Detailed information for compound 2076150

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.426 | Formula: C21H22F3N5O4
  • H donors: 1 H acceptors: 6 LogP: -1.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.O=C(N1CCC2(C1)CN(c1ccccc1)C(=O)CN2C)c1ccnnc1
  • InChi: 1S/C19H21N5O2.C2HF3O2/c1-22-12-17(25)24(16-5-3-2-4-6-16)14-19(22)8-10-23(13-19)18(26)15-7-9-20-21-11-15;3-2(4,5)1(6)7/h2-7,9,11H,8,10,12-14H2,1H3;(H,6,7)
  • InChiKey: ZLQYAOGVYYJKNZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0791 0.1899
Onchocerca volvulus 0.0054 0.0561 0.0315
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0155 0.19 0.5658
Toxoplasma gondii aminopeptidase n, putative 0.0054 0.0561 0.0522
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Schistosoma mansoni peroxidasin 0.0086 0.0977 0.0905
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0721 0.9441 0.9433
Schistosoma mansoni hypothetical protein 0.0368 0.4742 0.47
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0054 0.0561 0.0519
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.1658 0.1536
Plasmodium falciparum thioredoxin reductase 0.0762 1 1
Onchocerca volvulus Matrilysin homolog 0.044 0.5695 0.8223
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0356 0.0277
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.007 0.077 0.0635
Echinococcus granulosus sulfide:quinone oxidoreductase 0.007 0.077 0.0635
Brugia malayi Matrixin family protein 0.0479 0.6223 0.6168
Loa Loa (eye worm) hypothetical protein 0.0054 0.0561 0.0483
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0561 0.0561
Echinococcus granulosus protein cereblon 0.0325 0.4164 0.4079
Loa Loa (eye worm) beta-lactamase 0.0039 0.0356 0.0277
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0194 0.2422 0.2312
Onchocerca volvulus Dual oxidase homolog 0.0086 0.0977 0.0956
Brugia malayi follicle stimulating hormone receptor 0.0252 0.3188 0.3089
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0264 0.3357 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.007 0.077 0.077
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0356 0.1061
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0264 0.3357 0.3357
Loa Loa (eye worm) hypothetical protein 0.01 0.1174 0.1101
Onchocerca volvulus Chorion peroxidase homolog 0.0086 0.0977 0.0956
Loa Loa (eye worm) hypothetical protein 0.0198 0.2477 0.2415
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0155 0.19 0.1781
Onchocerca volvulus 0.0281 0.3581 0.4967
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.007 0.077 0.0671
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.007 0.077 0.0635
Toxoplasma gondii aminopeptidase N, putative 0.0054 0.0561 0.0522
Mycobacterium ulcerans aminopeptidase N PepN 0.0054 0.0561 0.0682
Plasmodium vivax ferrodoxin reductase, putative 0.007 0.077 0.0729
Trichomonas vaginalis esterase, putative 0.0039 0.0356 0.1061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0356 0.028
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.007 0.077 0.077
Onchocerca volvulus 0.0155 0.19 0.2377
Entamoeba histolytica disulphide oxidoreductase, putative 0.007 0.077 0.1849
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0155 0.19 0.1835
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.077 0.0635
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Trypanosoma cruzi NADH dehydrogenase, putative 0.007 0.077 0.077
Loa Loa (eye worm) aminopeptidase N 0.0155 0.19 0.1833
Brugia malayi glutamate synthase 0.007 0.077 0.0635
Loa Loa (eye worm) hypothetical protein 0.0054 0.0561 0.0483
Plasmodium falciparum thioredoxin reductase 0.0264 0.3357 0.3286
Schistosoma mansoni glutamate synthase 0.007 0.077 0.0697
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0356 0.0215
Trypanosoma cruzi trypanothione reductase, putative 0.0762 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.007 0.077 0.0429
Loa Loa (eye worm) TATA binding protein associated factor 0.0054 0.0561 0.0483
Loa Loa (eye worm) matrixin family protein 0.044 0.5695 0.566
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0155 0.19 0.19
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.19 0.19
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0264 0.3357 0.3357
Echinococcus multilocularis protein cereblon 0.0325 0.4164 0.4079
Mycobacterium ulcerans aminopeptidase N PepN 0.0155 0.19 0.5142
Mycobacterium ulcerans glutamate synthase subunit beta 0.007 0.077 0.1378
Brugia malayi hypothetical protein 0.0132 0.1597 0.1475
Onchocerca volvulus Protein cereblon homolog 0.0325 0.4164 0.5865
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0791 0.0791
Giardia lamblia NADH oxidase lateral transfer candidate 0.0264 0.3357 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0264 0.3357 0.326
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.007 0.077 0.1378
Entamoeba histolytica hypothetical protein, conserved 0.0325 0.4164 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.01 0.1174 0.1045
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.01 0.1174 0.1174
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0264 0.3357 0.3328
Loa Loa (eye worm) hypothetical protein 0.0472 0.6123 0.6091
Mycobacterium ulcerans dehydrogenase 0.007 0.077 0.1378
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.007 0.077 0.2293
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0264 0.3357 0.3286
Schistosoma mansoni sulfide quinone reductase 0.007 0.077 0.0697
Brugia malayi hypothetical protein 0.0086 0.0977 0.0845
Loa Loa (eye worm) programmed cell death 8 0.007 0.077 0.0694
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.007 0.077 0.1378
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.007 0.077 0.0732
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0791 0.0656
