TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 465.426 | Formula: C21H22F3N5O4
H donors: 1 H acceptors: 6 LogP: -1.16 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.O=C(N1CCC2(C1)CN(c1ccccc1)C(=O)CN2C)c1ccnnc1
InChi: 1S/C19H21N5O2.C2HF3O2/c1-22-12-17(25)24(16-5-3-2-4-6-16)14-19(22)8-10-23(13-19)18(26)15-7-9-20-21-11-15;3-2(4,5)1(6)7/h2-7,9,11H,8,10,12-14H2,1H3;(H,6,7)
InChiKey: ZLQYAOGVYYJKNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0281	0.3581	0.4967
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.007	0.077	0.0635
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.1804	0.1739
Mycobacterium ulcerans	hydrolase	0.0241	0.3053	0.8985
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.007	0.077	0.0732
Echinococcus multilocularis	protein cereblon	0.0325	0.4164	0.4079
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0155	0.19	0.19
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.007	0.077	0.1378
Plasmodium vivax	glutathione reductase, putative	0.0762	1	1
Leishmania major	hypothetical protein, conserved	0.007	0.077	0.077
Mycobacterium ulcerans	ferredoxin reductase	0.007	0.077	0.1378
Schistosoma mansoni	hypothetical protein	0.0137	0.1658	0.1591
Toxoplasma gondii	aminopeptidase n, putative	0.0054	0.0561	0.0522
Leishmania major	hypothetical protein, conserved	0.007	0.077	0.077
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.007	0.077	0.0429
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.007	0.077	0.1849
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.007	0.077	0.077
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0388	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.007	0.077	0.0635
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0054	0.0561	0.0486
Echinococcus multilocularis	geminin	0.0368	0.4742	0.4665
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.007	0.077	0.0429
Brugia malayi	follicle stimulating hormone receptor	0.0252	0.3188	0.3089
Leishmania major	trypanothione reductase	0.0762	1	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2477	0.2415
Trichomonas vaginalis	mercuric reductase, putative	0.0264	0.3357	1
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.007	0.077	0.0429
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.007	0.077	0.0671
Entamoeba histolytica	disulphide oxidoreductase, putative	0.007	0.077	0.1849
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0264	0.3357	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0356	0.1061
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0054	0.0561	0.0561
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.007	0.077	0.2293
Loa Loa (eye worm)	hypothetical protein	0.0345	0.4428	0.4383
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0721	0.9441	0.9433
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Onchocerca volvulus		0.0086	0.0977	0.0956
Onchocerca volvulus	Matrilysin homolog	0.0198	0.2477	0.3266
Toxoplasma gondii	NADPH-glutathione reductase	0.0264	0.3357	0.333
Loa Loa (eye worm)	programmed cell death 8	0.007	0.077	0.0694
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.007	0.077	0.0429
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0264	0.3357	1
Trichomonas vaginalis	glutamate synthase, putative	0.007	0.077	0.2293
Schistosoma mansoni	glutamate synthase	0.007	0.077	0.0697
Leishmania major	hypothetical protein, conserved	0.0039	0.0356	0.0356
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0264	0.3357	0.3112
Schistosoma mansoni	peroxidasin	0.0086	0.0977	0.0905
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0356	0.0277
Plasmodium vivax	thioredoxin reductase, putative	0.0762	1	1
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0054	0.0561	0.0486
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0264	0.3357	0.3357
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Loa Loa (eye worm)	TATA binding protein associated factor	0.0054	0.0561	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0472	0.6123	0.6091
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0054	0.0561	0.0561
Brugia malayi	Blistered cuticle protein 3	0.0086	0.0977	0.0845
Echinococcus granulosus	geminin	0.0368	0.4742	0.4665
Mycobacterium tuberculosis	Probable oxidoreductase	0.0264	0.3357	0.3112
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.01	0.1174	0.1174
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	aminopeptidase N	0.0155	0.19	0.1833
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.007	0.077	0.077
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.077	0.077
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.007	0.077	0.1378
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.007	0.077	0.0732
Plasmodium falciparum	glutathione reductase	0.0762	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0356	0.1061
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Trichomonas vaginalis	esterase, putative	0.0039	0.0356	0.1061
Toxoplasma gondii	ABC1 family protein	0.0039	0.0356	0.0316
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.007	0.077	0.0635
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0264	0.3357	1
Echinococcus granulosus	peroxidasin	0.0086	0.0977	0.0845
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0426	0.551	0.5473
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0252	0.3188	0.3133
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2477	0.2415
Echinococcus multilocularis	glutamate synthase	0.007	0.077	0.0635
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0264	0.3357	0.3328
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Onchocerca volvulus	Protein cereblon homolog	0.0325	0.4164	0.5865
