TDR Targets

Basic information

Technical information

TDR Targets ID: 235145
Name: 4-N-(3-bromophenyl)-6-N-(2-morpholin-4-ylethy ldiazenyl)quinazoline-4,6-diamine
MW: 456.339 | Formula: C20H22BrN7O
H donors: 2 H acceptors: 2 LogP: 4.14 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cccc(c1)Nc1ncnc2c1cc(N/N=N/CCN1CCOCC1)cc2
InChi: 1S/C20H22BrN7O/c21-15-2-1-3-16(12-15)25-20-18-13-17(4-5-19(18)22-14-23-20)26-27-24-6-7-28-8-10-29-11-9-28/h1-5,12-14H,6-11H2,(H,24,26)(H,22,23,25)
InChiKey: CGULORJBJPSDAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N4-(3-bromophenyl)-N6-(2-morpholinoethylazo)quinazoline-4,6-diamine
N4-(3-bromophenyl)-N6-(2-morpholin-4-ylethyldiazenyl)quinazoline-4,6-diamine
[4-(3-bromoanilino)quinazolin-6-yl]-(2-morpholinoethylazo)amine
N-(3-bromophenyl)-N'-(2-morpholin-4-ylethyldiazenyl)quinazoline-4,6-diamine
N-(3-bromophenyl)-N'-(2-morpholinoethylazo)quinazoline-4,6-diamine
[4-[(3-bromophenyl)amino]quinazolin-6-yl]-(2-morpholinoethylazo)amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	high affinity choline transporter 1	0.0354	0.8497	0.8497
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0038
Schistosoma mansoni	cpg binding protein	0.0031	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0045	0.0053
Schistosoma mansoni	cpg binding protein	0.0031	0.0491	0.0491
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.4191	0.4932
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0304	0.0304
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0304	0.0357
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0409	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Brugia malayi	Sodium:solute symporter family protein	0.0039	0.0696	0.0819
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0038
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0304	0.0413
Onchocerca volvulus		0.0135	0.3062	0.4165
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0033	0.0038
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0135	0.3062	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0093	0.011
Brugia malayi	Protein kinase domain containing protein	0.0058	0.1155	0.1359
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0135	0.3062	1
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0304	0.0357
Schistosoma mansoni	tyrosine kinase	0.0058	0.1155	0.1155
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0304	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0304	0.0357
Schistosoma mansoni	inositol transporter	0.0039	0.0696	0.0696
Schistosoma mansoni	coup transcription factor	0.0023	0.0304	0.0304
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1095	0.2708
Onchocerca volvulus		0.0029	0.045	0.0612
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0039	0.0696	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0135	0.3062	0.3604
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0304	0.0304
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0304	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0304	0.0357
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0304	0.0357
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1259	0.1259
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0304	0.0304
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0304	0.0357
Onchocerca volvulus		0.0027	0.0409	0.0556
Schistosoma mansoni	tyrosine kinase	0.0058	0.1155	0.1155
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0033	0.0038
Plasmodium falciparum	polyprenol reductase, putative	0.0135	0.3062	1
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0304	0.0304
Echinococcus granulosus	insulin receptor	0.0058	0.1155	0.1155
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0304	0.0357
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.4191	0.4191
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0304	0.0304
Echinococcus multilocularis	lamin	0.0027	0.0409	0.0409
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0135	0.3062	1
Plasmodium vivax	polyprenol reductase, putative	0.0135	0.3062	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0045	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Echinococcus granulosus	intermediate filament protein	0.0027	0.0409	0.0409
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0304	0.0304
Brugia malayi	nuclear receptor RXR	0.0012	0.0033	0.0038
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0135	0.3062	0.3062
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0409	0.0481
Brugia malayi	ecdysteroid receptor	0.0023	0.0304	0.0357
Echinococcus granulosus	cpg binding protein	0.0031	0.0491	0.0491
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0135	0.3062	0.3062
Echinococcus multilocularis	solute carrier family 5	0.0039	0.0696	0.0696
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.4191	0.4932
Onchocerca volvulus		0.0308	0.7353	1
Schistosoma mansoni	sodium/solute symporter	0.0039	0.0696	0.0696
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0039	0.0696	0.0696
Brugia malayi	hypothetical protein	0.0017	0.0139	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0696	0.0819
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0304	0.0357
