TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.365 | Formula: C21H20BrN2OS-
H donors: 0 H acceptors: 1 LogP: 5.57 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)c1ccccc1)Cn1c(=N)sc2c1CCCC2.[Br-]
InChi: 1S/C21H20N2OS.BrH/c22-21-23(18-8-4-5-9-20(18)25-21)14-19(24)17-12-10-16(11-13-17)15-6-2-1-3-7-15;/h1-3,6-7,10-13,22H,4-5,8-9,14H2;1H/p-1
InChiKey: GESONADEPAPQDG-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	EGF-like domain containing protein	0.0029	0.0745	0.0409
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0033	0.0921	0.2068
Brugia malayi	Animal haem peroxidase family protein	0.0089	0.3107	0.2856
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0026	0.0622	0.481
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0029	0.0745	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1355	0.1041
Onchocerca volvulus		0.0042	0.1263	0.2926
Echinococcus granulosus	fibropellin Ia	0.0029	0.0745	0.143
Echinococcus multilocularis	protein jagged 2	0.0029	0.0745	0.143
Echinococcus granulosus	slit 2 protein	0.0029	0.0745	0.143
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Mycobacterium ulcerans	polyketide synthase	0.0026	0.0622	0.0388
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1355	0.3644
Schistosoma mansoni	hypothetical protein	0.0035	0.0984	0.0656
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0921	1
Brugia malayi	notch-like transmembrane receptor	0.0029	0.0745	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0022	0.0501	0.0451
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0014	0.0155	0.1505
Echinococcus multilocularis	protein jagged 1	0.0029	0.0745	0.143
Schistosoma mansoni	notch	0.0029	0.0745	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0147	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Brugia malayi	hypothetical protein	0.0089	0.3107	0.2856
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.0563	0.5463
Schistosoma mansoni	peroxidasin	0.0089	0.3107	0.2856
Echinococcus multilocularis	neurogenic locus notch protein	0.0029	0.0745	0.143
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0351	0.011
Onchocerca volvulus	Peroxidase homolog	0.0089	0.3107	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1206	0.116
Loa Loa (eye worm)	fatty acid synthase	0.0024	0.0551	0.0501
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0024	0.0563	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0026	0.0622	0.481
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Brugia malayi	hypothetical protein	0.0035	0.0984	0.0656
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0023	0.0534	0.5182
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Onchocerca volvulus	Neurogenic locus notch homolog	0.0029	0.0745	0.0936
Brugia malayi	Blistered cuticle protein 3	0.0089	0.3107	0.2856
Loa Loa (eye worm)	hepatopoietin HPO2	0.0033	0.0921	0.0873
Onchocerca volvulus	Fatty acid synthase homolog	0.0043	0.1322	0.3151
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0026	0.0622	0.0388
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0351	0.03
Brugia malayi	Augmenter of liver regeneration	0.0033	0.0921	0.0591
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0622	0.6033
Schistosoma mansoni	hypothetical protein	0.0029	0.0745	0.0409
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0036	0.1031	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Brugia malayi	Delta serrate ligand family protein	0.0029	0.0745	0.0409
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0019	0.0378	0.0139
Onchocerca volvulus		0.0029	0.0745	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0023	0.0534	0.5182
Loa Loa (eye worm)	glutaminase 2	0.0264	1	1
Echinococcus granulosus	peroxidasin	0.0089	0.3107	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.1355	0.1309
Echinococcus multilocularis	protein jagged 1	0.0029	0.0745	0.143
Onchocerca volvulus	Peroxidasin homolog	0.0089	0.3107	1
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0622	0.0388
Onchocerca volvulus		0.0089	0.3107	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0029	0.0745	0.0409
Echinococcus granulosus	neural cadherin	0.0029	0.0745	0.143
Brugia malayi	Cadherin domain containing protein	0.0029	0.0745	0.0409
Mycobacterium ulcerans	glutaminase	0.0264	1	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0024	0.0563	0.4065
Brugia malayi	EGF-like domain containing protein	0.0029	0.0745	0.0409
Onchocerca volvulus	Dual oxidase homolog	0.0089	0.3107	1
Echinococcus multilocularis	notch	0.0029	0.0745	0.143
Schistosoma mansoni	hypothetical protein	0.0029	0.0745	0.0409
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0921	0.5
Onchocerca volvulus		0.0029	0.0745	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0921	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0984	0.2298
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Onchocerca volvulus		0.0029	0.0745	0.0936
