TDR Targets

Basic information

Technical information

TDR Targets ID: 207322
Name: N-[2-[2-(2,2-dimethylpropanoylamino)phenyl]di sulfanylphenyl]-2,2-dimethylpropanamide
MW: 416.6 | Formula: C22H28N2O2S2
H donors: 2 H acceptors: 2 LogP: 5.18 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(C)(C)C)Nc1ccccc1SSc1ccccc1NC(=O)C(C)(C)C
InChi: 1S/C22H28N2O2S2/c1-21(2,3)19(25)23-15-11-7-9-13-17(15)27-28-18-14-10-8-12-16(18)24-20(26)22(4,5)6/h7-14H,1-6H3,(H,23,25)(H,24,26)
InChiKey: DDZIFEIGSSYBIV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[2-(2,2-dimethylpropanoylamino)phenyl]disulfanylphenyl]-2,2-dimethyl-propanamide
N-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]phenyl]disulfanylphenyl]-2,2-dimethylpropanamide
2,2-dimethyl-N-[2-[2-(pivaloylamino)phenyl]disulfanylphenyl]propionamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholesteryl ester transfer protein, plasma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0272	0.063	0.0607
Onchocerca volvulus		0.0147	0.0199	0.216
Loa Loa (eye worm)	hypothetical protein	0.0592	0.1731	0.1914
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0381	0.1004	0.1214
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0272	0.063	0.0735
Leishmania major	hypothetical protein, conserved	0.0304	0.074	0.1519
Loa Loa (eye worm)	hypothetical protein	0.1161	0.3688	0.4109
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.1741	0.5682	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0272	0.063	0.0735
Brugia malayi	hypothetical protein	0.0125	0.0126	0.0124
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0272	0.063	0.0735
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0272	0.063	0.0607
Schistosoma mansoni	hypothetical protein	0.0215	0.0434	0.0411
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0272	0.063	0.0735
Entamoeba histolytica	aldose reductase, putative	0.0331	0.0832	0.1428
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0147	0.0199	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Trypanosoma brucei	prostaglandin f synthase	0.0331	0.0832	0.1715
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1253	0.4002	0.7031
Onchocerca volvulus		0.0272	0.063	0.75
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1161	0.3688	0.4444
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0381	0.1004	0.1732
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0125	0.0126	0.0102
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0381	0.1004	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0215	0.0434	0.046
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0377	0.0991	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.2997	1	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0125	0.0126	0.0102
Trypanosoma brucei	aldo-keto reductase, putative	0.0331	0.0832	0.1715
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1126	0.3567	0.6263
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0272	0.063	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0277	0.0284
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0913	0.2835	0.4968
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0331	0.0832	0.098
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0272	0.063	0.0607
Leishmania major	aldo-keto reductase-like protein	0.0331	0.0832	0.1715
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2494	0.8269	0.8265
Brugia malayi	hypothetical protein	0.0125	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0215	0.0434	0.0525
Schistosoma mansoni	neurotransmitter gated ion channel	0.0147	0.0199	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.0592	0.1731	0.3016
Onchocerca volvulus		0.0272	0.063	0.75
Entamoeba histolytica	hypothetical protein	0.0215	0.0434	0.0725
Brugia malayi	Cation transporter family protein	0.0272	0.063	0.0735
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0215	0.0434	0.0725
Onchocerca volvulus		0.0331	0.0832	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0536	0.1539	0.1519
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0215	0.0434	0.4186
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Loa Loa (eye worm)	oxidoreductase	0.0331	0.0832	0.0906
Loa Loa (eye worm)	acetylcholine receptor protein	0.0125	0.0126	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0377	0.0991	0.1709
Loa Loa (eye worm)	ACC-1 protein	0.0272	0.063	0.0679
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0272	0.063	0.0607
Onchocerca volvulus		0.0125	0.0126	0.1263
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0272	0.063	0.0607
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0147	0.0199	0.0212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1466	0.4734	0.4722
Brugia malayi	N-terminal motif family protein	0.0175	0.0296	0.0329
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0215	0.0434	0.4186
Trypanosoma cruzi	aldo/keto reductase, putative	0.0331	0.0832	0.1006
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0331	0.0832	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1466	0.4734	1
Onchocerca volvulus		0.0272	0.063	0.75
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0272	0.063	0.0607
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0147	0.0199	0.0212
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0874	0.2698	0.4726
Onchocerca volvulus		0.0125	0.0126	0.1263
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0272	0.063	0.0735
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0215	0.0434	0.0525
Plasmodium vivax	hypothetical protein, conserved	0.0215	0.0434	0.4186
Loa Loa (eye worm)	oxidoreductase	0.0331	0.0832	0.0906
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2494	0.8269	1
Brugia malayi	hypothetical protein	0.0125	0.0126	0.0124
Loa Loa (eye worm)	phosphatidylinositol 3	0.0215	0.0434	0.046
Schistosoma mansoni	nAChR subunit	0.0272	0.063	0.0607
