Detailed information for compound 253647

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.354 | Formula: C20H18O5
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@]1(C)C[C@H](c2ccccc2)c2c(O1)c1cccc(c1oc2=O)O
  • InChi: 1S/C20H18O5/c1-20(23-2)11-14(12-7-4-3-5-8-12)16-18(25-20)13-9-6-10-15(21)17(13)24-19(16)22/h3-10,14,21H,11H2,1-2H3/t14-,20+/m1/s1
  • InChiKey: ZYGQQWWTOAMQBQ-VLIAUNLRSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.426
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.0548
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2508 0.7021
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Treponema pallidum methionine aminopeptidase (map) 0.0045 0.0434 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Loa Loa (eye worm) Smad1 0.0008 0.0024 0.0063
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1272 0.3387
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.029 0.6684
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0223 0.4905
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0431
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0196 0.4507
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0045 0.0434 0.5
Chlamydia trachomatis glycogen phosphorylase 0.033 0.3572 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0297 0.0791
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0024 0.0063
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.0434
Echinococcus granulosus geminin 0.0167 0.1775 0.4728
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.005
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0019 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0227 0.1467
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1272 0.3387
Giardia lamblia Glycogen phosphorylase 0.033 0.3572 1
Entamoeba histolytica hypothetical protein 0.0026 0.0223 0.0623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.0434
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0019 0.008
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0196 0.4507
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.0634
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0019 0.008
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0019 0.0431
Echinococcus multilocularis smad 0.0008 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.4507
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0066
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0066
Toxoplasma gondii methionine aminopeptidase 0.0045 0.0434 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0152 0.3505
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0024 0.0063
Schistosoma mansoni glycogen phosphorylase 0.033 0.3572 0.9515
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0045 0.0434 0.1157
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1085 0.2889
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.029 0.6684
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.1157
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Echinococcus granulosus GPCR family 2 0.0033 0.0297 0.0791
Echinococcus multilocularis Glycosyl transferase, family 35 0.033 0.3572 0.3572
Echinococcus multilocularis glycogen phosphorylase 0.033 0.3572 0.3572
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0045 0.0434 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0966 0.0966
Echinococcus granulosus glycogen phosphorylase 0.033 0.3572 0.9515
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.5003
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0019 0.008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0257 0.5914
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Echinococcus multilocularis Smad4 0.0008 0.0024 0.0024
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.426
Leishmania major importin beta-1 subunit, putative 0.0026 0.0223 0.5125
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.0071 0.072 0.1918
Schistosoma mansoni Smad4 0.0008 0.0024 0.0063
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0152 0.0898
Brugia malayi Importin beta-1 subunit 0.0032 0.029 0.0813
Plasmodium vivax importin-beta 2, putative 0.0032 0.029 0.6684
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0227 0.1398
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0297 0.0831
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0045 0.0434 0.2852
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0045 0.0434 0.2794
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Schistosoma mansoni hypothetical protein 0.0071 0.072 0.1918
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Brugia malayi carbohydrate phosphorylase 0.033 0.3572 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.1085 0.2889
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0966 0.0966
Trichomonas vaginalis ran, putative 0.0024 0.0196 0.0548
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0019 0.008
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Echinococcus granulosus Glycosyl transferase family 35 0.033 0.3572 0.9515
Entamoeba histolytica glycogen phosphorylase, putative 0.033 0.3572 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.0634
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0297 0.0791
Brugia malayi RNA, U transporter 1 0.0092 0.095 0.266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0257 0.0684
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Entamoeba histolytica glycogen phosphorylase, putative 0.033 0.3572 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0257 0.0684
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.4507
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.0521
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.3754 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0227 0.1398
Schistosoma mansoni hypothetical protein 0.0167 0.1775 0.4728
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0019 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.5003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.005
Echinococcus granulosus Smad4 0.0008 0.0024 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0223 0.0623
Onchocerca volvulus 0.0233 0.2508 0.7005
Schistosoma mansoni hypothetical protein 0.0346 0.3754 1
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0024 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0223 0.0623
Onchocerca volvulus 0.0027 0.0227 0.0585
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0297 0.0831
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0024 0.0063
Brugia malayi MH2 domain containing protein 0.0121 0.1272 0.356
