Detailed information for compound 215400

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 605.202 | Formula: C34H49ClO7
  • H donors: 2 H acceptors: 3 LogP: 4.57 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@@H]([C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@H](O2)C/C=C(\C)/[C@H](Cl)[C@@H](C)/C=C/C=C\2/[C@]3([C@H](C(=O)O1)C=C(C)[C@H]([C@H]3OC2)O)O)C
  • InChi: 1S/C34H49ClO7/c1-7-19(2)30-22(5)13-14-33(42-30)17-26-16-25(41-33)12-11-21(4)28(35)20(3)9-8-10-24-18-39-31-29(36)23(6)15-27(32(37)40-26)34(24,31)38/h8-11,15,19-20,22,25-31,36,38H,7,12-14,16-18H2,1-6H3/b9-8+,21-11+,24-10+/t19-,20-,22-,25+,26-,27-,28+,29+,30+,31+,33+,34+/m0/s1
  • InChiKey: YNMLUPLDAJOVTM-UPBRIKLCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus carbonic anhydrase 0.0029 0.0351 0.0848
Schistosoma mansoni amine GPCR 0.0169 0.2682 0.314
Echinococcus granulosus neuropeptide receptor A26 0.0169 0.2682 0.6476
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0021 0.0051
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Toxoplasma gondii hypothetical protein 0.0044 0.0594 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.001 0.0029 0.007
Echinococcus granulosus phd:f box containing protein 0.0009 0.0021 0.0051
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0044 0.0594 0.1435
Mycobacterium ulcerans DNA polymerase IV 0.001 0.0029 0.0094
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0169 0.2682 0.314
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0169 0.2682 0.6476
Echinococcus granulosus biogenic amine 5HT receptor 0.0169 0.2682 0.6476
Echinococcus granulosus neuropeptide receptor 0.0169 0.2682 0.6476
Brugia malayi G-protein coupled receptor 0.0169 0.2682 0.6476
Schistosoma mansoni lamin 0.0016 0.0131 0.0153
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.001 0.0029 0.0234
Schistosoma mansoni opsin-like receptor 0.0169 0.2682 0.314
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0048 0.0676 0.1633
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0351 0.0411
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0048 0.0676 0.0792
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0594 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Onchocerca volvulus Neuropeptide F receptor homolog 0.0169 0.2682 0.6361
Loa Loa (eye worm) RNA binding protein 0.0032 0.0395 0.0395
Mycobacterium ulcerans aldehyde dehydrogenase 0.0035 0.0459 1
Schistosoma mansoni chromobox protein 0.0039 0.0521 0.061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0035 0.0459 0.1107
Brugia malayi jmjC domain containing protein 0.0034 0.044 0.1063
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus g protein coupled receptor 0.0169 0.2682 0.6476
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0029 0.0146
Brugia malayi jmjC domain containing protein 0.0009 0.0021 0.0051
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0016 0.0039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0468 0.1129
Loa Loa (eye worm) hypothetical protein 0.0044 0.0594 0.0594
Echinococcus granulosus chromobox protein 1 0.0039 0.0521 0.1257
Brugia malayi neuropeptide F receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis dna polymerase kappa 0.001 0.0029 0.007
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus peptide allatostatin:somatostatin 0.0169 0.2682 0.6476
Echinococcus multilocularis musashi 0.0016 0.0131 0.0316
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0594 1
Trypanosoma brucei DNA polymerase eta, putative 0.001 0.0029 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.001 0.0029 0.0146
Toxoplasma gondii aldehyde dehydrogenase 0.0035 0.0459 0.7719
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0016 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0521 0.9195
Schistosoma mansoni neuropeptide receptor 0.0169 0.2682 0.314
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.044 0.0515
Echinococcus multilocularis neuropeptide s receptor 0.0169 0.2682 0.6476
Brugia malayi Dopamine receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0169 0.2682 0.6476
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0044 0.0594 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0085 0.0204
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0169 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0039 0.0515 0.0515
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0014 0.0096 0.1637
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0468 0.0468
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0016 0.0016
Brugia malayi G protein-coupled receptor F59B2.13 0.0169 0.2682 0.6476
Loa Loa (eye worm) G-protein coupled receptor 0.0169 0.2682 0.2682
Trichomonas vaginalis ap endonuclease, putative 0.0009 0.0025 0.016
Onchocerca volvulus 0.0169 0.2682 0.6361
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Echinococcus granulosus GPCR family 2 0.0036 0.0468 0.1129
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0127 0.2029
Schistosoma mansoni biogenic amine receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0257 0.4142 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni neuropeptide receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0029 0.0351 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0044 0.0594 0.1435