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.007 0.077 0.0429
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.19 0.19
Mycobacterium ulcerans ferredoxin reductase 0.007 0.077 0.1378
Loa Loa (eye worm) hypothetical protein 0.0198 0.2477 0.2415
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.007 0.077 0.1849
Trichomonas vaginalis glutamate synthase, putative 0.007 0.077 0.2293
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Toxoplasma gondii ABC1 family protein 0.0039 0.0356 0.0316
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Loa Loa (eye worm) thioredoxin reductase 0.0762 1 1
Brugia malayi hypothetical protein 0.0325 0.4164 0.4079
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0054 0.0561 0.0459
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.3165 0.2913
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0264 0.3357 0.3357
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0356 0.1061
Loa Loa (eye worm) RecQ helicase 0.0023 0.0144 0.0063
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.007 0.077 0.0635
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0054 0.0561 0.0561
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.01 0.1174 0.1103
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0241 0.3053 0.2796
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.0977 0.0903
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Leishmania major hypothetical protein, conserved 0.0039 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0325 0.4164 0.4118
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0264 0.3357 0.333
Mycobacterium tuberculosis Probable dehydrogenase 0.007 0.077 0.0429
Brugia malayi Blistered cuticle protein 3 0.0086 0.0977 0.0845
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Leishmania major hypothetical protein, conserved 0.007 0.077 0.077
Trypanosoma brucei Aminopeptidase M1, putative 0.0155 0.19 0.19
Brugia malayi Thioredoxin reductase 0.0762 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0356 0.028
Onchocerca volvulus 0.0086 0.0977 0.0956
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1804 0.1739
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0264 0.3357 0.3328
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.077 0.077
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.3357 0.3112
Loa Loa (eye worm) hypothetical protein 0.0371 0.4784 0.4741
Brugia malayi beta-lactamase 0.0039 0.0356 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.077 0.077
Brugia malayi Peroxidasin 0.0086 0.0977 0.0845
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0356 0.0215
Trypanosoma cruzi NADH dehydrogenase, putative 0.007 0.077 0.077
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0264 0.3357 0.326
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.007 0.077 0.1378
Echinococcus multilocularis glutamate synthase 0.007 0.077 0.0635
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0561 0.0561
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.007 0.077 0.0635
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0155 0.19 0.1835
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.0977 0.0903
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0264 0.3357 1
Toxoplasma gondii NADPH-glutathione reductase 0.0264 0.3357 0.333
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.077 0.0635
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Loa Loa (eye worm) hypothetical protein 0.0241 0.3053 0.2996
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0155 0.19 0.19
Onchocerca volvulus Peroxidasin homolog 0.0086 0.0977 0.0956
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0264 0.3357 0.3357
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0054 0.0561 0.0561
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.007 0.077 0.0732
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.007 0.077 0.0729
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Mycobacterium tuberculosis Putative ferredoxin reductase 0.007 0.077 0.0429
Loa Loa (eye worm) matrix metalloproteinase 0.0198 0.2477 0.2415
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.007 0.077 0.0429
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Leishmania major hypothetical protein, conserved 0.007 0.077 0.077
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Trypanosoma cruzi Aminopeptidase M1, putative 0.0155 0.19 0.19
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.007 0.077 0.1378
Leishmania major trypanothione reductase 0.0762 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.077 0.0635
Plasmodium falciparum ferrodoxin reductase-like protein 0.007 0.077 0.0671
Loa Loa (eye worm) hypothetical protein 0.0054 0.0561 0.0483
Plasmodium falciparum glutathione reductase 0.0264 0.3357 0.3286
Entamoeba histolytica aminopeptidase, putative 0.0155 0.19 0.4562
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0791 0.0715
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Toxoplasma gondii aminopeptidase N protein 0.0054 0.0561 0.0522
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0356 0.0356
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0356 0.0215
Trichomonas vaginalis glutathione reductase, putative 0.0264 0.3357 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.007 0.077 0.2293
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0054 0.0561 0.0483
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0356 0.0356
Toxoplasma gondii thioredoxin reductase 0.0762 1 1
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0264 0.3357 0.3357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0054 0.0561 0.0519
Schistosoma mansoni disulfide oxidoreductase 0.007 0.077 0.0697
Onchocerca volvulus 0.0198 0.2477 0.3266
Leishmania major NADH dehydrogenase, putative 0.007 0.077 0.077