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.007	0.077	0.2293
Plasmodium vivax	ferrodoxin reductase, putative	0.007	0.077	0.0729
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0072	0.0791	0.0656
Loa Loa (eye worm)	hypothetical protein	0.007	0.077	0.0694
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0356	0.0356
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.326
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.007	0.077	0.1378
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.0791	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0561	0.0483
Trypanosoma cruzi	aminopeptidase, putative	0.0155	0.19	0.19
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0137	0.1658	0.1536
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.007	0.077	0.0429
Echinococcus granulosus	glutamate synthase	0.007	0.077	0.0635
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0054	0.0561	0.0561
Onchocerca volvulus		0.0526	0.6849	1
Toxoplasma gondii	aminopeptidase N protein	0.0054	0.0561	0.0522
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.007	0.077	0.077
Trichomonas vaginalis	glutamate synthase, putative	0.007	0.077	0.2293
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Entamoeba histolytica	aminopeptidase, putative	0.0155	0.19	0.4562
Toxoplasma gondii	thioredoxin reductase	0.0762	1	1
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.007	0.077	0.1849
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.077	0.077
Schistosoma mansoni	glutamate synthase	0.007	0.077	0.0697
Trypanosoma brucei	Aminopeptidase M1, putative	0.0155	0.19	0.19
Mycobacterium ulcerans	aminopeptidase N PepN	0.0054	0.0561	0.0682
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Brugia malayi	TATA binding protein associated factor	0.0054	0.0561	0.0423
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.007	0.077	0.0729
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.0791	0.0791
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.326
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.007	0.077	0.0429
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Brugia malayi	hypothetical protein	0.0132	0.1597	0.1475
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	matrixin family protein	0.0479	0.6223	0.6192
Onchocerca volvulus		0.0198	0.2477	0.3266
Toxoplasma gondii	aminopeptidase N, putative	0.0054	0.0561	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Mycobacterium tuberculosis	Probable reductase	0.007	0.077	0.0429
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0388	0.0248
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.007	0.077	0.077
Trichomonas vaginalis	glutathione reductase, putative	0.0264	0.3357	1
Onchocerca volvulus		0.0086	0.0977	0.0956
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.007	0.077	0.1378
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0054	0.0561	0.0459
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Brugia malayi	Hemopexin family protein	0.0281	0.3581	0.3487
Schistosoma mansoni	peroxidasin	0.0086	0.0977	0.0905
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.007	0.077	0.0694
Loa Loa (eye worm)	matrix metalloproteinase	0.0198	0.2477	0.2415
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.007	0.077	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0371	0.4784	0.4741
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0054	0.0561	0.0423
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.007	0.077	0.0635
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0264	0.3357	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.3053	0.2996
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0356	0.028
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Schistosoma mansoni	hypothetical protein	0.0368	0.4742	0.47
Trypanosoma cruzi	trypanothione reductase, putative	0.0264	0.3357	0.3357
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0264	0.3357	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.007	0.077	0.0429
Trypanosoma brucei	aminopeptidase, putative	0.0054	0.0561	0.0561
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.007	0.077	0.1378
Schistosoma mansoni	sulfide quinone reductase	0.007	0.077	0.0697
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0054	0.0561	0.0561
Brugia malayi	Peptidase family M1 containing protein	0.0526	0.6849	0.6803
Loa Loa (eye worm)	blistered cuticle protein 3	0.0086	0.0977	0.0903
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0264	0.3357	0.3112
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0072	0.0791	0.0717
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.007	0.077	0.0635
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0356	0.0356
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0264	0.3357	0.3357
Plasmodium falciparum	ferrodoxin reductase-like protein	0.007	0.077	0.0671
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.3357
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.007	0.077	0.1849
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0264	0.3357	0.3357
Onchocerca volvulus	Peroxidase homolog	0.0086	0.0977	0.0956
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0356	0.0277
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0264	0.3357	1
Schistosoma mansoni	disulfide oxidoreductase	0.007	0.077	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0325	0.4164	0.4116
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.007	0.077	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Brugia malayi	beta-lactamase family protein	0.0039	0.0356	0.0215
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.007	0.077	0.0635