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0169 0.2682 0.6476
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0169 0.2682 0.6476
Brugia malayi G protein-coupled receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0169 0.2682 0.6476
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0009 0.0025 0.006
Schistosoma mansoni ap endonuclease 0.0009 0.0025 0.0029
Echinococcus multilocularis carbonic anhydrase II 0.0127 0.1986 0.4794
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0169 0.2682 0.6476
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127 0.1986 0.4794
Entamoeba histolytica hypothetical protein 0.0014 0.0096 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0016 0.0019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0009 0.0025 0.042
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0044 0.0594 0.0594
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0029 0.0634
Schistosoma mansoni neuropeptide F-like receptor 0.0169 0.2682 0.314
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0395 0.0462
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Brugia malayi Heterochromatin protein 1 0.0039 0.0521 0.1257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus multilocularis geminin 0.0163 0.2584 0.6238
Schistosoma mansoni alpha-1 adrenergic receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0008 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni opsin-like receptor 0.0169 0.2682 0.314
Brugia malayi GnHR receptor homolog 0.0169 0.2682 0.6476
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0022 0.0234 0.0258
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0044 0.0594 0.1435
Echinococcus multilocularis tar DNA binding protein 0.0032 0.0395 0.0953
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0169 0.2682 0.6476
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0594 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0351 0.0351
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0016 0.0019
Schistosoma mansoni hypothetical protein 0.0169 0.2682 0.314
Giardia lamblia DINP protein human, muc B family 0.001 0.0029 1
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0169 0.2682 0.6476
Onchocerca volvulus 0.0169 0.2682 0.6361
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0016 0.0039
Onchocerca volvulus 0.0169 0.2682 0.6361
Onchocerca volvulus 0.0169 0.2682 0.6361
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0021 0.0025
Brugia malayi MH2 domain containing protein 0.0108 0.1667 0.4025
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0547
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0126
Schistosoma mansoni ap endonuclease 0.0009 0.0025 0.0029
Schistosoma mansoni hypothetical protein 0.0029 0.0351 0.0411
Schistosoma mansoni hypothetical protein 0.0163 0.2584 0.3025
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Onchocerca volvulus 0.0257 0.4142 1
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0351 0.0411
Loa Loa (eye worm) hypothetical protein 0.0044 0.0594 0.0594
Brugia malayi chromobox protein homolog 3 0.0022 0.0234 0.0565
Brugia malayi larval opioid receptor 0.0169 0.2682 0.6476
Onchocerca volvulus 0.0017 0.0155 0.0061
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0016 0.0039
Loa Loa (eye worm) melatonin receptor type 1A 0.0169 0.2682 0.2682
Schistosoma mansoni hypothetical protein 0.0169 0.2682 0.314
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0044 0.0594 0.1435
Echinococcus multilocularis chromobox protein 1 0.0039 0.0521 0.1257
Echinococcus granulosus serotonin transporter 0.0257 0.4142 1
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0468 0.1129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0249 0.0291
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0014 0.0096 0.1615
Echinococcus granulosus hypothetical protein 0.0169 0.2682 0.6476
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0169 0.2682 0.2682
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0044 0.0594 0.1435
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Onchocerca volvulus 0.0044 0.0594 0.1155
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Brugia malayi Dopamine receptor protein 2 0.0169 0.2682 0.6476
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Echinococcus multilocularis neuropeptides capa receptor 0.0169 0.2682 0.6476
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0016 0.0039
Echinococcus granulosus tachykinin peptides receptor 99D 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.001 0.0029 0.0146
Schistosoma mansoni neuropeptide F-like receptor 0.0169 0.2682 0.314
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Schistosoma mansoni hypothetical protein 0.0169 0.2682 0.314
Echinococcus granulosus neuropeptide s receptor 0.0169 0.2682 0.6476
Plasmodium falciparum amino acid transporter, putative 0.0044 0.0594 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus tm gpcr rhodopsin 0.0169 0.2682 0.6476
