TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 513.67 | Formula: C32H39N3O3
H donors: 1 H acceptors: 3 LogP: 3.55 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(N1C[C@H](C(C1)c1ccccc1)CN1CCC(CC1)c1cnc(o1)Cc1ccccc1)CC1CC1
InChi: 1S/C32H39N3O3/c36-32(37)29(17-24-11-12-24)35-21-27(28(22-35)25-9-5-2-6-10-25)20-34-15-13-26(14-16-34)30-19-33-31(38-30)18-23-7-3-1-4-8-23/h1-10,19,24,26-29H,11-18,20-22H2,(H,36,37)/t27-,28?,29?/m0/s1
InChiKey: FVHNVQXWBIUQGH-VSPYUBNUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0059	0.0877	0.2825
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0028	0.009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Schistosoma mansoni	nAChR subunit	0.0025	0.0212	0.0212
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0025	0.0212	0.0683
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0028	0.0297
Echinococcus multilocularis	neuropeptide receptor A26	0.0507	0.9842	0.9842
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0025	0.0212	0.0212
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.1819	0.9695
Loa Loa (eye worm)	ACC-1 protein	0.0025	0.0212	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0877	0.2825
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0061	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0422	0.2247
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0028	0.0028
Echinococcus granulosus	mitogen activated protein kinase 3	0.0056	0.0813	0.0813
Giardia lamblia	Glycogen phosphorylase	0.0109	0.1876	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0028	0.0149
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0047	0.0642	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1819	0.1819
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0359	0.3805
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0028	0.0028
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0359	0.1912
Toxoplasma gondii	protease inhibitor PI2	0.004	0.0505	0.1327
Onchocerca volvulus		0.017	0.3106	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0422	0.0422
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0025	0.0212	0.0212
Echinococcus granulosus	chromobox protein 1	0.0068	0.106	0.106
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0813	0.4335
Leishmania major	cathepsin L-like protease	0.0016	0.0028	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Leishmania major	glucose transporter, lmgt3	0.0033	0.0359	0.3805
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0521	0.2778
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.004	0.0505	0.1327
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0359	0.1912
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0193	0.3563	0.3563
Echinococcus granulosus	agrin	0.004	0.0505	0.0505
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1819	0.1819
Leishmania major	glucose transporter, lmgt1	0.0033	0.0359	0.3805
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0025	0.0212	0.0212
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0025	0.0212	0.0683
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0025	0.0212	0.0683
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0025	0.0212	0.0212
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.0682	0.2196
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0056	0.0813	0.0813
Schistosoma mansoni	hypothetical protein	0.0298	0.5657	0.5657
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0877	0.2825
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0028	0.0028
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0025	0.0212	0.0683
Loa Loa (eye worm)	hypothetical protein	0.004	0.0505	0.1625
Leishmania major	glucose transporter, lmgt2	0.0033	0.0359	0.3805
Echinococcus multilocularis	neuropeptide s receptor	0.0507	0.9842	0.9842
Onchocerca volvulus		0.0049	0.0682	0.2196
Echinococcus multilocularis	General substrate transporter	0.0091	0.1521	0.1521
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0056	0.0813	0.8626
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.2029	0.6531
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0359	0.3805
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0056	0.0813	0.2619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Echinococcus multilocularis	chromobox protein 1	0.0068	0.106	0.106
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0059	0.0877	0.0877
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0025	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0359	0.1912
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0059	0.0877	0.2825
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0422	0.2247
Echinococcus granulosus	General substrate transporter	0.0091	0.1521	0.1521
Echinococcus multilocularis	glycine receptor subunit beta	0.0025	0.0212	0.0212
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0521	0.1678
Onchocerca volvulus		0.0016	0.0028	0.009
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Schistosoma mansoni	organic anion transporter	0.0059	0.0877	0.0877
Plasmodium vivax	hexose transporter	0.0106	0.1819	1
Leishmania major	cathepsin L-like protease	0.0062	0.0943	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0025	0.0212	0.0212
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0205	0.3802	1
Onchocerca volvulus		0.0025	0.0212	0.0683
Schistosoma mansoni	glycogen phosphorylase	0.0109	0.1876	0.1876
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0109	0.1876	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0422	0.1357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Schistosoma mansoni	chromobox protein	0.0068	0.106	0.106
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0813	0.4335
Loa Loa (eye worm)	hypothetical protein	0.017	0.3106	1
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.0682	0.0682
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0241	0.1285
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.0682	0.0682
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0025	0.0212	0.0683
Brugia malayi	sodium-independent organic anion transporter family protein	0.0059	0.0877	0.2825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0422	0.0422
