Detailed information for compound 18723

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.757 | Formula: C17H14ClFN2O2
  • H donors: 1 H acceptors: 3 LogP: 3.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCc1nc2c(n1Cc1ccc(cc1)Cl)ccc(c2)F
  • InChi: 1S/C17H14ClFN2O2/c18-12-3-1-11(2-4-12)10-21-15-6-5-13(19)9-14(15)20-16(21)7-8-17(22)23/h1-6,9H,7-8,10H2,(H,22,23)
  • InChiKey: AOOOZXBUFXKFSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Src64B 0.0768 0.0508 0.0508
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1909 0.1542 0.1542
Brugia malayi protein-tyrosine kinase 0.0701 0.0448 0.0448
Brugia malayi Tyrosine-protein kinase abl-1 0.0239 0.0029 0.0029
Onchocerca volvulus 0.1909 0.1542 0.1542
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.1909 0.1542 0.1542
Brugia malayi Fibronectin type III domain containing protein 0.0483 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0483 0.0251 0.0251
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0292 0.0077 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0001 0.0001
Schistosoma mansoni titin 0.0207 0.0001 0.0001
Echinococcus multilocularis lachesin 0.0291 0.0076 0.0076
Echinococcus multilocularis hemicentin 1 0.0338 0.0119 0.0119
Loa Loa (eye worm) norepinephrine transporter 1.1247 1 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.5
Loa Loa (eye worm) hypothetical protein 0.0483 0.0251 0.0251
Schistosoma mansoni cell adhesion molecule 0.0291 0.0076 0.0076
Brugia malayi hypothetical protein 0.1909 0.1542 0.1542
Echinococcus granulosus defective proboscis extension response 0.0483 0.0251 0.0251
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0353 0.0133 0.0133
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0768 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0483 0.0251 0.0251
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0291 0.0076 0.0076
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0768 0.0508 0.0508
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0768 0.0508 0.0508
Schistosoma mansoni tyrosine kinase 0.0768 0.0508 0.0508
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1909 0.1542 0.1542
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase otk 0.0291 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.1909 0.1542 0.1542
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.1542
Brugia malayi SRC-1 0.0768 0.0508 0.0508
Echinococcus multilocularis insulin receptor 0.0353 0.0133 0.0133
Schistosoma mansoni nephrin 0.0291 0.0076 0.0076
Echinococcus multilocularis twitchin 0.0207 0.0001 0.0001
Loa Loa (eye worm) serotonin transporter b 1.1247 1 1
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Echinococcus granulosus titin 0.0207 0.0001 0.0001
Plasmodium falciparum transporter, putative 0.1909 0.1542 0.5
Loa Loa (eye worm) hypothetical protein 0.1909 0.1542 0.1542
Toxoplasma gondii hypothetical protein 0.1909 0.1542 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0527 0.029 0.029
Echinococcus granulosus tyrosine protein kinase Lyn 0.0769 0.0509 0.0509
Schistosoma mansoni tyrosine kinase 0.0423 0.0196 0.0196
Loa Loa (eye worm) TK/EGFR protein kinase 0.0895 0.0623 0.0623
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0768 0.0508 0.0508
Echinococcus multilocularis roundabout 2 0.0774 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0527 0.029 0.029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Echinococcus multilocularis roundabout 2 0.0291 0.0076 0.0076
Schistosoma mansoni sodium/chloride dependent transporter 0.1909 0.1542 0.1542
Echinococcus granulosus lachesin 0.0291 0.0076 0.0076
Echinococcus granulosus roundabout 2 0.0291 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.1909 0.1542 0.1542
Schistosoma mansoni cell adhesion molecule 0.0291 0.0076 0.0076
Onchocerca volvulus 0.0253 0.0042 0.0042
Echinococcus granulosus sodium and chloride dependent glycine 0.1909 0.1542 0.1542
Loa Loa (eye worm) hypothetical protein 1.1247 1 1
Loa Loa (eye worm) TK protein kinase 0.4214 0.363 0.363
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.1909 0.1542 0.5
Plasmodium vivax amine transporter, putative 0.1909 0.1542 0.5
Loa Loa (eye worm) hypothetical protein 0.1909 0.1542 0.1542
Schistosoma mansoni septate junction protein 0.0291 0.0076 0.0076
Schistosoma mansoni tyrosine kinase 0.0239 0.0029 0.0029
Echinococcus granulosus neuroglian 0.069 0.0438 0.0438
Brugia malayi hypothetical protein 0.0483 0.0251 0.0251
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.1542
Echinococcus granulosus tyrosine protein kinase Fyn 0.0768 0.0508 0.0508
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0291 0.0076 0.0076
Echinococcus multilocularis 0.0246 0.0036 0.0036
Brugia malayi protein unc-22 0.0207 0.0001 0.0001
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.1542
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Echinococcus granulosus c src tyrosine kinase 0.0239 0.0029 0.0029
Schistosoma mansoni tyrosine kinase 0.0239 0.0029 0.0029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0239 0.0029 0.0029
Echinococcus granulosus tyrosine protein kinase otk 0.0291 0.0076 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0671 0.0421 0.0421
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.4008 0.3443 0.3443