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0608 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0351 0.0411
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Echinococcus multilocularis allatostatin A receptor 0.0169 0.2682 0.6476
Brugia malayi Serotonin receptor 0.0169 0.2682 0.6476
Schistosoma mansoni carbonic anhydrase 0.0029 0.0351 0.0411
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0085 0.0204
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0594 0.1435
Treponema pallidum sodium- and chloride- dependent transporter 0.0257 0.4142 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0594 0.0594
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0169 0.2682 0.314
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0351 0.0848
Schistosoma mansoni hypothetical protein 0.0078 0.1163 0.1361
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0395 0.0462
Echinococcus granulosus neuropeptide Y receptor 0.0169 0.2682 0.6476
Brugia malayi jmjC domain containing protein 0.0034 0.044 0.1063
Onchocerca volvulus 0.0169 0.2682 0.6361
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0029
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0257 0.4142 0.4849
Echinococcus multilocularis serotonin receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) serotonin transporter b 0.0257 0.4142 0.4142
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0085 0.0204
Echinococcus granulosus neuropeptides capa receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0044 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.044 0.0515
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0614 0.1482
Echinococcus granulosus g-protein coupled receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0023 0.0249 0.0249
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0351 0.0848
Loa Loa (eye worm) hypothetical protein 0.0029 0.0351 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0547
Echinococcus multilocularis GPCR, family 2 0.0036 0.0468 0.1129
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0016 0.0039
Echinococcus granulosus fmrfamide receptor 0.0169 0.2682 0.6476
Brugia malayi ImpB/MucB/SamB family protein 0.001 0.0029 0.007
Loa Loa (eye worm) hypothetical protein 0.0257 0.4142 0.4142
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni sodium/chloride dependent transporter 0.0044 0.0594 0.0696
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.1762 0.4253
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0594 0.0696
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0468 0.1129
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.001 0.0029 0.007
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Onchocerca volvulus 0.0169 0.2682 0.6361
Loa Loa (eye worm) TYRA-2 protein 0.0169 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0257 0.4142 0.4142
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0034 0.044 0.1063
Echinococcus granulosus lamin dm0 0.0016 0.0131 0.0316
Onchocerca volvulus 0.0169 0.2682 0.6361
Schistosoma mansoni sodium/chloride dependent transporter 0.0044 0.0594 0.0696
Loa Loa (eye worm) hypothetical protein 0.0029 0.0351 0.0351
Echinococcus granulosus sodium and chloride dependent glycine 0.0044 0.0594 0.1435
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0021 0.0106
Echinococcus granulosus chromobox protein 1 0.0039 0.0521 0.1257
Toxoplasma gondii hypothetical protein 0.0044 0.0594 1
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.1163 0.2807
Brugia malayi jmjC domain containing protein 0.0009 0.0021 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0351 0.0848
Schistosoma mansoni hypothetical protein 0.0169 0.2682 0.314
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0014 0.0096 0.1637
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0009 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0127 0.2029
Leishmania major DNA polymerase eta, putative 0.001 0.0029 0.0146
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0169 0.2682 0.314
Plasmodium vivax JmjC domain containing protein 0.0009 0.0021 0.0356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0023 0.0249 0.06
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0169 0.2682 0.6476
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0351 0.0848
Leishmania major hypothetical protein, conserved 0.0009 0.0021 0.0106
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0351 0.0848
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0468 0.1129
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0035 0.0459 1
Brugia malayi putative neuropeptide receptor NPR1 0.0169 0.2682 0.6476
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0169 0.2682 0.6476
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0234 0.3973
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0029 0.0146
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0009 0.0025 0.006
Echinococcus multilocularis serotonin transporter 0.0257 0.4142 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0009 0.0021 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0009 0.0025 0.0126
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus multilocularis neuropeptide FF receptor 2 0.0169 0.2682 0.6476
