Detailed information for compound 2073937

Basic information

Technical information
  • TDR Targets ID: 2073937
  • Name: N,N-diethyl-2-[tris(2-diethylaminoethoxy)sily loxy]ethanamine
  • MW: 492.811 | Formula: C24H56N4O4Si
  • H donors: 0 H acceptors: 0 LogP: 3.33 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCO[Si](OCCN(CC)CC)(OCCN(CC)CC)OCCN(CC)CC)CC
  • InChi: 1S/C24H56N4O4Si/c1-9-25(10-2)17-21-29-33(30-22-18-26(11-3)12-4,31-23-19-27(13-5)14-6)32-24-20-28(15-7)16-8/h9-24H2,1-8H3
  • InChiKey: NQESJUSXUOPEDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • diethyl-[2-[tris(2-diethylaminoethoxy)silyloxy]ethyl]amine
  • 18867-06-6
  • 4-04-00-01492 (Beilstein Handbook Reference)
  • BRN 1806736
  • Silane, tetrakis(2-diethylaminoethoxy)-
  • Tetrakis(2-diethylaminoethoxy)silane
  • NCI60_010750

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide FF receptor 2 0.0067 0.1166 1
Schistosoma mansoni adenosine diphosphatase 0.004 0.0658 0.4068
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.002 0.0288 0.1783
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0067 0.1166 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0132 0.1132
Brugia malayi RE15519p 0.0067 0.1166 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.001 0.0094 0.1432
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Onchocerca volvulus 0.0067 0.1166 1
Brugia malayi sulfakinin receptor protein 0.0067 0.1166 1
Echinococcus granulosus fmrfamide receptor 0.0067 0.1166 1
Brugia malayi hypothetical protein 0.0067 0.1166 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Brugia malayi AKH receptor 0.0067 0.1166 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1166 1
Plasmodium vivax thioredoxin reductase, putative 0.0029 0.0444 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Plasmodium vivax glutathione reductase, putative 0.0029 0.0444 1
Toxoplasma gondii Nucleoside-diphosphatase 0.0026 0.0402 0.6118
Echinococcus granulosus neuropeptide FF receptor 2 0.0067 0.1166 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0067 0.1166 1
Brugia malayi endonuclease G, mitochondrial precursor 0.0012 0.0137 0.1173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Brugia malayi follicle stimulating hormone receptor 0.0067 0.1166 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0027 0.0003
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0067 0.1166 1
Brugia malayi Nucleoside-diphosphatase mig-23 0.0026 0.0402 0.3453
Echinococcus granulosus hypothetical protein 0.0067 0.1166 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0065 0.1131 0.8837
Brugia malayi ORL1-like opioid receptor 0.0067 0.1166 1
Trypanosoma cruzi hypothetical protein, conserved 0.054 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.1166 0.7208
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0067 0.1166 0.7208
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.002 0.0287 0.2463
Schistosoma mansoni hypothetical protein 0.0012 0.0132 0.0816
Toxoplasma gondii GDA1/CD39 (nucleoside phosphatase) family protein 0.004 0.0658 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0067 0.1166 1
Schistosoma mansoni lipoxygenase 0.0012 0.0132 0.0816
Schistosoma mansoni growth hormone secretagogue receptor 0.0067 0.1166 0.7208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Schistosoma mansoni guanosine-diphosphatase 0.0026 0.0402 0.2489
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.1166 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.1166 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0033 0.0534 0.4582
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0033 0.0534 0.4582
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.013 0.0103
Trypanosoma brucei endonuclease G, putative 0.0012 0.0137 0.0113
Onchocerca volvulus 0.0067 0.1166 1
Echinococcus multilocularis neuropeptide receptor 0.0067 0.1166 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.1166 1
Brugia malayi GnHR receptor homolog 0.0067 0.1166 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.001 0.0094 0.0071
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0027 0.0003
Brugia malayi Serotonin receptor 0.0067 0.1166 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0067 0.1166 1
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0044 0.0728 0.6248
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.1166 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0402 0.0377
Brugia malayi Serotonin receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) TYRA-2 protein 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) doublecortin family protein 0.0012 0.0132 0.1132
Brugia malayi neuropeptide F receptor 0.0067 0.1166 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.001 0.0094 0.0071
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Brugia malayi hypothetical protein 0.0067 0.1166 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0073 0.1267 1
Schistosoma mansoni hypothetical protein 0.0067 0.1166 0.7208
Onchocerca volvulus 0.0067 0.1166 1
Toxoplasma gondii GDA1/CD39 (nucleoside phosphatase) family protein 0.0026 0.0402 0.6118
Echinococcus multilocularis Polycystic kidney disease protein 0.0012 0.0132 0.1132
Onchocerca volvulus 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.002 0.0287 0.2463
