Detailed information for compound 2076151

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.46 | Formula: C18H23F3N4O3S
  • H donors: 1 H acceptors: 4 LogP: -0.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O(Cc1ncn2c1CN(CCC2)Cc1nccs1)CC1CC1.OC(=O)C(F)(F)F
  • InChi: 1S/C16H22N4OS.C2HF3O2/c1-5-19(9-16-17-4-7-22-16)8-15-14(18-12-20(15)6-1)11-21-10-13-2-3-13;3-2(4,5)1(6)7/h4,7,12-13H,1-3,5-6,8-11H2;(H,6,7)
  • InChiKey: QUPFXPIGUCPJRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.007 0.077 0.1378
Loa Loa (eye worm) hypothetical protein 0.01 0.1174 0.1101
Echinococcus multilocularis geminin 0.0368 0.4742 0.4665
Loa Loa (eye worm) glutathione reductase 0.0762 1 1
Loa Loa (eye worm) animal heme peroxidase 0.046 0.5972 0.5939
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0356 0.0356
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.077 0.0635
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.077 0.077
Schistosoma mansoni hypothetical protein 0.0368 0.4742 0.47
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.007 0.077 0.0635
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0762 1 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.007 0.077 0.077
Brugia malayi Peptidase family M1 containing protein 0.0155 0.19 0.1781
Entamoeba histolytica glutamate synthase beta subunit, putative 0.007 0.077 0.1849
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.007 0.077 0.0635
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0356 0.0356
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.1804 0.1684
Loa Loa (eye worm) hypothetical protein 0.0054 0.0561 0.0483
Plasmodium falciparum thioredoxin reductase 0.0762 1 1
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0388 0.0248
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.007 0.077 0.077
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.3357 0.3112
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0721 0.9441 0.9433
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.077 0.0732
Treponema pallidum NADH oxidase 0.0264 0.3357 1
Leishmania major hypothetical protein, conserved 0.007 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0264 0.3357 1
Echinococcus multilocularis aminopeptidase N 0.0526 0.6849 0.6803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0264 0.3357 0.3357
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0791 0.0656
Onchocerca volvulus 0.046 0.5972 0.8649
Brugia malayi Animal haem peroxidase family protein 0.046 0.5972 0.5913
Leishmania major NADH dehydrogenase, putative 0.007 0.077 0.077
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0356 0.1061
Onchocerca volvulus Peroxidasin homolog 0.046 0.5972 0.8649
Trypanosoma brucei aminopeptidase, putative 0.0054 0.0561 0.0561
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.007 0.077 0.0635
Trichomonas vaginalis esterase, putative 0.0039 0.0356 0.1061
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0054 0.0561 0.0483
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0264 0.3357 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0241 0.3053 0.2796
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0264 0.3357 0.3357
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.007 0.077 0.1378
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0054 0.0561 0.0459
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.007 0.077 0.0635
Plasmodium vivax ferrodoxin reductase, putative 0.007 0.077 0.0729
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0264 0.3357 0.326
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.007 0.077 0.0635
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0264 0.3357 0.3357
Brugia malayi TATA binding protein associated factor 0.0054 0.0561 0.0423
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.007 0.077 0.1378
Trypanosoma brucei trypanothione reductase 0.0762 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0356 0.0215
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.077 0.2293
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Onchocerca volvulus 0.046 0.5972 0.8649
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Trichomonas vaginalis glutamate synthase, putative 0.007 0.077 0.2293
Brugia malayi beta-lactamase 0.0039 0.0356 0.0215
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.007 0.077 0.1378
Trichomonas vaginalis glutamate synthase, putative 0.007 0.077 0.2293
Loa Loa (eye worm) hypothetical protein 0.007 0.077 0.0694
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.007 0.077 0.1378
Onchocerca volvulus Matrilysin homolog 0.044 0.5695 0.8223
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Schistosoma mansoni aminopeptidase A (M01 family) 0.0054 0.0561 0.0486
Echinococcus granulosus peroxidasin 0.046 0.5972 0.5913
Plasmodium falciparum glutathione reductase 0.0762 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0264 0.3357 0.326
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0264 0.3357 0.3328
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.3357 0.3112
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0194 0.2422 0.2312
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0054 0.0561 0.0561
Onchocerca volvulus 0.046 0.5972 0.8649
Mycobacterium ulcerans monoxygenase 0.007 0.077 0.1378
Leishmania major hypothetical protein, conserved 0.0039 0.0356 0.0356
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.3357 0.3112
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.007 0.077 0.1378
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0356 0.1061
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.01 0.1174 0.1103
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0791 0.1899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.3165 0.2913