Echinococcus multilocularis sodium and chloride dependent glycine 0.0044 0.0594 0.1435
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Loa Loa (eye worm) MH2 domain-containing protein 0.0108 0.1667 0.1667
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0127 0.1986 0.4794
Loa Loa (eye worm) hypothetical protein 0.0044 0.0594 0.0594
Onchocerca volvulus 0.0169 0.2682 0.6361
Echinococcus granulosus biogenic amine 5HT receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis L aminoadipate semialdehyde 0.0048 0.0676 0.1633
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0021 0.0025
Echinococcus granulosus sex peptide receptor 0.0169 0.2682 0.6476
Onchocerca volvulus 0.0169 0.2682 0.6361
Schistosoma mansoni intermediate filament proteins 0.0016 0.0131 0.0153
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0351 0.0848
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.044 0.1063
Loa Loa (eye worm) transcription factor SMAD2 0.0108 0.1667 0.1667
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0169 0.2682 0.314
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0029 0.0146
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0016 0.0039
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0169 0.2682 0.6476
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0127 0.1986 1
Plasmodium falciparum carbonic anhydrase 0.0029 0.0351 0.5914
Schistosoma mansoni DNA polymerase eta 0.001 0.0029 0.0034
Echinococcus granulosus intermediate filament protein 0.0016 0.0131 0.0316
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.001 0.0029 0.0634
Leishmania major DNA polymerase kappa, putative 0.001 0.0029 0.0146
Brugia malayi Melatonin receptor type 1A 0.0169 0.2682 0.6476
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0023 0.0249 0.06
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0565 1
Echinococcus multilocularis G protein coupled receptor 139 0.0169 0.2682 0.6476
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0023 0.0249 0.06
Trichomonas vaginalis ap endonuclease, putative 0.0009 0.0025 0.016
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0169 0.2682 0.6361
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0262 0.4479
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0016 0.0039
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0547
Echinococcus granulosus 7TM GPCR rhodopsin 0.0169 0.2682 0.6476
Echinococcus granulosus carbonic anhydrase II 0.0127 0.1986 0.4794
Loa Loa (eye worm) hypothetical protein 0.0013 0.0085 0.0085
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0034 0.044 0.1063
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0682 0.0799
Echinococcus multilocularis fmrfamide receptor 0.0169 0.2682 0.6476
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0169 0.2682 0.6476
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Echinococcus granulosus alpha 1A adrenergic receptor 0.0169 0.2682 0.6476
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0009 0.0021 0.0051
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0014 0.0096 0.2092
Onchocerca volvulus 0.0169 0.2682 0.6361
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0614 0.0614
Schistosoma mansoni biogenic amine (5HT) receptor 0.0169 0.2682 0.314
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis neuropeptide receptor A26 0.0169 0.2682 0.6476
Schistosoma mansoni opsin-like receptor 0.0169 0.2682 0.314
Echinococcus granulosus tm gpcr rhodopsin 0.0169 0.2682 0.6476
Echinococcus multilocularis lamin dm0 0.0016 0.0131 0.0316
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0014 0.0096 1
Leishmania major carbonic anhydrase-like protein 0.0127 0.1986 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.1762 0.4253
Entamoeba histolytica deoxycytidyl transferase, putative 0.001 0.0029 0.0576
Toxoplasma gondii hypothetical protein 0.0029 0.0351 0.5914
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0594 0.1435
Trichomonas vaginalis DNA polymerase eta, putative 0.001 0.0029 0.0234
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0044 0.0594 0.0696
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0016 0.0019
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0127 0.1986 1
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0021 0.0051
Echinococcus multilocularis sex peptide receptor 0.0169 0.2682 0.6476
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0021 0.0051
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Brugia malayi jmjC domain containing protein 0.0009 0.0021 0.0051
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0021 0.0021
Brugia malayi jmjC domain containing protein 0.0009 0.0021 0.0051
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0009 0.0025 0.0126
Brugia malayi Intermediate filament tail domain containing protein 0.0016 0.0131 0.0316
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0044 0.0594 0.1435
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0021 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0169 0.2682 0.314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0009 0.0025 0.0126
