214 0.00868485 0.0192211
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Loa Loa (eye worm) hypothetical protein 0.00238453 0.00247446 0.00428757
Brugia malayi nuclear hormone receptor 0.0131952 0.0594866 0.134618
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105269 0.0454148 1
Echinococcus granulosus g protein coupled receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Brugia malayi GnHR receptor homolog 0.00658834 0.0246441 0.0554726
Echinococcus multilocularis serotonin receptor 0.00658834 0.0246441 0.0724787
Echinococcus granulosus NADPH cytochrome P450 reductase 0.00208768 0.000908983 0.000965662
Loa Loa (eye worm) hypothetical protein 0.0397596 0.19958 0.452386
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) FAD binding domain-containing protein 0.00208768 0.000908983 0.000728629
Plasmodium falciparum cysteine proteinase falcipain 2a 0.00356214 0.00868485 0.0176905
Echinococcus granulosus Furin 1 0.00322768 0.00692101 0.0190797
Toxoplasma gondii calcium binding egf domain-containing protein 0.0041538 0.0118051 0.0337952
Loa Loa (eye worm) neuropeptide F receptor 0.00658834 0.0246441 0.0546879
Schistosoma mansoni hypothetical protein 0.00541424 0.0184522 0.0182333
Brugia malayi Melatonin receptor type 1A 0.00658834 0.0246441 0.0554726
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00658834 0.0246441 0.0244265
Echinococcus multilocularis voltage gated potassium channel 0.00204278 0.000672206 0.000252262
Onchocerca volvulus 0.0854352 0.440459 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Echinococcus granulosus ecdysone induced protein 78C 0.0131952 0.0594866 0.177458
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) melatonin receptor type 1A 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) hypothetical protein 0.00209891 0.00096819 0.000863231
Loa Loa (eye worm) hypothetical protein 0.00400457 0.0110181 0.0237107
Echinococcus multilocularis g protein coupled receptor 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis neuropeptide receptor 0.00658834 0.0246441 0.0724787
Schistosoma mansoni metabotropic glutamate receptor 0.00336442 0.00764213 0.00742075
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Schistosoma mansoni growth hormone secretagogue receptor 0.00658834 0.0246441 0.0244265
Brugia malayi nuclear receptor RXR 0.00622437 0.0227247 0.0511126
Loa Loa (eye worm) hypothetical protein 0.0041538 0.0118051 0.0254997
Echinococcus granulosus neuropeptides capa receptor 0.00658834 0.0246441 0.0724787
Onchocerca volvulus Protein ultraspiracle homolog 0.0131952 0.0594866 0.133151
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00658834 0.0246441 0.0538712
Onchocerca volvulus 0.00356214 0.00868485 0.0175582
Schistosoma mansoni hypothetical protein 0.00209891 0.00096819 0.000745312
Giardia lamblia Furin precursor putative serine protease 0.00279044 0.00461515 0.254008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0131952 0.0594866 0.133899
Loa Loa (eye worm) trypsin family protein 0.00209891 0.00096819 0.000863231
Plasmodium falciparum plasmepsin VII 0.0153583 0.0708944 0.159221
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0153583 0.0708944 0.159833
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0546667 0.278195 0.836418
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0041538 0.0118051 0.0115846
Echinococcus multilocularis thyroid hormone receptor alpha 0.0242536 0.117806 0.353171
Brugia malayi Nuclear hormone receptor-like 1 0.00697082 0.0266612 0.0600545
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Schistosoma mansoni nuclear receptor nhr-48 0.00622437 0.0227247 0.0225066
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00622437 0.0227247 0.0495038
Trypanosoma brucei GMP reductase 0.00350084 0.00836157 0.0176713
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi Dopamine receptor 0.00658834 0.0246441 0.0554726
Trypanosoma cruzi cysteine peptidase, putative 0.00356214 0.00868485 0.0184063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Brugia malayi flavodoxin family protein 0.00208768 0.000908983 0.00155812
Plasmodium falciparum cysteine proteinase falcipain 3 0.00356214 0.00868485 0.0176905
Loa Loa (eye worm) hypothetical protein 0.00356214 0.00868485 0.0184063
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.00622437 0.0227247 0.0666955
Trypanosoma cruzi cytochrome P450 reductase, putative 0.00208768 0.000908983 0.000728629
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus multilocularis protein dispatched 1 0.00435627 0.0128728 0.0370124
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0041538 0.0118051 0.0254997
Brugia malayi Cathepsin L-like precursor 0.00238453 0.00247446 0.00511411
Onchocerca volvulus 0.00238453 0.00247446 0.0034273
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Loa Loa (eye worm) hypothetical protein 0.0041538 0.0118051 0.0254997
