TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 305.347 | Formula: C16H20FN3O2
H donors: 1 H acceptors: 2 LogP: 2.11 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C(N(C)C)CNC(=O)c1c(C)noc1C
InChi: 1S/C16H20FN3O2/c1-10-15(11(2)22-19-10)16(21)18-9-14(20(3)4)12-5-7-13(17)8-6-12/h5-8,14H,9H2,1-4H3,(H,18,21)
InChiKey: JCZXCFAHPTXOKO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0036	0.0026	0.5
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.4565	1	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0189	0.0364	0.0364
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0031	0.0016	0.0016
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0094	0.0094
Echinococcus granulosus	tyrosine protein kinase HCK	0.003	0.0014	0.0014
Toxoplasma gondii	casein kinase I	0.0065	0.0091	0.1052
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0066	0.0094	0.0094
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0036	0.0026	0.5
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0066	0.0094	0.0094
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0066	0.0094	0.0094
Schistosoma mansoni	serine/threonine protein kinase	0.0335	0.0686	0.0686
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0066	0.0094	0.0094
Leishmania major	protein kinase, putative	0.0315	0.0642	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0036	0.0026	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0034	0.0022	0.0022
Trichomonas vaginalis	CMGC family protein kinase	0.0189	0.0364	0.5296
Echinococcus granulosus	mitogen activated protein kinase 3	0.0189	0.0364	0.0364
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0315	0.0642	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0037	0.0029	0.0029
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.03	0.0609	0.0609
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0189	0.0364	0.5484
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.4565	1	1
Echinococcus granulosus	aurora kinase A	0.0315	0.0642	0.0642
Brugia malayi	Cytochrome P450 family protein	0.01	0.0167	0.0167
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0034	0.0022	0.0022
Trypanosoma cruzi	cytochrome P450, putative	0.0065	0.0091	0.1051
Entamoeba histolytica	protein kinase, putative	0.0066	0.0094	0.1274
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.03	0.0609	0.9461
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0031	0.0016	0.0016
Giardia lamblia	Kinase, AGC AKT	0.03	0.0609	0.9398
Leishmania major	casein kinase, putative	0.0065	0.0091	0.1052
Toxoplasma gondii	AGC kinase	0.0066	0.0094	0.1098
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0065	0.0091	0.0091
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0094	0.0094
Echinococcus granulosus	protein kinase c iota type	0.0066	0.0094	0.0094
Echinococcus granulosus	protein kinase C gamma type	0.0066	0.0094	0.0094
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0036	0.0026	0.5
Loa Loa (eye worm)	TK protein kinase	0.0034	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0037	0.0029	0.0029
Loa Loa (eye worm)	AUR protein kinase	0.0315	0.0642	0.0642
Onchocerca volvulus		0.0045	0.0048	0.0673
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0045	0.0048	0.0352
Loa Loa (eye worm)	cytochrome P450 family protein	0.0065	0.0091	0.0091
Echinococcus multilocularis	casein kinase I gamma	0.0335	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0094	0.0094
Brugia malayi	Cytochrome P450 family protein	0.0036	0.0026	0.0026
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0036	0.0026	0.5
Brugia malayi	serine/threonine kinase 12	0.0315	0.0642	0.0642
Loa Loa (eye worm)	TK protein kinase	0.003	0.0014	0.0014
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0066	0.0094	0.0094
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0066	0.0094	0.0094
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0029	0.0029
Giardia lamblia	Aurora kinase	0.0315	0.0642	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0036	0.0026	0.5
Loa Loa (eye worm)	AUR protein kinase	0.0315	0.0642	0.0642
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0034	0.0022	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0094	0.0094
Entamoeba histolytica	protein kinase, putative	0.0066	0.0094	0.1274
Echinococcus granulosus	protein kinase c epsilon type	0.0066	0.0094	0.0094
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0036	0.0026	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0037	0.0029	0.0029
Trypanosoma brucei	casein kinase I, isoform 2	0.0065	0.0091	0.1052
Entamoeba histolytica	protein kinase, putative	0.0315	0.0642	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0036	0.0026	0.5
Onchocerca volvulus		0.0328	0.0669	0.9395
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0094	0.0094
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0066	0.0094	0.0094
Echinococcus multilocularis	aurora kinase A	0.0315	0.0642	0.0642
Echinococcus multilocularis	casein kinase I alpha	0.0065	0.0091	0.0091
Echinococcus granulosus	casein kinase I alpha	0.0065	0.0091	0.0091
Entamoeba histolytica	protein kinase, putative	0.0066	0.0094	0.1274
Brugia malayi	Protein kinase domain containing protein	0.0335	0.0686	0.0686
Echinococcus multilocularis	casein kinase I delta	0.0065	0.0091	0.0091
Echinococcus granulosus	casein kinase i	0.0065	0.0091	0.0091