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0025	0.0212	0.0212
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0028	0.009
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0025	0.0212	0.0683
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0056	0.0813	0.2139
Onchocerca volvulus	Putative organic anion transporter	0.0059	0.0877	0.2825
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0359	0.3805
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0025	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.004	0.0505	0.1625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Onchocerca volvulus		0.0059	0.0877	0.2825
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0025	0.0212	0.0212
Brugia malayi	Heterochromatin protein 1	0.0068	0.106	0.3412
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0359	0.1912
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Brugia malayi	MH2 domain containing protein	0.0116	0.2029	0.6531
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0422	0.0422
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0943	1
Brugia malayi	prostaglandin transporter	0.0059	0.0877	0.2825
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.017	0.3106	0.3106
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0642	0.3324
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Schistosoma mansoni	hypothetical protein	0.0106	0.1819	0.1819
Echinococcus granulosus	follistatin	0.004	0.0505	0.0505
Brugia malayi	excitatory GABA receptor EXP-1A	0.0025	0.0212	0.0683
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0422	0.447
Echinococcus granulosus	Glycosyl transferase family 35	0.0109	0.1876	0.1876
Schistosoma mansoni	nAChR subunit	0.0025	0.0212	0.0212
Trypanosoma cruzi	hexose transporter	0.0033	0.0359	0.3805
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Plasmodium falciparum	hexose transporter	0.0106	0.1819	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0943	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.3106	1
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.004	0.0505	0.1327
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.0818	0.0818
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0813	0.0813
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0813	0.8626
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0642	0.3324
Trypanosoma brucei	protein kinase, putative	0.0056	0.0813	0.8626
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0025	0.0212	0.0212
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0359	0.1912
Echinococcus multilocularis	cysteine protease	0.0016	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Echinococcus granulosus	cathepsin l1	0.0016	0.0028	0.0028
Giardia lamblia	Kinase, CMGC MAPK	0.0056	0.0813	0.4335
Echinococcus granulosus	mitogen activated protein kinase	0.0056	0.0813	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.0818	0.0818
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Schistosoma mansoni	hypothetical protein	0.0515	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0212	0.0683
Echinococcus granulosus	glycine receptor subunit beta	0.0025	0.0212	0.0212
Schistosoma mansoni	hypothetical protein	0.0515	1	1
Leishmania major	cathepsin L-like protease	0.0062	0.0943	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0422	0.0422
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.004	0.0505	0.1625
Loa Loa (eye worm)	hypothetical protein	0.004	0.0505	0.1625
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0359	0.3805
Loa Loa (eye worm)	MBCTL1	0.0056	0.0818	0.2632
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0056	0.0813	0.8626
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0025	0.0212	0.0212
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0422	0.0422
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0028	0.0154
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.004	0.0505	0.1327
Onchocerca volvulus	Putative organic anion transporter	0.0059	0.0877	0.2825
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1819	0.1819
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0028	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0463	0.247
Echinococcus multilocularis	nAChR subunit	0.0025	0.0212	0.0212
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0028	0.009
Onchocerca volvulus		0.0059	0.0877	0.2825
Echinococcus multilocularis	chromobox protein 1	0.0068	0.106	0.106
Onchocerca volvulus		0.017	0.3106	1
Chlamydia trachomatis	glycogen phosphorylase	0.0109	0.1876	0.5
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1819	0.1819
Entamoeba histolytica	glycogenphosphorylase, putative	0.0047	0.0642	0.3324
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0682	0.0682
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0212	0.0683
Toxoplasma gondii	transporter, major facilitator family protein	0.0059	0.0877	0.2308
Onchocerca volvulus		0.0016	0.0028	0.009
Onchocerca volvulus		0.0025	0.0212	0.0683
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0359	0.1912
Brugia malayi	chromobox protein homolog 3	0.0038	0.0463	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0877	0.2825
Onchocerca volvulus		0.004	0.0505	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0109	0.1876	0.604
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1819	0.1819
Entamoeba histolytica	glycogen phosphorylase, putative	0.0109	0.1876	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0877	0.2825
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.1819	0.4784
Schistosoma mansoni	organic anion transporter	0.0059	0.0877	0.0877
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0422	0.447
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.106	0.5649
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0025	0.0212	0.0212
Leishmania major	cathepsin L-like protease	0.0016	0.0028	0.0297
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0422	0.447
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0025	0.0212	0.0212
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0056	0.0813	0.8626
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0028	0.0028
