TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 504.712 | Formula: C24H36N6O2S2
H donors: 2 H acceptors: 4 LogP: 5.19 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CN(C(C)C)C(C)C)Nc1sc2c(n1)cc1c(c2)sc(n1)NC(=O)CN(C(C)C)C(C)C
InChi: 1S/C24H36N6O2S2/c1-13(2)29(14(3)4)11-21(31)27-23-25-17-9-18-20(10-19(17)33-23)34-24(26-18)28-22(32)12-30(15(5)6)16(7)8/h9-10,13-16H,11-12H2,1-8H3,(H,25,27,31)(H,26,28,32)
InChiKey: WTAWZPKLNXUAPK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0044	0.0056	0.0896
Trypanosoma cruzi	hypothetical protein, conserved	0.1159	0.3446	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0231	0.0623	0.0611
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0056	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0044	0.0056	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0044	0.0056	0.0044
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0231	0.0623	0.174
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0162
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0056	0.0162
Schistosoma mansoni	hypothetical protein	0.0343	0.0964	0.3097
Echinococcus multilocularis	snurportin 1	0.0343	0.0964	0.0953
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0056	0.0087
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0076	0.0064
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0097	0.0153
Loa Loa (eye worm)	matrix metalloproteinase	0.0739	0.2168	0.3552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0056	0.0896
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0044	0.0056	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0018	0.0101
Echinococcus granulosus	snurportin 1	0.0343	0.0964	0.0953
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0343	0.0964	0.1577
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0044	0.0056	0.0896
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0896
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0231	0.0623	0.0611
Schistosoma mansoni	hypothetical protein	0.1047	0.3107	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0044	0.0056	0.0044
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0056	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.013	0.0317	0.4935
Schistosoma mansoni	hypothetical protein	0.0039	0.0041	0.0122
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0044	0.0056	0.0896
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0044	0.0056	0.0618
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.013	0.0317	0.0515
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0044	0.0056	0.0162
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0056	0.0044
Entamoeba histolytica	hypothetical protein	0.013	0.0317	0.5085
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0044	0.0056	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0362	0.0589
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0231	0.0623	0.0611
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0896
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0056	0.0087
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0044	0.0056	0.017
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0531	0.1535	0.4937
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0231	0.0623	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0086	0.0182	0.0527
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.013	0.0317	0.0919
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0231	0.0623	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0044	0.0056	0.0044
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0278	0.0452
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0044	0.0056	0.0162
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.013	0.0317	0.1011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0056	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0056	0.0087
Brugia malayi	Matrixin family protein	0.0739	0.2168	0.3552
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0044	0.0056	0.0162
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0056	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0231	0.0623	0.1808
Onchocerca volvulus	Matrilysin homolog	0.0739	0.2168	0.3835
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0097	0.0153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.0317	0.0515
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0044	0.0056	0.0044
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0044	0.0056	0.017
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0044	0.0056	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0231	0.0623	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Brugia malayi	Fibulin-1 precursor	0.003	0.0012	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0101	0.0227	0.0215
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0231	0.0623	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0056	0.0087
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0056	0.0896
Onchocerca volvulus		0.0044	0.0056	0.0093
Schistosoma mansoni	hypothetical protein	0.0101	0.0227	0.0721
Loa Loa (eye worm)	matrixin family protein	0.2031	0.6098	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0086	0.0182	0.2916
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0076	0.0119
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0156
Echinococcus multilocularis		0.0044	0.0056	0.0044
Entamoeba histolytica	hypothetical protein	0.0044	0.0056	0.0896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0056	0.0712
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0076	0.0234
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0056	0.0044
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.293	0.8835	0.8833
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0044	0.0056	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0227	0.3643
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Loa Loa (eye worm)	matrixin family protein	0.1638	0.4905	0.8042
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0231	0.0623	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0044	0.0056	0.0156
Mycobacterium ulcerans	hydrolase	0.09	0.2658	0.5
Brugia malayi	FAT domain containing protein	0.0101	0.0227	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0227	0.0367
Toxoplasma gondii	FATC domain-containing protein	0.013	0.0317	0.4986
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.3313	1	1
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	0.0156
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0044	0.0056	0.0896
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.003	0.0012	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0056	0.0896
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0044	0.0056	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0097	0.0153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0739	0.2168	0.3552
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0056	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0018	0.0025
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Loa Loa (eye worm)	AStacin protease	0.0058	0.0098	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0056	0.0087
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0231	0.0623	0.174
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0044	0.0056	0.0896
Brugia malayi	Matrixin family protein	0.0739	0.2168	0.3552
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0231	0.0623	0.1017
Brugia malayi	Importin beta-1 subunit	0.0032	0.0018	0.0025
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0097	0.0153
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.09	0.2658	0.4355
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0056	0.0712
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	0.0162
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.013	0.0317	0.0515
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0056	0.0087
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0278	0.0452
Schistosoma mansoni	hypothetical protein	0.0044	0.0056	0.017
Echinococcus multilocularis	Zinc finger, PHD finger	0.0044	0.0056	0.0044
Brugia malayi	Hemopexin family protein	0.1047	0.3107	0.5093
Leishmania major	hypothetical protein, conserved	0.1203	0.3581	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0044	0.0056	0.0162
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0044	0.0056	0.0087
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.09	0.2658	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0896
