TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 658.534 | Formula: C23H27F9N4O6S
H donors: 3 H acceptors: 7 LogP: 0.33 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(CCN1CCN(Cc2c1nccc2)Cc1cccs1)C
InChi: 1S/C17H24N4S.3C2HF3O2/c1-19(2)8-10-21-11-9-20(14-16-6-4-12-22-16)13-15-5-3-7-18-17(15)21;3*3-2(4,5)1(6)7/h3-7,12H,8-11,13-14H2,1-2H3;3*(H,6,7)
InChiKey: MYTAKPMOQIJNDI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Echinococcus granulosus	neuropeptides capa receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0152	0.9949	0.9949
Onchocerca volvulus		0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0152	0.9949	0.9949
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0152	0.9949	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0152	0.9949	1
Schistosoma mansoni	biogenic amine receptor	0.0152	0.9949	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0152	0.9949	1
Schistosoma mansoni	neuropeptide receptor	0.0152	0.9949	1
Echinococcus granulosus	orexin receptor type 2	0.0152	0.9949	0.9949
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	myosin xvIII	0.0152	0.9949	1
Echinococcus multilocularis		0.0025	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0152	0.9949	1
Brugia malayi	follicle stimulating hormone receptor	0.0152	0.9949	0.9949
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0025	0.0665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Schistosoma mansoni	neuropeptide receptor	0.0152	0.9949	1
Schistosoma mansoni	histamine h1 receptor	0.0152	0.9949	1
Echinococcus granulosus	neuropeptide receptor	0.0152	0.9949	0.9949
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0025	0.0665	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0025	0.0665	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0152	0.9949	0.9949
Brugia malayi	RE15519p	0.0152	0.9949	0.9949
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0152	0.9949	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0025	0.0665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Brugia malayi	G protein-coupled receptor	0.0152	0.9949	0.9949
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0152	0.9949	0.9949
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0025	0.0665	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0152	0.9949	0.9949
Brugia malayi	putative neuropeptide receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0152	0.9949	0.9949
Brugia malayi	Serotonin receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1199	0.1205
Brugia malayi	G-protein coupled receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0153	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0152	0.9949	1
Brugia malayi	GnHR receptor homolog	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0665	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0152	0.9949	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0152	0.9949	1
Brugia malayi	cytochrome P450	0.0025	0.0665	0.0665
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0152	0.9949	0.9949
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0152	0.9949	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0025	0.0665	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0025	0.0665	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0152	0.9949	0.9949
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Echinococcus granulosus	g protein coupled receptor	0.0152	0.9949	0.9949
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0152	0.9949	0.9949
Schistosoma mansoni	neuropeptide receptor	0.0152	0.9949	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0152	0.9949	0.9949
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0025	0.0665	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0152	0.9949	1
Brugia malayi	Serotonin receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0152	0.9949	1
Echinococcus multilocularis	jun protein	0.0153	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0152	0.9949	0.9949
Brugia malayi	Dopamine receptor protein 2	0.0152	0.9949	0.9949
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0152	0.9949	0.9949
Onchocerca volvulus		0.0152	0.9949	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0152	0.9949	0.9949
Echinococcus multilocularis	dro:myosuppressin receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus granulosus	neuropeptide s receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	neuropeptide F receptor	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0025	0.0665	0.5
Echinococcus multilocularis	serotonin receptor	0.0152	0.9949	0.9949
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0025	0.0665	0.5
Onchocerca volvulus		0.012	0.7598	0.7637
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0152	0.9949	0.9949
Brugia malayi	G-protein coupled receptor	0.0152	0.9949	0.9949
Onchocerca volvulus		0.0152	0.9949	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0152	0.9949	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0025	0.0665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.1539	0.1539
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0152	0.9949	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0025	0.0665	0.5
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	amine GPCR	0.0152	0.9949	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0152	0.9949	0.9949
Echinococcus granulosus	tm gpcr rhodopsin	0.0152	0.9949	0.9949
Brugia malayi	AKH receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Onchocerca volvulus		0.0152	0.9949	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	biogenic amine receptor	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0152	0.9949	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0025	0.0665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus granulosus	jun protein	0.0153	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0025	0.0665	0.5
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0152	0.9949	1
Echinococcus multilocularis	fmrfamide receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Echinococcus granulosus	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0152	0.9949	1
Echinococcus multilocularis	g protein coupled receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	biogenic amine receptor	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	hypothetical protein	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0025	0.0665	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	hypothetical protein	0.0152	0.9949	1
Loa Loa (eye worm)	cytochrome P450	0.0025	0.0665	0.0668
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Schistosoma mansoni	opsin-like receptor	0.0152	0.9949	1
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.1539	0.1539
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0152	0.9949	1
Mycobacterium leprae	putative cytochrome p450	0.0025	0.0665	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0665	0.0668
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0665	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0025	0.0665	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0149	0.9693	0.9743
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0025	0.0665	0.5
Echinococcus multilocularis	sodium channel protein	0.0034	0.1278	0.1278
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0152	0.9949	0.9949
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0025	0.0665	0.5
Echinococcus granulosus	somatostatin receptor	0.0152	0.9949	0.9949
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0025	0.0665	0.5
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0025	0.0665	0.5
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0025	0.0665	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0025	0.0665	0.5
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0025	0.0665	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	cytochrome P450 2K1	0.0025	0.0665	0.0665
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0152	0.9949	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0025	0.0665	0.5
