TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 465.426 | Formula: C21H22F3N5O4
H donors: 1 H acceptors: 6 LogP: -1.16 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.O=C(N1CCC2(C1)CN(c1ccccc1)C(=O)CN2C)c1ccnnc1
InChi: 1S/C19H21N5O2.C2HF3O2/c1-22-12-17(25)24(16-5-3-2-4-6-16)14-19(22)8-10-23(13-19)18(26)15-7-9-20-21-11-15;3-2(4,5)1(6)7/h2-7,9,11H,8,10,12-14H2,1H3;(H,6,7)
InChiKey: ZLQYAOGVYYJKNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0252	0.3188	0.3133
Plasmodium vivax	ferrodoxin reductase, putative	0.007	0.077	0.0729
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.007	0.077	0.0635
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0054	0.0561	0.0459
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.007	0.077	0.1378
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.007	0.077	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0241	0.3053	0.2996
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0264	0.3357	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.007	0.077	0.2293
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Brugia malayi	Thioredoxin reductase	0.0762	1	1
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.007	0.077	0.1378
Schistosoma mansoni	hypothetical protein	0.0368	0.4742	0.47
Brugia malayi	TATA binding protein associated factor	0.0054	0.0561	0.0423
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0356	0.0215
Trichomonas vaginalis	glutamate synthase, putative	0.007	0.077	0.2293
Loa Loa (eye worm)	hypothetical protein	0.007	0.077	0.0694
Trichomonas vaginalis	glutamate synthase, putative	0.007	0.077	0.2293
Brugia malayi	hypothetical protein	0.0325	0.4164	0.4079
Brugia malayi	beta-lactamase	0.0039	0.0356	0.0215
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0264	0.3357	0.3357
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.007	0.077	0.1378
Schistosoma mansoni	hypothetical protein	0.0281	0.3581	0.353
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0054	0.0561	0.0486
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0054	0.0561	0.0561
Trypanosoma cruzi	trypanothione reductase, putative	0.0762	1	1
Echinococcus granulosus	geminin	0.0368	0.4742	0.4665
Treponema pallidum	NADH oxidase	0.0264	0.3357	1
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.007	0.077	0.1378
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0155	0.19	0.1781
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.025	0.3165	0.2913
Onchocerca volvulus		0.0155	0.19	0.2377
Loa Loa (eye worm)	hypothetical protein	0.01	0.1174	0.1101
Brugia malayi	follicle stimulating hormone receptor	0.0252	0.3188	0.3089
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0054	0.0561	0.0561
Trichomonas vaginalis	mercuric reductase, putative	0.0264	0.3357	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0356	0.0356
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0241	0.3053	0.2951
Mycobacterium ulcerans	monoxygenase	0.007	0.077	0.1378
Trypanosoma brucei	trypanothione reductase	0.0762	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0356	0.0356
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.007	0.077	0.1378
Mycobacterium tuberculosis	Probable oxidoreductase	0.0264	0.3357	0.3112
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.007	0.077	0.0635
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.077	0.077
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.007	0.077	0.077
Plasmodium falciparum	glutathione reductase	0.0762	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0356	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.007	0.077	0.0635
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.007	0.077	0.1849
Brugia malayi	Blistered cuticle protein 3	0.0086	0.0977	0.0845
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.007	0.077	0.0635
Mycobacterium ulcerans	hydrolase	0.0241	0.3053	0.8985
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.007	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0561	0.0483
Leishmania major	trypanothione reductase	0.0762	1	1
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0388	0.0248
Leishmania major	hypothetical protein, conserved	0.007	0.077	0.077
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2477	0.2415
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.1804	0.1739
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.007	0.077	0.0732
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0721	0.9441	0.9433
Toxoplasma gondii	NADPH-glutathione reductase	0.0264	0.3357	0.333
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0072	0.0791	0.1899
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0356	0.1061
Leishmania major	NADH dehydrogenase, putative	0.007	0.077	0.077
Brugia malayi	Peptidase family M1 containing protein	0.0526	0.6849	0.6803
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0194	0.2422	0.2312
Trypanosoma brucei	Aminopeptidase M1, putative	0.0155	0.19	0.19
Trichomonas vaginalis	esterase, putative	0.0039	0.0356	0.1061
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0054	0.0561	0.0483
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.326
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.007	0.077	0.0635
Trypanosoma brucei	aminopeptidase, putative	0.0054	0.0561	0.0561
Onchocerca volvulus	Dual oxidase homolog	0.0086	0.0977	0.0956
Onchocerca volvulus		0.0198	0.2477	0.3266
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0155	0.19	0.19
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Loa Loa (eye worm)	aminopeptidase N	0.0155	0.19	0.1833
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.007	0.077	0.077
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.007	0.077	0.0429