Schistosoma mansoni voltage-gated potassium channel 0.00688909 0.0262302 0.0260129
Brugia malayi ecdysone receptor 0.00622437 0.0227247 0.0511126
Brugia malayi nuclear hormone receptor family member nhr-6 0.00622437 0.0227247 0.0511126
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.00208768 0.000908983 0.000728629
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00658834 0.0246441 0.0546879
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.00202691 0.000588481 0.00133606
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.00858828 0.0351912 0.104257
Onchocerca volvulus 0.00356214 0.00868485 0.0175582
Echinococcus multilocularis protein patched 0.00400457 0.0110181 0.0314241
Brugia malayi Dopamine receptor protein 1 0.00658834 0.0246441 0.0554726
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00204278 0.000672206 0.00102028
Brugia malayi G protein-coupled receptor F59B2.13 0.00658834 0.0246441 0.0554726
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Echinococcus granulosus biogenic amine 5HT receptor 0.00658834 0.0246441 0.0724787
Brugia malayi neuropeptide F receptor 0.00658834 0.0246441 0.0554726
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.00279044 0.00461515 0.0138807
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus multilocularis glycoprotein Antigen 5 0.00209891 0.00096819 0.00114405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Loa Loa (eye worm) nuclear receptor NHR-67 0.00622437 0.0227247 0.0503243
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.00208768 0.000908983 0.000965662
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0649616 0.332487 0.754538
Onchocerca volvulus Neuropeptide F receptor homolog 0.00658834 0.0246441 0.0538712
Schistosoma mansoni thyroid hormone receptor 0.0242536 0.117806 0.117609
Brugia malayi hypothetical protein 0.00622437 0.0227247 0.0511126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00658834 0.0246441 0.0244265
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0649616 0.332487 1
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.00279044 0.00461515 0.0138807
Loa Loa (eye worm) hypothetical protein 0.0041538 0.0118051 0.0254997
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0131952 0.0594866 0.134618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0131952 0.0594866 0.133899
Echinococcus multilocularis neuropeptides capa receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Onchocerca volvulus 0.00356214 0.00868485 0.0175582
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Echinococcus granulosus orexin receptor type 2 0.00658834 0.0246441 0.0724787
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis neuropeptide FF receptor 2 0.0240206 0.116577 0.349468
Onchocerca volvulus 0.00356214 0.00868485 0.0175582
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Schistosoma mansoni cathepsin D (A01 family) 0.191536 1 1
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Brugia malayi aspartic protease BmAsp-1, identical 0.0153583 0.0708944 0.160531
Echinococcus multilocularis nuclear receptor nhr 48 0.00622437 0.0227247 0.0666955
Brugia malayi putative neuropeptide receptor NPR1 0.00658834 0.0246441 0.0554726
Schistosoma mansoni biogenic amine receptor 0.00658834 0.0246441 0.0244265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.00208768 0.000908983 0.00206372
Brugia malayi Trypsin family protein 0.00209891 0.00096819 0.00169261
Brugia malayi Niemann-Pick C1 protein precursor 0.0105269 0.0454148 0.102654
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Schistosoma mansoni voltage-gated potassium channel 0.00688909 0.0262302 0.0260129
Trypanosoma cruzi fatty acid desaturase, putative 0.0854352 0.440459 1
Echinococcus multilocularis neuropeptide receptor A26 0.00658834 0.0246441 0.0724787
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00622437 0.0227247 0.0666955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Schistosoma mansoni hypothetical protein 0.00658834 0.0246441 0.0244265
Brugia malayi Cathepsin L-like precursor 0.00356214 0.00868485 0.0192211
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0152997 0.0705854 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0649616 0.332487 0.332338
Leishmania major fatty-acid desaturase, putative 0.0854352 0.440459 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Brugia malayi aspartic protease BmAsp-2, identical 0.0153583 0.0708944 0.160531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00202691 0.000588481 0.000830094
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.00400457 0.0110181 0.0237107
Leishmania major hypothetical protein, conserved 0.0121177 0.0538045 0.122156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0131952 0.0594866 0.177458
Echinococcus multilocularis fibrillin 1 0.0041538 0.0118051 0.0337952
Trypanosoma cruzi GMP reductase 0.00350084 0.00836157 0.0176713