Schistosoma mansoni	nAChR subunit	0.0125	0.0126	0.0102
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0465	0.1295	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0337	0.0854	0.0931
Echinococcus multilocularis		0.0215	0.0434	0.0411
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0536	0.1539	0.1861
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Echinococcus multilocularis	aldo keto reductase	0.0331	0.0832	0.081
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.1741	0.5682	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0125	0.0126	0.0124
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0215	0.0434	0.046
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0689	0.2064	0.2473
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0215	0.0434	0.1031
Trypanosoma cruzi	aldo/keto reductase, putative	0.0096	0.0024	0.0029
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0961	0.2998	0.5963
Onchocerca volvulus		0.0125	0.0126	0.1263
Schistosoma mansoni	nAChR subunit	0.0272	0.063	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1466	0.4734	0.5726
Leishmania major	phosphatidylinositol kinase, putative	0.0215	0.0434	0.0871
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.1256	0.4013	0.4838
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1433	0.4623	0.8128
Giardia lamblia	Aldose reductase	0.0331	0.0832	0.0924
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0272	0.063	0.0607
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0272	0.063	0.0735
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0762	0.2315	0.4864
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0381	0.1004	0.208
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1253	0.4002	0.7031
Onchocerca volvulus		0.0331	0.0832	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0381	0.1004	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.1741	0.5682	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0272	0.063	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0913	0.2835	0.5968
Mycobacterium leprae	conserved hypothetical protein	0.0215	0.0434	0.5079
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2494	0.8269	0.8265
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0272	0.063	0.0735
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0913	0.2835	0.5968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1253	0.4002	0.7031
Onchocerca volvulus		0.0331	0.0832	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0272	0.063	0.0679
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0331	0.0832	0.1715
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0215	0.0434	0.0725
Schistosoma mansoni	nAChR subunit	0.0272	0.063	0.0607
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0215	0.0434	0.0411
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0689	0.2064	0.2044
Loa Loa (eye worm)	hypothetical protein	0.0331	0.0832	0.0906
Loa Loa (eye worm)	phosphatidylinositol 3	0.0474	0.1324	0.1458
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.08	0.137
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0272	0.063	0.0679
Echinococcus multilocularis	glycine receptor subunit beta	0.0272	0.063	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1083	0.3418	0.5998
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0272	0.063	0.0607
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0215	0.0434	0.0498
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0272	0.063	0.0735
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0215	0.0434	0.1031
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.1161	0.3688	0.3672
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Loa Loa (eye worm)	oxidoreductase	0.0331	0.0832	0.0906
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1253	0.4002	1
Onchocerca volvulus		0.0272	0.063	0.75
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0913	0.2835	0.4968
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0331	0.0832	0.1428
Entamoeba histolytica	aldose reductase, putative	0.0331	0.0832	0.1428
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1296	0.4152	0.8764
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0381	0.1004	0.0982
Loa Loa (eye worm)	hypothetical protein	0.058	0.1689	0.1867
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0536	0.1539	0.1837
Mycobacterium ulcerans	oxidoreductase	0.0331	0.0832	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.1269	0.4058	0.7129
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Loa Loa (eye worm)	hypothetical protein	0.0337	0.0854	0.0931
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0689	0.2064	0.3604
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0215	0.0434	0.0725
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0215	0.0434	0.0411
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0689	0.2064	0.2495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1296	0.415	0.7292
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0215	0.0434	0.0871
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0536	0.1539	0.1519
Mycobacterium leprae	Conserved hypothetical protein	0.0235	0.0503	0.5922
Brugia malayi	Cation transporter family protein	0.0272	0.063	0.0735
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0125	0.0126	0.0102
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Loa Loa (eye worm)	ACC-1 protein	0.0272	0.063	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Trichomonas vaginalis	aldo/keto reductase, putative	0.0331	0.0832	0.1428
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0125	0.0126	0.0114
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0384	0.1017	0.1754
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0536	0.1539	0.1519