Schistosoma mansoni hypothetical protein 0.0325 0.4164 0.4118
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.007 0.077 0.1378
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Plasmodium vivax thioredoxin reductase, putative 0.0762 1 1
Loa Loa (eye worm) blistered cuticle protein 3 0.046 0.5972 0.5939
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.007 0.077 0.1378
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.007 0.077 0.0732
Loa Loa (eye worm) matrix metalloproteinase 0.0198 0.2477 0.2415
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.077 0.077
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.007 0.077 0.0635
Loa Loa (eye worm) RecQ helicase 0.0023 0.0144 0.0063
Mycobacterium tuberculosis Putative ferredoxin reductase 0.007 0.077 0.0429
Onchocerca volvulus 0.0198 0.2477 0.3266
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0471 0.611 0.6079
Mycobacterium leprae PROBABLE HYDROLASE 0.0241 0.3053 0.8985
Leishmania major hypothetical protein, conserved 0.007 0.077 0.077
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0264 0.3357 0.3357
Trichomonas vaginalis apoptosis inducing factor, putative 0.007 0.077 0.2293
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0264 0.3357 0.3305
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.007 0.077 0.077
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0791 0.0791
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0791 0.0791
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.007 0.077 0.0429
Trypanosoma cruzi aminopeptidase, putative 0.0054 0.0561 0.0561
Schistosoma mansoni hypothetical protein 0.007 0.077 0.0697
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0054 0.0561 0.0561
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.007 0.077 0.1378
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.3188 0.3133
Loa Loa (eye worm) hypothetical protein 0.0054 0.0561 0.0483
Brugia malayi hypothetical protein 0.046 0.5972 0.5913
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0241 0.3053 0.2951
Schistosoma mansoni glutamate synthase 0.007 0.077 0.0697
Trypanosoma brucei hypothetical protein, conserved 0.007 0.077 0.077
Trypanosoma brucei NADH dehydrogenase 0.007 0.077 0.077
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.007 0.077 0.1378
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0054 0.0561 0.0561
Trichomonas vaginalis mercuric reductase, putative 0.0264 0.3357 1
Toxoplasma gondii thioredoxin reductase 0.0762 1 1
Loa Loa (eye worm) animal heme peroxidase 0.046 0.5972 0.5939
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.007 0.077 0.077
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1804 0.1739
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0264 0.3357 0.3286
Onchocerca volvulus 0.0155 0.19 0.2377
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0356 0.0215
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.007 0.077 0.0429
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.007 0.077 0.0671
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.01 0.1174 0.1174
Mycobacterium ulcerans ferredoxin reductase 0.007 0.077 0.1378
Trypanosoma brucei Aminopeptidase M1, putative 0.0155 0.19 0.19
Brugia malayi beta-lactamase family protein 0.0039 0.0356 0.0215
Loa Loa (eye worm) matrixin family protein 0.0479 0.6223 0.6192
Onchocerca volvulus Peroxidase homolog 0.046 0.5972 0.8649
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.007 0.077 0.0732
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0264 0.3357 0.3357
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.19 0.19
Mycobacterium ulcerans NADH dehydrogenase 0.007 0.077 0.1378
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.007 0.077 0.0429
Mycobacterium tuberculosis Probable reductase 0.007 0.077 0.0429
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0561 0.0423
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.007 0.077 0.0429
Echinococcus granulosus geminin 0.0368 0.4742 0.4665
Loa Loa (eye worm) hypothetical protein 0.0371 0.4784 0.4741
Loa Loa (eye worm) animal heme peroxidase 0.046 0.5972 0.5939
Onchocerca volvulus Matrilysin homolog 0.0198 0.2477 0.3266
Brugia malayi hypothetical protein 0.0155 0.19 0.1781
Brugia malayi hypothetical protein 0.0325 0.4164 0.4079
Leishmania major trypanothione reductase 0.0762 1 1
Brugia malayi Peptidase family M1 containing protein 0.0526 0.6849 0.6803
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0264 0.3357 0.3357
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0264 0.3357 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0791 0.0656
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0155 0.19 0.5658
Mycobacterium ulcerans aminopeptidase N PepN 0.0054 0.0561 0.0682
Loa Loa (eye worm) hypothetical protein 0.0241 0.3053 0.2996
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0144 0.0429
Loa Loa (eye worm) beta-lactamase 0.0039 0.0356 0.0277
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Onchocerca volvulus 0.0526 0.6849 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0264 0.3357 1
Brugia malayi Animal haem peroxidase family protein 0.046 0.5972 0.5913
Schistosoma mansoni hypothetical protein 0.0137 0.1658 0.1591
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.007 0.077 0.1849
Brugia malayi hypothetical protein 0.0054 0.0561 0.0423
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.007 0.077 0.0429
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.007 0.077 0.0635
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.007 0.077 0.0635
Loa Loa (eye worm) hypothetical protein 0.01 0.1174 0.1101
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.1658 0.1536
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0264 0.3357 1