Brugia malayi Animal haem peroxidase family protein 0.0086 0.0977 0.0845
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.007 0.077 0.0729
Loa Loa (eye worm) hypothetical protein 0.01 0.1174 0.1101
Entamoeba histolytica thioredoxin reductase, putative 0.007 0.077 0.1849
Schistosoma mansoni hypothetical protein 0.0137 0.1658 0.1591
Trichomonas vaginalis mercuric reductase, putative 0.0264 0.3357 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0054 0.0561 0.0486
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0356 0.0356
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.007 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.007 0.077 0.077
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Echinococcus granulosus peroxidasin 0.0086 0.0977 0.0845
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.007 0.077 0.0635
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.007 0.077 0.1849
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0264 0.3357 0.3357
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0356 0.1061
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0356 0.1061
Brugia malayi hypothetical protein 0.0054 0.0561 0.0423
Schistosoma mansoni peroxidasin 0.0086 0.0977 0.0905
Brugia malayi beta-lactamase family protein 0.0039 0.0356 0.0215
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.3188 0.3133
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0054 0.0561 0.0486
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.007 0.077 0.0635
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0791 0.0791
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Onchocerca volvulus Peroxidase homolog 0.0086 0.0977 0.0956
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Onchocerca volvulus Matrilysin homolog 0.0198 0.2477 0.3266
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.3357 0.3112
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0054 0.0561 0.167
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0194 0.2422 0.2312
Trypanosoma brucei hypothetical protein, conserved 0.007 0.077 0.077
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.3357 0.3112
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.007 0.077 0.1378
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.007 0.077 0.1378
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0144 0.0429
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.0977 0.0903
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0762 1 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.007 0.077 0.0635
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0264 0.3357 0.3357
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0054 0.0561 0.0459
Schistosoma mansoni glutamate synthase 0.007 0.077 0.0697
Brugia malayi beta-lactamase family protein 0.0039 0.0356 0.0215
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0791 0.0791
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0264 0.3357 0.3286
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0388 0.0248
Loa Loa (eye worm) peptidase family M1 containing protein 0.0426 0.551 0.5473
Loa Loa (eye worm) glutathione reductase 0.0762 1 1
Schistosoma mansoni hypothetical protein 0.007 0.077 0.0697
Loa Loa (eye worm) hypothetical protein 0.0325 0.4164 0.4116
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.077 0.0732
Brugia malayi Animal haem peroxidase family protein 0.0086 0.0977 0.0845
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0264 0.3357 0.326
Onchocerca volvulus Peroxidasin homolog 0.0086 0.0977 0.0956
Onchocerca volvulus 0.0526 0.6849 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0791 0.0656
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.077 0.2293
Mycobacterium ulcerans NADH dehydrogenase 0.007 0.077 0.1378
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Trypanosoma cruzi trypanothione reductase, putative 0.0264 0.3357 0.3357
Onchocerca volvulus 0.0086 0.0977 0.0956
Loa Loa (eye worm) hypothetical protein 0.0345 0.4428 0.4383
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0791 0.0656
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.007 0.077 0.0635
Trypanosoma brucei NADH dehydrogenase 0.007 0.077 0.077
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.007 0.077 0.0671
Brugia malayi Peptidase family M1 containing protein 0.0526 0.6849 0.6803
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.007 0.077 0.0635
Mycobacterium ulcerans hydrolase 0.0241 0.3053 0.8985
Loa Loa (eye worm) hypothetical protein 0.007 0.077 0.0694
Brugia malayi Animal haem peroxidase family protein 0.0086 0.0977 0.0845
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.007 0.077 0.0694
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0264 0.3357 0.3305
Mycobacterium tuberculosis Probable reductase 0.007 0.077 0.0429
Echinococcus multilocularis geminin 0.0368 0.4742 0.4665
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.007 0.077 0.1378
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Trypanosoma brucei Aminopeptidase M1, putative 0.0155 0.19 0.19
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Loa Loa (eye worm) matrixin family protein 0.0479 0.6223 0.6192
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0144 0.0429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Echinococcus multilocularis aminopeptidase N 0.0526 0.6849 0.6803
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0264 0.3357 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.077 0.2293
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.007 0.077 0.0429
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.007 0.077 0.0429
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.007 0.077 0.077
Treponema pallidum NADH oxidase 0.0264 0.3357 1
Brugia malayi hypothetical protein 0.0155 0.19 0.1781