Echinococcus granulosus g protein coupled receptor 0.0067 0.1166 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0065 0.1131 0.8837
Schistosoma mansoni neuropeptide receptor 0.0067 0.1166 0.7208
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0278 0.0255
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0067 0.1166 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.001 0.0094 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0067 0.1166 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.002 0.0288 0.1783
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.1166 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.001 0.0094 0.0808
Toxoplasma gondii NADPH-glutathione reductase 0.001 0.0094 0.1432
Echinococcus granulosus neuropeptide s receptor 0.0067 0.1166 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.1166 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.001 0.0094 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0017 0.0229 0.1961
Echinococcus multilocularis g-protein coupled receptor 0.0067 0.1166 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0067 0.1166 0.7208
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.001 0.0094 0.2121
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Loa Loa (eye worm) thioredoxin reductase 0.0029 0.0444 0.3812
Loa Loa (eye worm) hypothetical protein 0.0017 0.0229 0.1961
Trypanosoma brucei nucleoside diphosphatase, putative 0.004 0.0658 0.0636
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Brugia malayi Thrombospondin type 1 domain containing protein 0.0044 0.0728 0.6248
Trypanosoma cruzi trypanothione reductase, putative 0.001 0.0094 0.0071
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0067 0.1166 1
Echinococcus multilocularis Endonuclease G 0.0012 0.0137 0.1173
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.1166 1
Echinococcus multilocularis g protein coupled receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.1166 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.1166 0.7208
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0402 0.0377
Loa Loa (eye worm) glutathione reductase 0.0029 0.0444 0.3812
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0278 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.1166 0.7208
Trypanosoma cruzi nucleoside phosphatase, putative 0.0026 0.0402 0.038
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0026 0.0402 0.3453
Echinococcus granulosus 7TM GPCR rhodopsin 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Brugia malayi hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.1166 1
Plasmodium falciparum apyrase, putative 0.0026 0.0402 0.9058
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Schistosoma mansoni rab6-interacting 0.0012 0.0132 0.0816
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1166 1
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Trypanosoma brucei trypanothione reductase 0.0029 0.0444 0.0422
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis G protein coupled receptor 139 0.0067 0.1166 1
Echinococcus granulosus sex peptide receptor 0.0067 0.1166 1
Plasmodium falciparum thioredoxin reductase 0.0029 0.0444 1
Brugia malayi glutathione reductase 0.0029 0.0444 0.3812
Mycobacterium ulcerans flavoprotein disulfide reductase 0.001 0.0094 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0067 0.1166 0.7208
Echinococcus multilocularis serotonin receptor 0.0067 0.1166 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0067 0.1166 0.7208
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.002 0.0288 0.2474
Leishmania major trypanothione reductase 0.0029 0.0444 0.0422
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0012 0.0137 0.0113
Brugia malayi hypothetical protein 0.0067 0.1166 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0012 0.0137 0.0113
Echinococcus multilocularis serotonin receptor 0.0067 0.1166 1
Toxoplasma gondii thioredoxin reductase 0.0029 0.0444 0.6754
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Onchocerca volvulus 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0067 0.1166 0.7208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Loa Loa (eye worm) RecQ helicase 0.0012 0.013 0.1116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0073 0.1267 1
Onchocerca volvulus 0.0067 0.1166 1
Echinococcus multilocularis fmrfamide receptor 0.0067 0.1166 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0067 0.1166 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.001 0.0094 0.0808
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0027 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.0012 0.0132 0.1908
Echinococcus multilocularis dro:myosuppressin receptor 0.0067 0.1166 1
Echinococcus granulosus 3'partial|ectonucleoside triphosphate diphosphohydrolase 0.0026 0.0402 0.3453
Echinococcus multilocularis fmrfamide receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Onchocerca volvulus 0.0067 0.1166 1
Schistosoma mansoni amine GPCR 0.0067 0.1166 0.7208
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.001 0.0094 0.0583
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Leishmania major ATP diphosphohydrolase 0.004 0.0658 0.0636
Schistosoma mansoni guanosine-diphosphatase 0.0026 0.0402 0.2489
