Detailed information for compound 207985

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.763 | Formula: C17H12ClN5O
  • H donors: 3 H acceptors: 4 LogP: 3.98 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)c1[nH]nc2c1c(ncn2)Nc1cccc(c1)Cl
  • InChi: 1S/C17H12ClN5O/c18-11-2-1-3-12(8-11)21-16-14-15(10-4-6-13(24)7-5-10)22-23-17(14)20-9-19-16/h1-9,24H,(H2,19,20,21,22,23)
  • InChiKey: DTGDQRLXHBUCRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens protein kinase C, alpha Starlite/ChEMBL References
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis insulin receptor 0.0062 0.0225 0.0566
Brugia malayi isocitrate dehydrogenase 0.0018 0.003 0.0136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0106
Schistosoma mansoni tyrosine kinase 0.0096 0.0377 0.3489
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.0202 0.0509
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.2264 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0116 0.0468 0.118
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0095 0.0374 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0184 0.0463
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0095 0.0374 1
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.086 0.3771 0.5
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0095 0.0374 1
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0095 0.0374 0.346
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.0202 0.0509
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0015 0.002 0.0093
Brugia malayi cell division control protein 2 homolog 0.0052 0.0184 0.0836
Echinococcus multilocularis serine threonine protein kinase 0.006 0.0218 0.0549
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0184 0.4482
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0163 0.0741
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0184 0.4925
Echinococcus granulosus muscleblind protein 0.0507 0.2201 1
Echinococcus multilocularis protein kinase c iota type 0.0018 0.0032 0.0082
Brugia malayi Protein kinase domain containing protein 0.0013 0.001 0.0047
Schistosoma mansoni tyrosine kinase 0.0254 0.108 1
Echinococcus multilocularis muscleblind protein 1 0.0507 0.2201 0.5545
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.2264 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.003 0.0076
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.397 1
Brugia malayi Protein kinase domain containing protein 0.0062 0.0225 0.1022
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0184 0.0836
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.003 0.0278
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0013 0.001 0.0276
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0013 0.001 0.0026
Echinococcus granulosus growth factor receptor bound protein 2 0.0016 0.0023 0.0106
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0184 0.4482
Loa Loa (eye worm) hypothetical protein 0.0048 0.0163 0.0741
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.0023 0.0217
Brugia malayi SH2 domain containing protein 0.0013 0.001 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.025 0.232
Brugia malayi hypothetical protein 0.0013 0.001 0.0047
Echinococcus granulosus protein kinase c iota type 0.0018 0.0032 0.0147
Brugia malayi Isocitrate dehydrogenase 0.0018 0.003 0.0136
Echinococcus multilocularis N chimaerin 0.0015 0.002 0.0051
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0101 0.0399 0.1812
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0184 0.4925
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.002 0.0189
Brugia malayi Protein kinase domain containing protein 0.0013 0.001 0.0047
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.013 0.0328
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Schistosoma mansoni tyrosine kinase 0.0101 0.0399 0.3696
Loa Loa (eye worm) hypothetical protein 0.0507 0.2201 1
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.0769 0.1937
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.003 0.0076
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0184 0.0463
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.003 0.0803
Brugia malayi Furin-like cysteine rich region family protein 0.0184 0.0769 0.3493
Loa Loa (eye worm) hypothetical protein 0.0095 0.0374 0.1697
Echinococcus multilocularis 0.0056 0.0199 0.0502
Echinococcus granulosus tyrosine kinase 0.0048 0.0167 0.0757
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0062 0.0225 0.1022
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.003 0.0136
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.2264 1 0.5
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0095 0.0374 1
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.0202 0.0918
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0095 0.0374 0.346
Echinococcus granulosus c src tyrosine kinase 0.0021 0.0046 0.0208
Echinococcus granulosus tyrosine protein kinase Srms 0.0013 0.001 0.0047
Loa Loa (eye worm) TK/EGFR protein kinase 0.0184 0.0769 0.3493
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.0635 0.2883
Echinococcus granulosus tyrosine protein kinase Lyn 0.0057 0.0205 0.0933
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.0202 0.0918
Brugia malayi Tyrosine-protein kinase abl-1 0.0116 0.0468 0.2128
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0095 0.0374 1
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0095 0.0374 1
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0023 0.0106
Schistosoma mansoni tyrosine kinase 0.0013 0.001 0.0095
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.0769 0.3493
