Detailed information for compound 256345

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.354 | Formula: C20H18O5
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@]1(C)C[C@H](c2ccccc2)c2c(O1)c1cccc(c1oc2=O)O
  • InChi: 1S/C20H18O5/c1-20(23-2)11-14(12-7-4-3-5-8-12)16-18(25-20)13-9-6-10-15(21)17(13)24-19(16)22/h3-10,14,21H,11H2,1-2H3/t14-,20-/m1/s1
  • InChiKey: ZYGQQWWTOAMQBQ-JLTOFOAXSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0045 0.0434 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0019 0.0052
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0019 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.426
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0431
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0045 0.0434 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0045 0.0434 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Echinococcus granulosus glycogen phosphorylase 0.033 0.3572 0.9515
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.0634
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1272 0.3387
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.1506 0.4216
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0019 0.0019
Echinococcus granulosus Smad4 0.0008 0.0024 0.0063
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2508 0.7021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.5003
Echinococcus multilocularis glycogen phosphorylase 0.033 0.3572 0.3572
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0227 0.0634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0966 0.2572
Plasmodium vivax importin-beta 2, putative 0.0032 0.029 0.6684
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1085 0.2889
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0257 0.0684
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.005
Schistosoma mansoni importin beta-1 0.0032 0.029 0.0773
Brugia malayi Pre-SET motif family protein 0.0205 0.2195 0.6145
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0045 0.0434 1
Echinococcus granulosus Glycosyl transferase family 35 0.033 0.3572 0.9515
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0245 0.0652
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0019 0.008
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.1157
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.029 0.6684
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0045 0.0434 0.2852
Trichomonas vaginalis glycogen phosphorylase, putative 0.033 0.3572 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0227 0.1467
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0297 0.0297
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0019 0.005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.4507
Echinococcus multilocularis importin subunit beta 1 0.0032 0.029 0.029
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.0548
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.005
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0024 0.0063
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0045 0.0434 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Echinococcus multilocularis smad 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0019 0.008
Toxoplasma gondii methionine aminopeptidase 0.0045 0.0434 1
Chlamydia trachomatis glycogen phosphorylase 0.033 0.3572 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.0434
Echinococcus granulosus glycogen phosphorylase 0.033 0.3572 0.9515
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.4507
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.029 0.6684
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0223 0.4905
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0966 0.2703
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Trichomonas vaginalis ran, putative 0.0024 0.0196 0.0548
Schistosoma mansoni ran 0.0024 0.0196 0.0521
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0297 0.0297
Trypanosoma brucei methionine aminopeptidase, putative 0.0045 0.0434 1
Giardia lamblia Glycogen phosphorylase 0.033 0.3572 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.005
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0019 0.008
Schistosoma mansoni hypothetical protein 0.0071 0.072 0.1918
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Schistosoma mansoni hypothetical protein 0.0167 0.1775 0.4728
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0604
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0966 0.2572
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0019 0.0431
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0196 0.0196
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.1157
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0966 0.0966
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0045 0.0434 0.2794
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0227 0.1398
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0966 0.0966
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0019 0.0052
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0066
Echinococcus multilocularis Glycosyl transferase, family 35 0.033 0.3572 0.3572
Echinococcus granulosus GPCR family 2 0.0033 0.0297 0.0791
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0019 0.0431
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Brugia malayi Importin beta-1 subunit 0.0032 0.029 0.0813
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0045 0.0434 0.1157
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0196 0.4507
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Echinococcus multilocularis GPCR, family 2 0.0033 0.0297 0.0297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0152 0.0971
Entamoeba histolytica glycogen phosphorylase, putative 0.033 0.3572 1
Schistosoma mansoni Smad4 0.0008 0.0024 0.0063
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0223 0.0623
Loa Loa (eye worm) hypothetical protein 0.0033 0.0297 0.0791
Onchocerca volvulus 0.0027 0.0227 0.0585
Schistosoma mansoni glycogen phosphorylase 0.033 0.3572 0.9515
Schistosoma mansoni hypothetical protein 0.0346 0.3754 1
Entamoeba histolytica glycogen phosphorylase, putative 0.033 0.3572 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0019 0.008
Entamoeba histolytica Ran family GTPase 0.0024 0.0196 0.0548
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0227 0.1467
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0227 0.1398
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Onchocerca volvulus 0.0233 0.2508 0.7005
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0143 0.1506 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0019 0.008
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0227 0.0634
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Plasmodium falciparum importin beta, putative 0.0032 0.029 0.6684
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0019 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0152 0.0898
Echinococcus granulosus smad 0.0008 0.0024 0.0063
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Loa Loa (eye worm) hypothetical protein 0.0104 0.1085 0.2889
