TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.089 | Formula: C21H14O4
H donors: 0 H acceptors: 2 LogP: 4.26 Rotable bonds: 4
Rule of 5 violations (Lipinski): 0
SMILES: O=c1cc(OCC(=O)c2ccc3c(c2)cccc3)c2c(o1)cccc2
InChi: InChI=1S/C21H14O4/c22-18(16-10-9-14-5-1-2-6-15(14)11-16)13-24-20-12-21(23)25-19-8-4-3-7-17(19)20/h1-12H,13H2
InChiKey: VLBPQSZKFVICAD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1161	0.7503	0.79
Onchocerca volvulus		0.0094	0.0342	1
Brugia malayi	FAT domain containing protein	0.0213	0.1142	0.1202
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0871	0.5559	0.5698
Brugia malayi	hypothetical protein	0.0213	0.1142	0.1202
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0094	0.0342	0.036
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0342	0.036
Loa Loa (eye worm)	hypothetical protein	0.0182	0.093	0.0979
Schistosoma mansoni	survival motor neuron protein	0.0043	0.0002	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0787	0.4995	0.5082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0863	0.5501	0.5634
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0094	0.0342	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0072	0.0197	0.5366
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0342	0.036
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1458	0.9498	1
Echinococcus granulosus	peptidase Clp S14 family	0.0048	0.003	0.0031
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0094	0.0342	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1084	0.699	0.7261
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0094	0.0342	0.0213
Mycobacterium leprae	conserved hypothetical protein	0.0094	0.0342	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0091	0.0096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0787	0.4995	0.5082
Loa Loa (eye worm)	hypothetical protein	0.0276	0.1562	0.1644
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0091	0.0096
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.116	0.7495	0.7813
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0094	0.0342	0.036
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0094	0.0342	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0276	0.1562	0.1644
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0094	0.0342	0.036
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0094	0.0342	0.036
Echinococcus granulosus	serine protein kinase ATM	0.0276	0.1562	0.1644
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0489	0.2993	0.3151
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0213	0.1142	0.1142
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0489	0.2993	0.3151
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0094	0.0342	0.036
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0342	0.036
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0276	0.1562	0.1332
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0072	0.0197	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0489	0.2993	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.116	0.7495	0.7813
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0276	0.1562	0.1332
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0094	0.0342	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0489	0.2993	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1458	0.9498	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1458	0.9498	1
Entamoeba histolytica	hypothetical protein	0.0276	0.1562	0.1332
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0489	0.2993	0.2895
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0489	0.2993	0.2993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0871	0.5559	0.5698
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0489	0.2993	0.3151
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1458	0.9498	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0048	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0307	0.1773	0.1867
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0094	0.0342	0.036
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0342	0.036
Echinococcus multilocularis		0.0094	0.0342	0.0342
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0342	0.036
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1458	0.9498	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0276	0.1562	0.1644
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1458	0.9498	0.9498
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0094	0.0342	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0489	0.2993	0.2895
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0094	0.0342	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0489	0.2993	0.3151
Schistosoma mansoni	hypothetical protein	0.0043	0.0002	0.0003
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0213	0.1142	0.1202
Trichomonas vaginalis	conserved hypothetical protein	0.0307	0.1773	0.1563
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0182	0.093	0.0979
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0978	0.6276	0.6481
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0094	0.0342	0.036
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0094	0.0342	0.036
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0091	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0871	0.5559	0.5698
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0489	0.2993	0.2895
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.0091	0.0096
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1161	0.7503	0.79
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0276	0.1562	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0787	0.4995	0.5082
Leishmania major	hypothetical protein, unknown function	0.0094	0.0342	0.036
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0094	0.0342	0.036
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0072	0.0197	0.5
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0276	0.1562	0.1562
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0489	0.2993	0.3151
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1458	0.9498	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0094	0.0342	0.036
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0094	0.0342	0.036
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0094	0.0342	0.0213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0863	0.5501	0.5634
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1084	0.699	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0182	0.093	0.0642
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0276	0.1562	0.1644
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0276	0.1562	0.1644
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0094	0.0342	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0094	0.0342	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0094	0.0342	0.0342
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0094	0.0342	0.036
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0094	0.0342	0.0342
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.116	0.7495	0.7813
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0786	0.4987	0.5074