Schistosoma mansoni tyrosine kinase 0.0353 0.0133 0.0133
Echinococcus granulosus tyrosine protein kinase HCK 0.0633 0.0386 0.0386
Brugia malayi Immunoglobulin I-set domain containing protein 0.4214 0.363 0.363
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0567 0.0327 0.0327
Echinococcus granulosus peroxidasin 0.0291 0.0076 0.0076
Echinococcus granulosus fibroblast growth factor receptor 4 0.4008 0.3443 0.3443
Onchocerca volvulus Putative titin 0.0253 0.0042 0.0042
Schistosoma mansoni cell adhesion molecule 0.0291 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase Blk 0.0701 0.0448 0.0448
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0768 0.0508 0.0508
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0671 0.0421 0.0421
Echinococcus multilocularis c src tyrosine kinase 0.0239 0.0029 0.0029
Echinococcus multilocularis sodium and chloride dependent glycine 0.1909 0.1542 0.1542
Echinococcus multilocularis tyrosine protein kinase Abl 0.0239 0.0029 0.0029
Schistosoma mansoni nephrin 0.069 0.0438 0.0438
Schistosoma mansoni tyrosine kinase 0.4008 0.3443 0.3443
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0291 0.0076 0.0076
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0291 0.0076 0.0076
Echinococcus multilocularis peroxidasin 0.0291 0.0076 0.0076
Loa Loa (eye worm) SRC-1 0.0768 0.0508 0.0508
Echinococcus multilocularis neuroglian 0.0291 0.0076 0.0076
Echinococcus granulosus roundabout 2 0.0774 0.0514 0.0514
Plasmodium falciparum amino acid transporter, putative 0.1909 0.1542 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0239 0.0029 0.0029
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.1909 0.1542 0.1542
Schistosoma mansoni tyrosine kinase 0.0527 0.029 0.029
Schistosoma mansoni roundabout 0.0291 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase HCK 0.0633 0.0386 0.0386
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Echinococcus granulosus epidermal growth factor receptor 0.0527 0.029 0.029
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0483 0.0251 0.0251
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.1909 0.1542 0.1542
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.031 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 1.1247 1 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0291 0.0076 0.0076
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0207 0.0001 0.0001
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0291 0.0076 0.0076
Echinococcus multilocularis sodium and chloride dependent glycine 0.1909 0.1542 0.1542
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Schistosoma mansoni tyrosine kinase 0.0423 0.0196 0.0196
Echinococcus multilocularis tyrosine protein kinase Srms 0.0701 0.0448 0.0448
Echinococcus multilocularis Immunoglobulin 0.0483 0.0251 0.0251
Echinococcus granulosus neuroglian 0.0291 0.0076 0.0076
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0353 0.0133 0.0133
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0291 0.0076 0.0076
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.4008 0.3443 0.3443
Schistosoma mansoni tyrosine kinase 0.0353 0.0133 0.0133
Plasmodium vivax hypothetical protein, conserved 0.1909 0.1542 0.5
Echinococcus multilocularis titin 0.0207 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0768 0.0508 0.0508
Treponema pallidum sodium- and chloride- dependent transporter 1.1247 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0821 0.0556 0.0556
Schistosoma mansoni neuroglian 0.0291 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0701 0.0448 0.0448
Onchocerca volvulus 0.1909 0.1542 0.1542
Schistosoma mansoni titin 0.0338 0.0119 0.0119
Echinococcus multilocularis fibroblast growth factor receptor 4 0.4008 0.3443 0.3443
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0768 0.0508 0.0508
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0291 0.0076 0.0076
Echinococcus granulosus titin 0.0207 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0291 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0567 0.0327 0.0327
Echinococcus multilocularis Immunoglobulin 0.0483 0.0251 0.0251
Loa Loa (eye worm) TK/ROR protein kinase 0.031 0.0094 0.0094
Schistosoma mansoni cell adhesion molecule 0.0567 0.0327 0.0327
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.1542
Echinococcus granulosus serotonin transporter 1.1247 1 1
Echinococcus granulosus hemicentin 1 0.0338 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.1909 0.1542 0.1542
Echinococcus granulosus twitchin 0.0691 0.0438 0.0438
Schistosoma mansoni tyrosine kinase 0.0395 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0483 0.0251 0.0251
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0701 0.0448 0.0448
Brugia malayi Furin-like cysteine rich region family protein 0.0895 0.0623 0.0623
Echinococcus granulosus sodium and chloride dependent glycine 0.1909 0.1542 0.1542
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Schistosoma mansoni sodium/chloride dependent transporter 1.1247 1 1
Loa Loa (eye worm) TK protein kinase 0.0701 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.1909 0.1542 0.1542
Echinococcus granulosus tyrosine kinase 0.0701 0.0448 0.0448
Echinococcus multilocularis neuroglian 0.069 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.031 0.0094 0.0094