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0397596 0.19958 0.452386
Loa Loa (eye worm) hypothetical protein 0.00697082 0.0266612 0.0592736
Echinococcus multilocularis somatostatin receptor 0.00658834 0.0246441 0.0724787
Echinococcus granulosus G protein coupled receptor 139 0.00658834 0.0246441 0.0724787
Plasmodium vivax cysteine repeat modular protein 1, putative 0.00957014 0.0403692 0.0916526
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Onchocerca volvulus 0.00622437 0.0227247 0.0495038
Echinococcus granulosus glycoprotein Antigen 5 0.00209891 0.00096819 0.00114405
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Trypanosoma brucei C-8 sterol isomerase, putative 0.0397596 0.19958 0.452386
Schistosoma mansoni retinoic acid receptor RXR 0.0131952 0.0594866 0.0592768
Brugia malayi larval opioid receptor 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131952 0.0594866 0.134618
Echinococcus granulosus neuropeptide receptor A26 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi neuropeptide F receptor 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0131952 0.0594866 0.133899
Brugia malayi nuclear receptor NHR-67 0.00622437 0.0227247 0.0511126
Echinococcus granulosus Niemann Pick C1 protein 0.0105269 0.0454148 0.13506
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0397596 0.19958 0.45284
Leishmania major p450 reductase, putative 0.00208768 0.000908983 0.00206372
Loa Loa (eye worm) hypothetical protein 0.0153583 0.0708944 0.159833
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0131952 0.0594866 0.134618
Toxoplasma gondii aspartyl protease 0.0153583 0.0708944 0.211829
Schistosoma mansoni hypothetical protein 0.00209891 0.00096819 0.000745312
Brugia malayi Trypsin-like protease protein 5 0.00209891 0.00096819 0.00169261
Echinococcus granulosus fmrfamide receptor 0.00658834 0.0246441 0.0724787
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.00697082 0.0266612 0.026444
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.00350084 0.00836157 0.0176713
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Schistosoma mansoni voltage-gated potassium channel 0.00204278 0.000672206 0.000449262
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.00350084 0.00836157 0.0184867
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0041538 0.0118051 0.0263087
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.00697082 0.0266612 0.0785561
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Echinococcus multilocularis neuropeptide Y receptor 0.00658834 0.0246441 0.0724787
Echinococcus granulosus nuclear receptor nhr 48 0.00622437 0.0227247 0.0666955
Loa Loa (eye worm) TK/ROR protein kinase 0.00957014 0.0403692 0.0904374
Onchocerca volvulus 0.0854352 0.440459 1
Loa Loa (eye worm) hypothetical protein 0.00697082 0.0266612 0.0592736
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.00208768 0.000908983 0.00206372
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Echinococcus granulosus serotonin receptor 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis hypothetical protein 0.00279044 0.00461515 0.0138807
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049444 0.0159744 0.0463574
Schistosoma mansoni cathepsin F (C01 family) 0.00356214 0.00868485 0.00846369
Plasmodium falciparum plasmepsin IV 0.0649616 0.332487 0.754359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00658834 0.0246441 0.0724787
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Brugia malayi Nuclear hormone receptor E75 0.00622437 0.0227247 0.0511126
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.0041538 0.0118051 0.0254997
Schistosoma mansoni cathepsin D (A01 family) 0.191536 1 1
Mycobacterium ulcerans hypothetical protein 0.00209891 0.00096819 0.000781212
Schistosoma mansoni memapsin-2 (A01 family) 0.0153583 0.0708944 0.0706872
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Trypanosoma cruzi hypothetical protein, conserved 0.00957014 0.0403692 0.0904374
Plasmodium vivax vivapain-2 0.00356214 0.00868485 0.0197177
Schistosoma mansoni alpha-1 adrenergic receptor 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.0240206 0.116577 0.263687
Echinococcus multilocularis neuropeptide s receptor 0.00658834 0.0246441 0.0724787
Leishmania major phosphatidylinositol 3-related kinase, putative 0.00202691 0.000588481 0.00133606
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0041538 0.0118051 0.0254997
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00356214 0.00868485 0.0243941
Schistosoma mansoni cytochrome P450 reductase 0.00208768 0.000908983 0.000686092
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0131952 0.0594866 0.134618
Echinococcus granulosus tachykinin peptides receptor 99D 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis cathepsin L cysteine protease 0.00356214 0.00868485 0.0243941