Echinococcus multilocularis ectonucleotide 0.0017 0.0229 0.1961
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0007 0.0045 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0067 0.1166 0.7208
Brugia malayi Dopamine receptor protein 1 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus granulosus somatostatin receptor 0.0067 0.1166 1
Brugia malayi G-protein coupled receptor 0.0067 0.1166 1
Brugia malayi hypothetical protein 0.0067 0.1166 1
Plasmodium falciparum thioredoxin reductase 0.001 0.0094 0.2121
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Schistosoma mansoni rotamase 0.002 0.0287 0.1775
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0065 0.1131 0.8837
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0288 0.2474
Brugia malayi hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0278 0.0255
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0067 0.1166 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.001 0.0094 0.2121
Leishmania major dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.001 0.0094 0.0071
Treponema pallidum NADH oxidase 0.001 0.0094 0.5
Onchocerca volvulus 0.0067 0.1166 1
Brugia malayi putative neuropeptide receptor NPR1 0.0067 0.1166 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Schistosoma mansoni hypothetical protein 0.0067 0.1166 0.7208
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0067 0.1166 1
Echinococcus granulosus bloom syndrome protein 0.0012 0.013 0.1116
Echinococcus granulosus g protein coupled receptor 0.0067 0.1166 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.1166 0.7208
Brugia malayi hypothetical protein 0.0067 0.1166 1
Onchocerca volvulus 0.0067 0.1166 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.001 0.0094 0.5
Trichomonas vaginalis guanosine-diphosphatase, putative 0.0026 0.0402 0.0377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Mycobacterium tuberculosis Probable reductase 0.0065 0.1131 0.8837
Toxoplasma gondii NTPase II 0.0026 0.0402 0.6118
Schistosoma mansoni amine GPCR 0.0067 0.1166 0.7208
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis g protein coupled receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0402 0.3453
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.1132
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.1166 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.002 0.0278 0.0255
Schistosoma mansoni histamine h1 receptor 0.0067 0.1166 0.7208
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.1132
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0067 0.1166 1
Schistosoma mansoni amine GPCR 0.0067 0.1166 0.7208
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.1166 0.7208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Trypanosoma cruzi endonuclease G, putative 0.0012 0.0137 0.0113
Brugia malayi hypothetical protein 0.0012 0.0132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Trypanosoma brucei nucleoside phosphatase, putative 0.004 0.0658 0.0636
Schistosoma mansoni polycystin 1-related 0.0012 0.0132 0.0816
Echinococcus granulosus Endonuclease G 0.0012 0.0137 0.1173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Schistosoma mansoni opsin-like receptor 0.0067 0.1166 0.7208
Brugia malayi G-protein coupled receptor 0.0067 0.1166 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.1166 0.7208
Onchocerca volvulus 0.002 0.0288 0.1512
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.1166 1
Plasmodium falciparum glutathione reductase 0.001 0.0094 0.2121
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0026 0.0402 0.3453
Schistosoma mansoni rab6-interacting 0.0012 0.0132 0.0816
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.1166 1
Schistosoma mansoni endonuclease related 0.0012 0.0137 0.0845
Echinococcus multilocularis bloom syndrome protein 0.0012 0.013 0.1116
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.001 0.0103 0.2321
Brugia malayi hypothetical protein 0.0067 0.1166 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis g protein coupled receptor 0.0067 0.1166 1
Brugia malayi Dopamine receptor 0.0067 0.1166 1
Schistosoma mansoni adenoreceptor 0.0067 0.1166 0.7208
Trichomonas vaginalis guanosine-diphosphatase, putative 0.0026 0.0402 0.0377
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.001 0.0094 1
Trypanosoma cruzi nucleoside phosphatase, putative 0.004 0.0658 0.0636
Echinococcus granulosus g protein coupled receptor 0.0067 0.1166 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Brugia malayi hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis neuropeptide receptor 0.0067 0.1166 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0065 0.1131 0.8837
Brugia malayi hypothetical protein 0.0012 0.0132 0.1132
Echinococcus granulosus g-protein coupled receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0085 0.0731
Echinococcus granulosus 7tm_1 domain containing protein 0.0067 0.1166 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.1166 1
Echinococcus granulosus neuropeptide receptor 0.0067 0.1166 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.001 0.0094 0.0071
Onchocerca volvulus 0.0067 0.1166 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0057 0.086
Onchocerca volvulus 0.0067 0.1166 1
Schistosoma mansoni biogenic amine receptor 0.0067 0.1166 0.7208