Schistosoma mansoni	slit	0.0029	0.0745	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Brugia malayi	Calcium binding EGF domain containing protein	0.0029	0.0745	0.0409
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0024	0.0563	0.0328
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0024	0.0563	0.022
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0351	0.2853
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0029	0.0745	0.143
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0024	0.0563	0.5463
Entamoeba histolytica	hypothetical protein	0.0035	0.0984	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0745	0.0409
Schistosoma mansoni	notch	0.0029	0.0745	0.0409
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Mycobacterium ulcerans	polyketide synthase Pks13	0.0036	0.1031	0.0807
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Mycobacterium ulcerans	thioesterase	0.002	0.0406	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Onchocerca volvulus	Chorion peroxidase homolog	0.0089	0.3107	1
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0501	0.0156
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0024	0.0563	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0019	0.0378	0.0139
Loa Loa (eye worm)	animal heme peroxidase	0.0089	0.3107	0.307
Echinococcus granulosus	protein jagged 1	0.0029	0.0745	0.143
Echinococcus multilocularis	peroxidasin	0.0089	0.3107	1
Brugia malayi	EGF-like domain containing protein	0.0029	0.0745	0.0409
Toxoplasma gondii	type I fatty acid synthase, putative	0.0026	0.0622	0.638
Onchocerca volvulus	Slit protein homolog	0.0029	0.0745	0.0936
Onchocerca volvulus	Peroxidase homolog	0.0089	0.3107	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0024	0.0563	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Schistosoma mansoni	hypothetical protein	0.0029	0.0745	0.0409
Echinococcus multilocularis	fibropellin Ia	0.0029	0.0745	0.143
Loa Loa (eye worm)	animal heme peroxidase	0.0089	0.3107	0.307
Brugia malayi	EGF-like domain containing protein	0.0029	0.0745	0.0409
Entamoeba histolytica	hypothetical protein	0.0035	0.0984	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Schistosoma mansoni	hypothetical protein	0.0029	0.0745	0.0409
Schistosoma mansoni	notch	0.0029	0.0745	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Echinococcus granulosus	protein jagged 2	0.0029	0.0745	0.143
Echinococcus granulosus	neurogenic locus protein delta	0.0029	0.0745	0.143
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0016	0.0231	0.1642
Brugia malayi	Animal haem peroxidase family protein	0.0089	0.3107	0.2856
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1355	0.1041
Onchocerca volvulus		0.0089	0.3107	1
Loa Loa (eye worm)	animal heme peroxidase	0.0089	0.3107	0.307
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0351	0.011
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Schistosoma mansoni	cell polarity protein	0.0029	0.0745	0.0409
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0921	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0984	0.0656
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0921	1
Mycobacterium tuberculosis	Probable thioesterase TesA	0.002	0.0406	0.3934
Echinococcus multilocularis	slit 2 protein	0.0029	0.0745	0.143
Echinococcus multilocularis	neurogenic locus protein delta	0.0029	0.0745	0.143
Loa Loa (eye worm)	animal heme peroxidase	0.0089	0.3107	0.307
Echinococcus granulosus	neurogenic locus notch protein	0.0029	0.0745	0.143
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Schistosoma mansoni	notch	0.0029	0.0745	0.0409
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0026	0.0622	0.6033
Echinococcus multilocularis	neural cadherin	0.0029	0.0745	0.143
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0026	0.0622	0.481
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1355	0.3644
Schistosoma mansoni	laminin gamma-3 chain	0.0029	0.0745	0.0409
Schistosoma mansoni	peroxidasin	0.0089	0.3107	0.2856
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0029	0.0745	0.143
Brugia malayi	Muscle positioning protein 4	0.0029	0.0745	0.0409
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1355	0.3644
Schistosoma mansoni	septate junction protein	0.0029	0.0745	0.0409
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.1355	0.1041
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0036	0.1031	1
Loa Loa (eye worm)	Notch2	0.0029	0.0745	0.0696
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0033	0.0921	0.2068
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0351	0.3402
Leishmania major	hypothetical protein, conserved	0.0033	0.0921	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0089	0.3107	0.307
Brugia malayi	Cadherin domain containing protein	0.0029	0.0745	0.0409
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Entamoeba histolytica	hypothetical protein	0.0035	0.0984	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Echinococcus granulosus	notch	0.0029	0.0745	0.143