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0169 0.2682 0.314
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0021 0.0025
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0009 0.0021 0.0106
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0565 1
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0021 0.0051
Schistosoma mansoni biogenic amine (5HT) receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus dna polymerase kappa 0.001 0.0029 0.007
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0009 0.0021 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Trypanosoma brucei carbonic anhydrase-like protein 0.0127 0.1986 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0044 0.0594 0.1435
Plasmodium falciparum transporter, putative 0.0044 0.0594 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0169 0.2682 0.6476
Brugia malayi intermediate filament protein 0.0016 0.0131 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.0035 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0016 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0395 0.0462
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0016 0.0019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.001 0.0029 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0169 0.2682 0.2682
Loa Loa (eye worm) solute carrier family 6 member 4 0.0257 0.4142 0.4142
Schistosoma mansoni neuropeptide f receptor 76f 0.0169 0.2682 0.314
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0014 0.0096 0.0172
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0614 0.1482
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0085 0.0099
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Toxoplasma gondii exonuclease III APE 0.0009 0.0025 0.042
Onchocerca volvulus 0.0169 0.2682 0.6361
Schistosoma mansoni amine GPCR 0.0521 0.8542 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0009 0.0025 0.0126
Echinococcus granulosus carbonic anhydrase 0.0029 0.0351 0.0848
Brugia malayi ImpB/MucB/SamB family protein 0.001 0.0029 0.007
Echinococcus granulosus orexin receptor type 2 0.0169 0.2682 0.6476
Brugia malayi G-protein coupled receptor 0.0169 0.2682 0.6476
Brugia malayi TAR-binding protein 0.0032 0.0395 0.0953
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0249 0.0291
Schistosoma mansoni terminal deoxycytidyl transferase 0.001 0.0029 0.0034
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0009 0.0021 0.0051
Echinococcus granulosus geminin 0.0163 0.2584 0.6238
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Echinococcus multilocularis serotonin receptor 0.0169 0.2682 0.6476
Mycobacterium ulcerans DNA polymerase IV 0.001 0.0029 0.0094
Schistosoma mansoni histamine h1 receptor 0.0169 0.2682 0.314
Schistosoma mansoni jumonji domain containing protein 0.0034 0.044 0.0515
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0594 0.0696
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0169 0.2682 0.2682
Brugia malayi RNA recognition motif domain containing protein 0.0032 0.0395 0.0953
Echinococcus granulosus 7tm_1 domain containing protein 0.0169 0.2682 0.6476
Echinococcus multilocularis dro:myosuppressin receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0169 0.2682 0.6476
Brugia malayi hypothetical protein 0.0044 0.0594 0.1435
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0594 0.0696
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0085 0.0099
Echinococcus multilocularis neuropeptide Y receptor 0.0169 0.2682 0.6476
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0023 0.0249 0.06
Schistosoma mansoni neuropeptide receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni sodium-dependent amino acid transporter 0.0044 0.0594 0.0696
Onchocerca volvulus 0.0169 0.2682 0.6361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.044 0.1063
Loa Loa (eye worm) hypothetical protein 0.0044 0.0594 0.0594
Schistosoma mansoni aldehyde dehydrogenase 0.0035 0.0459 0.0537
Onchocerca volvulus 0.0169 0.2682 0.6361
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0169 0.2682 0.314
Onchocerca volvulus 0.0048 0.0676 0.136
Schistosoma mansoni amine GPCR 0.0169 0.2682 0.314
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0032 0.0395 0.0395
Trypanosoma brucei DNA polymerase IV, putative 0.001 0.0029 0.0146
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0521 0.9195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Loa Loa (eye worm) G-protein coupled receptor 0.0169 0.2682 0.2682
Onchocerca volvulus 0.0044 0.0594 0.1155
Echinococcus granulosus carbonic anhydrase 0.0029 0.0351 0.0848
Loa Loa (eye worm) hypothetical protein 0.0078 0.1163 0.1163
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni biogenic amine receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0169 0.2682 0.6476
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0024 0.0262 0.0327
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0169 0.2682 0.2682
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0014 0.0096 0.1615
Mycobacterium ulcerans aldehyde dehydrogenase 0.0035 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus multilocularis neuropeptides capa receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0044 0.0594 0.1435