Trichomonas vaginalis conserved hypothetical protein 0.054 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0067 0.1166 1
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0444 0.0422
Trichomonas vaginalis adenosine diphosphatase, putative 0.0026 0.0402 0.0377
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0067 0.1166 1
Trichomonas vaginalis adenosine diphosphatase, putative 0.0026 0.0402 0.0377
Echinococcus granulosus thioredoxin glutathione reductase 0.0029 0.0444 0.3812
Brugia malayi Thioredoxin reductase 0.0029 0.0444 0.3812
Onchocerca volvulus 0.0067 0.1166 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0067 0.1166 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.1166 1
Schistosoma mansoni lipoxygenase 0.0033 0.0534 0.3303
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.001 0.0094 0.0071
Schistosoma mansoni hypothetical protein 0.0044 0.0728 0.4503
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.001 0.0094 0.0071
Schistosoma mansoni hypothetical protein 0.0067 0.1166 0.7208
Brugia malayi larval opioid receptor 0.0067 0.1166 1
Brugia malayi Melatonin receptor type 1A 0.0067 0.1166 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0067 0.1166 0.7208
Loa Loa (eye worm) hypothetical protein 0.002 0.0288 0.2474
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.1166 0.7208
Schistosoma mansoni ATP-diphosphohydrolase 1 0.0026 0.0402 0.2489
Trichomonas vaginalis adenosine diphosphatase, putative 0.0026 0.0402 0.0377
Echinococcus multilocularis somatostatin receptor 0.0067 0.1166 1
Echinococcus multilocularis neuropeptide s receptor 0.0067 0.1166 1
Echinococcus granulosus G protein coupled receptor 139 0.0067 0.1166 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0287 0.0261
Schistosoma mansoni myosin xvIII 0.0067 0.1166 0.7208
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.1166 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.001 0.0094 0.0071
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.1166 0.7208
Echinococcus granulosus tachykinin peptides receptor 99D 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Plasmodium falciparum nucleoside-diphosphatase, putative 0.0026 0.0402 0.9058
Loa Loa (eye worm) melatonin receptor type 1A 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus granulosus neuropeptide receptor A26 0.0067 0.1166 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0183 0.1574
Trypanosoma cruzi hypothetical protein 0.054 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.0012 0.0132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus granulosus ectonucleotide 0.0017 0.0229 0.1961
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Brugia malayi Dopamine receptor protein 2 0.0067 0.1166 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Echinococcus multilocularis RUN 0.0012 0.0132 0.1132
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.001 0.0094 0.0808
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Trypanosoma cruzi hypothetical protein, conserved 0.054 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.001 0.0094 0.093
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.1166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.1166 0.7208
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.1267 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.002 0.0278 0.0255
Schistosoma mansoni hypothetical protein 0.0067 0.1166 0.7208
Echinococcus multilocularis neuropeptide receptor A26 0.0067 0.1166 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0029 0.0444 0.2985
Plasmodium falciparum glutathione reductase 0.0029 0.0444 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.001 0.0094 0.5
Toxoplasma gondii GDA1/CD39 (nucleoside phosphatase) family protein 0.0026 0.0402 0.6118
Onchocerca volvulus 0.0044 0.0728 0.5769
Trypanosoma cruzi endonuclease G, putative 0.0012 0.0137 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1166 1
Trypanosoma brucei nucleoside 2-deoxyribosyltransferase 0.054 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0065 0.1131 0.8837
Trypanosoma cruzi hypothetical protein, conserved 0.054 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.001 0.0094 0.093
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0067 0.1166 0.7208
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0073 0.1267 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0132 0.1132
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0026 0.0402 0.3453
Leishmania major dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Trichomonas vaginalis DNA helicase recq1, putative 0.0012 0.013 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1166 1
Echinococcus granulosus orexin receptor type 2 0.0067 0.1166 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Trichomonas vaginalis mercuric reductase, putative 0.001 0.0094 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1166 1
Echinococcus granulosus ectonucleoside triphosphate diphosphohydrolase 0.0026 0.0402 0.3453
Onchocerca volvulus 0.0067 0.1166 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0006 0.0024 0.0359
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.002 0.0288 0.1783
Schistosoma mansoni neuropeptide receptor 0.0067 0.1166 0.7208
Echinococcus granulosus RUN 0.0012 0.0132 0.1132