Echinococcus multilocularis	mitogen activated protein kinase	0.0056	0.0813	0.0813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0359	0.3805
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0877	0.2825
Onchocerca volvulus		0.0016	0.0028	0.009
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0025	0.0212	0.0212
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0359	0.3805
Schistosoma mansoni	chromobox protein	0.0068	0.106	0.106
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0028	0.009
Loa Loa (eye worm)	agrin synaptic family protein	0.004	0.0505	0.1625
Entamoeba histolytica	glycogen phosphorylase, putative	0.0109	0.1876	1
Onchocerca volvulus		0.0025	0.0212	0.0683
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0212	0.0683
Onchocerca volvulus		0.0016	0.0028	0.009
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0422	0.447
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0025	0.0212	0.0212
Onchocerca volvulus		0.003	0.0299	0.0962
Leishmania major	cathepsin L-like protease	0.0016	0.0028	0.0297
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0463	0.1492
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0025	0.0212	0.0683
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0025	0.0212	0.0212
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.004	0.0505	0.1327
Loa Loa (eye worm)	ACC-1 protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0463	0.247
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Schistosoma mansoni	glucose transport protein	0.0106	0.1819	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Echinococcus granulosus	glycine receptor subunit beta	0.0025	0.0212	0.0212
Toxoplasma gondii	cathepsin CPL	0.0016	0.0028	0.0074
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0241	0.1285
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0056	0.0813	0.8626
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.1819	0.1819
Brugia malayi	Cation transporter family protein	0.0025	0.0212	0.0683
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0025	0.0212	0.0683
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	sodium-independent organic anion transporter family protein	0.0059	0.0877	0.2825
Onchocerca volvulus	Putative organic anion transporter	0.0059	0.0877	0.2825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Loa Loa (eye worm)	ctsf protein	0.0016	0.0028	0.009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0463	0.1492
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0059	0.0877	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Loa Loa (eye worm)	LGC-31 protein	0.0025	0.0212	0.0683
Plasmodium vivax	vivapain-2	0.0016	0.0028	0.0154
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0677	0.7184
Schistosoma mansoni	nAChR subunit	0.0025	0.0212	0.0212
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0028	0.009
Leishmania major	cathepsin L-like protease	0.0016	0.0028	0.0297
Echinococcus granulosus	neuropeptide receptor A26	0.0507	0.9842	0.9842
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	carbohydrate phosphorylase	0.0109	0.1876	0.604
Loa Loa (eye worm)	hypothetical protein	0.003	0.0299	0.0962
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0025	0.0212	0.0683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Echinococcus granulosus	chromobox protein 1	0.0068	0.106	0.106
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0422	0.1357
Onchocerca volvulus		0.0016	0.0028	0.009
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0212	0.0683
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0943	1
Loa Loa (eye worm)	fibroinase	0.0016	0.0028	0.009
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0028	0.009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.0682	0.0682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0028	0.0149
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.0818	0.0818
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0422	0.0422
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0682	0.0682
Onchocerca volvulus		0.0016	0.0028	0.009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0028	0.0028
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0025	0.0212	0.0683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0028	0.009
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0028	0.009
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0025	0.0212	0.0212
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.2029	0.6531
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1819	0.1819
Brugia malayi	hypothetical protein	0.0059	0.0877	0.2825
Brugia malayi	Sugar transporter family protein	0.0106	0.1819	0.5856
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0109	0.1876	0.1876
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0359	0.1912
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0813	0.4335
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0028	0.009
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0193	0.3563	0.3563
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0813	0.8626
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0943	1
Trypanosoma cruzi	MFS transporter, putative	0.0059	0.0877	0.9304
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0028	0.009
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.017	0.3106	0.3106
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.0818	0.2632
Schistosoma mansoni	nAChR subunit	0.0025	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.004	0.0505	0.1625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	secreted modular calcium-binding protein 1	0.004	0.0505	0.1625
Brugia malayi	SPARC precursor	0.004	0.0505	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.004	0.0505	0.1625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0028	0.0149
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	mbt repeat family protein	0.0049	0.0682	0.2196
Onchocerca volvulus		0.0059	0.0877	0.2825
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0025	0.0212	0.0683
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0025	0.0212	0.0683
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.0682	0.2196
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0521	0.2778