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Loa Loa (eye worm) hypothetical protein 0.0649616 0.332487 0.754538
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0131952 0.0594866 0.177458
Echinococcus multilocularis g protein coupled receptor 0.00658834 0.0246441 0.0724787
Echinococcus granulosus neuropeptide receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00238453 0.00247446 0.00428757
Echinococcus granulosus enteropeptidase 0.00209891 0.00096819 0.00114405
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0131952 0.0594866 0.177458
Schistosoma mansoni furin-1 (S08 family) 0.00609564 0.0220458 0.0218276
Echinococcus granulosus Tolloid protein 1 0.0041538 0.0118051 0.0337952
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0131952 0.0594866 0.134618
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0164588 0.076698 1
Brugia malayi Pepsin A precursor 0.0153583 0.0708944 0.160531
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus Nuclear hormone receptor HR96 0.00622437 0.0227247 0.0666955
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus multilocularis ecdysone induced protein 78C 0.0131952 0.0594866 0.177458
Echinococcus granulosus Nuclear hormone receptor HR96 0.00622437 0.0227247 0.0666955
Brugia malayi Dopamine receptor protein 2 0.00658834 0.0246441 0.0554726
Brugia malayi nuclear hormone receptor 0.00622437 0.0227247 0.0511126
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0131952 0.0594866 0.177458
Echinococcus granulosus voltage gated potassium channel 0.00204278 0.000672206 0.000252262
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00658834 0.0246441 0.0546879
Schistosoma mansoni hypothetical protein 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) cysteine protease 0.00356214 0.00868485 0.0184063
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) fibroinase 0.00356214 0.00868485 0.0184063
Schistosoma mansoni adenoreceptor 0.00658834 0.0246441 0.0244265
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00658834 0.0246441 0.0554726
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.00238453 0.00247446 0.00428757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus granulosus rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Toxoplasma gondii IMP dehydrogenas 0.00350084 0.00836157 0.0234201
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00658834 0.0246441 0.0554726
Loa Loa (eye worm) hypothetical protein 0.0153583 0.0708944 0.159833
Loa Loa (eye worm) acyl-CoA desaturase 0.0854352 0.440459 1
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Loa Loa (eye worm) hypothetical protein 0.00476094 0.015007 0.0327789
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Loa Loa (eye worm) hypothetical protein 0.00209891 0.00096819 0.000863231
Trypanosoma cruzi GMP reductase 0.00350084 0.00836157 0.0176713
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Trichomonas vaginalis sulfite reductase, putative 0.00208768 0.000908983 0.00273389
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Onchocerca volvulus 0.00356214 0.00868485 0.0175582
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0131952 0.0594866 0.0592768
Trypanosoma cruzi fatty acid desaturase, putative 0.0854352 0.440459 1
Brugia malayi nuclear receptor NHR-88 0.00622437 0.0227247 0.0511126
Loa Loa (eye worm) hypothetical protein 0.00208768 0.000908983 0.000728629
Brugia malayi cathepsin L-like precursor 0.00238453 0.00247446 0.00511411
Echinococcus granulosus tissue type plasminogen activator 0.00957014 0.0403692 0.119858
Brugia malayi Calcium binding EGF domain containing protein 0.0041538 0.0118051 0.0263087
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0131952 0.0594866 0.133151
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00658834 0.0246441 0.0724787
Echinococcus granulosus expressed conserved protein 0.0101752 0.04356 0.129472
Echinococcus granulosus rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Schistosoma mansoni cathepsin F (C01 family) 0.00356214 0.00868485 0.00846369
Echinococcus multilocularis orexin receptor type 2 0.00658834 0.0246441 0.0724787
Brugia malayi steroid hormone receptor 0.0131952 0.0594866 0.134618
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.00350084 0.00836157 0.5
Schistosoma mansoni nuclear hormone receptor 0.0131952 0.0594866 0.0592768
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.00209891 0.00096819 0.000745312
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00322768 0.00692101 0.0208159
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Echinococcus multilocularis Mastin 0.00209891 0.00096819 0.00114405
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Schistosoma mansoni hypothetical protein 0.00541424 0.0184522 0.0182333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0131952 0.0594866 0.133899
Entamoeba histolytica cysteine protease, putative 0.00356214 0.00868485 0.180616