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0536	0.1539	0.2677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1296	0.415	0.7292
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.2706	0.474
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0321	0.08	0.0967
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0272	0.063	0.0735
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1466	0.4734	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1741	0.5682	0.6871
Echinococcus granulosus	glycine receptor subunit beta	0.0272	0.063	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1083	0.342	0.6002
Schistosoma mansoni	nAChR subunit	0.0272	0.063	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Trypanosoma cruzi	target of rapamycin kinase 3	0.1296	0.4152	0.5021
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1466	0.4734	0.5713
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0592	0.1731	0.429
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0215	0.0434	0.0525
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0215	0.0434	0.0411
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0689	0.2064	0.3604
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1466	0.4734	0.8325
Loa Loa (eye worm)	hypothetical protein	0.0377	0.0991	0.1084
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0215	0.0434	0.4186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.125	0.3995	0.7017
Echinococcus multilocularis	Zinc finger, PHD finger	0.0381	0.1004	0.0982
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0381	0.1004	0.0982
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2494	0.8269	0.8265
Loa Loa (eye worm)	GABA receptor subunit	0.0147	0.0199	0.0196
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0215	0.0434	0.4186
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Echinococcus granulosus	aldo keto reductase	0.0331	0.0832	0.081
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0381	0.1004	0.1732
Brugia malayi	FAT domain containing protein	0.0377	0.0991	0.1173
Entamoeba histolytica	hypothetical protein	0.0147	0.0199	0.0308
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.1526	0.4942	0.8693
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Toxoplasma gondii	aldose reductase, putative	0.0331	0.0832	0.203
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0272	0.063	0.0607
Entamoeba histolytica	hypothetical protein	0.0536	0.1539	0.2677
Loa Loa (eye worm)	phosphatidylinositol 3	0.0215	0.0434	0.046
Echinococcus multilocularis	nAChR subunit	0.0147	0.0199	0.0175
Echinococcus granulosus	glycine receptor subunit beta	0.0272	0.063	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0125	0.0126	0.0124
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0272	0.063	0.0679
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0974	0.3045	0.5339
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0147	0.0199	0.0212
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0381	0.1004	0.2463
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0272	0.063	0.0735
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0215	0.0434	0.0871
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0215	0.0434	0.0498
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0215	0.0434	0.0725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1296	0.415	0.7292
Onchocerca volvulus		0.0147	0.0199	0.216
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1089	0.3438	0.6034
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0272	0.063	0.0607
Loa Loa (eye worm)	phosphatidylinositol 3	0.0215	0.0434	0.046
Loa Loa (eye worm)	oxidoreductase	0.0331	0.0832	0.0906
Brugia malayi	hypothetical protein	0.0125	0.0126	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Echinococcus granulosus	nAChR subunit	0.0272	0.063	0.0607
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0689	0.2064	0.3604
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1083	0.3418	0.5998
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0554	0.1601	0.3348
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0536	0.1539	0.1861
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0331	0.0832	0.098
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0272	0.063	0.0607
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Echinococcus granulosus	aldo keto reductase	0.0331	0.0832	0.081
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0272	0.063	0.0607
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0272	0.063	0.0607
Schistosoma mansoni	acetylcholine receptor-related	0.0125	0.0126	0.0102
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0272	0.063	0.0735
Schistosoma mansoni	neurotransmitter gated ion channel	0.0125	0.0126	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0536	0.1539	0.3216
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0215	0.0434	0.0725
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0215	0.0434	0.0525
Loa Loa (eye worm)	oxidoreductase	0.0331	0.0832	0.0906
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0272	0.063	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1083	0.342	0.6002
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0296	0.0305
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0147	0.0199	0.0175
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0215	0.0434	0.0525
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0689	0.2064	0.3604
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0272	0.063	0.0607
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0272	0.063	0.0735
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.2706	0.474
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0272	0.063	0.0735
Loa Loa (eye worm)	phosphatidylinositol 3	0.125	0.3995	0.4453
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0331	0.0832	0.1428
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.1269	0.4058	0.7129
