Detailed information for compound 256247

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.915 | Formula: C22H18ClN3O2S
  • H donors: 2 H acceptors: 2 LogP: 6.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1Cl)/C(=N\OCc1ccccc1)/CSc1nc2c([nH]1)cccc2
  • InChi: 1S/C22H18ClN3O2S/c23-17-12-16(10-11-21(17)27)20(26-28-13-15-6-2-1-3-7-15)14-29-22-24-18-8-4-5-9-19(18)25-22/h1-12,27H,13-14H2,(H,24,25)/b26-20-
  • InChiKey: WENDKNAMAIEMQU-QOMWVZHYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0007 0.0017 0.0504
Schistosoma mansoni cpg binding protein 0.0021 0.0071 0.0084
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0018 0.0021
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.2156 0.8485 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0026 0.0092 0.0108
Echinococcus granulosus cpg binding protein 0.0022 0.0076 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0163 0.0192
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0007 0.0017 0.0064
Brugia malayi steroid hormone receptor 0.0007 0.0018 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0018 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0017 0.002
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0018 0.0021
Schistosoma mansoni nuclear receptor 0.0003 0.0003 0.0003
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2156 0.8485 0.8485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0005 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0017 0.003
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2156 0.8485 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0018 0.0021
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 0.8485
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0008 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0018 0.0021
Schistosoma mansoni topbp1 0.0007 0.0017 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0018 0.0021
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0007 0.0017 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0009 0.0011
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.2156 0.8485 0.8485
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0017 0.0017
Echinococcus multilocularis geminin 0.0123 0.0473 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0123 0.0473 0.0557
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0003 0.0003 0.0003
Echinococcus multilocularis cpg binding protein 0.0022 0.0076 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0018 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Brugia malayi hypothetical protein 0.0007 0.0017 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0007
Brugia malayi DKFZp564C0469 protein 0.0007 0.0017 0.002
Schistosoma mansoni chromosome transmission fidelity factor 0.0007 0.0017 0.002
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2156 0.8485 1
Schistosoma mansoni microtubule-associated protein tau 0.05 0.196 0.231
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0018 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0018 0.0031
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0018 0.0021
Echinococcus multilocularis replication factor c subunit 1 0.0007 0.0017 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Echinococcus granulosus Nuclear hormone receptor HR96 0.0003 0.0003 0.0003
Onchocerca volvulus 0.0003 0.0003 0.0076
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0018 0.0021
Brugia malayi nuclear receptor RXR 0.0003 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0017 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0014 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0026 0.0092 0.0108
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1479 0.582 0.6859
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Echinococcus granulosus nuclear receptor nhr 48 0.0003 0.0003 0.0003
Brugia malayi tailless protein 0.0003 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0003 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.2156 0.8485 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0017 0.003
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Plasmodium falciparum replication factor C subunit 1, putative 0.0007 0.0017 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0018 0.0021
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.254 1 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1376 0.5414 0.9455
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0018 0.0021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0018 0.0021
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0007 0.0017 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0018 0.0031
Onchocerca volvulus Huntingtin homolog 0.0089 0.0339 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1376 0.5414 0.638
Echinococcus granulosus replication factor c subunit 1 0.0007 0.0017 0.002
Brugia malayi nuclear receptor NHR-67 0.0003 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0018 0.0021
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0004 0.0004 0.0005
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2156 0.8485 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0018 0.0031
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0004 0.0004 0.0005
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0017 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0018 0.0031
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0004 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0008 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0017 0.0017
Echinococcus multilocularis nibrin 0.0007 0.0017 0.002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0003 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Entamoeba histolytica hypothetical protein 0.0026 0.0092 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0018 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0017 0.002
Entamoeba histolytica hypothetical protein 0.0026 0.0092 0.0108
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1456 0.5726 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 0.8485
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0171 0.0664 0.116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0018 0.0021