Leishmania major cysteine peptidase A (CPA) 0.00356214 0.00868485 0.0197177
Echinococcus granulosus rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Trypanosoma cruzi hypothetical protein, conserved 0.0117771 0.0520083 0.116898
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis transmembrane protease serine 3 0.00209891 0.00096819 0.00114405
Plasmodium vivax aspartyl proteinase, putative 0.0153583 0.0708944 0.160956
Trypanosoma cruzi fatty acid desaturase, putative 0.0854352 0.440459 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Plasmodium falciparum plasmepsin II 0.0649616 0.332487 0.754359
Plasmodium vivax aspartyl protease, putative 0.0153583 0.0708944 0.160956
Echinococcus multilocularis neuropeptides capa receptor 0.00658834 0.0246441 0.0724787
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0131952 0.0594866 0.0592768
Brugia malayi Protein kinase domain containing protein 0.00957014 0.0403692 0.0911924
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00658834 0.0246441 0.0546879
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00238453 0.00247446 0.00744226
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.032383 0.160677 0.482342
Plasmodium falciparum plasmepsin VIII, putative 0.0153583 0.0708944 0.159221
Echinococcus granulosus cathepsin l1 0.00238453 0.00247446 0.00568238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Onchocerca volvulus Bile acid receptor homolog 0.0131952 0.0594866 0.133151
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0153583 0.0708944 0.0706872
Schistosoma mansoni opsin-like receptor 0.00658834 0.0246441 0.0244265
Schistosoma mansoni hypothetical protein 0.0110584 0.048218 0.0480057
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0131952 0.0594866 0.0592768
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.000745312
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus neuropeptide s receptor 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis sterol regulatory element binding protein 0.00400457 0.0110181 0.0314241
Echinococcus granulosus tm gpcr rhodopsin 0.057514 0.293211 0.88166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00238453 0.00247446 0.00744226
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.000745312
Echinococcus multilocularis neuropeptide receptor 0.0221087 0.106494 0.319089
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Echinococcus multilocularis g protein coupled receptor 0.00658834 0.0246441 0.0724787
Echinococcus multilocularis cysteine protease 0.00356214 0.00868485 0.0243941
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.00209891 0.00096819 0.00114405
Echinococcus granulosus metabotropic glutamate receptor 2 0.00336442 0.00764213 0.0212524
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00624851 0.0228519 0.0670791
Onchocerca volvulus Arrow homolog 0.0041538 0.0118051 0.0246578
Schistosoma mansoni amine GPCR 0.00658834 0.0246441 0.0244265
Schistosoma mansoni nuclear hormone receptor 0.00622437 0.0227247 0.0225066
Brugia malayi neuroendocrine convertase 1 precursor 0.00888609 0.0367617 0.082998
Echinococcus multilocularis fmrfamide receptor 0.00658834 0.0246441 0.0724787
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0131952 0.0594866 0.134618
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.00279044 0.00461515 0.0138807
Trypanosoma cruzi cruzipain precursor, putative 0.00356214 0.00868485 0.0184063
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Brugia malayi FAD binding domain containing protein 0.00208768 0.000908983 0.00155812
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00658834 0.0246441 0.0244265
Schistosoma mansoni neuropeptide receptor 0.00658834 0.0246441 0.0244265
Onchocerca volvulus 0.0153583 0.0708944 0.159108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00697082 0.0266612 0.026444
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus multilocularis FTZ F1 alpha 0.0131952 0.0594866 0.177458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Trichomonas vaginalis conserved hypothetical protein 0.00279044 0.00461515 0.0138807
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Loa Loa (eye worm) nuclear hormone receptor 0.00622437 0.0227247 0.0503243
Brugia malayi Trypsin family protein 0.00209891 0.00096819 0.00169261
Brugia malayi hypothetical protein 0.00697082 0.0266612 0.0600545
Loa Loa (eye worm) DR-78 0.00622437 0.0227247 0.0503243
Schistosoma mansoni hypothetical protein 0.00541424 0.0184522 0.0182333
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.00350084 0.00836157 0.00814034
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0649616 0.332487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Brugia malayi hypothetical protein 0.0153583 0.0708944 0.160531
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00322768 0.00692101 0.0208159