Schistosoma mansoni glutamate synthase 0.007 0.077 0.0697
Trichomonas vaginalis glutathione reductase, putative 0.0264 0.3357 1
Loa Loa (eye worm) programmed cell death 8 0.007 0.077 0.0694
Brugia malayi Animal haem peroxidase family protein 0.046 0.5972 0.5913
Loa Loa (eye worm) hypothetical protein 0.0345 0.4428 0.4383
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0264 0.3357 0.3328
Schistosoma mansoni hypothetical protein 0.0281 0.3581 0.353
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0264 0.3357 0.3286
Loa Loa (eye worm) hypothetical protein 0.0472 0.6123 0.6091
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0054 0.0561 0.167
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Echinococcus multilocularis thioredoxin glutathione reductase 0.0762 1 1
Brugia malayi Animal haem peroxidase family protein 0.046 0.5972 0.5913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.007 0.077 0.2293
Entamoeba histolytica thioredoxin reductase, putative 0.007 0.077 0.1849
Entamoeba histolytica hypothetical protein, conserved 0.0325 0.4164 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0356 0.1061
Echinococcus multilocularis protein cereblon 0.0325 0.4164 0.4079
Entamoeba histolytica disulphide oxidoreductase, putative 0.007 0.077 0.1849
Loa Loa (eye worm) animal heme peroxidase 0.046 0.5972 0.5939
Plasmodium falciparum glutathione reductase 0.0264 0.3357 0.3286
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.077 0.0732
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0054 0.0561 0.0486
Trypanosoma brucei Aminopeptidase M1, putative 0.0155 0.19 0.19
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.007 0.077 0.0429
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0194 0.2422 0.2312
Toxoplasma gondii NADPH-glutathione reductase 0.0264 0.3357 0.333
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.077 0.0635
Schistosoma mansoni disulfide oxidoreductase 0.007 0.077 0.0697
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Onchocerca volvulus 0.0281 0.3581 0.4967
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.007 0.077 0.1849
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Brugia malayi Hemopexin family protein 0.0281 0.3581 0.3487
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0356 0.1061
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0791 0.0717
Onchocerca volvulus 0.0054 0.0561 0.0315
Giardia lamblia NADH oxidase lateral transfer candidate 0.0264 0.3357 1
Schistosoma mansoni sulfide quinone reductase 0.007 0.077 0.0697
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.077 0.0635
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0356 0.0356
Trypanosoma cruzi NADH dehydrogenase, putative 0.007 0.077 0.077
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.007 0.077 0.1849
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.1658 0.1536
Brugia malayi hypothetical protein 0.0132 0.1597 0.1475
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.007 0.077 0.0429
Toxoplasma gondii aminopeptidase n, putative 0.0054 0.0561 0.0522
Onchocerca volvulus Protein cereblon homolog 0.0325 0.4164 0.5865
Loa Loa (eye worm) aminopeptidase N 0.0155 0.19 0.1833
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.01 0.1174 0.1045
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0155 0.19 0.1835
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0791 0.0715
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.007 0.077 0.0429
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.007 0.077 0.077
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0054 0.0561 0.0486
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Schistosoma mansoni glutamate synthase 0.007 0.077 0.0697
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.3357 0.3357
Echinococcus multilocularis glutamate synthase 0.007 0.077 0.0635
Toxoplasma gondii aminopeptidase N, putative 0.0054 0.0561 0.0522
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.077 0.0635
Plasmodium falciparum thioredoxin reductase 0.0264 0.3357 0.3286
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.007 0.077 0.077
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.19 0.19
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0054 0.0561 0.0561
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0054 0.0561 0.0459
Echinococcus granulosus protein cereblon 0.0325 0.4164 0.4079
Loa Loa (eye worm) thioredoxin reductase 0.0762 1 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0791 0.0656
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Trypanosoma cruzi NADH dehydrogenase, putative 0.007 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0356 0.028
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.007 0.077 0.2293
Echinococcus granulosus thioredoxin glutathione reductase 0.0762 1 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0198 0.2477 0.2417
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.007 0.077 0.0429
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.007 0.077 0.077
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0054 0.0561 0.0423
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.3357 1
Echinococcus multilocularis peroxidasin 0.046 0.5972 0.5913
Loa Loa (eye worm) hypothetical protein 0.0198 0.2477 0.2415
Onchocerca volvulus Chorion peroxidase homolog 0.046 0.5972 0.8649
Brugia malayi beta-lactamase family protein 0.0039 0.0356 0.0215
Loa Loa (eye worm) TATA binding protein associated factor 0.0054 0.0561 0.0483
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0155 0.19 0.5658
Onchocerca volvulus Peroxidasin homolog 0.046 0.5972 0.8649
Toxoplasma gondii ABC1 family protein 0.0039 0.0356 0.0316
Echinococcus granulosus sulfide:quinone oxidoreductase 0.007 0.077 0.0635
