TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 461.447 | Formula: C27H16FN5O2
H donors: 0 H acceptors: 5 LogP: 4.89 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N(CC#Cc2ccc3c(c2)c(nc2n3c(C)nn2)c2ccccc2F)C(=O)c2c1cccc2
InChi: 1S/C27H16FN5O2/c1-16-30-31-27-29-24(20-10-4-5-11-22(20)28)21-15-17(12-13-23(21)33(16)27)7-6-14-32-25(34)18-8-2-3-9-19(18)26(32)35/h2-5,8-13,15H,14H2,1H3
InChiKey: RQIZUSPLFBIPST-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	platelet-activating factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	g-protein coupled receptor	platelet-activating factor receptor	342 aa	302 aa	22.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0053	0.0724
Onchocerca volvulus		0.0464	0.5415	1
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family member	0.0006	0.0013	0.0154
Trypanosoma cruzi	glutathione-S-transferase/glutaredoxin, putative	0.0464	0.5415	1
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0013	0.002
Trypanosoma cruzi	glutathione-S-transferase/glutaredoxin, putative	0.0464	0.5415	1
Entamoeba histolytica	Flap nuclease, putative	0.0027	0.027	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0087	0.0156
Leishmania major	cathepsin L-like protease	0.0066	0.0727	0.1322
Toxoplasma gondii	cathepsin CPL	0.0017	0.0152	0.0277
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0013	0.002
Onchocerca volvulus		0.0017	0.0152	0.0127
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.2884	1
Entamoeba histolytica	exonuclease, putative	0.0006	0.0013	0.0475
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.07	1
Onchocerca volvulus		0.0031	0.0317	0.0437
Toxoplasma gondii	prostaglandin-E synthase	0.0464	0.5415	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0152	0.5624
Brugia malayi	hypothetical protein	0.0464	0.5415	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.07	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0317	0.0305
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.01	0.018
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0013	0.002
Echinococcus granulosus	cathepsin l1	0.0017	0.0152	0.2023
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0152	0.5624
Leishmania major	cytochrome p450-like protein	0.0013	0.01	0.0161
Trypanosoma cruzi	cruzipain precursor, putative	0.0006	0.0015	0.0024
Entamoeba histolytica	recQ family helicase, putative	0.0012	0.0087	0.3205
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0006	0.0015	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Plasmodium vivax	DNA repair protein RAD2, putative	0.0006	0.0013	0.0404
Plasmodium vivax	vivapain-1	0.0009	0.0053	0.1659
Trypanosoma cruzi	DNA repair protein RAD2, putative	0.0006	0.0013	0.002
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0053	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0152	0.0484
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0084	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0152	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0015	0.0024
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0013	0.002
Leishmania major	cathepsin L-like protease	0.0017	0.0152	0.0257
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Trypanosoma brucei	Prostaglandin E synthase	0.0464	0.5415	1
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0027	0.027	0.0476
Plasmodium falciparum	flap endonuclease 1	0.0027	0.027	1
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0027	0.027	0.0495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0084	0.0249
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0317	0.4517
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0727	0.1339
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Leishmania major	cathepsin L-like protease	0.0017	0.0152	0.0257
Giardia lamblia	Flap structure-specific endonuclease	0.0027	0.027	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.07	0.1272
Echinococcus multilocularis	flap endonuclease 1	0.0027	0.027	0.0258
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.056	0.1031
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0055	0.0098
Leishmania major	cathepsin L-like protease	0.0017	0.0152	0.0257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Loa Loa (eye worm)	flap endonuclease-1	0.0027	0.027	0.0495
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0087	0.0136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Loa Loa (eye worm)	cysteine protease	0.0017	0.0152	0.0277
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Entamoeba histolytica	exonuclease, putative	0.0006	0.0013	0.0475
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0055	0.0042
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.07	0.1289
Loa Loa (eye worm)	XPG I-region family protein	0.0006	0.0013	0.002
Loa Loa (eye worm)	fibroinase	0.0017	0.0152	0.0277
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0152	0.0257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0053	0.0074
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0727	0.1339
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0152	0.0257
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.07	1
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0152	0.0127
Plasmodium vivax	unspecified product	0.0006	0.0015	0.0469
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0152	0.0257
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0009	0.0053	0.1548
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0208	0.0195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0013	0.002
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.07	0.5
Loa Loa (eye worm)	ctsf protein	0.0017	0.0152	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0152	0.2023
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0152	0.0257
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0053	0.1949
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0317	0.0305
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0084	0.3118
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0053	0.0724
Leishmania major	cathepsin L-like protease	0.0066	0.0727	0.1322
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0055	0.0756
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0053	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0464	0.5415	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0317	0.4431
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0208	0.0361
Trypanosoma cruzi	DNA repair protein RAD2, putative	0.0006	0.0013	0.002
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.07	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0006	0.0015	0.0024
Leishmania major	cathepsin L-like protease	0.0017	0.0152	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0015	0.0024
Onchocerca volvulus		0.0017	0.0152	0.0127
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0152	0.5624
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0053	0.1949
Onchocerca volvulus		0.0017	0.0152	0.0127
Onchocerca volvulus		0.0017	0.0152	0.0127
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0055	0.0612
Plasmodium vivax	SET domain protein, putative	0.0031	0.0317	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Plasmodium vivax	vivapain-2	0.0017	0.0152	0.4786
Plasmodium vivax	vivapain-2	0.0017	0.0152	0.4786
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0015	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0013	0.002
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0087	0.0136
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0152	0.0257
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0053	0.0579
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0152	0.5405
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0208	0.068
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0053	0.0074
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family	0.0006	0.0013	0.0154
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0152	0.0257
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0084	0.0132
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Plasmodium vivax	vivapain-3	0.0009	0.0053	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.0053	0.0093
