Detailed information for compound 255082

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.354 | Formula: C20H18O5
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@]1(C)C[C@@H](c2ccccc2)c2c(O1)c1cccc(c1oc2=O)O
  • InChi: 1S/C20H18O5/c1-20(23-2)11-14(12-7-4-3-5-8-12)16-18(25-20)13-9-6-10-15(21)17(13)24-19(16)22/h3-10,14,21H,11H2,1-2H3/t14-,20+/m0/s1
  • InChiKey: ZYGQQWWTOAMQBQ-VBKZILBWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glycogen phosphorylase, putative 0.033 0.3572 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0297 0.0297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0227 0.1467
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0019 0.008
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.1157
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0245 0.0652
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0045 0.0434 0.2852
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.029 0.6684
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.0548
Echinococcus multilocularis importin subunit beta 1 0.0032 0.029 0.029
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0045 0.0434 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0024 0.0063
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.005
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0019 0.005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.4507
Echinococcus granulosus glycogen phosphorylase 0.033 0.3572 0.9515
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.4507
Echinococcus multilocularis smad 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Chlamydia trachomatis glycogen phosphorylase 0.033 0.3572 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0019 0.008
Toxoplasma gondii methionine aminopeptidase 0.0045 0.0434 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0966 0.2703
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Schistosoma mansoni ran 0.0024 0.0196 0.0521
Trichomonas vaginalis ran, putative 0.0024 0.0196 0.0548
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0223 0.4905
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.029 0.6684
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0431
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0045 0.0434 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0045 0.0434 1
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0019 0.0052
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0045 0.0434 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0019 0.0052
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1272 0.3387
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.1506 0.4216
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.0634
Echinococcus granulosus glycogen phosphorylase 0.033 0.3572 0.9515
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Echinococcus multilocularis glycogen phosphorylase 0.033 0.3572 0.3572
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2508 0.7021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.5003
Echinococcus granulosus Smad4 0.0008 0.0024 0.0063
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Brugia malayi Pre-SET motif family protein 0.0205 0.2195 0.6145
Schistosoma mansoni importin beta-1 0.0032 0.029 0.0773
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.005
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0257 0.0684
Echinococcus granulosus Glycosyl transferase family 35 0.033 0.3572 0.9515
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0045 0.0434 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.029 0.6684
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0966 0.2572
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.0634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1085 0.2889
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Schistosoma mansoni Smad4 0.0008 0.0024 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Echinococcus multilocularis GPCR, family 2 0.0033 0.0297 0.0297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0196 0.4507
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Entamoeba histolytica glycogen phosphorylase, putative 0.033 0.3572 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0152 0.0971
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Schistosoma mansoni glycogen phosphorylase 0.033 0.3572 0.9515
Onchocerca volvulus 0.0027 0.0227 0.0585
Loa Loa (eye worm) hypothetical protein 0.0033 0.0297 0.0791
Schistosoma mansoni hypothetical protein 0.0346 0.3754 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0223 0.0623
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0227 0.1467
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0227 0.1398
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0019 0.008
Entamoeba histolytica Ran family GTPase 0.0024 0.0196 0.0548
Entamoeba histolytica glycogen phosphorylase, putative 0.033 0.3572 1
Plasmodium falciparum importin beta, putative 0.0032 0.029 0.6684
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0019 0.0052
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0143 0.1506 1
Onchocerca volvulus 0.0233 0.2508 0.7005
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0227 0.0634
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0019 0.008
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0019 0.008
Schistosoma mansoni hypothetical protein 0.0071 0.072 0.1918
Trypanosoma brucei methionine aminopeptidase, putative 0.0045 0.0434 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.005
Giardia lamblia Glycogen phosphorylase 0.033 0.3572 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Schistosoma mansoni hypothetical protein 0.0167 0.1775 0.4728
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0966 0.0966
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.1157
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0045 0.0434 0.2794
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0019 0.0431
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0196 0.0196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0966 0.2572
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Echinococcus granulosus GPCR family 2 0.0033 0.0297 0.0791
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0045 0.0434 0.1157
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Brugia malayi Importin beta-1 subunit 0.0032 0.029 0.0813
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0019 0.0431
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0019 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0966 0.0966
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0227 0.1398
Echinococcus multilocularis Glycosyl transferase, family 35 0.033 0.3572 0.3572