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0773
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0019 0.005
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0066
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0196 0.0521
Mycobacterium ulcerans methionine aminopeptidase 0.0045 0.0434 0.2794
Chlamydia trachomatis methionine aminopeptidase 0.0045 0.0434 0.0825
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0143 0.1506 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0297 0.0791
Schistosoma mansoni glycogen phosphorylase 0.0143 0.1506 0.4012
Onchocerca volvulus Glycogen phosphorylase homolog 0.033 0.3572 1
Brugia malayi Methionine aminopeptidase protein type I 0.0045 0.0434 0.1216
Loa Loa (eye worm) hypothetical protein 0.0071 0.072 0.1918
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0019 0.0431
Leishmania major importin beta-1 subunit, putative 0.0026 0.0223 0.5125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0196 0.426
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0045 0.0434 1
Entamoeba histolytica hypothetical protein 0.0026 0.0223 0.0623
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0019 0.005
Brugia malayi RNA, U transporter 1 0.0092 0.095 0.266
Echinococcus multilocularis glycogen phosphorylase 0.033 0.3572 0.3572
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Loa Loa (eye worm) hypothetical protein 0.0029 0.0257 0.0684
Loa Loa (eye worm) Smad1 0.0008 0.0024 0.0063
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0019 0.008
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0019 0.0431
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0045 0.0434 0.0434
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.072 0.2016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0891
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1085 0.3036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1085 0.3036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Treponema pallidum methionine aminopeptidase (map) 0.0045 0.0434 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0297 0.0791
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0297 0.0791
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0223 0.0623
Onchocerca volvulus 0.0029 0.0257 0.067
Loa Loa (eye worm) methionine aminopeptidase type I 0.0045 0.0434 0.1157
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Echinococcus granulosus p2X purinoceptor 4 0.0069 0.07 0.1863
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0024 0.0024
Brugia malayi Smad1 0.0008 0.0024 0.0066
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0024 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0257 0.0684
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0257 0.0257
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0019 0.008
Schistosoma mansoni smad 0.0008 0.0024 0.0063
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0045 0.0434 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.1506 0.4216
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0297 0.0831
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0019 0.008
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0045 0.0434 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0257 0.0684
Echinococcus granulosus geminin 0.0167 0.1775 0.4728
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Entamoeba histolytica glycogenphosphorylase, putative 0.0143 0.1506 0.4216
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0152 0.3505
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0024 0.0063
Schistosoma mansoni ran 0.0024 0.0196 0.0521
Brugia malayi MH2 domain containing protein 0.0121 0.1272 0.356
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0024 0.0024
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0196 0.0521
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0223 0.0623
Schistosoma mansoni hypothetical protein 0.0167 0.1775 0.4728
Loa Loa (eye worm) oxidoreductase 0.0008 0.0019 0.005
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0045 0.0434 0.2852
Schistosoma mansoni P2X receptor subunit 0.0069 0.07 0.1863
Echinococcus granulosus importin subunit beta 1 0.0032 0.029 0.0773
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0045 0.0434 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0257 0.5914
Schistosoma mansoni glycogen phosphorylase 0.033 0.3572 0.9515
Echinococcus multilocularis Smad4 0.0008 0.0024 0.0024
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0227 0.1398
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0227 0.5218
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Echinococcus multilocularis p2X purinoceptor 4 0.0069 0.07 0.07
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0152 0.3505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0966 0.2572
Toxoplasma gondii methionine aminopeptidase 0.0045 0.0434 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0227 0.0634
Leishmania major GTP-binding protein, putative 0.0024 0.0196 0.4507
Loa Loa (eye worm) glycogen phosphorylase 0.033 0.3572 0.9515
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0024 0.0063
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0791
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.029 0.6684
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0966 0.2572
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0297 0.0831
Echinococcus multilocularis geminin 0.0167 0.1775 0.1775
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0227 0.1398
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1272 0.3387
Brugia malayi Pre-SET motif family protein 0.0029 0.0257 0.0719
Trichomonas vaginalis glycogen phosphorylase, putative 0.033 0.3572 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0227 0.1398
Echinococcus multilocularis snurportin 1 0.0346 0.3754 0.3754
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0227 0.1398
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0066
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.3754 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2195 0.5848
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0045 0.0434 1
Echinococcus granulosus snurportin 1 0.0346 0.3754 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0227 0.5003
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0019 0.0052
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0045 0.0434 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0024 0.0063
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0406
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0196 0.4507
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0019 0.0431
Plasmodium vivax SET domain protein, putative 0.0029 0.0257 0.5914
Brugia malayi carbohydrate phosphorylase 0.033 0.3572 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0063

Activities

Activity type Activity value Assay description Source Reference
RPF (ADMET) = 15.1 pM nM-1 Rate of metabolism in liver microsomes (BNF treated rats) ChEMBL. 3981543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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