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0036	0.0026	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0037	0.0029	0.0029
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.1039	0.2235	0.2235
Loa Loa (eye worm)	cytochrome P450 family protein	0.0065	0.0091	0.0091
Loa Loa (eye worm)	CYP4Cod1	0.0065	0.0091	0.0091
Giardia lamblia	Kinase, CMGC MAPK	0.0189	0.0364	0.4953
Schistosoma mansoni	atypical protein kinase C	0.0066	0.0094	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0094	0.0094
Brugia malayi	Cytochrome P450 family protein	0.0065	0.0091	0.0091
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0065	0.0091	1
Trichomonas vaginalis	AGC family protein kinase	0.0315	0.0642	1
Trypanosoma cruzi	casein kinase, putative	0.0065	0.0091	0.1052
Schistosoma mansoni	protein kinase	0.0315	0.0642	0.0642
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0315	0.0642	0.0642
Toxoplasma gondii	aurora kinase	0.0315	0.0642	1
Trypanosoma cruzi	casein kinase, putative	0.0065	0.0091	0.1052
Brugia malayi	Protein kinase domain containing protein	0.1039	0.2235	0.2235
Echinococcus granulosus	Protein kinase C brain isozyme	0.0066	0.0094	0.0094
Echinococcus multilocularis	casein kinase I delta	0.0065	0.0091	0.0091
Entamoeba histolytica	casein kinase 1, putative	0.0065	0.0091	0.1228
Loa Loa (eye worm)	cytochrome P450 family protein	0.01	0.0167	0.0167
Schistosoma mansoni	protein kinase	0.0065	0.0091	0.0091
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0189	0.0364	0.5484
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0036	0.0026	0.5
Loa Loa (eye worm)	casein kinase	0.0316	0.0643	0.0643
Trichomonas vaginalis	CK1 family protein kinase	0.0065	0.0091	0.068
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0315	0.0642	1
Echinococcus multilocularis	serine threonine protein kinase	0.0066	0.0094	0.0094
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0066	0.0094	0.0094
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0189	0.0364	0.0364
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0037	0.0029	0.0029
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0066	0.0094	0.0094
Loa Loa (eye worm)	cytochrome P450	0.0036	0.0026	0.0026
Echinococcus multilocularis	casein kinase I alpha	0.0065	0.0091	0.0091
Trypanosoma brucei	protein kinase, putative	0.0189	0.0364	0.5484
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0029	0.0029
Trypanosoma brucei	aurora B kinase	0.0315	0.0642	1
Trichomonas vaginalis	CMGC family protein kinase	0.0189	0.0364	0.5296
Echinococcus granulosus	cytochrome P450 2K1	0.0036	0.0026	0.0026
Brugia malayi	p70 ribosomal S6 kinase beta	0.0066	0.0094	0.0094
Brugia malayi	MAP kinase sur-1	0.0189	0.0364	0.0364
Echinococcus granulosus	NDR protein kinase	0.0066	0.0094	0.0094
Entamoeba histolytica	protein kinase domain containing protein	0.0315	0.0642	1
Leishmania major	cytochrome p450-like protein	0.0065	0.0091	0.1051
Echinococcus multilocularis	tyrosine protein kinase HCK	0.003	0.0014	0.0014
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0036	0.0026	0.5
Echinococcus granulosus	casein kinase I delta	0.0065	0.0091	0.0091
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Echinococcus multilocularis	mitogen activated protein kinase	0.0189	0.0364	0.0364
Echinococcus multilocularis	rho associated protein kinase	0.0347	0.0712	0.0712
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0066	0.0094	0.0094
Trichomonas vaginalis	CMGC family protein kinase	0.0189	0.0364	0.5296
Schistosoma mansoni	serine/threonine protein kinase	0.4565	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0094	0.0094
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0066	0.0094	0.0094
Trichomonas vaginalis	CK1 family protein kinase	0.0065	0.0091	0.068
Trichomonas vaginalis	CMGC family protein kinase	0.0189	0.0364	0.5296
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0189	0.0364	0.5484
Brugia malayi	protein-tyrosine kinase	0.0034	0.0022	0.0022
Brugia malayi	Cytochrome P450 family protein	0.0065	0.0091	0.0091
Schistosoma mansoni	serine/threonine kinase	0.0066	0.0094	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0315	0.0642	1
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.4565	1	1
Trypanosoma cruzi	casein kinase, putative	0.0065	0.0091	0.1052
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.0091	0.0091
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0066	0.0094	0.0094
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0347	0.0712	0.0712
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0189	0.0364	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0013
Echinococcus multilocularis	casein kinase i	0.0065	0.0091	0.0091
Brugia malayi	casein kinase 1, delta	0.0065	0.0091	0.0091
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0066	0.0094	0.1098
Echinococcus granulosus	tyrosine protein kinase Blk	0.0034	0.0022	0.0022
Echinococcus granulosus	casein kinase I delta	0.0065	0.0091	0.0091
Echinococcus multilocularis		0.0036	0.0026	0.0026
Mycobacterium leprae	putative cytochrome p450	0.0036	0.0026	0.5
Schistosoma mansoni	hypothetical protein	0.0036	0.0026	0.0026
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0066	0.0094	0.0094
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0036	0.0026	0.5
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0066	0.0094	0.0094
Schistosoma mansoni	tyrosine kinase	0.0037	0.0029	0.0029