Schistosoma mansoni cpg binding protein 0.0022 0.0076 0.0089
Echinococcus granulosus microtubule associated protein 2 0.05 0.196 0.231
Schistosoma mansoni cpg binding protein 0.0022 0.0076 0.0089
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0003 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0026 0.0092 0.0108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0014 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Brugia malayi F/Y-rich N-terminus family protein 0.0006 0.0014 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0003 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0009 0.0011
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1376 0.5414 0.9455
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 0.8485
Brugia malayi ecdysone receptor 0.0003 0.0003 0.0003
Schistosoma mansoni nuclear receptor nhr-48 0.0003 0.0003 0.0003
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0003 0.0003 0.0076
Brugia malayi Nuclear hormone receptor E75 0.0003 0.0003 0.0003
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0676 0.2654 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2156 0.8485 0.8485
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.254 1 1
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0018 0.0021
Onchocerca volvulus 0.0003 0.0003 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0018 0.0021
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.07 0.2748 0.2748
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.07 0.2748 0.2748
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0003 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0018 0.0021
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.2156 0.8485 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0018 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0018 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0004 0.0005
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1376 0.5414 0.638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0018 0.0031
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.2156 0.8485 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0003 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0018 0.0031
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.0018 0.0526
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0007 0.0017 0.0017
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0676 0.2654 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0123 0.0473 0.0557
Brugia malayi nuclear hormone receptor family member odr-7 0.0003 0.0003 0.0003
Loa Loa (eye worm) nuclear receptor NHR-67 0.0003 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0007
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.254 1 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1376 0.5414 0.638
Schistosoma mansoni DNA ligase IV 0.0007 0.0017 0.002
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0007 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0089 0.0339 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0026 0.0092 0.0108
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0008 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0018 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0003 0.0003 0.0003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0018 0.0021
Loa Loa (eye worm) histone methyltransferase 0.0006 0.0014 0.0025
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 0.8485
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1376 0.5414 0.638
Brugia malayi hypothetical protein 0.0004 0.0004 0.0005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0003 0.0003 0.0003
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.07 0.2748 0.2748
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Brugia malayi hypothetical protein 0.0003 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.1376 0.5414 0.9455
Schistosoma mansoni nuclear hormone receptor 0.0003 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0018 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0018 0.0021
Echinococcus granulosus survival motor neuron protein 1 0.0171 0.0664 0.0783
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0008 0.0009
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0017 0.002
Brugia malayi hypothetical protein 0.0003 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0026 0.0092 0.0108
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0007 0.0017 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0018 0.0021
Brugia malayi Pax transcription activation domain interacting protein 0.0007 0.0017 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0039 0.0144 0.017
Schistosoma mansoni coup transcription factor 0.0007 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.2156 0.8485 1
Brugia malayi nuclear hormone receptor 0.0003 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Echinococcus granulosus geminin 0.0123 0.0473 0.0557
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0003 0.0003 0.0076
Brugia malayi nuclear hormone receptor family member nhr-6 0.0003 0.0003 0.0003
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2156 0.8485 1
Echinococcus multilocularis survival motor neuron protein 1 0.0171 0.0664 0.0783
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0018 0.0021
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0007 0.0017 0.0017
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.07 0.2748 0.2748
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0071 0.0124
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2156 0.8485 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2156 0.8485 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0017 0.003
Brugia malayi conserved hypotetical protein 0.0003 0.0003 0.0003
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0017 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0018 0.0021
Brugia malayi hypothetical protein 0.0171 0.0664 0.0783
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0018 0.0021
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2156 0.8485 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0018 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0017 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0018 0.0021