Onchocerca volvulus		0.0086	0.0977	0.0956
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0356	0.0215
Schistosoma mansoni	peroxidasin	0.0086	0.0977	0.0905
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0241	0.3053	0.2796
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.007	0.077	0.0732
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.007	0.077	0.0429
Mycobacterium ulcerans	NADH dehydrogenase	0.007	0.077	0.1378
Mycobacterium tuberculosis	Probable reductase	0.007	0.077	0.0429
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0054	0.0561	0.0423
Mycobacterium ulcerans	ferredoxin reductase	0.007	0.077	0.1378
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.007	0.077	0.0671
Brugia malayi	Peroxidasin	0.0086	0.0977	0.0845
Loa Loa (eye worm)	matrixin family protein	0.0479	0.6223	0.6192
Brugia malayi	beta-lactamase family protein	0.0039	0.0356	0.0215
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0264	0.3357	0.3328
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0137	0.1658	0.1536
Echinococcus granulosus	protein cereblon	0.0325	0.4164	0.4079
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0264	0.3357	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0264	0.3357	0.3357
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.007	0.077	0.0429
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0264	0.3357	0.3357
Onchocerca volvulus		0.0086	0.0977	0.0956
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0072	0.0791	0.0656
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.326
Echinococcus multilocularis	aminopeptidase N	0.0526	0.6849	0.6803
Loa Loa (eye worm)	thioredoxin reductase	0.0762	1	1
Mycobacterium leprae	PROBABLE HYDROLASE	0.0241	0.3053	0.8985
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0144	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0356	0.0277
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0155	0.19	0.19
Onchocerca volvulus	Protein cereblon homolog	0.0325	0.4164	0.5865
Loa Loa (eye worm)	matrix metalloproteinase	0.0198	0.2477	0.2415
Onchocerca volvulus		0.0526	0.6849	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0054	0.0561	0.0682
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Brugia malayi	hypothetical protein	0.0054	0.0561	0.0423
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.007	0.077	0.1849
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.007	0.077	0.0635
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.007	0.077	0.0429
Entamoeba histolytica	hypothetical protein, conserved	0.0325	0.4164	1
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.007	0.077	0.0635
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0356	0.1061
Trypanosoma cruzi	trypanothione reductase, putative	0.0264	0.3357	0.3357
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.007	0.077	0.1378
Toxoplasma gondii	thioredoxin reductase	0.0762	1	1
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.007	0.077	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0264	0.3357	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0072	0.0791	0.0656
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0155	0.19	0.19
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0264	0.3357	0.3112
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.007	0.077	0.0635
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Trypanosoma brucei	Aminopeptidase M1, putative	0.0155	0.19	0.19
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.01	0.1174	0.1174
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0144	0.0063
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.007	0.077	0.0429
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.007	0.077	0.0732
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.007	0.077	0.1378
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.007	0.077	0.077
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Trichomonas vaginalis	apoptosis inducing factor, putative	0.007	0.077	0.2293
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0471	0.611	0.6079
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0155	0.19	0.1835
Leishmania major	hypothetical protein, conserved	0.007	0.077	0.077
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0198	0.2477	0.2417
Trypanosoma cruzi	aminopeptidase, putative	0.0054	0.0561	0.0561
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.0791	0.0791
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.007	0.077	0.0429
Schistosoma mansoni	hypothetical protein	0.007	0.077	0.0697
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0072	0.0791	0.0791
Mycobacterium ulcerans	aminopeptidase N PepN	0.0155	0.19	0.5142
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0054	0.0561	0.0561
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.007	0.077	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0561	0.0483
Schistosoma mansoni	glutamate synthase	0.007	0.077	0.0697
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0426	0.551	0.5473
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0264	0.3357	0.3286
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.007	0.077	0.1378
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0054	0.0561	0.0561
Plasmodium vivax	thioredoxin reductase, putative	0.0762	1	1
Brugia malayi	Hemopexin family protein	0.0281	0.3581	0.3487
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.077	0.077
Trypanosoma brucei	NADH dehydrogenase	0.007	0.077	0.077
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0072	0.0791	0.0656
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0054	0.0561	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.007	0.077	0.0635