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.003 0.0076
Loa Loa (eye worm) TK protein kinase 0.0048 0.0167 0.0757
Brugia malayi Protein kinase c protein 2 0.0057 0.0206 0.0934
Echinococcus granulosus protein kinase C gamma type 0.006 0.0218 0.0991
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0062 0.0225 0.0566
Schistosoma mansoni tyrosine kinase 0.0013 0.001 0.0095
Echinococcus granulosus insulin receptor 0.0062 0.0225 0.1022
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0144 0.0364
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.0167 0.042
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.086 0.3771 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.003 0.0076
Loa Loa (eye worm) TK protein kinase 0.004 0.013 0.0592
Echinococcus multilocularis growth factor receptor bound protein 2 0.0016 0.0023 0.0059
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0184 0.0836
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.005 0.0173 0.0787
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0095 0.0374 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0202 0.0918
Echinococcus multilocularis raf serine:threonine protein kinase 0.0012 0.0006 0.0016
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.0202 0.0509
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.0167 0.042
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.003 0.0803
Schistosoma mansoni unc-13 (munc13) 0.0011 0 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.0167 0.0757
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0095 0.0374 0.0941
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0184 0.0836
Schistosoma mansoni tyrosine kinase 0.0056 0.0202 0.1871
Echinococcus multilocularis tyrosine protein kinase shark 0.0013 0.001 0.0026
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0015 0.002 0.0093
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0184 0.0836
Echinococcus granulosus raf serine:threonine protein kinase 0.0012 0.0006 0.0029
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0184 0.4925
Loa Loa (eye worm) hypothetical protein 0.01 0.0397 0.1802
Schistosoma mansoni nck2/grb4 0.0016 0.0023 0.0217
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0202 0.0509
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.0202 0.0918
Entamoeba histolytica protein kinase, putative 0.004 0.013 0.3488
Brugia malayi protein-tyrosine kinase 0.0048 0.0167 0.0757
Brugia malayi SH2 domain containing protein 0.0013 0.001 0.0047
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.0202 0.0509
Schistosoma mansoni vav2 0.0015 0.002 0.0189
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0021 0.0046 0.0115
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0184 0.4482
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0184 0.0836
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.003 0.0076
Echinococcus multilocularis NCK adaptor protein 0.0016 0.0023 0.0059
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0095 0.0374 1
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0184 0.0836
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0095 0.0374 0.1697
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0144 0.0656
Loa Loa (eye worm) TK/ABL protein kinase 0.0262 0.1116 0.5069
Echinococcus granulosus N chimaerin 0.0015 0.002 0.0093
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0184 0.4925
Brugia malayi Sex muscle abnormal protein 5 0.0016 0.0023 0.0106
Schistosoma mansoni tyrosine kinase 0.0101 0.0399 0.3696
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0021 0.0046 0.0208
Loa Loa (eye worm) TK/INSR protein kinase 0.0062 0.0225 0.1022
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0016 0.0023 0.0217
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.0202 0.0918
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.002 0.0039 0.0178
Schistosoma mansoni tyrosine kinase 0.0096 0.0377 0.3489
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.0202 0.0509
Brugia malayi Protein kinase domain containing protein 0.0013 0.001 0.0047
Brugia malayi Protein kinase domain containing protein 0.0013 0.001 0.0047
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.013 0.0592
Brugia malayi Protein kinase domain containing protein 0.0052 0.0184 0.0836
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0067 0.025 0.0631
Schistosoma mansoni tyrosine kinase 0.0056 0.0202 0.1871
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0095 0.0374 0.1697
Echinococcus multilocularis tyrosine kinase 0.0013 0.001 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0009 0.0087
Schistosoma mansoni tyrosine kinase 0.0184 0.0769 0.7122
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.082
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0184 0.0463
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Brugia malayi Muscleblind-like protein 0.0507 0.2201 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0006 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.025 0.232
Schistosoma mansoni adapter molecule crk 0.0016 0.0023 0.0217
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0021 0.0046 0.0423
Echinococcus granulosus tyrosine kinase 0.0013 0.001 0.0047
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.0202 0.0509
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0184 0.4482
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0184 0.4925
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.003 0.0803
Echinococcus granulosus protein kinase c epsilon type 0.002 0.0039 0.0178
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0202 0.0918
