Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1B | References | |
Homo sapiens | adrenoceptor alpha 1D | References | |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1239 | 0.1239 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0443 | 0.4018 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0443 | 0.4018 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.004 | 0.0035 | 0.0088 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.3738 | 0.9305 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0161 | 0.1239 | 0.3084 |
Echinococcus multilocularis | serotonin receptor | 0.0161 | 0.1239 | 0.3084 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0036 | 0.0003 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0135 | 0.0974 | 0.2425 |
Loa Loa (eye worm) | hypothetical protein | 0.1048 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0443 | 0.4018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.4018 | 0.4018 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1048 | 1 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0036 | 0.0003 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0423 | 0.3826 | 0.9524 |
Toxoplasma gondii | hypothetical protein | 0.1048 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0036 | 0.0003 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0131 | 0.0937 | 0.2332 |
Loa Loa (eye worm) | hypothetical protein | 0.1048 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0135 | 0.0974 | 0.2425 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0135 | 0.0974 | 0.2425 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.004 | 0.0035 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0443 | 0.4018 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0161 | 0.1239 | 0.3084 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0443 | 0.4018 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.004 | 0.0035 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.004 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1239 | 0.1239 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0443 | 0.4018 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0135 | 0.0974 | 0.0974 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0161 | 0.1239 | 0.3084 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | mg kg-1 | Percent reduction in apomorphine induced climbing in mouse at 50 mg/Kg of compound given perorally; Inactive | ChEMBL. | 10464021 |
ED50 (functional) | 0 mg kg-1 | Percent reduction in apomorphine induced climbing in mouse at 50 mg/Kg of compound given perorally; Inactive | ChEMBL. | 10464021 |
ED50 (functional) | 0 mg kg-1 | Induction of catalepsy in rat after ip administration; Not tested | ChEMBL. | 10464021 |
Ki (binding) | = 17 nM | Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligand | ChEMBL. | 10464021 |
Ki (binding) | = 17 nM | Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligand | ChEMBL. | 10464021 |
Ki (binding) | = 30 nM | Binding affinity of the compound to the dopamine receptor D2L in rat brain membranes | ChEMBL. | 10464021 |
Ki (binding) | = 30 nM | Binding affinity of the compound to the dopamine receptor D2L in rat brain membranes | ChEMBL. | 10464021 |
Ki (binding) | = 94 nM | Binding affinity towards Alpha-1 adrenergic receptor in human cortex membranes | ChEMBL. | 10464021 |
Ki (binding) | = 94 nM | Binding affinity towards Alpha-1 adrenergic receptor in human cortex membranes | ChEMBL. | 10464021 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.