Schistosoma mansoni zinc finger protein 0.0003 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0003 0.0003 0.0003
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2156 0.8485 0.8485
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0003 0.0003 0.0003
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0007 0.0017 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0018 0.0031
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.2156 0.8485 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0008 0.0009
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.2156 0.8485 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2156 0.8485 0.8485
Brugia malayi nuclear hormone receptor 0.0007 0.0018 0.0021
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.07 0.2748 0.3239
Brugia malayi hypothetical protein 0.0007 0.0017 0.002
Brugia malayi nuclear receptor NHR-88 0.0003 0.0003 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0018 0.0021
Loa Loa (eye worm) DR-78 0.0003 0.0003 0.0005
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0017 0.002
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.07 0.2748 0.2748
Brugia malayi CXXC zinc finger family protein 0.0021 0.0071 0.0084
Echinococcus multilocularis microtubule associated protein 2 0.05 0.196 0.231
Echinococcus granulosus thyroid hormone receptor alpha 0.0003 0.0003 0.0003
Echinococcus granulosus nibrin 0.0007 0.0017 0.002
Onchocerca volvulus 0.0021 0.0071 0.2095
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Trichomonas vaginalis replication factor C large subunit, putative 0.0007 0.0017 0.002
Brugia malayi ecdysteroid receptor 0.0007 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Toxoplasma gondii ATPase, AAA family protein 0.0007 0.0017 0.002
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0018 0.0021
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.2156 0.8485 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2156 0.8485 0.8485
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0018 0.0021
Plasmodium vivax replication factor C subunit 1, putative 0.0007 0.0017 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0018 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.0004 0.0005
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0003 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0007 0.0017 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0018 0.0021
Onchocerca volvulus 0.0035 0.0127 0.374
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0018 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0008 0.0009
Schistosoma mansoni nuclear receptor 0.0003 0.0003 0.0003
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.2156 0.8485 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Loa Loa (eye worm) nuclear hormone receptor 0.0003 0.0003 0.0005
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0018 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0007 0.0017 0.003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0008 0.0009
Trichomonas vaginalis helicase, putative 0.0005 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0017 0.003
Echinococcus multilocularis nuclear receptor nhr 48 0.0003 0.0003 0.0003
Brugia malayi nuclear receptor NHR-88 0.0007 0.0018 0.0021
Brugia malayi hypothetical protein 0.0004 0.0004 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0018 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.0018 0.0526
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0018 0.0021
Brugia malayi orphan nuclear receptor NR2E1 0.0003 0.0003 0.0003
Onchocerca volvulus 0.0007 0.0018 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0004 0.0004 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0018 0.0021
Schistosoma mansoni hypothetical protein 0.0035 0.0127 0.0149
Loa Loa (eye worm) hypothetical protein 0.0089 0.0339 0.0592
Onchocerca volvulus Huntingtin homolog 0.0089 0.0339 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0779 0.306 0.3607
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2156 0.8485 0.8485
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2156 0.8485 1
Brugia malayi Nuclear hormone receptor E75 0.0003 0.0003 0.0003
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0007 0.0017 0.002
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0003 0.0003 0.0003
Schistosoma mansoni survival motor neuron protein 0.0035 0.0127 0.0149
Loa Loa (eye worm) hypothetical protein 0.0007 0.0018 0.0031
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2156 0.8485 1
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0008 0.0009
Brugia malayi topoisomerase 0.0007 0.0017 0.002
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2156 0.8485 0.8485
Brugia malayi hypothetical protein 0.0089 0.0339 0.0399
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.0018 0.0526
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0018 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0017 0.002
Echinococcus granulosus mixed lineage leukemia protein mll 0.0005 0.0009 0.0011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0003 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0026 0.0092 0.0108
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0127 0.0149
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1456 0.5726 1
Schistosoma mansoni topbp1 0.0007 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0004 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0017 0.002
Brugia malayi hypothetical protein 0.0026 0.0092 0.0108
Loa Loa (eye worm) hypothetical protein 0.0003 0.0003 0.0005
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0779 0.306 0.3607
Giardia lamblia Replication factor C, subunit 1 0.0007 0.0017 0.002
Brugia malayi nuclear receptor RXR 0.0004 0.0004 0.0005

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 500 uM Binding affinity towards cloned human glucagon receptor in BHK cells. ChEMBL. 9857085
Ki (binding) > 500 uM Binding affinity towards cloned human glucagon receptor in BHK cells. ChEMBL. 9857085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.