Leishmania major phosphopantetheinyl transferase-like protein 0.0014 0.0096 0.0483
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Onchocerca volvulus 0.0044 0.0594 0.1155
Schistosoma mansoni amine GPCR 0.0169 0.2682 0.314
Schistosoma mansoni myosin xvIII 0.0169 0.2682 0.314
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0021 0.0106
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0021 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Echinococcus granulosus neuropeptide Y receptor 0.0169 0.2682 0.6476
Brugia malayi exodeoxyribonuclease III family protein 0.0009 0.0025 0.006
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0262 0.4479
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0395 0.0462
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0468 0.1129
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0021 0.0051
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0351 0.0848
Schistosoma mansoni hypothetical protein 0.0036 0.0468 0.0547
Brugia malayi Dopamine receptor protein 1 0.0169 0.2682 0.6476
Echinococcus granulosus G protein coupled receptor 139 0.0169 0.2682 0.6476
Schistosoma mansoni neuropeptide receptor 0.0169 0.2682 0.314
Schistosoma mansoni hypothetical protein 0.0163 0.2584 0.3025
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0029 0.0146
Schistosoma mansoni adenoreceptor 0.0169 0.2682 0.314
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Schistosoma mansoni aldehyde dehydrogenase 0.0035 0.0459 0.0537
Echinococcus granulosus L aminoadipate semialdehyde 0.0048 0.0676 0.1633
Brugia malayi sulfakinin receptor protein 0.0169 0.2682 0.6476
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0016 0.0019
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0085 0.0204
Echinococcus multilocularis g protein coupled receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0044 0.0594 0.0594
Echinococcus granulosus dro:myosuppressin receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0131 0.0131
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0021 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0169 0.2682 0.314
Echinococcus multilocularis neuropeptide receptor 0.0169 0.2682 0.6476
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0127 0.1986 0.2325
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0614 0.1482
Loa Loa (eye worm) norepinephrine transporter 0.0257 0.4142 0.4142
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0009 0.0025 0.0545
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0035 0.0459 0.1107
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0594 0.0696
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0009 0.0025 0.042
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0085 0.0204
Plasmodium vivax amine transporter, putative 0.0044 0.0594 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.1762 0.1762
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0594 0.0696
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0594 0.0696
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0127 0.1986 0.2325
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0594 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0014 0.0096 0.1615
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) carbonic anhydrase 3 0.0127 0.1986 0.1986
Onchocerca volvulus 0.0169 0.2682 0.6361
Brugia malayi putative neuropeptide receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus neuropeptides capa receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Loa Loa (eye worm) neuropeptide F receptor 0.0169 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0044 0.0594 0.0594
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0009 0.0021 0.0356
Echinococcus multilocularis chromobox protein 1 0.0039 0.0521 0.1257
Echinococcus multilocularis dna polymerase eta 0.001 0.0029 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0234 0.3973
Brugia malayi RNA binding protein 0.0032 0.0395 0.0953
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0169 0.2682 0.314
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0682 0.0799
Echinococcus granulosus neuropeptide receptor 0.0169 0.2682 0.6476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Echinococcus multilocularis sodium and chloride dependent glycine 0.0044 0.0594 0.1435
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0044 0.0594 0.1435
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus multilocularis G-protein coupled receptor, putative 0.0169 0.2682 0.6476
Brugia malayi neuropeptide F receptor 0.0169 0.2682 0.6476
Echinococcus granulosus tm gpcr rhodopsin 0.0169 0.2682 0.6476
Loa Loa (eye worm) intermediate filament protein 0.0016 0.0131 0.0131
Echinococcus multilocularis orexin receptor type 2 0.0169 0.2682 0.6476
Echinococcus granulosus g protein coupled receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis fmrfamide receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis neuropeptide receptor 0.0169 0.2682 0.6476
Schistosoma mansoni chromobox protein 0.0039 0.0521 0.061