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.002 0.0189
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0095 0.0374 1
Schistosoma mansoni tyrosine kinase 0.0021 0.0046 0.0423
Echinococcus multilocularis protein kinase c epsilon type 0.002 0.0039 0.0099
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0163 0.0411
Plasmodium vivax protein kinase Crk2 0.0052 0.0184 0.4482
Schistosoma mansoni tyrosine kinase 0.0021 0.0046 0.0423
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0095 0.0374 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0067 0.025 0.1138
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Loa Loa (eye worm) SRC-1 0.0056 0.0202 0.0918
Schistosoma mansoni atypical protein kinase C 0.0018 0.0032 0.03
Brugia malayi protein kinase C II. 0.002 0.0039 0.0178
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0202 0.0509
Echinococcus granulosus epidermal growth factor receptor 0.0101 0.0399 0.1812
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0184 0.4482
Brugia malayi RhoGAP domain containing protein 0.0015 0.002 0.0093
Brugia malayi Protein kinase domain containing protein 0.0013 0.001 0.0047
Loa Loa (eye worm) hypothetical protein 0.0507 0.2201 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.0167 0.0757
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0184 0.4925
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.003 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0184 0.1704
Brugia malayi Variant SH3 domain containing protein 0.0015 0.002 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0167 0.042
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0262 0.1116 0.2811
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0023 0.0106
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.003 0.0803
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0184 0.4925
Onchocerca volvulus 0.0095 0.0374 1
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0184 0.4482
Brugia malayi SRC-1 0.0056 0.0202 0.0918
Echinococcus granulosus NCK adaptor protein 0.0016 0.0023 0.0106
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0202 0.0509
Echinococcus granulosus tyrosine protein kinase shark 0.0013 0.001 0.0047
Loa Loa (eye worm) hypothetical protein 0.0055 0.0195 0.0888
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0184 0.0463
Echinococcus multilocularis muscleblind protein 0.0507 0.2201 0.5545
Schistosoma mansoni tyrosine kinase 0.0062 0.0225 0.2083
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0184 0.1704
Schistosoma mansoni tyrosine kinase 0.0096 0.0377 0.3489
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0013 0.001 0.0047
Echinococcus granulosus tyrosine protein kinase ABL1 0.0262 0.1116 0.5069
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0184 0.4925
Echinococcus multilocularis epidermal growth factor receptor 0.0101 0.0399 0.1005
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0163 0.0411
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0184 0.0836
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0202 0.0918
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.0023 0.0217
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.001 0.0047
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0016 0.0023 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0039 0.0362
Schistosoma mansoni tyrosine kinase 0.0062 0.0225 0.2083
Plasmodium falciparum protein kinase 5 0.0052 0.0184 0.4482
Echinococcus multilocularis c src tyrosine kinase 0.0021 0.0046 0.0115
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0047
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0015 0.002 0.0051
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0023 0.0106

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.006 uM Inhibitory activity against epidermal growth factor receptor tyrosine kinase. ChEMBL. 9357527
IC50 (binding) = 0.006 uM Inhibitory activity against epidermal growth factor receptor tyrosine kinase. ChEMBL. 9357527
IC50 (binding) = 0.24 uM Inhibitory activity against v-Abl tyrosine kinase ChEMBL. 9357527
IC50 (binding) = 0.24 uM Inhibitory activity against v-Abl tyrosine kinase ChEMBL. 9357527
IC50 (binding) = 0.26 uM Inhibitory activity against CDK1 Ser/Thr kinase ChEMBL. 9357527
IC50 (binding) = 0.26 uM Inhibitory activity against CDK1 Ser/Thr kinase ChEMBL. 9357527
IC50 (functional) = 0.5 uM Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells. ChEMBL. 9357527
IC50 (functional) = 0.5 uM Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells. ChEMBL. 9357527
IC50 (functional) = 0.56 uM Inhibition of proliferation of EGF-dependent BALB/MK cells. ChEMBL. 9357527
IC50 (functional) = 0.56 uM Inhibition of proliferation of EGF-dependent BALB/MK cells. ChEMBL. 9357527
IC50 (binding) = 1.85 uM Inhibitory activity against protein kinase C alpha tyrosine kinase. ChEMBL. 9357527
IC50 (binding) = 1.85 uM Inhibitory activity against protein kinase C alpha tyrosine kinase. ChEMBL. 9357527
IC50 (binding) = 8.55 uM Inhibitory activity against c-Src tyrosine kinase ChEMBL. 9357527
IC50 (binding) = 8.55 uM Inhibitory activity against c-Src tyrosine kinase ChEMBL. 9357527
IC50 (functional) > 10 uM Inhibition of PDGF stimulated tyrosine phosphorylation in BALB/c3t3 cells. ChEMBL. 9357527
IC50 (functional) > 10 uM Inhibition of PDGF stimulated tyrosine phosphorylation in BALB/c3t3 cells. ChEMBL. 9357527

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 9357527

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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