Echinococcus granulosus	protein jagged 1	0.0029	0.0745	0.143
Entamoeba histolytica	hypothetical protein	0.0035	0.0984	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Echinococcus multilocularis	neurogenic locus protein delta	0.0029	0.0745	0.143
Onchocerca volvulus		0.0089	0.3107	1
Brugia malayi	Animal haem peroxidase family protein	0.0089	0.3107	0.2856
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Brugia malayi	GCC2 and GCC3 family protein	0.0029	0.0745	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0029	0.0745	0.0936
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0024	0.0563	0.5463
Loa Loa (eye worm)	notch protein	0.0029	0.0745	0.0696
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Brugia malayi	EGF-like domain containing protein	0.0029	0.0745	0.0409
Echinococcus granulosus	delta-like protein 1	0.0029	0.0745	0.143
Echinococcus granulosus	protein jagged 2	0.0029	0.0745	0.143
Brugia malayi	EGF-like domain containing protein	0.0029	0.0745	0.0409
Mycobacterium ulcerans	thioesterase TesA	0.002	0.0406	0.0167
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0351	0.2853
Schistosoma mansoni	notch	0.0029	0.0745	0.0409
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0024	0.0563	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Echinococcus granulosus	neurogenic locus notch protein	0.0029	0.0745	0.143
Trypanosoma brucei	unspecified product	0.0019	0.0351	0.2853
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Onchocerca volvulus	Putative cubilin	0.0029	0.0745	0.0936
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0984	0.2298
Echinococcus granulosus	neurogenic locus notch protein 4	0.0029	0.0745	0.143
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1355	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1355	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0351	0.03
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0921	0.5
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.002	0.0391	0.3792
Brugia malayi	Animal haem peroxidase family protein	0.0089	0.3107	0.2856
Mycobacterium ulcerans	polyketide synthase	0.0024	0.0563	0.0328
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0046	0.141	0.1098
Giardia lamblia	High cysteine protein	0.0029	0.0745	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Brugia malayi	Calcium binding EGF domain containing protein	0.0029	0.0745	0.0409
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0022	0.0501	0.4861
Toxoplasma gondii	type I fatty acid synthase, putative	0.0017	0.0291	0.2366
Echinococcus multilocularis	neurogenic locus notch protein	0.0029	0.0745	0.143
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Brugia malayi	EGF-like domain containing protein	0.0029	0.0745	0.0409
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0921	1
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.002	0.0406	0.2064
Brugia malayi	Peroxidasin	0.0089	0.3107	0.2856
Mycobacterium leprae	Polyketide synthase Pks13	0.0036	0.1031	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Schistosoma mansoni	glutaminase	0.0264	1	1
Onchocerca volvulus		0.0029	0.0745	0.0936
Onchocerca volvulus		0.0029	0.0745	0.0936
Loa Loa (eye worm)	glutaminase	0.0264	1	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0351	0.3402
Schistosoma mansoni	hypothetical protein	0.0029	0.0745	0.0409
Schistosoma mansoni	notch	0.0029	0.0745	0.0409
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0351	0.2853
Schistosoma mansoni	hypothetical protein	0.0029	0.0745	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0745	0.0696
Trichomonas vaginalis	glutaminase, putative	0.0264	1	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0019	0.0378	0.172
Toxoplasma gondii	EGF family domain-containing protein	0.0029	0.0745	0.7871
Onchocerca volvulus	Peroxidasin homolog	0.0089	0.3107	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Brugia malayi	Animal haem peroxidase family protein	0.0089	0.3107	0.2856
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0921	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0026	0.0622	0.6033
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0351	0.2853
Loa Loa (eye worm)	hypothetical protein	0.0089	0.3107	0.307
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0351	0.2853
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0017	0.0297	0.288
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0029	0.0745	0.0409

Activities

Activity type	Activity value	Assay description	Source	Reference
cLog D	= 3.01	Lipophilicity of the compound determined	ChEMBL.	12408720
EC25 (functional)	= 340 nM	Effective concentration to induce 25 % protection of rat PC12 cells from camptothecin-induced cell death	ChEMBL.	12408720
EC50 (functional)	= 770 nM	Effective concentration to induce 50 % protection of rat PC12 cells from camptothecin-induced cell death	ChEMBL.	12408720

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 345976

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 254184