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0025	0.0665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	opsin-like receptor	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0025	0.0665	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0152	0.9949	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0025	0.0665	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0152	0.9949	0.9949
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0025	0.0665	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Brugia malayi	hypothetical protein	0.012	0.7598	0.7598
Schistosoma mansoni	hypothetical protein	0.0025	0.0665	0.0668
Brugia malayi	ORL1-like opioid receptor	0.0152	0.9949	0.9949
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0025	0.0665	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0152	0.9949	0.9949
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0665	0.0665
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Onchocerca volvulus		0.0152	0.9949	1
Schistosoma mansoni	adenoreceptor	0.0152	0.9949	1
Schistosoma mansoni	jun-related protein	0.0124	0.7904	0.7945
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0152	0.9949	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Echinococcus granulosus	allatostatin A receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0025	0.0665	0.5
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0025	0.0665	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0152	0.9949	0.9949
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	g protein coupled receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0665	0.0668
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0025	0.0665	0.5
Onchocerca volvulus		0.0152	0.9949	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.1221	0.5
Echinococcus multilocularis	serotonin receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.1539	0.1547
Onchocerca volvulus		0.0152	0.9949	1
Schistosoma mansoni	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0152	0.9949	0.9949
Brugia malayi	larval opioid receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Echinococcus granulosus	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Schistosoma mansoni	cytochrome P450	0.0025	0.0665	0.0668
Echinococcus multilocularis	neuropeptides capa receptor	0.0152	0.9949	0.9949
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0152	0.9949	0.9949
Brugia malayi	Dopamine receptor protein 1	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Echinococcus multilocularis	fmrfamide receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0034	0.1278	0.1278
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0152	0.9949	0.9949
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0665	0.0665
Brugia malayi	G protein-coupled receptor F59B2.13	0.0152	0.9949	0.9949
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0025	0.0665	0.5
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0025	0.0665	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0025	0.0665	0.5
Brugia malayi	Melatonin receptor type 1A	0.0152	0.9949	0.9949
Echinococcus granulosus	serotonin receptor	0.0152	0.9949	0.9949
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0025	0.0665	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0025	0.0665	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0665	0.5
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0665	0.0665
Schistosoma mansoni	amine GPCR	0.0152	0.9949	1
Loa Loa (eye worm)	CYP4Cod1	0.0025	0.0665	0.0668
Loa Loa (eye worm)	G-protein coupled receptor	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Echinococcus granulosus	sex peptide receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	hypothetical protein	0.0124	0.7904	0.7945
Echinococcus granulosus	G protein coupled receptor 139	0.0152	0.9949	0.9949
Echinococcus granulosus	hypothetical protein	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	amine GPCR	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0152	0.9949	0.9949
Echinococcus granulosus	sodium channel protein	0.0034	0.1278	0.1278
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0025	0.0665	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0152	0.9949	0.9949
Echinococcus multilocularis	g-protein coupled receptor	0.0152	0.9949	0.9949
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0152	0.9949	0.9949
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0025	0.0665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	allatostatin A receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	neuropeptide F-like receptor	0.0152	0.9949	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.1539	0.1539
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0152	0.9949	0.9949
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1776	0.1785
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0025	0.0665	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.1221	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0152	0.9949	0.9949
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0152	0.9949	0.9949
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0025	0.0665	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0152	0.9949	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0152	0.9949	1
Brugia malayi	Dopamine receptor	0.0152	0.9949	0.9949
Brugia malayi	neuropeptide F receptor	0.0152	0.9949	0.9949
Echinococcus multilocularis	sex peptide receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0152	0.9949	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0025	0.0665	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0152	0.9949	0.9949
Onchocerca volvulus		0.0152	0.9949	1
Echinococcus multilocularis	neuropeptide receptor	0.0152	0.9949	0.9949
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0152	0.9949	0.9949
Loa Loa (eye worm)	TYRA-2 protein	0.0152	0.9949	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0152	0.9949	1
Echinococcus multilocularis	somatostatin receptor	0.0152	0.9949	0.9949
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Schistosoma mansoni	opsin-like receptor	0.0152	0.9949	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0152	0.9949	0.9949
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Brugia malayi	sulfakinin receptor protein	0.0152	0.9949	0.9949
Schistosoma mansoni	amine GPCR	0.0152	0.9949	1
Brugia malayi	neuropeptide F receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0152	0.9949	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0034	0.1278	1
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0025	0.0665	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	neuropeptide receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	tm gpcr rhodopsin	0.0152	0.9949	0.9949
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0025	0.0665	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus granulosus	fmrfamide receptor	0.0152	0.9949	0.9949
Schistosoma mansoni	amine GPCR	0.0152	0.9949	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0152	0.9949	0.9949
Echinococcus multilocularis	neuropeptide receptor A26	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0025	0.0665	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0152	0.9949	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0152	0.9949	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	7tm_1 domain containing protein	0.0152	0.9949	0.9949
Mycobacterium leprae	Conserved hypothetical protein	0.0025	0.0665	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0153	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0152	0.9949	0.9949
Echinococcus granulosus	g protein coupled receptor	0.0152	0.9949	0.9949
Echinococcus granulosus	g protein coupled receptor	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Brugia malayi	hypothetical protein	0.0152	0.9949	0.9949
Loa Loa (eye worm)	hypothetical protein	0.0152	0.9949	1
Onchocerca volvulus		0.0152	0.9949	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0025	0.0665	0.5
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0025	0.0665	0.5
Schistosoma mansoni	hypothetical protein	0.0152	0.9949	1
Schistosoma mansoni	neuropeptide receptor	0.0152	0.9949	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0152	0.9949	1
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1776	0.1785

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3504378

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2077084