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0125	0.0126	0.0114
Schistosoma mansoni	nAChR subunit	0.0272	0.063	0.0607
Echinococcus multilocularis	aldo keto reductase	0.0331	0.0832	0.081
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1466	0.4734	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0272	0.063	0.0735
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1296	0.415	0.7292
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0331	0.0832	0.1428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0913	0.2835	0.4968
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0125	0.0126	0.0102
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0125	0.0126	0.0124
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0474	0.1324	0.1601
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0434	0.046
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0536	0.1539	0.1519
Schistosoma mansoni	aldo-keto reductase	0.0331	0.0832	0.081
Giardia lamblia	GTOR	0.1466	0.4734	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0853	0.2628	0.4603
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0381	0.1004	0.208
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0272	0.063	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0536	0.1539	0.1699
Brugia malayi	Cation transporter family protein	0.0272	0.063	0.0735
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0125	0.0126	0.0124
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0215	0.0434	0.0411
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0125	0.0126	0.0124
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0215	0.0434	0.0411
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0689	0.2064	0.4329
Plasmodium vivax	hypothetical protein	0.0215	0.0434	0.4186
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0331	0.0832	0.098
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1466	0.4734	0.8325
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1466	0.4734	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0331	0.0832	0.1715
Brugia malayi	hypothetical protein	0.0125	0.0126	0.0124
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0689	0.2064	0.3604
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0272	0.063	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1083	0.3418	0.5998
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1083	0.342	0.6002
Entamoeba histolytica	protein kinase rad3, putative	0.0536	0.1539	0.2677
Onchocerca volvulus		0.0331	0.0832	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0331	0.0832	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0215	0.0434	0.0411
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Echinococcus granulosus	aldehyde reductase	0.0235	0.0503	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0215	0.0434	0.5079
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1741	0.5682	0.6871
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0125	0.0126	0.0102
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0272	0.063	0.0679
Schistosoma mansoni	nAChR subunit	0.0272	0.063	0.0607
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Echinococcus granulosus	serine protein kinase ATM	0.0536	0.1539	0.1519
Schistosoma mansoni	aldo-keto reductase	0.0331	0.0832	0.081
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0536	0.1539	0.2677
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0147	0.0199	0.0175
Echinococcus granulosus	aldo keto reductase	0.0331	0.0832	0.081
Entamoeba histolytica	hypothetical protein	0.0215	0.0434	0.0725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1083	0.342	0.6002
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1741	0.5682	0.6862
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0215	0.0434	0.0498
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0272	0.063	0.0679
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1466	0.4734	0.4722
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1466	0.4734	0.8325
Trypanosoma cruzi	aldo-keto reductase	0.0331	0.0832	0.1006
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0215	0.0434	0.0411
Echinococcus multilocularis	aldehyde reductase	0.0235	0.0503	0.0479
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0381	0.1004	0.1189
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0377	0.0991	0.0969
Trichomonas vaginalis	aldo/keto reductase, putative	0.0331	0.0832	0.1428
Schistosoma mansoni	nAChR subunit	0.0272	0.063	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1466	0.4734	0.8325
Echinococcus multilocularis	aldo keto reductase	0.0331	0.0832	0.081
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Onchocerca volvulus		0.0331	0.0832	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1466	0.4734	0.4722
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1126	0.3567	0.6263
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0381	0.1004	0.208
Onchocerca volvulus		0.0272	0.063	0.75
Schistosoma mansoni	pol-related	0.0331	0.0832	0.081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1253	0.4002	0.7031
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0523	0.1494	0.2464
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0272	0.063	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1253	0.4002	0.7031
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Leishmania major	hypothetical protein, unknown function	0.0215	0.0434	0.0871
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0272	0.063	0.0607
Echinococcus multilocularis	serine protein kinase ATM	0.0536	0.1539	0.1519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0321	0.08	0.137
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0272	0.063	0.0735
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.2997	1	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Loa Loa (eye worm)	LGC-31 protein	0.0272	0.063	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1296	0.415	0.7292