Trypanosoma cruzi	aminopeptidase, putative	0.0054	0.0561	0.0561
Schistosoma mansoni	sulfide quinone reductase	0.007	0.077	0.0697
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.007	0.077	0.0429
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0054	0.0561	0.167
Leishmania major	hypothetical protein, conserved	0.007	0.077	0.077
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0356	0.0314
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.007	0.077	0.077
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.3305
Loa Loa (eye worm)	glutathione reductase	0.0762	1	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0054	0.0561	0.0423
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0356	0.0215
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Brugia malayi	hypothetical protein	0.0155	0.19	0.1781
Brugia malayi	glutamate synthase	0.007	0.077	0.0635
Onchocerca volvulus		0.0155	0.19	0.2377
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0155	0.19	0.5658
Brugia malayi	beta-lactamase	0.0039	0.0356	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0561	0.0483
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0155	0.19	0.1835
Schistosoma mansoni	hypothetical protein	0.0281	0.3581	0.353
Onchocerca volvulus		0.007	0.077	0.0637
Onchocerca volvulus	Chorion peroxidase homolog	0.0086	0.0977	0.0956
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.007	0.077	0.1378
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.007	0.077	0.1378
Mycobacterium leprae	PROBABLE HYDROLASE	0.0241	0.3053	0.8985
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.007	0.077	0.0635
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0054	0.0561	0.0423
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.007	0.077	0.0635
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0264	0.3357	0.3286
Onchocerca volvulus	Matrilysin homolog	0.044	0.5695	0.8223
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0264	0.3357	0.3112
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Onchocerca volvulus	Peroxidasin homolog	0.0086	0.0977	0.0956
Entamoeba histolytica	hypothetical protein, conserved	0.0325	0.4164	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0155	0.19	0.5142
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	matrixin family protein	0.044	0.5695	0.566
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.007	0.077	0.0635
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.007	0.077	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2477	0.2415
Echinococcus granulosus	aminopeptidase N	0.0526	0.6849	0.6803
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.3357
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.1804	0.1739
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0072	0.0791	0.0656
Loa Loa (eye worm)	hypothetical protein	0.01	0.1174	0.1101
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.007	0.077	0.0635
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0356	0.0356
Onchocerca volvulus	Dual oxidase homolog	0.0086	0.0977	0.0956
Brugia malayi	Peptidase family M1 containing protein	0.0155	0.19	0.1781
Trypanosoma cruzi	trypanothione reductase, putative	0.0762	1	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.1174	0.1101
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0072	0.0791	0.0791
Brugia malayi	hypothetical protein	0.0325	0.4164	0.4079
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Treponema pallidum	NADH oxidase	0.0264	0.3357	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Toxoplasma gondii	selenide, water dikinase	0.007	0.077	0.0732
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0054	0.0561	0.0561
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.01	0.1174	0.1045
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0264	0.3357	0.3357
Echinococcus multilocularis	peroxidasin	0.0086	0.0977	0.0845
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0264	0.3357	0.333
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0072	0.0791	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0264	0.3357	0.3357
Echinococcus granulosus	thioredoxin glutathione reductase	0.0762	1	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0144	0.0429
Brugia malayi	hypothetical protein	0.0086	0.0977	0.0845
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.007	0.077	0.077
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0072	0.0791	0.1899
Onchocerca volvulus	Peroxidase homolog	0.0086	0.0977	0.0956
Schistosoma mansoni	hypothetical protein	0.0325	0.4164	0.4118
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.007	0.077	0.0732
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0155	0.19	0.1781
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.007	0.077	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.007	0.077	0.0635
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.0791	0.0791
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0148	0.1804	0.1684
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0356	0.0215
Trichomonas vaginalis	apoptosis inducing factor, putative	0.007	0.077	0.2293
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0144	0.0429
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.007	0.077	0.0635
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.007	0.077	0.0429
Schistosoma mansoni	hypothetical protein	0.007	0.077	0.0697
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0054	0.0561	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0561	0.0483
Echinococcus granulosus	protein cereblon	0.0325	0.4164	0.4079
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0155	0.19	0.19