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0025	0.0212	0.0212
Schistosoma mansoni	glycogen phosphorylase	0.0047	0.0642	0.0642
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0025	0.0212	0.0212
Echinococcus granulosus	glycogen phosphorylase	0.0109	0.1876	0.1876
Leishmania major	cathepsin L-like protease	0.0016	0.0028	0.0297
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0047	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0682	0.2196
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0943	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0025	0.0212	0.0212
Onchocerca volvulus		0.0059	0.0877	0.2825
Schistosoma mansoni	nAChR subunit	0.0025	0.0212	0.0212
Schistosoma mansoni	nAChR subunit	0.0025	0.0212	0.0212
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.0818	0.0818
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.0682	0.0682
Leishmania major	cathepsin L-like protease	0.0062	0.0943	1
Schistosoma mansoni	follistatin	0.004	0.0505	0.0505
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.004	0.0505	0.1625
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.106	0.5649
Schistosoma mansoni	glucose transport protein	0.0106	0.1819	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0877	0.2825
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0025	0.0212	0.0212
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0025	0.0212	0.0683
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Onchocerca volvulus		0.0059	0.0877	0.2825
Loa Loa (eye worm)	hypothetical protein	0.0158	0.2871	0.9243
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0025	0.0212	0.0212
Brugia malayi	sodium-independent organic anion transporter family protein	0.0059	0.0877	0.2825
Echinococcus multilocularis	expressed protein	0.004	0.0505	0.0505
Loa Loa (eye worm)	glycogen phosphorylase	0.0109	0.1876	0.604
Echinococcus multilocularis	glycogen phosphorylase	0.0109	0.1876	0.1876
Schistosoma mansoni	glucose transport protein	0.0106	0.1819	0.1819
Onchocerca volvulus	Putative nachr subunit	0.0025	0.0212	0.0683
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0059	0.0877	0.0877
Echinococcus granulosus	neuropeptide s receptor	0.0507	0.9842	0.9842
Schistosoma mansoni	nAChR subunit	0.0025	0.0212	0.0212
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0025	0.0212	0.0683
Echinococcus multilocularis	geminin	0.0515	1	1
Brugia malayi	MAP kinase sur-1	0.0056	0.0813	0.2619
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0422	0.0422
Echinococcus granulosus	glycogen phosphorylase	0.0109	0.1876	0.1876
Echinococcus multilocularis	glycine receptor subunit beta	0.0025	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0818	0.2632
Schistosoma mansoni	agrin	0.004	0.0505	0.0505
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0056	0.0813	0.8626
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0028	0.0154
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0422	0.2129
Onchocerca volvulus		0.017	0.3106	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0028	0.0028
Echinococcus multilocularis	cysteine protease	0.0016	0.0028	0.0028
Loa Loa (eye worm)	sugar transporter	0.0106	0.1819	0.5856
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.004	0.0505	0.1625
Echinococcus granulosus	nAChR subunit	0.0025	0.0212	0.0212
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0359	0.3805
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.106	0.3412
Echinococcus multilocularis	glycogen phosphorylase	0.0109	0.1876	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0059	0.0877	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0212	0.0683
Echinococcus multilocularis	follistatin	0.004	0.0505	0.0505
Echinococcus multilocularis	agrin	0.004	0.0505	0.0505
Onchocerca volvulus		0.0016	0.0028	0.009
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.0682	0.0682
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0359	0.3805
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0028	0.0028
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.004	0.0505	0.1625
Brugia malayi	Cation transporter family protein	0.017	0.3106	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1819	0.1819
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0422	0.0422
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0835	0.8858
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0025	0.0212	0.0212
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0028	0.0154
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0028	0.0149
Brugia malayi	Cation transporter family protein	0.0025	0.0212	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0877	0.2825
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0028	0.009
Brugia malayi	mbt repeat family protein	0.0049	0.0682	0.2196
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0813	0.4335
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0422	0.2247
Plasmodium vivax	vivapain-2	0.0016	0.0028	0.0154
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0359	0.3805
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0028	0.009
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0025	0.0212	0.0212
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0028	0.0028
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0359	0.3805
Loa Loa (eye worm)	cysteine protease	0.0016	0.0028	0.009
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0025	0.0212	0.0212
Schistosoma mansoni	glycogen phosphorylase	0.0109	0.1876	0.1876
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0109	0.1876	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.0818	0.0818
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0028	0.0297
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0025	0.0212	0.0683
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0422	0.2247

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.6 nM	Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand	ChEMBL.	15177445
IC50 (functional)	= 3.7 nM	Anti viral activity was determined in anti HIV-1 infectivity assay in HeLa Magi cells	ChEMBL.	15177445

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 289261

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 188798