Echinococcus multilocularis	cysteine protease	0.0017	0.0152	0.0139
Brugia malayi	Flap endonuclease-1	0.0027	0.027	0.0476
Onchocerca volvulus		0.0017	0.0152	0.0127
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0013	0.002
Trichomonas vaginalis	flap endonuclease-1, putative	0.0027	0.027	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0152
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0317	0.4517
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0152	0.2146
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0727	0.1339
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0152	0.0257
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.0053	0.0093
Onchocerca volvulus		0.0249	0.2884	0.5251
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0152	0.2023
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0317	0.0582
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.01	0.018
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.01	0.018
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.0053	0.0093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0055	0.0098
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0053	0.1949
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0055	0.0612
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0015	0.0121	0.0221
Echinococcus granulosus	cathepsin l1	0.0012	0.0084	0.1039
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0152	0.0257
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0055	0.0098
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0027	0.027	0.0495
Echinococcus granulosus	flap endonuclease 1	0.0027	0.027	0.3743
Brugia malayi	Pre-SET motif family protein	0.0031	0.0317	0.0564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0055	0.0078
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0053	0.0724
Entamoeba histolytica	recQ family DNA helicase	0.0005	0.0002	0.0077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Plasmodium vivax	exonuclease I, putative	0.0006	0.0013	0.0404
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.01	0.0161
Leishmania major	glutathione-S-transferase/glutaredoxin, putative	0.0464	0.5415	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0152	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0053	0.0139
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0208	0.038
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0009	0.0053	0.0093
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0317	0.4517
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0009	0.0055	0.1635
Trypanosoma cruzi	cysteine protease, putative	0.0009	0.0053	0.0093
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0152	0.0139
Entamoeba histolytica	cysteine proteinase, putative	0.0009	0.0053	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0155	0.0283
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0239	0.3395
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Brugia malayi	Cytochrome P450 family protein	0.0013	0.01	0.0161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Brugia malayi	cathepsin L-like precursor	0.0012	0.0084	0.0132
Schistosoma mansoni	exonuclease	0.0006	0.0013	0.0154
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0208	0.2841
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0304	0.4233
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0152	0.0139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0053	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0152
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0152	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0317	0.0582
Brugia malayi	cathepsin F-like cysteine proteinase	0.0006	0.0015	0.0004
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0087	0.0257
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.01	0.018
Entamoeba histolytica	cysteine protease, putative	0.0009	0.0053	0.1949
Entamoeba histolytica	DNA-repair protein, putative	0.0006	0.0013	0.0475
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0176	0.6357
Onchocerca volvulus		0.0017	0.0152	0.0127
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0152	0.2146
Leishmania major	cathepsin L-like protease	0.0017	0.0152	0.0257
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0208	0.068
Entamoeba histolytica	cysteine proteinase 2	0.0009	0.0053	0.1949
Brugia malayi	Cytochrome P450 family protein	0.0013	0.01	0.0161
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.0153	0.2164
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0055	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0152	0.0277
Onchocerca volvulus		0.0017	0.0152	0.0127
Treponema pallidum	ATP-dependent DNA helicase	0.0005	0.0002	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0317	0.4517
Echinococcus granulosus	cathepsin L	0.0009	0.0053	0.0579
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0055	0.0756
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0152	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Giardia lamblia	Sgs1 DNA helicase, putative	0.0009	0.0055	0.1635
Entamoeba histolytica	cysteine proteinase 1, putative	0.0009	0.0053	0.1949
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0152	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0152
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.0659	0.1214
Echinococcus multilocularis	cathepsin L	0.0009	0.0053	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Leishmania major	cathepsin L-like protease	0.0066	0.0727	0.1322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0084	0.0249
Brugia malayi	Pre-SET motif family protein	0.0219	0.2527	0.4654
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0152	0.5405
Brugia malayi	Cathepsin L-like precursor	0.0006	0.0015	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0013	0.002
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0015	0.0124	0.3894
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0056	0.0099
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.01	0.018
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0152	0.5405
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0152	0.0484
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0152	0.0139
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.07	0.0688
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0152	0.0139
Echinococcus granulosus	cysteine protease	0.0009	0.0053	0.0579
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0084	0.1177
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0055	0.0098
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0055	0.0042
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0027	0.027	0.0476
Schistosoma mansoni	cathepsin s	0.0006	0.0015	0.0183
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0727	0.1339
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0152	0.0484
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0727	0.1322
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0152	0.0277
Echinococcus multilocularis	cysteine protease	0.0017	0.0152	0.0139
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.07	1
Plasmodium vivax	flap endonuclease 1, putative	0.0027	0.027	0.8511
Trypanosoma cruzi	cysteine peptidase, putative	0.0006	0.0015	0.0024
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0084	0.0132
Plasmodium vivax	unspecified product	0.0009	0.0053	0.1659
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.2527	0.4665

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 300 nM	PAF-antagonist activity determined in dog platelets by PAF-binding assay	ChEMBL.	2002463
IC50 (binding)	= 300 nM	PAF-antagonist activity determined in dog platelets by PAF-binding assay	ChEMBL.	2002463
Inhibition (functional)	= 1 %	Inhibition of PAF-induced bronchoconstriction in the guinea pig, (1 mg/kg) intravenously at one-minute pretreatment time	ChEMBL.	2002463
Inhibition (functional)	= 1 %	Inhibition of PAF-induced bronchoconstriction in the guinea pig, (1 mg/kg) intravenously at one-minute pretreatment time	ChEMBL.	2002463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL20196

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 23127