TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 642.469 | Formula: C23H27F9N4O7
H donors: 3 H acceptors: 7 LogP: -0.29 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(CCN1CCN(Cc2c1nccc2)Cc1ccco1)C
InChi: 1S/C17H24N4O.3C2HF3O2/c1-19(2)8-10-21-11-9-20(14-16-6-4-12-22-16)13-15-5-3-7-18-17(15)21;3*3-2(4,5)1(6)7/h3-7,12H,8-11,13-14H2,1-2H3;3*(H,6,7)
InChiKey: YXZAGESOCNQSDO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1194	0.1194
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1769	0.1769
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0662	0.5
Brugia malayi	Dopamine receptor	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0151	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.1533	0.1533
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0025	0.0662	0.5
Echinococcus granulosus	sodium channel protein	0.0033	0.1273	0.1273
Echinococcus multilocularis	g-protein coupled receptor	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0025	0.0662	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0151	1	1
Brugia malayi	Dopamine receptor protein 2	0.0151	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Brugia malayi	GnHR receptor homolog	0.0151	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0025	0.0662	0.5
Brugia malayi	sulfakinin receptor protein	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0025	0.0662	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0151	1	1
Brugia malayi	putative neuropeptide receptor	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0151	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0151	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	1	1
Schistosoma mansoni	opsin-like receptor	0.0151	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0025	0.0662	0.5
Echinococcus multilocularis	sodium channel protein	0.0033	0.1273	0.1273
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Echinococcus granulosus	fmrfamide receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0025	0.0662	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	1	1
Echinococcus granulosus	jun protein	0.0151	0.9961	0.9961
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus granulosus	neuropeptide receptor	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus granulosus	orexin receptor type 2	0.0151	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0025	0.0662	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0151	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0151	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1769	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0025	0.0662	0.5
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0025	0.0662	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0151	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	sex peptide receptor	0.0151	1	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0151	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0025	0.0662	0.5
Echinococcus granulosus	cytochrome P450 2K1	0.0025	0.0662	0.0662
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0151	1	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0662	0.0662
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0025	0.0662	0.5
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0025	0.0662	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0025	0.0662	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0151	1	1
Schistosoma mansoni	adenoreceptor	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0025	0.0662	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0151	1	1
Brugia malayi	G-protein coupled receptor	0.0151	1	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0662	0.0662
Schistosoma mansoni	hypothetical protein	0.0025	0.0662	0.0662
Onchocerca volvulus		0.0118	0.7568	0.7568
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0025	0.0662	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0151	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0662	0.0662
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0025	0.0662	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0151	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0151	1	1
Echinococcus multilocularis	sex peptide receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0025	0.0662	0.5
Schistosoma mansoni	jun-related protein	0.0122	0.7874	0.7874
Echinococcus granulosus	G protein coupled receptor 139	0.0151	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.1533	0.1533
Echinococcus multilocularis	neuropeptide receptor	0.0151	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0032	0.1216	0.5
Onchocerca volvulus		0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0151	1	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0662	0.0662
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0151	1	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0033	0.1273	1
Brugia malayi	bZIP transcription factor family protein	0.0151	0.9961	0.9961
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0151	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0151	1	1
Schistosoma mansoni	cytochrome P450	0.0025	0.0662	0.0662
Brugia malayi	neuropeptide F receptor	0.0151	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0151	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0025	0.0662	0.5
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0025	0.0662	0.5
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0025	0.0662	0.5
Brugia malayi	Melatonin receptor type 1A	0.0151	1	1
Echinococcus granulosus	g protein coupled receptor	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Brugia malayi	larval opioid receptor	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0025	0.0662	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0025	0.0662	0.5
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	hypothetical protein	0.0122	0.7874	0.7874
Echinococcus granulosus	neuropeptide Y receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Echinococcus granulosus	serotonin receptor	0.0151	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0151	1	1
Schistosoma mansoni	opsin-like receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0025	0.0662	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0151	1	1
Loa Loa (eye worm)	CYP4Cod1	0.0025	0.0662	0.0662
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0151	1	1
Brugia malayi	hypothetical protein	0.0118	0.7568	0.7568
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0151	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0025	0.0662	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0025	0.0662	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0151	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0151	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Echinococcus multilocularis	serotonin receptor	0.0151	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	1	1
Echinococcus multilocularis	serotonin receptor	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.1533	0.1533
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0025	0.0662	0.5
Echinococcus granulosus	neuropeptide receptor	0.0151	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0025	0.0662	0.5
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0025	0.0662	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	1	1
Echinococcus granulosus	neuropeptide receptor A26	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0151	1	1
Echinococcus multilocularis	somatostatin receptor	0.0151	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0151	1	1
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0151	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0151	1	1
Brugia malayi	AKH receptor	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0151	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0025	0.0662	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0151	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0025	0.0662	0.5
Schistosoma mansoni	opsin-like receptor	0.0151	1	1
Loa Loa (eye worm)	cytochrome P450	0.0025	0.0662	0.0662
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Schistosoma mansoni	biogenic amine receptor	0.0151	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Echinococcus granulosus	g protein coupled receptor	0.0151	1	1
Echinococcus granulosus	g protein coupled receptor	0.0151	1	1
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.9655	0.9655
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0025	0.0662	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium leprae	putative cytochrome p450	0.0025	0.0662	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0662	0.0662
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.1533	0.1533
Brugia malayi	neuropeptide F receptor	0.0151	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0662	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0151	1	1
Echinococcus granulosus	allatostatin A receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0025	0.0662	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0151	1	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0033	0.1273	0.1273
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0025	0.0662	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0025	0.0662	0.5
Onchocerca volvulus		0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	jun protein	0.0151	0.9961	0.9961
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0151	1	1
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0151	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0151	0.9961	0.9961
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0151	1	1
Schistosoma mansoni	biogenic amine receptor	0.0151	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0151	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0151	1	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Onchocerca volvulus		0.0151	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0025	0.0662	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0151	1	1
Echinococcus multilocularis		0.0025	0.0662	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	myosin xvIII	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	1	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0662	0.0662
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0025	0.0662	0.5
Schistosoma mansoni	histamine h1 receptor	0.0151	1	1
Echinococcus granulosus	somatostatin receptor	0.0151	1	1
Brugia malayi	G-protein coupled receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Brugia malayi	G protein-coupled receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0025	0.0662	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0662	0.0662
Onchocerca volvulus		0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0151	1	1
Brugia malayi	Dopamine receptor protein 1	0.0151	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0032	0.1216	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0151	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	1	1
Brugia malayi	RE15519p	0.0151	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0151	0.9961	0.9961
Echinococcus granulosus	hypothetical protein	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0025	0.0662	0.5
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Brugia malayi	Serotonin receptor	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0025	0.0662	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0151	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0151	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0151	1	1
Brugia malayi	cytochrome P450	0.0025	0.0662	0.0662
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0151	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0151	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Schistosoma mansoni	biogenic amine receptor	0.0151	1	1
Brugia malayi	ORL1-like opioid receptor	0.0151	1	1
Brugia malayi	Serotonin receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0025	0.0662	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0151	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0025	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0151	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3504380

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2077085