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0264	0.3357	0.3286
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0264	0.3357	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0155	0.19	0.19
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0198	0.2477	0.2417
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0471	0.611	0.6079
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0264	0.3357	0.3328
Onchocerca volvulus		0.0054	0.0561	0.0315
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0054	0.0561	0.0519
Leishmania major	NADH dehydrogenase, putative	0.007	0.077	0.077
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0721	0.9441	0.9433
Loa Loa (eye worm)	thioredoxin reductase	0.0762	1	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0155	0.19	0.1835
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0264	0.3357	0.326
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0054	0.0561	0.0561
Plasmodium falciparum	thioredoxin reductase	0.0264	0.3357	0.3286
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.007	0.077	0.1849
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0054	0.0561	0.0459
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0194	0.2422	0.2312
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0144	0.0063
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0155	0.19	0.19
Brugia malayi	Thioredoxin reductase	0.0762	1	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0072	0.0791	0.0656
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0241	0.3053	0.2796
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.025	0.3165	0.2913
Trypanosoma brucei	trypanothione reductase	0.0762	1	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0356	0.0215
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Brugia malayi	Matrixin family protein	0.0479	0.6223	0.6168
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.007	0.077	0.2293
Mycobacterium ulcerans	dehydrogenase	0.007	0.077	0.1378
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0155	0.19	0.19
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Mycobacterium ulcerans	NADH dehydrogenase	0.007	0.077	0.1378
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0137	0.1658	0.1536
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.01	0.1174	0.1103
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0356	0.028
Mycobacterium ulcerans	monoxygenase	0.007	0.077	0.1378
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.007	0.077	0.1378
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.007	0.077	0.077
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0356	0.1061
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0762	1	1
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.007	0.077	0.1378
Onchocerca volvulus	Matrix metalloproteinase homolog	0.044	0.5695	0.8223
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.007	0.077	0.0635
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.077	0.077
Mycobacterium ulcerans	glutamate synthase subunit beta	0.007	0.077	0.1378
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0356	0.1061
Plasmodium falciparum	thioredoxin reductase	0.0762	1	1
Brugia malayi	Peptidase family M1 containing protein	0.0054	0.0561	0.0423
Echinococcus multilocularis	aminopeptidase N	0.0526	0.6849	0.6803
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0054	0.0561	0.0519
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.007	0.077	0.1378
Brugia malayi	Peroxidasin	0.0086	0.0977	0.0845
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.007	0.077	0.0729
Schistosoma mansoni	glutamate synthase	0.007	0.077	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Plasmodium falciparum	glutathione reductase	0.0264	0.3357	0.3286
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.007	0.077	0.0429
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0054	0.0561	0.0486
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0194	0.2422	0.2312
Trypanosoma brucei	Aminopeptidase M1, putative	0.0155	0.19	0.19
Brugia malayi	beta-lactamase family protein	0.0039	0.0356	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Trypanosoma brucei	NADH dehydrogenase	0.007	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.007	0.077	0.0732
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0356	0.1061
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.007	0.077	0.0429
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0241	0.3053	0.2951
Schistosoma mansoni	hypothetical protein	0.0368	0.4742	0.47
Onchocerca volvulus	Peroxidasin homolog	0.0086	0.0977	0.0956
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.007	0.077	0.0671
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.007	0.077	0.1849
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.007	0.077	0.1378
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0762	1	1
Mycobacterium ulcerans	hypothetical protein	0.007	0.077	0.1378
Onchocerca volvulus		0.0086	0.0977	0.0956
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0155	0.19	0.5658
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0264	0.3357	1
Trypanosoma cruzi	NADH dehydrogenase, putative	0.007	0.077	0.077
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.007	0.077	0.2293
Brugia malayi	hypothetical protein	0.0054	0.0561	0.0423
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0054	0.0561	0.0423
Trypanosoma cruzi	NADH dehydrogenase, putative	0.007	0.077	0.077
Entamoeba histolytica	thioredoxin reductase, putative	0.007	0.077	0.1849
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3499878

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2076150