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0135	0.3062	0.3604
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0014	0.0014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0304	0.0357
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0304	0.0304
Echinococcus multilocularis	musashi	0.0027	0.0409	0.0409
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0304	0.0357
Loa Loa (eye worm)	TK/INSR protein kinase	0.0058	0.1155	0.1359
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	1
Onchocerca volvulus		0.0023	0.0304	0.0413
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0304	0.0357
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0304	0.0357
Brugia malayi	hypothetical protein	0.0012	0.0033	0.0038
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0093	0.011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0304	0.0357
Echinococcus multilocularis	lamin dm0	0.0027	0.0409	0.0409
Brugia malayi	intermediate filament protein	0.0027	0.0409	0.0481
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0304	0.0304
Echinococcus granulosus	lamin dm0	0.0027	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0308	0.7353	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0304	0.0304
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0409	0.0481
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0135	0.3062	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0304	0.0304
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0304	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Echinococcus multilocularis	insulin receptor	0.0058	0.1155	0.1155
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0304	0.0304
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0039	0.0696	0.0696
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0135	0.3062	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0038
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0039	0.0696	0.1228
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0397	0.0467
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0304	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0304	0.0357
Schistosoma mansoni	tyrosine kinase	0.018	0.4191	0.4191
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0304	0.0357
Onchocerca volvulus		0.0039	0.0696	0.0947
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0135	0.3062	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Echinococcus granulosus	synaptic glycoprotein sc2	0.0135	0.3062	0.3062
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0304	0.0357
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0304	0.0413
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0304	0.0304
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0033	0.0033
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0304	0.0357
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0057	0.0057
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0039	0.0696	0.0696
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0057	0.0057
Brugia malayi	hypothetical protein	0.0012	0.0033	0.0038
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0014	0.0014
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0304	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0304	0.0357
Schistosoma mansoni	lamin	0.0027	0.0409	0.0409
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0304	0.0357
Schistosoma mansoni	hypothetical protein	0.0172	0.3984	0.3984
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0039	0.0696	0.0696
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0304	0.0304
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0304	0.0304
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0135	0.3062	0.3062
Echinococcus multilocularis		0.0056	0.111	0.111
Brugia malayi	hypothetical protein	0.0308	0.7353	0.8653
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0135	0.3062	0.3062
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0057	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Echinococcus granulosus	geminin	0.0172	0.3984	0.3984
Echinococcus granulosus	solute carrier family 5	0.0039	0.0696	0.0696
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0135	0.3062	0.5
Schistosoma mansoni	high-affinity choline transporter	0.0354	0.8497	0.8497
Loa Loa (eye worm)	hypothetical protein	0.0135	0.3062	0.3604
Schistosoma mansoni	tyrosine kinase	0.0097	0.2126	0.2126
Brugia malayi	CXXC zinc finger family protein	0.0029	0.045	0.053
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0304	0.0304
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0039	0.0696	0.0696
Entamoeba histolytica	hypothetical protein	0.0135	0.3062	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0304	0.0304
Brugia malayi	Synaptic glycoprotein SC2	0.0135	0.3062	0.3604
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0304	0.0357
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	0.5
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0135	0.3062	1
Schistosoma mansoni	inositol transporter	0.0039	0.0696	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0135	0.3062	0.3604
Echinococcus granulosus	high affinity choline transporter 1	0.0354	0.8497	0.8497
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.2126	0.2126