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0094	0.0342	0.036
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0094	0.0342	0.036
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0072	0.0197	0.5
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1458	0.9498	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0342	0.036
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0489	0.2993	0.3151
Loa Loa (eye worm)	phosphatidylinositol 3	0.1458	0.9498	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0094	0.0342	0.0213
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0072	0.0197	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0787	0.4995	0.5082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.116	0.7495	0.7813
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0072	0.0197	0.0197
Echinococcus multilocularis	survival motor neuron protein 1	0.0213	0.1142	0.1142
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0094	0.0342	0.036
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0094	0.0342	0.0213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0786	0.4987	0.5074
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1458	0.9498	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0489	0.2993	0.3151
Toxoplasma gondii	FATC domain-containing protein	0.0276	0.1562	0.2009
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0072	0.0197	0.5
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0276	0.1562	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0197	0.0208
Loa Loa (eye worm)	phosphatidylinositol 3	0.0489	0.2993	0.3151
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0072	0.0197	0.0208
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0094	0.0342	0.0213
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.093	0.0642
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1084	0.699	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0276	0.1562	0.1644
Leishmania major	phosphatidylinositol kinase, putative	0.0094	0.0342	0.036
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0342	0.036
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0091	0.0096
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0094	0.0342	0.0342
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0094	0.0342	0.036
Echinococcus multilocularis	serine protein kinase ATM	0.0276	0.1562	0.1562
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0094	0.0342	0.036
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0342	0.036
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0094	0.0342	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1458	0.9498	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0489	0.2993	0.3151
Loa Loa (eye worm)	hypothetical protein	0.0213	0.1142	0.1202
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0094	0.0342	0.036
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1458	0.9498	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0094	0.0342	0.036
Plasmodium vivax	hypothetical protein, conserved	0.0094	0.0342	1
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0094	0.0342	0.036
Schistosoma mansoni	hypothetical protein	0.0213	0.1142	0.1202
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0489	0.2993	0.3151
Loa Loa (eye worm)	hypothetical protein	0.0297	0.1705	0.1795
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0342	0.036
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0689	0.4339	0.4569
Schistosoma mansoni	hypothetical protein	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0391	0.2337	0.2178
Trypanosoma cruzi	target of rapamycin kinase 3	0.1161	0.7503	0.79
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1458	0.9498	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0043	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0342	0.036
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0342	0.036
Entamoeba histolytica	protein kinase rad3, putative	0.0276	0.1562	0.1332
Brugia malayi	jmjC domain containing protein	0.0057	0.0091	0.0096
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0094	0.0342	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.1142	0.1202
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0606	0.3776	0.3975
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.116	0.7495	0.7813
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0276	0.1562	0.1332
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0342	0.036
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0094	0.0342	0.036
Giardia lamblia	GTOR	0.1458	0.9498	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0072	0.0197	0.0208
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0094	0.0342	0.036
Leishmania major	hypothetical protein, conserved	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1084	0.699	0.7261
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0094	0.0342	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0786	0.4987	0.5074
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0091	0.0096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0946	0.6064	0.625
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1084	0.699	0.7261
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0094	0.0342	0.036
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0276	0.1562	0.1644
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1084	0.699	0.7261
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0091	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1084	0.699	0.7261
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0072	0.0197	0.5
Echinococcus granulosus	survival motor neuron protein 1	0.0213	0.1142	0.1202
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1245	0.8067	0.8437
Brugia malayi	jmjC domain containing protein	0.0057	0.0091	0.0096
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0091	0.0096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1084	0.699	0.7261
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1458	0.9498	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1458	0.9498	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0094	0.0342	0.0342
Echinococcus multilocularis	Zinc finger, PHD finger	0.0094	0.0342	0.0342
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0094	0.0342	0.036
Plasmodium vivax	hypothetical protein	0.0094	0.0342	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0276	0.1562	0.1644
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0094	0.0342	0.036
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0094	0.0342	0.036
Onchocerca volvulus		0.0094	0.0342	1
Trichomonas vaginalis	conserved hypothetical protein	0.0213	0.1142	0.0873
Brugia malayi	Probable ClpP-like protease	0.0072	0.0197	0.0208
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1458	0.9498	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0307	0.1773	0.232

Activities

Activity type	Activity value	Assay description	Source	Reference
FC (binding)	= 1.52	Activation of Nrf2 in human HSC3-ARE9 cells assessed as increase of ARE-mediated luciferase expression at 50 uM after 24 hrs relative to control	ChEMBL.	26519930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3741449

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2197563