Entamoeba histolytica glutamate synthase beta subunit, putative 0.007 0.077 0.1849
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.077 0.0732
Schistosoma mansoni hypothetical protein 0.0281 0.3581 0.353
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.007 0.077 0.0429
Echinococcus multilocularis peroxidasin 0.0086 0.0977 0.0845
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Onchocerca volvulus 0.0086 0.0977 0.0956
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.007 0.077 0.1849
Plasmodium vivax glutathione reductase, putative 0.0762 1 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0155 0.19 0.5658
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.3357 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.007 0.077 0.0429
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.007 0.077 0.0429
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0264 0.3357 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Echinococcus granulosus aminopeptidase N 0.0526 0.6849 0.6803
Echinococcus granulosus glutamate synthase 0.007 0.077 0.0635
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.1658 0.1536
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0791 0.0791
Brugia malayi Peptidase family M1 containing protein 0.0155 0.19 0.1781
Brugia malayi TATA binding protein associated factor 0.0054 0.0561 0.0423
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1804 0.1739
Trypanosoma cruzi aminopeptidase, putative 0.0155 0.19 0.19
Entamoeba histolytica glutamate synthase beta subunit, putative 0.007 0.077 0.1849
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.077 0.0635
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0241 0.3053 0.2951
Echinococcus granulosus geminin 0.0368 0.4742 0.4665
Leishmania major hypothetical protein, conserved 0.007 0.077 0.077
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.007 0.077 0.1378
Mycobacterium leprae PROBABLE HYDROLASE 0.0241 0.3053 0.8985
Loa Loa (eye worm) animal heme peroxidase 0.0086 0.0977 0.0903
Trypanosoma cruzi aminopeptidase, putative 0.0054 0.0561 0.0561
Brugia malayi Hemopexin family protein 0.0281 0.3581 0.3487
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0054 0.0561 0.0561
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.007 0.077 0.077
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.007 0.077 0.0429
Brugia malayi Animal haem peroxidase family protein 0.0086 0.0977 0.0845
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.007 0.077 0.077
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0471 0.611 0.6079
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.007 0.077 0.1378
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0054 0.0561 0.0423
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.077 0.0732
Schistosoma mansoni hypothetical protein 0.0368 0.4742 0.47
Trypanosoma brucei aminopeptidase, putative 0.0054 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Trypanosoma brucei trypanothione reductase 0.0762 1 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.007 0.077 0.1378
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0791 0.0717
Plasmodium falciparum glutathione reductase 0.0762 1 1
Schistosoma mansoni sulfide quinone reductase 0.007 0.077 0.0697
Trichomonas vaginalis glutamate synthase, putative 0.007 0.077 0.2293
Loa Loa (eye worm) hypothetical protein 0.0086 0.0977 0.0903
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0388 0.0248
Loa Loa (eye worm) blistered cuticle protein 3 0.0086 0.0977 0.0903
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0264 0.3357 0.3112
Mycobacterium ulcerans monoxygenase 0.007 0.077 0.1378
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.007 0.077 0.0635
Plasmodium vivax thioredoxin reductase, putative 0.0762 1 1
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.007 0.077 0.1378
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0198 0.2477 0.2417
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0561 0.0423
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0721 0.9441 0.9433
Brugia malayi Animal haem peroxidase family protein 0.0086 0.0977 0.0845
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0356 0.1061
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.1804 0.1684
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Onchocerca volvulus Matrix metalloproteinase homolog 0.044 0.5695 0.8223
Loa Loa (eye worm) hypothetical protein 0.0198 0.2477 0.2415
Toxoplasma gondii selenide, water dikinase 0.007 0.077 0.0732
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.007 0.077 0.1378
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0264 0.3357 0.3357
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Onchocerca volvulus 0.007 0.077 0.0637
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.007 0.077 0.2293
Echinococcus multilocularis thioredoxin glutathione reductase 0.0762 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0264 0.3357 1
Onchocerca volvulus Peroxidase homolog 0.0086 0.0977 0.0956
Brugia malayi Peptidase family M1 containing protein 0.0054 0.0561 0.0423
Schistosoma mansoni glutamate synthase 0.007 0.077 0.0697
Mycobacterium ulcerans hypothetical protein 0.007 0.077 0.1378
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0264 0.3357 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0762 1 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0054 0.0561 0.0486
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0356 0.0314
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0054 0.0561 0.0561
Echinococcus granulosus leukotriene A 4 hydrolase 0.0054 0.0561 0.0423
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0561 0.0423

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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