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0231	0.0623	0.1808
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0041	0.0062
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0018	0.0006
Brugia malayi	Matrixin family protein	0.0739	0.2168	0.3552
Leishmania major	hypothetical protein, unknown function	0.0044	0.0056	0.0156
Echinococcus multilocularis	Tolloid protein 1	0.0093	0.0205	0.0193
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0231	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0193	0.0312
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0983	0.2912	0.9371
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	0.0896
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0231	0.0623	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0056	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0044	0.0056	0.0044
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0044	0.0056	0.0896
Mycobacterium leprae	PROBABLE HYDROLASE	0.09	0.2658	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0231	0.0623	0.1808
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0056	0.0044
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.013	0.0317	0.0305
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0093	0.0205	0.065
Brugia malayi	Calcium binding EGF domain containing protein	0.003	0.0012	0.0015
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0076	0.0064
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.293	0.8835	0.8833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0044	0.0056	0.0618
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0041	0.0062
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0076	0.0234
Giardia lamblia	GTOR	0.0231	0.0623	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0056	0.0896
Entamoeba histolytica	hypothetical protein	0.0044	0.0056	0.0896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Brugia malayi	RNA, U transporter 1	0.0091	0.0199	0.0321
Onchocerca volvulus		0.1047	0.3107	0.5498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Entamoeba histolytica	hypothetical protein	0.0044	0.0056	0.0896
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	0.0162
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0076	0.0064
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	0.0618
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.013	0.0317	0.0305
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0044	0.0056	0.0162
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0044	0.0056	0.0044
Onchocerca volvulus	Matrix metalloproteinase homolog	0.1638	0.4905	0.8682
Echinococcus multilocularis	serine protein kinase ATM	0.013	0.0317	0.0305
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0044	0.0056	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0056	0.0712
Plasmodium vivax	hypothetical protein	0.0044	0.0056	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0231	0.0623	0.174
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0044	0.0056	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0056	0.0896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0182	0.0293
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Onchocerca volvulus	Matrilysin homolog	0.1883	0.5648	1
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0182	0.2916
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0076	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0085	0.0135
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0056	0.0087
Entamoeba histolytica	hypothetical protein	0.0044	0.0056	0.0896
Loa Loa (eye worm)	hypothetical protein	0.09	0.2658	0.4355
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0056	0.0156
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0076	0.0119
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0231	0.0623	0.1808
Onchocerca volvulus		0.0739	0.2168	0.3835
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0231	0.0623	1
Brugia malayi	Matrixin family protein	0.0739	0.2168	0.3552
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.013	0.0317	0.0919
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0231	0.0623	0.1997
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0145	0.0362	0.5727
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.013	0.0317	0.5085
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0044	0.0056	0.017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0056	0.0618
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0044	0.0056	0.017
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0093	0.0205	0.0331
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0231	0.0623	0.174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0044	0.0056	0.0896
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0231	0.0623	0.0611
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0056	0.0712
Onchocerca volvulus		0.0044	0.0056	0.0093
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0056	0.0162
Brugia malayi	MH2 domain containing protein	0.0118	0.0278	0.0452
Loa Loa (eye worm)	hypothetical protein	0.003	0.0012	0.0015
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0044	0.0056	0.017
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0044	0.0056	0.0896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0018	0.0006
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0044	0.0056	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0145	0.0362	0.5811
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0231	0.0623	0.174
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0044	0.0056	0.0896
Brugia malayi	Matrixin family protein	0.2031	0.6098	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0231	0.0623	0.1808
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0056	0.0087
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0231	0.0623	0.1997
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Echinococcus granulosus	serine protein kinase ATM	0.013	0.0317	0.0305
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0231	0.0623	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0983	0.2912	0.4772
Leishmania major	phosphatidylinositol kinase, putative	0.0044	0.0056	0.0156
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0056	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0739	0.2168	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0056	0.0087
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0056	0.0712
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0044	0.0056	0.0896
Schistosoma mansoni	importin beta-1	0.0032	0.0018	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0044	0.0056	0.017
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0101	0.0227	0.0215
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0076	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.0362	0.5811
Loa Loa (eye worm)	phosphatidylinositol 3	0.0231	0.0623	0.1017
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0145	0.0362	0.5683
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0317	0.5085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0231	0.0623	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0044	0.0056	0.0087
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0056	0.0896
Echinococcus granulosus	Tolloid protein 1	0.0093	0.0205	0.0193
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0896
Entamoeba histolytica	protein kinase rad3, putative	0.013	0.0317	0.5085
Schistosoma mansoni	fkbp-rapamycin associated protein	0.013	0.0317	0.1011
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0044	0.0056	0.0618
Loa Loa (eye worm)	phosphatidylinositol 3	0.0231	0.0623	0.1017

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= -5 %	Antiinflammatory activity in D-adjuvant induced arthiritis in rat measured by the change in body weight	ChEMBL.	1732553
Inhibition (functional)	= 0 %	Antiinflammatory activity against carrageenan induced rat paw edema (CPE), dosed orally	ChEMBL.	1732553
Inhibition (functional)	= 0 %	Antiinflammatory activity against D-adjuvant arthiritis in injected rat paw at the dose of 50 mg/kg by oral administration	ChEMBL.	1732553
Inhibition (functional)	= 0 %	Antiinflammatory activity against D-adjuvant arthiritis in uninjected rat paw at the dose of 50 mg/kg by oral administration	ChEMBL.	1732553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL118879

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 208319