Trypanosoma cruzi Aminopeptidase M1, putative 0.0155 0.19 0.19
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0155 0.19 0.19
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0054 0.0561 0.0519
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0264 0.3357 0.3357
Brugia malayi Peptidase family M1 containing protein 0.0054 0.0561 0.0423
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0791 0.0791
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0264 0.3357 0.3357
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Plasmodium vivax glutathione reductase, putative 0.0762 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0762 1 1
Brugia malayi glutamate synthase 0.007 0.077 0.0635
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Schistosoma mansoni sulfide quinone reductase 0.007 0.077 0.0697
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0356 0.1061
Brugia malayi Thioredoxin reductase 0.0762 1 1
Mycobacterium ulcerans hydrolase 0.0241 0.3053 0.8985
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0388 0.0248
Echinococcus granulosus leukotriene A 4 hydrolase 0.0054 0.0561 0.0423
Brugia malayi follicle stimulating hormone receptor 0.0252 0.3188 0.3089
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Mycobacterium ulcerans aminopeptidase N PepN 0.0155 0.19 0.5142
Trypanosoma cruzi trypanothione reductase, putative 0.0264 0.3357 0.3357
Loa Loa (eye worm) hypothetical protein 0.0054 0.0561 0.0483
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0356 0.028
Onchocerca volvulus Dual oxidase homolog 0.046 0.5972 0.8649
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.19 0.1781
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.007 0.077 0.1378
Brugia malayi Matrixin family protein 0.0479 0.6223 0.6168
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0264 0.3357 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.007 0.077 0.0729
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0264 0.3357 0.326
Mycobacterium ulcerans hypothetical protein 0.007 0.077 0.1378
Onchocerca volvulus Matrix metalloproteinase homolog 0.044 0.5695 0.8223
Echinococcus granulosus aminopeptidase N 0.0526 0.6849 0.6803
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0264 0.3357 0.333
Echinococcus granulosus glutamate synthase 0.007 0.077 0.0635
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0356 0.0215
Onchocerca volvulus Peroxidase homolog 0.046 0.5972 0.8649
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.007 0.077 0.0671
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0144 0.0429
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.007 0.077 0.0729
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.077 0.0732
Schistosoma mansoni peroxidasin 0.046 0.5972 0.594
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0561 0.0561
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0561 0.0423
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.007 0.077 0.0694
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277
Leishmania major hypothetical protein, conserved 0.007 0.077 0.077
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0054 0.0561 0.0519
Trypanosoma cruzi aminopeptidase, putative 0.0155 0.19 0.19
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1804 0.1739
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0155 0.19 0.1835
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0721 0.9441 0.9433
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.007 0.077 0.1378
Mycobacterium tuberculosis Probable dehydrogenase 0.007 0.077 0.0429
Loa Loa (eye worm) hypothetical protein 0.0325 0.4164 0.4116
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0155 0.19 0.19
Loa Loa (eye worm) hypothetical protein 0.0198 0.2477 0.2415
Loa Loa (eye worm) matrixin family protein 0.044 0.5695 0.566
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.077 0.2293
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.077 0.2293
Brugia malayi Blistered cuticle protein 3 0.046 0.5972 0.5913
Entamoeba histolytica glutamate synthase beta subunit, putative 0.007 0.077 0.1849
Onchocerca volvulus 0.007 0.077 0.0637
Brugia malayi Animal haem peroxidase family protein 0.046 0.5972 0.5913
Schistosoma mansoni hypothetical protein 0.0368 0.4742 0.47
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0356 0.0277
Schistosoma mansoni peroxidasin 0.046 0.5972 0.594
Entamoeba histolytica aminopeptidase, putative 0.0155 0.19 0.4562
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Brugia malayi Peroxidasin 0.046 0.5972 0.5913
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.007 0.077 0.0635
Loa Loa (eye worm) hypothetical protein 0.046 0.5972 0.5939
Toxoplasma gondii selenide, water dikinase 0.007 0.077 0.0732
Mycobacterium ulcerans dehydrogenase 0.007 0.077 0.1378
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0155 0.19 0.1781
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0356 0.0314
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0264 0.3357 0.3112
Loa Loa (eye worm) hypothetical protein 0.0198 0.2477 0.2415
Brugia malayi Matrixin family protein 0.0198 0.2477 0.2367
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.077 0.077
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.007 0.077 0.0635
Plasmodium falciparum ferrodoxin reductase-like protein 0.007 0.077 0.0671
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0791 0.0791
Mycobacterium ulcerans glutamate synthase subunit beta 0.007 0.077 0.1378
Toxoplasma gondii aminopeptidase N protein 0.0054 0.0561 0.0522
Loa Loa (eye worm) peptidase family M1 containing protein 0.0426 0.551 0.5473
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0277

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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