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1085 0.3036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.072 0.2016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1085 0.3036
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0066
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.0434
Loa Loa (eye worm) methionine aminopeptidase type I 0.0045 0.0434 0.1157
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Onchocerca volvulus 0.0029 0.0257 0.067
Brugia malayi Smad1 0.0008 0.0024 0.0066
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0024 0.0024
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0297 0.0791
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Treponema pallidum methionine aminopeptidase (map) 0.0045 0.0434 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0297 0.0791
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0223 0.0623
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0045 0.0434 1
Schistosoma mansoni smad 0.0008 0.0024 0.0063
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0019 0.008
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0297 0.0831
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.1506 0.4216
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0024 0.0063
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0257 0.0684
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0257 0.0257
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0152 0.3505
Entamoeba histolytica glycogenphosphorylase, putative 0.0143 0.1506 0.4216
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0024 0.0063
Echinococcus granulosus geminin 0.0167 0.1775 0.4728
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0045 0.0434 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0773
Loa Loa (eye worm) hypothetical protein 0.0104 0.1085 0.2889
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0196 0.0521
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0066
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.005
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Echinococcus granulosus smad 0.0008 0.0024 0.0063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0152 0.0898
Onchocerca volvulus Glycogen phosphorylase homolog 0.033 0.3572 1
Brugia malayi Methionine aminopeptidase protein type I 0.0045 0.0434 0.1216
Schistosoma mansoni glycogen phosphorylase 0.0143 0.1506 0.4012
Loa Loa (eye worm) hypothetical protein 0.0071 0.072 0.1918
Mycobacterium ulcerans methionine aminopeptidase 0.0045 0.0434 0.2794
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0297 0.0791
Chlamydia trachomatis methionine aminopeptidase 0.0045 0.0434 0.0825
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0143 0.1506 1
Entamoeba histolytica hypothetical protein 0.0026 0.0223 0.0623
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0019 0.005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.426
Leishmania major importin beta-1 subunit, putative 0.0026 0.0223 0.5125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0019 0.0431
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0045 0.0434 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0431
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0019 0.008
Echinococcus multilocularis glycogen phosphorylase 0.033 0.3572 0.3572
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Brugia malayi RNA, U transporter 1 0.0092 0.095 0.266
Loa Loa (eye worm) hypothetical protein 0.0029 0.0257 0.0684
Loa Loa (eye worm) Smad1 0.0008 0.0024 0.0063
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.029 0.6684
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1272 0.3387
Brugia malayi Pre-SET motif family protein 0.0029 0.0257 0.0719
Echinococcus multilocularis geminin 0.0167 0.1775 0.1775
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0966 0.2572
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0297 0.0831
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0227 0.1398
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Leishmania major GTP-binding protein, putative 0.0024 0.0196 0.4507
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0024 0.0063
Loa Loa (eye worm) glycogen phosphorylase 0.033 0.3572 0.9515
Echinococcus multilocularis snurportin 1 0.0346 0.3754 0.3754
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Trichomonas vaginalis glycogen phosphorylase, putative 0.033 0.3572 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0227 0.1398
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Echinococcus granulosus snurportin 1 0.0346 0.3754 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0045 0.0434 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.5003
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0024 0.0063
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0019 0.0052
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0066
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.3754 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2195 0.5848
Brugia malayi carbohydrate phosphorylase 0.033 0.3572 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0196 0.4507
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Plasmodium vivax SET domain protein, putative 0.0029 0.0257 0.5914
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.0521
Schistosoma mansoni hypothetical protein 0.0167 0.1775 0.4728
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0223 0.0623
Schistosoma mansoni ran 0.0024 0.0196 0.0521
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0024 0.0024
Brugia malayi MH2 domain containing protein 0.0121 0.1272 0.356
Echinococcus granulosus importin subunit beta 1 0.0032 0.029 0.0773
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0045 0.0434 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0045 0.0434 0.2852
Loa Loa (eye worm) oxidoreductase 0.0008 0.0019 0.005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0227 0.1398
Echinococcus multilocularis Smad4 0.0008 0.0024 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Schistosoma mansoni glycogen phosphorylase 0.033 0.3572 0.9515
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0257 0.5914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Toxoplasma gondii methionine aminopeptidase 0.0045 0.0434 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0257 0.0257
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0152 0.3505
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406

Activities

Activity type Activity value Assay description Source Reference
RPF (ADMET) = 34.6 pM nM-1 Rate of metabolism in liver microsomes (BNF treated rats) ChEMBL. 3981543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.