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0066	0.0094	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0065	0.0091	0.0091
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0036	0.0026	0.5
Echinococcus multilocularis	casein kinase I alpha	0.0065	0.0091	0.0091
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Loa Loa (eye worm)	AUR protein kinase	0.0315	0.0642	0.0642
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0037	0.0029	0.0029
Echinococcus multilocularis	protein kinase c epsilon type	0.0066	0.0094	0.0094
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0029	0.0029
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.0364	0.0364
Echinococcus granulosus	serine:threonine protein kinase N2	0.0066	0.0094	0.0094
Echinococcus granulosus	mitogen activated protein kinase	0.0189	0.0364	0.0364
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0037	0.0029	0.0029
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0029	0.0029
Entamoeba histolytica	protein kinase, putative	0.0066	0.0094	0.1274
Brugia malayi	serine/threonine-protein kinase 6	0.0315	0.0642	0.0642
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0315	0.0642	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0029	0.0029
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0036	0.0026	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0057	0.0072	0.0072
Trichomonas vaginalis	AGC family protein kinase	0.0315	0.0642	1
Schistosoma mansoni	serine/threonine protein kinase	0.0347	0.0712	0.0712
Brugia malayi	casein kinase I	0.0065	0.0091	0.0091
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0037	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0094	0.0094
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0065	0.0091	0.1052
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0189	0.0364	0.5484
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0347	0.0712	0.0712
Schistosoma mansoni	cytochrome P450	0.0036	0.0026	0.0026
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0189	0.0364	0.5484
Echinococcus multilocularis	protein kinase c iota type	0.0066	0.0094	0.0094
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0037	0.0029	0.0029
Echinococcus granulosus	rho-associated protein kinase 1	0.0347	0.0712	0.0712
Onchocerca volvulus		0.0347	0.0712	1
Entamoeba histolytica	casein kinase, putative	0.0065	0.0091	0.1228
Brugia malayi	protein kinase C II.	0.0066	0.0094	0.0094
Brugia malayi	cytochrome P450	0.0036	0.0026	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0094	0.0094
Echinococcus granulosus	casein kinase I alpha	0.0065	0.0091	0.0091
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0036	0.0026	0.5
Schistosoma mansoni	tyrosine kinase	0.0037	0.0029	0.0029
Trypanosoma cruzi	aurora B kinase, putative	0.0315	0.0642	1
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0315	0.0642	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0036	0.0026	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0315	0.0642	0.0642
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0036	0.0026	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Echinococcus granulosus	casein kinase I gamma	0.0335	0.0686	0.0686
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Mycobacterium leprae	Conserved hypothetical protein	0.0036	0.0026	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0037	0.0029	0.0029
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0029	0.0029
Brugia malayi	serine/threonine protein kinase 6	0.0315	0.0642	0.0642
Trypanosoma cruzi	casein kinase, putative	0.0065	0.0091	0.1052
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0315	0.0642	1
Entamoeba histolytica	protein kinase, putative	0.0315	0.0642	1
Trichomonas vaginalis	AGC family protein kinase	0.0315	0.0642	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0036	0.0026	0.5
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0065	0.0091	0.0091
Echinococcus granulosus	casein kinase I alpha	0.0065	0.0091	0.0091
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0347	0.0712	0.0712
Trichomonas vaginalis	CK1 family protein kinase	0.0065	0.0091	0.068
Entamoeba histolytica	protein kinase , putative	0.0315	0.0642	1
Trypanosoma cruzi	cytochrome P450, putative	0.0065	0.0091	0.1051
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0315	0.0642	0.0642
Brugia malayi	SRC-1	0.0037	0.0029	0.0029
Onchocerca volvulus		0.0065	0.0091	0.1277
Trypanosoma cruzi	casein kinase, putative	0.0065	0.0091	0.1052
Brugia malayi	Hr1 repeat family protein	0.0066	0.0094	0.0094
Echinococcus granulosus	tyrosine kinase	0.0034	0.0022	0.0022
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0036	0.0026	0.5
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0189	0.0364	0.5484
Loa Loa (eye worm)	SRC-1	0.0037	0.0029	0.0029
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0094	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0094	0.0729
Trypanosoma brucei	cytochrome P450, putative	0.0065	0.0091	0.1051
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0335	0.0686	0.0686
Schistosoma mansoni	serine/threonine protein kinase	0.0347	0.0712	0.0712
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0189	0.0364	0.5484
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0036	0.0026	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0034	0.0022	0.0022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3494579

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2072222