Trichomonas vaginalis glutathione reductase, putative 0.001 0.0094 0.0068
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0067 0.1166 1
Trichomonas vaginalis adenosine diphosphatase, putative 0.0026 0.0402 0.0377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.1166 0.7208
Echinococcus granulosus ectonucleoside triphosphate diphosphohydrolase 0.0026 0.0402 0.3453
Schistosoma mansoni loxhd1 0.0012 0.0132 0.0816
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0067 0.1166 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0067 0.1166 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0067 0.1166 0.7208
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0067 0.1166 1
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.1166 1
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.1166 0.7208
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Toxoplasma gondii peptidylprolyl isomerase 0.002 0.0278 0.4227
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0067 0.1166 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.002 0.0288 0.1783
Trichomonas vaginalis guanosine-diphosphatase, putative 0.0026 0.0402 0.0377
Leishmania major endonuclease G, putative 0.0012 0.0137 0.0113
Brugia malayi G protein-coupled receptor 0.0067 0.1166 1
Trichomonas vaginalis rotamase, putative 0.002 0.0278 0.0252
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0094 0.0071
Echinococcus granulosus peptide allatostatin:somatostatin 0.0067 0.1166 1
Onchocerca volvulus 0.002 0.0288 0.1512
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0012 0.0137 0.0113
Brugia malayi neuropeptide F receptor 0.0067 0.1166 1
Brugia malayi Bloom's syndrome protein homolog 0.0012 0.013 0.1116
Echinococcus granulosus neuropeptide receptor 0.0067 0.1166 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0067 0.1166 1
Plasmodium vivax nucleoside-diphosphatase mig-23, putative 0.0026 0.0402 0.8916
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.001 0.0094 1
Schistosoma mansoni amine GPCR 0.0067 0.1166 0.7208
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0067 0.1166 1
Echinococcus multilocularis orexin receptor type 2 0.0067 0.1166 1
Schistosoma mansoni biogenic amine receptor 0.0067 0.1166 0.7208
Onchocerca volvulus 0.0067 0.1166 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0067 0.1166 0.7208
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Brugia malayi Doublecortin family protein 0.0012 0.0132 0.1132
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0067 0.1166 1
Echinococcus multilocularis allatostatin A receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Brugia malayi putative neuropeptide receptor 0.0067 0.1166 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0132 0.1132
Trypanosoma cruzi hypothetical protein 0.054 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1166 0.7208
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0017 0.0229 0.1961
Schistosoma mansoni opsin-like receptor 0.0067 0.1166 0.7208
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0067 0.1166 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Echinococcus granulosus serotonin receptor 0.0067 0.1166 1
Echinococcus granulosus allatostatin A receptor 0.0067 0.1166 1
Echinococcus multilocularis sex peptide receptor 0.0067 0.1166 1
Trichomonas vaginalis adenosine/guanosine diphosphatase, putative 0.0026 0.0402 0.0377
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0183 0.1574
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0007 0.0045 0.0386
Echinococcus multilocularis thioredoxin glutathione reductase 0.0029 0.0444 0.3812
Echinococcus multilocularis expressed protein 0.002 0.0287 0.2463
Loa Loa (eye worm) hypothetical protein 0.0067 0.1166 1
Schistosoma mansoni amine GPCR 0.0067 0.1166 0.7208
Trypanosoma brucei endonuclease G, putative 0.0012 0.0137 0.0113
Onchocerca volvulus 0.0067 0.1166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1166 1
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0012 0.0137 0.2078
Schistosoma mansoni biogenic amine receptor 0.0067 0.1166 0.7208
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.002 0.0288 0.2474
Onchocerca volvulus 0.0067 0.1166 1
Schistosoma mansoni opsin-like receptor 0.0067 0.1166 0.7208
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0288 0.2474
Trypanosoma brucei endonuclease G, putative 0.0012 0.0137 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.1166 1
Trichomonas vaginalis rotamase, putative 0.002 0.0287 0.0261
Brugia malayi hypothetical protein 0.0067 0.1166 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0067 0.1166 1
Onchocerca volvulus 0.0067 0.1166 1
Echinococcus granulosus expressed protein 0.002 0.0287 0.2463
Leishmania major nucleoside phosphatase, putative,guanosine diphosphatase, putative 0.004 0.0658 0.0636
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0026 0.0402 0.3453
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0083 0.0516
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.001 0.0094 0.0071
Plasmodium falciparum LCCL domain-containing protein 0.0012 0.0132 0.297
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.1166 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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