Plasmodium falciparum plasmepsin I 0.0649616 0.332487 0.754359
Leishmania major cathepsin L-like protease 0.00356214 0.00868485 0.0197177
Echinococcus multilocularis rhodopsin orphan GPCR 0.00658834 0.0246441 0.0724787
Echinococcus granulosus peptide allatostatin:somatostatin 0.00658834 0.0246441 0.0724787
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Onchocerca volvulus 0.00356214 0.00868485 0.0175582
Onchocerca volvulus 0.0131952 0.0594866 0.133151
Brugia malayi Cathepsin L-like precursor 0.00356214 0.00868485 0.0192211
Brugia malayi tailless protein 0.00622437 0.0227247 0.0511126
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.00202691 0.000588481 0.00133606
Brugia malayi conserved hypotetical protein 0.00622437 0.0227247 0.0511126
Schistosoma mansoni neuropeptide receptor 0.00658834 0.0246441 0.0244265
Brugia malayi hypothetical protein 0.00658834 0.0246441 0.0554726
Brugia malayi Eukaryotic aspartyl protease family protein 0.0153583 0.0708944 0.160531
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0142467 0.0650319 0.0648233
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus g-protein coupled receptor 0.00658834 0.0246441 0.0724787
Plasmodium vivax aspartyl protease, putative 0.0153583 0.0708944 0.160956
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0649616 0.332487 1
Echinococcus granulosus FTZ F1 alpha 0.0131952 0.0594866 0.177458
Onchocerca volvulus 0.00658834 0.0246441 0.0538712
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.00356214 0.00868485 0.0184063
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.00363866 0.00908838 0.0201377
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0110584 0.048218 0.143506
Toxoplasma gondii aspartyl protease ASP1 0.0649616 0.332487 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Echinococcus multilocularis serotonin receptor 0.00658834 0.0246441 0.0724787
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Brugia malayi hypothetical protein 0.00622437 0.0227247 0.0511126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Echinococcus granulosus sterol regulatory element binding protein 0.00400457 0.0110181 0.0314241
Schistosoma mansoni cercarial elastase (S01 family) 0.00209891 0.00096819 0.000745312
Loa Loa (eye worm) proprotein convertase 2 0.00322768 0.00692101 0.0143964
Loa Loa (eye worm) hypothetical protein 0.0131952 0.0594866 0.133899
Loa Loa (eye worm) glutamate receptor 0.0040163 0.0110799 0.0238512
Trypanosoma brucei fatty acid desaturase, putative 0.0854352 0.440459 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00202691 0.000588481 0.000830094
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Leishmania major stearic acid desaturase, putative 0.0854352 0.440459 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Echinococcus granulosus sex peptide receptor 0.00658834 0.0246441 0.0724787
Schistosoma mansoni nuclear receptor 0.00622437 0.0227247 0.0225066
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00356214 0.00868485 0.0184063
Brugia malayi indoleamine 2,3-dioxygenase 0.0546667 0.278195 0.631415
Echinococcus granulosus 7tm_1 domain containing protein 0.00658834 0.0246441 0.0724787
Schistosoma mansoni hypothetical protein 0.00279044 0.00461515 0.00439308
Loa Loa (eye worm) hypothetical protein 0.00622437 0.0227247 0.0503243
Trichomonas vaginalis PIKK family atypical protein kinase 0.00202691 0.000588481 0.00176994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00356214 0.00868485 0.0261209
Schistosoma mansoni neuropeptide F-like receptor 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) aspartyl protease 6 0.0153583 0.0708944 0.159833
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0131952 0.0594866 0.177458
Loa Loa (eye worm) G-protein coupled receptor 0.00658834 0.0246441 0.0546879
Loa Loa (eye worm) hypothetical protein 0.00658834 0.0246441 0.0546879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00356214 0.00868485 0.0184063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00658834 0.0246441 0.0244265
Loa Loa (eye worm) hypothetical protein 0.00209891 0.00096819 0.000863231
Echinococcus multilocularis cathepsin L cysteine protease 0.00356214 0.00868485 0.0243941

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 0.97 uM Antiproliferative activity as Growth inhibition in CCRF-CEM Leukemia cell line ChEMBL. 10966746
IC50 (functional) = 18.79 nM Antimalarial activity in Plasmodium falciparum Indochina W2 clone ChEMBL. 10966746
IC50 (functional) = 23.74 nM Antimalarial activity in Plasmodium falciparum African D6 clone ChEMBL. 10966746
IC50 (functional) = 3.7 uM Antiproliferative activity in HeLa cells of Human cervix carcinoma ChEMBL. 10966746

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10966746
Plasmodium falciparum ChEMBL23 10966746

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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