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0245 0.0652
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0257 0.0257
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0227 0.1467
Schistosoma mansoni ran 0.0024 0.0196 0.0521
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0045 0.0434 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.072 0.2016
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0297 0.0791
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0196 0.0196
Brugia malayi Smad1 0.0008 0.0024 0.0066
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0019 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0019 0.008
Toxoplasma gondii methionine aminopeptidase 0.0045 0.0434 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Echinococcus multilocularis geminin 0.0167 0.1775 0.1775
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0297 0.0297
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0223 0.0623
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0019 0.0431
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.1506 0.4216
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0257 0.0684
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0019 0.008
Schistosoma mansoni smad 0.0008 0.0024 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Trichomonas vaginalis glycogen phosphorylase, putative 0.033 0.3572 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0045 0.0434 1
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0297 0.0297
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0045 0.0434 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.005
Plasmodium vivax SET domain protein, putative 0.0029 0.0257 0.5914
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0045 0.0434 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0019 0.005
Onchocerca volvulus 0.0029 0.0257 0.067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0966 0.2703
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0045 0.0434 0.2852
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0431
Echinococcus multilocularis importin subunit beta 1 0.0032 0.029 0.029
Echinococcus multilocularis snurportin 1 0.0346 0.3754 0.3754
Echinococcus granulosus glycogen phosphorylase 0.033 0.3572 0.9515
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1085 0.3036
Chlamydia trachomatis methionine aminopeptidase 0.0045 0.0434 0.0825
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0152 0.0971
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0196 0.0521
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0066
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0019 0.0431
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0143 0.1506 1
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0143 0.1506 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Echinococcus granulosus snurportin 1 0.0346 0.3754 1
Brugia malayi Pre-SET motif family protein 0.0205 0.2195 0.6145
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0019 0.005
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.1506 0.4216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0019 0.0052
Entamoeba histolytica glycogenphosphorylase, putative 0.0143 0.1506 0.4216
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0024 0.0063
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0045 0.0434 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2195 0.5848
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0227 0.1398
Echinococcus granulosus importin subunit beta 1 0.0032 0.029 0.0773
Schistosoma mansoni importin beta-1 0.0032 0.029 0.0773
Trichomonas vaginalis glycogen phosphorylase, putative 0.033 0.3572 1
Loa Loa (eye worm) methionine aminopeptidase type I 0.0045 0.0434 0.1157
Mycobacterium ulcerans methionine aminopeptidase 0.0045 0.0434 0.2794
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.1157
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0066
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0227 0.1398
Echinococcus granulosus smad 0.0008 0.0024 0.0063
Echinococcus multilocularis glycogen phosphorylase 0.033 0.3572 0.3572
Brugia malayi Pre-SET motif family protein 0.0029 0.0257 0.0719
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Schistosoma mansoni ran 0.0024 0.0196 0.0521
Onchocerca volvulus Glycogen phosphorylase homolog 0.033 0.3572 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0019 0.0052
Echinococcus multilocularis GPCR, family 2 0.0033 0.0297 0.0297
Schistosoma mansoni glycogen phosphorylase 0.033 0.3572 0.9515
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1085 0.3036
Plasmodium falciparum importin beta, putative 0.0032 0.029 0.6684
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0966 0.2572
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0045 0.0434 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0966 0.2572
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.029 0.6684
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0257 0.0257
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0152 0.3505
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0045 0.0434 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0045 0.0434 1
Brugia malayi Methionine aminopeptidase protein type I 0.0045 0.0434 0.1216
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0227 0.1398
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0227 0.0634
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0966 0.2572
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0773
Leishmania major GTP-binding protein, putative 0.0024 0.0196 0.4507
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0019 0.008
Trypanosoma brucei methionine aminopeptidase, putative 0.0045 0.0434 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0024 0.0024
Entamoeba histolytica Ran family GTPase 0.0024 0.0196 0.0548
Loa Loa (eye worm) hypothetical protein 0.0033 0.0297 0.0791
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Loa Loa (eye worm) glycogen phosphorylase 0.033 0.3572 0.9515
Schistosoma mansoni glycogen phosphorylase 0.0143 0.1506 0.4012
Schistosoma mansoni hypothetical protein 0.0167 0.1775 0.4728
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0019 0.0019

Activities

Activity type Activity value Assay description Source Reference
RPF (ADMET) = 14.9 pM nM-1 Rate of metabolism in liver microsomes (BNF treated rats) ChEMBL. 3981543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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