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.007	0.077	0.077
Entamoeba histolytica	aminopeptidase, putative	0.0155	0.19	0.4562
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0762	1	1
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0054	0.0561	0.0459
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.3357
Schistosoma mansoni	hypothetical protein	0.0368	0.4742	0.47
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0356	0.028
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Echinococcus multilocularis	peroxidasin	0.0086	0.0977	0.0845
Trypanosoma cruzi	NADH dehydrogenase, putative	0.007	0.077	0.077
Loa Loa (eye worm)	glutathione reductase	0.0762	1	1
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.007	0.077	0.2293
Schistosoma mansoni	hypothetical protein	0.0137	0.1658	0.1591
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.007	0.077	0.077
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0054	0.0561	0.0423
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.007	0.077	0.0429
Brugia malayi	hypothetical protein	0.0132	0.1597	0.1475
Trichomonas vaginalis	glutathione reductase, putative	0.0264	0.3357	1
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0264	0.3357	0.326
Onchocerca volvulus	Chorion peroxidase homolog	0.0086	0.0977	0.0956
Brugia malayi	beta-lactamase family protein	0.0039	0.0356	0.0215
Loa Loa (eye worm)	TATA binding protein associated factor	0.0054	0.0561	0.0483
Onchocerca volvulus	Peroxidasin homolog	0.0086	0.0977	0.0956
Onchocerca volvulus	Peroxidase homolog	0.0086	0.0977	0.0956
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.007	0.077	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0371	0.4784	0.4741
Toxoplasma gondii	ABC1 family protein	0.0039	0.0356	0.0316
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.0791	0.0791
Brugia malayi	Matrixin family protein	0.0198	0.2477	0.2367
Brugia malayi	Peptidase family M1 containing protein	0.0054	0.0561	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0054	0.0561	0.0519
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0155	0.19	0.19
Loa Loa (eye worm)	hypothetical protein	0.0472	0.6123	0.6091
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0264	0.3357	1
Loa Loa (eye worm)	programmed cell death 8	0.007	0.077	0.0694
Brugia malayi	Peptidase family M1 containing protein	0.0155	0.19	0.1781
Schistosoma mansoni	glutamate synthase	0.007	0.077	0.0697
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0264	0.3357	0.3357
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2477	0.2415
Schistosoma mansoni	hypothetical protein	0.0325	0.4164	0.4118
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0264	0.3357	0.3112
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0264	0.3357	0.3357
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0356	0.1061
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.007	0.077	0.2293
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0155	0.19	0.19
Loa Loa (eye worm)	hypothetical protein	0.0325	0.4164	0.4116
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0264	0.3357	0.3328
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0762	1	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0054	0.0561	0.167
Entamoeba histolytica	thioredoxin reductase, putative	0.007	0.077	0.1849
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.01	0.1174	0.1103
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.007	0.077	0.0429
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.3305
Entamoeba histolytica	disulphide oxidoreductase, putative	0.007	0.077	0.1849
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0054	0.0561	0.0486
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.007	0.077	0.0732
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Onchocerca volvulus		0.0054	0.0561	0.0315
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0072	0.0791	0.0717
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0356	0.1061
Brugia malayi	hypothetical protein	0.0155	0.19	0.1781
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.007	0.077	0.0635
Schistosoma mansoni	disulfide oxidoreductase	0.007	0.077	0.0697
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0264	0.3357	0.3286
Onchocerca volvulus		0.0281	0.3581	0.4967
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.007	0.077	0.1849
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0264	0.3357	1
Trypanosoma cruzi	NADH dehydrogenase, putative	0.007	0.077	0.077
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0356	0.0356
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.007	0.077	0.0635
Schistosoma mansoni	sulfide quinone reductase	0.007	0.077	0.0697
Onchocerca volvulus	Peroxidase homolog	0.0086	0.0977	0.0956
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.007	0.077	0.1849
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Loa Loa (eye worm)	animal heme peroxidase	0.0086	0.0977	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.007	0.077	0.0429
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0072	0.0791	0.0715
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.007	0.077	0.077
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0054	0.0561	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2477	0.2415
Onchocerca volvulus		0.0086	0.0977	0.0956
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Toxoplasma gondii	aminopeptidase n, putative	0.0054	0.0561	0.0522
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.007	0.077	0.0429
Schistosoma mansoni	glutamate synthase	0.007	0.077	0.0697
Trypanosoma cruzi	aminopeptidase, putative	0.0155	0.19	0.19