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0038
Brugia malayi	GH02984p	0.0354	0.8497	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0304	0.0357
Schistosoma mansoni	hypothetical protein	0.0415	1	1
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0345	0.8265	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0304	0.0304
Schistosoma mansoni	lamin	0.0027	0.0409	0.0409
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0033	0.0038
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0345	0.8265	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.045	0.053
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0304	0.0357
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0409	0.0409
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0038
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.4191	0.4191
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0304	0.0357
Brugia malayi	hypothetical protein	0.0026	0.0365	0.0429
Schistosoma mansoni	tyrosine kinase	0.0096	0.2101	0.2101
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0058	0.1155	0.1155
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0304	0.0304
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0013	0.0063	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0409	0.0481
Schistosoma mansoni	cpg binding protein	0.0029	0.045	0.045
Mycobacterium ulcerans	hypothetical protein	0.0135	0.3062	0.3657
Echinococcus granulosus	lamin	0.0027	0.0409	0.0409
Echinococcus granulosus	sodium:glucose cotransporter	0.0039	0.0696	0.0696
Onchocerca volvulus		0.0027	0.0409	0.0556
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.0135	0.3062	0.5
Brugia malayi	steroid hormone receptor	0.0023	0.0304	0.0357
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.3062	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0304	0.0357
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0304	0.0304
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0058	0.1155	0.1155
Echinococcus multilocularis	cpg binding protein	0.0031	0.0491	0.0491
Schistosoma mansoni	tyrosine kinase	0.0097	0.2126	0.2126
Schistosoma mansoni	hypothetical protein	0.0012	0.0014	0.0014
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0304	0.0304
Schistosoma mansoni	hypothetical protein	0.0172	0.3984	0.3984
Giardia lamblia	Synaptic glycoprotein SC2	0.0135	0.3062	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0304	0.0357
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0135	0.3062	1
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.0135	0.3062	0.5
Schistosoma mansoni	tyrosine kinase	0.0096	0.2101	0.2101
Echinococcus multilocularis	dnaJ subfamily B	0.0415	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0304	0.0304
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	1
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0135	0.3062	0.3062
Echinococcus multilocularis	geminin	0.0172	0.3984	0.3984
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0033	0.0033
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0304	0.0304
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.3062	0.5
Schistosoma mansoni	tyrosine kinase	0.0096	0.2101	0.2101
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	0.5
Loa Loa (eye worm)	hypothetical protein	0.0354	0.8497	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0304	0.0357
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0304	0.0304
Brugia malayi	nuclear hormone receptor	0.0023	0.0304	0.0357
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0304	0.0304
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0304	0.0304
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.2126	0.2126
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0365	0.0429
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0033	0.0033
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0135	0.3062	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.2126	0.2126

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.064 uM	In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).	ChEMBL.	13678409
IC50 (binding)	= 0.064 uM	In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).	ChEMBL.	13678409
IC50 (functional)	= 2.92 uM	Selective inhibition of serum stimulated growth of NIH3T3neu isogenic cells	ChEMBL.	13678409
IC50 (functional)	= 2.92 uM	Selective inhibition of serum stimulated growth of NIH3T3neu isogenic cells	ChEMBL.	13678409
IC50 (functional)	= 22.24 uM	Selective inhibition of serum stimulated growth of NIH3T3 isogenic cells	ChEMBL.	13678409
IC50 (functional)	= 22.24 uM	Selective inhibition of serum stimulated growth of NIH3T3 isogenic cells	ChEMBL.	13678409
IC50 (functional)	= 33 uM	In vitro inhibition of A431 (human carcinoma) cell basal growth.	ChEMBL.	13678409
IC50 (functional)	= 33 uM	In vitro inhibition of A431 (human carcinoma) cell basal growth.	ChEMBL.	13678409
Ratio (functional)	= 7.61	Ratio of inhibition of serum stimulated growth NIH3T3neu to that of NIH3T3 isogenic cells	ChEMBL.	13678409

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	13678409

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL137364
PubChem: 10276061

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 235145