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0016 0.0039
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0035 0.0459 0.231
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.001 0.0029 0.0029
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0169 0.2682 0.6476
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0127 0.1986 0.1986
Echinococcus granulosus allatostatin A receptor 0.0169 0.2682 0.6476
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0594 0.1435
Onchocerca volvulus 0.0169 0.2682 0.6361
Echinococcus granulosus rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Echinococcus granulosus lamin 0.0016 0.0131 0.0316
Brugia malayi cytoplasmic intermediate filament protein 0.0008 0.0009 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0395 0.0462
Onchocerca volvulus 0.0169 0.2682 0.6361
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0016 0.0131 0.0131
Mycobacterium leprae conserved hypothetical protein 0.0014 0.0096 0.5
Echinococcus granulosus dna polymerase eta 0.001 0.0029 0.007
Echinococcus granulosus somatostatin receptor 0.0169 0.2682 0.6476
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0021 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0249 0.0291
Brugia malayi AKH receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0169 0.2682 0.6476
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0023 0.0249 0.06
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Onchocerca volvulus 0.0169 0.2682 0.6361
Schistosoma mansoni lamin 0.0016 0.0131 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0169 0.2682 0.6476
Echinococcus granulosus tar DNA binding protein 0.0032 0.0395 0.0953
Loa Loa (eye worm) hypothetical protein 0.0048 0.0676 0.0676
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0468 0.1129
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0169 0.2682 0.2682
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0016 0.0039
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0021 0.0051
Brugia malayi Serotonin receptor 0.0169 0.2682 0.6476
Schistosoma mansoni growth hormone secretagogue receptor 0.0169 0.2682 0.314
Loa Loa (eye worm) TAR-binding protein 0.0032 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0155 0.0155
Trypanosoma brucei unspecified product 0.001 0.0029 0.0146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0169 0.2682 0.6476
Echinococcus multilocularis g-protein coupled receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) hypothetical protein 0.0114 0.1762 0.1762
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0044 0.0594 0.0696
Brugia malayi ORL1-like opioid receptor 0.0169 0.2682 0.6476
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0016 0.0039
Echinococcus multilocularis somatostatin receptor 0.0169 0.2682 0.6476
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0169 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0257 0.4142 0.4142
Echinococcus granulosus g protein coupled receptor 0.0169 0.2682 0.6476
Brugia malayi RE15519p 0.0169 0.2682 0.6476
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Brugia malayi follicle stimulating hormone receptor 0.0169 0.2682 0.6476
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0169 0.2682 0.314
Echinococcus multilocularis neuropeptide Y receptor 0.0169 0.2682 0.6476
Brugia malayi Tachykinin-like peptides receptor 99D 0.0169 0.2682 0.6476
Trypanosoma brucei DNA polymerase IV, putative 0.001 0.0029 0.0146
Echinococcus multilocularis lamin 0.0016 0.0131 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0169 0.2682 0.6476
Loa Loa (eye worm) heterochromatin protein 1 0.0039 0.0521 0.0521
Schistosoma mansoni biogenic amine receptor 0.0169 0.2682 0.314
Brugia malayi hypothetical protein 0.0169 0.2682 0.6476
Trypanosoma cruzi DNA polymerase eta, putative 0.001 0.0029 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0029 0.0146
Echinococcus granulosus serotonin receptor 0.0169 0.2682 0.6476
Schistosoma mansoni sodium/chloride dependent transporter 0.0257 0.4142 0.4849
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0169 0.2682 0.6476
Echinococcus multilocularis rhodopsin orphan GPCR 0.0169 0.2682 0.6476
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0351 0.0848
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0014 0.0096 0.1615
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0169 0.2682 0.314
Echinococcus multilocularis g protein coupled receptor 0.0169 0.2682 0.6476
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0468 0.0468
Schistosoma mansoni amine GPCR 0.0169 0.2682 0.314
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0096 0.0483

Activities

Activity type Activity value Assay description Source Reference
ED90 (functional) = 0.1 mg kg-1 Antiparasitic activity against Trichostrongylus colubriformis ChEMBL. 2913297
ED90 (functional) = 0.25 p.p.m. Antiparasitic activity against Tetranychus urticae ChEMBL. 2913297
ED90 (functional) = 0.5 p.p.m. Antiparasitic activity against Southern army worm ChEMBL. 2913297
Ki (binding) = 1 nM Displacement of ivermectin from avermectin receptor of C. elegans ChEMBL. 2913297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.