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0215	0.0434	0.0871
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1253	0.4002	0.7031
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0175	0.0296	0.3362
Schistosoma mansoni	nAChR subunit	0.0125	0.0126	0.0102
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0125	0.0126	0.0124
Onchocerca volvulus		0.0215	0.0434	0.5079
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1741	0.5682	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0381	0.1004	0.1732
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0381	0.1004	0.2463
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0331	0.0832	0.081
Echinococcus multilocularis	aldo keto reductase	0.0331	0.0832	0.081
Echinococcus multilocularis	glycine receptor subunit beta	0.0272	0.063	0.0607
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0272	0.063	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Onchocerca volvulus	Putative nachr subunit	0.0272	0.063	0.75
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0381	0.1004	0.1732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1466	0.4734	0.8325
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0272	0.063	0.0607
Onchocerca volvulus		0.0215	0.0434	0.5079
Leishmania major	prostaglandin f synthase, putative	0.0331	0.0832	0.1715
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.2706	0.474
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1466	0.4734	0.5726
Onchocerca volvulus		0.0331	0.0832	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0874	0.2698	0.4726
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Toxoplasma gondii	FATC domain-containing protein	0.0536	0.1539	0.3808
Trichomonas vaginalis	aldo-keto reductase, putative	0.0331	0.0832	0.1428
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0381	0.1004	0.0982
Entamoeba histolytica	aldose reductase, putative	0.0331	0.0832	0.1428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0919	0.2854	0.5001
Trichomonas vaginalis	aldo/keto reductase, putative	0.0331	0.0832	0.1428
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0381	0.1004	0.1099
Giardia lamblia	Aldose reductase	0.0331	0.0832	0.0924
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2494	0.8269	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0381	0.1004	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0215	0.0434	0.1031
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0913	0.2835	0.4968
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0272	0.063	0.0679
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.125	0.3995	0.8429
Echinococcus multilocularis	nAChR subunit	0.0272	0.063	0.0607
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1296	0.4152	0.8764
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0381	0.1004	0.0982
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0125	0.0126	0.0102
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0215	0.0434	0.0871
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0272	0.063	0.0607
Schistosoma mansoni	neurotransmitter gated ion channel	0.0125	0.0126	0.0102
Loa Loa (eye worm)	phosphatidylinositol 3	0.1466	0.4734	0.5283
Echinococcus granulosus	nAChR subunit	0.0147	0.0199	0.0175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1253	0.4002	0.7031
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0381	0.1004	0.0982
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0272	0.063	0.0607
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0536	0.1539	0.1837
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Onchocerca volvulus		0.0272	0.063	0.75
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0465	0.1295	0.1274
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.125	0.3995	0.8429
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2494	0.8269	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0272	0.063	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0272	0.063	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Loa Loa (eye worm)	phosphatidylinositol 3	0.2689	0.8941	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0215	0.0434	0.4186
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0215	0.0434	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0199	0.0196
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0331	0.0832	0.081
Entamoeba histolytica	hypothetical protein	0.0215	0.0434	0.0725
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0381	0.1004	0.1214
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0126	0.0114
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0331	0.0832	0.098
Loa Loa (eye worm)	hypothetical protein	0.0321	0.08	0.087
Schistosoma mansoni	hypothetical protein	0.0377	0.0991	0.0969
Echinococcus granulosus	hypothetical protein	0.0331	0.0832	0.081
Entamoeba histolytica	hypothetical protein	0.1433	0.4623	0.8128
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0272	0.063	0.0735
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0272	0.063	0.0607
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0272	0.063	0.0607
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.1161	0.3688	0.3672

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 uM	In vitro concentration required to inhibit 50% of cholesteryl ester transfer protein mediated cholesteryl ester transfer from HDL to VLDL and LDL in human plasma	ChEMBL.	11000011
IC50 (binding)	= 13 uM	In vitro concentration required to inhibit 50% of cholesteryl ester transfer protein mediated cholesteryl ester transfer from HDL to VLDL and LDL in human plasma	ChEMBL.	11000011

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 3346283

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 207322