Echinococcus multilocularis	glutamate synthase	0.007	0.077	0.0635
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0155	0.19	0.5658
Toxoplasma gondii	aminopeptidase N, putative	0.0054	0.0561	0.0522
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.007	0.077	0.1378
Mycobacterium tuberculosis	Probable dehydrogenase	0.007	0.077	0.0429
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0721	0.9441	0.9433
Onchocerca volvulus	Peroxidasin homolog	0.0086	0.0977	0.0956
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0264	0.3357	0.3357
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0264	0.3357	1
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.1804	0.1739
Schistosoma mansoni	peroxidasin	0.0086	0.0977	0.0905
Onchocerca volvulus	Matrilysin homolog	0.044	0.5695	0.8223
Onchocerca volvulus		0.007	0.077	0.0637
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.007	0.077	0.1849
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0264	0.3357	0.3112
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.007	0.077	0.2293
Loa Loa (eye worm)	matrixin family protein	0.044	0.5695	0.566
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0137	0.1658	0.1536
Echinococcus multilocularis	geminin	0.0368	0.4742	0.4665
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.007	0.077	0.0635
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0264	0.3357	1
Toxoplasma gondii	selenide, water dikinase	0.007	0.077	0.0732
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0356	0.0277
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0264	0.3357	0.3357
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0264	0.3357	0.3357
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.01	0.1174	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0977	0.0903
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0356	0.0314
Mycobacterium ulcerans	dehydrogenase	0.007	0.077	0.1378
Plasmodium falciparum	ferrodoxin reductase-like protein	0.007	0.077	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Toxoplasma gondii	aminopeptidase N protein	0.0054	0.0561	0.0522
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0264	0.3357	0.333
Mycobacterium ulcerans	glutamate synthase subunit beta	0.007	0.077	0.1378
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.0791	0.0791
Loa Loa (eye worm)	hypothetical protein	0.01	0.1174	0.1101
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.007	0.077	0.0635
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0356	0.1061
Schistosoma mansoni	sulfide quinone reductase	0.007	0.077	0.0697
Brugia malayi	glutamate synthase	0.007	0.077	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Plasmodium vivax	glutathione reductase, putative	0.0762	1	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0762	1	1
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.007	0.077	0.077
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0054	0.0561	0.0423
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0388	0.0248
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Plasmodium falciparum	thioredoxin reductase	0.0762	1	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0155	0.19	0.1835
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0356	0.028
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0155	0.19	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0561	0.0483
Plasmodium falciparum	thioredoxin reductase	0.0264	0.3357	0.3286
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.007	0.077	0.2293
Echinococcus granulosus	peroxidasin	0.0086	0.0977	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0345	0.4428	0.4383
Mycobacterium ulcerans	hypothetical protein	0.007	0.077	0.1378
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0155	0.19	0.5658
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.007	0.077	0.0729
Brugia malayi	Matrixin family protein	0.0479	0.6223	0.6168
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0194	0.2422	0.2312
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0264	0.3357	1
Onchocerca volvulus	Matrix metalloproteinase homolog	0.044	0.5695	0.8223
Brugia malayi	Animal haem peroxidase family protein	0.0086	0.0977	0.0845
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0148	0.1804	0.1684
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.007	0.077	0.1378
Plasmodium falciparum	glutathione reductase	0.0264	0.3357	0.3286
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0356	0.0215
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0144	0.0429
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.007	0.077	0.0671
Onchocerca volvulus	Matrilysin homolog	0.0198	0.2477	0.3266
Echinococcus granulosus	aminopeptidase N	0.0526	0.6849	0.6803
Echinococcus granulosus	glutamate synthase	0.007	0.077	0.0635
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.007	0.077	0.0732
Echinococcus multilocularis	protein cereblon	0.0325	0.4164	0.4079
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0054	0.0561	0.0561
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.007	0.077	0.0729
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0054	0.0561	0.0519
Leishmania major	hypothetical protein, conserved	0.007	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0356	0.0277
Loa Loa (eye worm)	blistered cuticle protein 3	0.0086	0.0977	0.0903
Brugia malayi	hypothetical protein	0.0086	0.0977	0.0845
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.007	0.077	0.0694
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0054	0.0561	0.0423

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3499878

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2076150