Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | angiotensin II receptor, type 2 | Starlite/ChEMBL | References |
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Angiotensin II type 2 (AT-2) receptor | Starlite/ChEMBL | References |
Oryctolagus cuniculus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | References |
Homo sapiens | angiotensin II receptor, type 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | 0 hr | Duration of action (inhibtion of AII pressor response) following peroral administration at dose 3.0 mg/kg; not determined; Duration ranges from <1 to 6 h | ChEMBL. | 7562905 |
Duration (functional) | > 6 hr | Duration of action (inhibtion of AII pressor response) following intravenous administration at dose 3.0 mg/kg; >6<24 | ChEMBL. | 7562905 |
Duration (functional) | > 6 hr | Duration of action (inhibtion of AII pressor response) following peroral administration at dose 10.0 mg/kg; >6<24 | ChEMBL. | 7562905 |
IC50 (binding) | = 8.823 | Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor | ChEMBL. | No reference |
IC50 (binding) | = 0.18 nM | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 0.18 nM | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 0.48 nM | In vitro inhibitory activity against angiotensin II type 1 receptor in rat adrenal membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 0.48 nM | In vitro inhibitory activity against angiotensin II type 1 receptor in rat adrenal membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 0.93 nM | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 0.93 nM | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 1.5 nM | In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 1.5 nM | In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 1.5 nM | Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor | ChEMBL. | No reference |
IC50 (binding) | = 4.1 nM | In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 4.1 nM | In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 24 nM | In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations. | ChEMBL. | 7562905 |
IC50 (binding) | = 24 nM | In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations. | ChEMBL. | 7562905 |
Inhibition (functional) | = 55 % | In vivo inhibtion of AII pressor response was measured in conscious, normotensive rats after peroral administration at dose 3.0 mg/kg | ChEMBL. | 7562905 |
Inhibition (functional) | = 100 % | In vivo inhibtion of AII pressor response was measured in conscious, normotensive rats after intravenous administration at dose 3.0 mg/kg | ChEMBL. | 7562905 |
Inhibition (functional) | = 100 % | In vivo inhibtion of AII pressor response was measured in conscious, normotensive rats after peroral administration at dose 10.0 mg/kg | ChEMBL. | 7562905 |
Ratio (binding) | = 0.2 | IC50 ratio of human adrenal AT2 receptor to AT1 receptor. | ChEMBL. | 7562905 |
Ratio (binding) | = 0.4 | IC50 ratio 0f AT2 to AT1 receptor (rat adrenal) | ChEMBL. | 7562905 |
Ratio (binding) | = 0.6 | IC50 ratio of AT2 receptor from rabbit aorta to AT1 receptor from rat midbrain. | ChEMBL. | 7562905 |
Ratio (binding) | = 0.2 | IC50 ratio of human adrenal AT2 receptor to AT1 receptor. | ChEMBL. | 7562905 |
Ratio (binding) | = 0.4 | IC50 ratio 0f AT2 to AT1 receptor (rat adrenal) | ChEMBL. | 7562905 |
Ratio (binding) | = 0.6 | IC50 ratio of AT2 receptor from rabbit aorta to AT1 receptor from rat midbrain. | ChEMBL. | 7562905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.