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Echinococcus granulosus roundabout 2 0.0291 0.0076 0.0076
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Loa Loa (eye worm) CAMK protein kinase 0.0207 0.0001 0.0001
Echinococcus granulosus insulin receptor 0.0353 0.0133 0.0133
Echinococcus granulosus tyrosine protein kinase Fyn 0.0768 0.0508 0.0508
Brugia malayi Immunoglobulin I-set domain containing protein 0.0207 0.0001 0.0001
Onchocerca volvulus Netrin receptor homolog 0.0253 0.0042 0.0042
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0291 0.0076 0.0076
Schistosoma mansoni tyrosine kinase 0.0423 0.0196 0.0196
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0291 0.0076 0.0076
Echinococcus granulosus tyrosine protein kinase Src42A 0.0597 0.0354 0.0354
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.1542
Schistosoma mansoni sodium/chloride dependent transporter 0.191 0.1543 0.1543
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1909 0.1542 0.1542
Echinococcus granulosus contactin 0.0338 0.0119 0.0119
Echinococcus granulosus tyrosine protein kinase Src42A 0.0768 0.0508 0.0508
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0239 0.0029 0.0029
Onchocerca volvulus 0.0207 0.0001 0.0001
Loa Loa (eye worm) solute carrier family 6 member 4 1.1247 1 1
Loa Loa (eye worm) hypothetical protein 0.1909 0.1542 0.1542
Loa Loa (eye worm) TK protein kinase 0.0633 0.0386 0.0386
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0483 0.0251 0.0251
Onchocerca volvulus Tyrosine kinase homolog 0.0357 0.0137 0.0137
Echinococcus multilocularis hemicentin 1 0.0291 0.0076 0.0076
Echinococcus multilocularis epidermal growth factor receptor 0.0895 0.0623 0.0623
Echinococcus multilocularis serotonin transporter 1.1247 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0768 0.0508 0.0508
Brugia malayi Protein kinase domain containing protein 0.0353 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0291 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 1.1247 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1909 0.1542 0.1542
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0701 0.0448 0.0448
Echinococcus multilocularis roundabout 2 0.0291 0.0076 0.0076
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1909 0.1542 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0597 0.0354 0.0354
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0483 0.0251 0.0251
Schistosoma mansoni norepinephrine/norepinephrine transporter 1.1247 1 1
Onchocerca volvulus 0.0253 0.0042 0.0042
Brugia malayi Prion-like- 0.0291 0.0076 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Schistosoma mansoni septate junction protein 0.0291 0.0076 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0768 0.0508 0.0508
Schistosoma mansoni tyrosine kinase 0.0895 0.0623 0.0623
Schistosoma mansoni vesicular amine transporter 0.0483 0.0251 0.0251
Echinococcus granulosus epidermal growth factor receptor 0.0895 0.0623 0.0623
Schistosoma mansoni sodium-dependent amino acid transporter 0.1909 0.1542 0.1542
Brugia malayi Peroxidasin 0.0291 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0483 0.0251 0.0251
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.1909 0.1542 0.1542
Loa Loa (eye worm) hypothetical protein 0.0774 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0483 0.0251 0.0251
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0768 0.0508 0.0508
Echinococcus granulosus tyrosine protein kinase Fyn 0.0768 0.0508 0.0508
Onchocerca volvulus 1.1247 1 1
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0338 0.0119 0.0119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.1909 0.1542 0.1542
Schistosoma mansoni tyrosine kinase 0.0527 0.029 0.029
Schistosoma mansoni hypothetical protein 0.0253 0.0042 0.0042
Echinococcus granulosus Immunoglobulin 0.0483 0.0251 0.0251
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0768 0.0508 0.0508
Loa Loa (eye worm) TK/INSR protein kinase 0.0353 0.0133 0.0133
Toxoplasma gondii hypothetical protein 0.1909 0.1542 0.5
Schistosoma mansoni tyrosine kinase 0.0768 0.0508 0.0508
Onchocerca volvulus 0.1909 0.1542 0.1542
Brugia malayi Immunoglobulin I-set domain containing protein 0.0483 0.0251 0.0251
Entamoeba histolytica protein kinase, putative 0.0633 0.0386 0.5

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Tested in vitro for percent inhibition against TXA2 / PGH-2 receptor using [125I]-PTA-OH in human platelets at 10 e-7 M ChEMBL. 8487256
Inhibition (binding) = 0 % Tested in vitro for percent inhibition against TXA2 / PGH-2 receptor using [125I]-PTA-OH in human platelets at 10 e-7 M ChEMBL. 8487256
Inhibition (binding) = 64 % In vitro for percent inhibition against TXA2 / PGH-2 receptor using [125I]-PTA-OH in human platelets at 10 e-5 M ChEMBL. 8487256
Inhibition (binding) = 64 % In vitro for percent inhibition against TXA2 / PGH-2 receptor using [125I]-PTA-OH in human platelets at 10 e-5 M ChEMBL. 8487256
Ki (binding) = 5.6 uM Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets ChEMBL. 8487256
Ki (binding) = 5.6 uM Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets ChEMBL. 8487256

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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